The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation by Yu-Xin Lei, Yang Liu, Li-Hua Xing, Yu-Jing Wu, Xue-Yin Wang, Fan-Hua Meng, Ya-Nan Lou, Zhao-Guo Ma, Lin Yuan, Shui-Xing Yu

“…Host innate immunity plays a pivotal role in the early detection and neutralization of invading pathogens. …”
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Empowering African Researchers: Insights from the EVA-GLOBAL Workshops by Gilbert N. Chofong, Stephen K. Torpko, Kone Nahoua, Faith T. Olayiwola, Shey R. Adamu, Leonard A. Afouda, Shina Salihu, Ubandoma Andefiki, Martial Tene Tayo, George Akumfi Ameyaw, Katja R. Richert-Pöggeler

“…Participants from various African coun­tries benefitted from both onsite and online lecture models, ensuring broad participation. The initiative reflects a con­certed effort to empower researchers and strengthen global capabilities in virus monitoring, detection and management, offering a promising perspective for improved disease control and agricultural resilience in LMICs. …”
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The importance of targeted next-generation sequencing based genomic profiling in the diagnosis of childhood acute myeloid leukemia: a single center experience by Dilek Kaçar, Büşranur Çavdarlı, Ayça Koca Yozgat, Melek Işık, Fatma Burçin Kurtipek, Fatma Tuba Yıldırım, Turan Bayhan, Dilek Gürlek Gökçebay, Namık Yaşar Özbek, Neşe Yaralı

“…Results. Variants were detected in 44.8% of patients, and 63.2% of them were in the signaling pathway genes. …”
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Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype by Maciej Wojszczyk, Julia Kulbacka, Karol Dziedzic, Filip Arczewski, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Witold Czyż, Piotr Pasek, Julia Ryniecka

“…It is estimated that LADA affects between 4% and 12% of adults initially diagnosed with type 2 diabetes, making it a more common disease entity than previously thought. …”
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Healthcare workers’ perspectives on integrated oral and antenatal health care at public health facilities in southwestern nigeria: a qualitative study by Love Bukola Ayamolowo, Oluwabunmi Samuel Ibitoye, Ayodeji Omobolanle Esan, Folahanmi Tomiwa Akinsolu, George Uchenna Eleje, Abideen Olurotimi Salako, Ifeoma Eugenia Idigbe, Joanne Lusher, Oliver Chukwujekwu Ezechi, Moréniké Oluwátóyìn Foláyan

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The prediction of haemophilic arthropathy progression based on MRI findings and clinical characteristics by Lu Zhang, Jinxia Guo, Shufang Wei, Jiajia Li, Yincong Dou, Tianming Cheng, Yinghui Ge, Tuo Zhang

“…The inclusion criteria were joints with a history of haemorrhage and initial/posttreatment reevaluation with X-ray and MRI. …”
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Informative Value of Combination of Molecular Genetic and Cytogenetic Diagnostic Methods in Myelofibrosis by Lozynskyy R., Voronyak M., Poluben L., Dmytrenko I., Lozynska M., Vygovska Ya., Maslyak Z.

“…All the patients underwent molecular genetic studies of blood to detect the JAK2V167F mutation. The mutational status of JAK2 gene was reexamined in 10 patients from 1 to 2 years after the initial examination. …”
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Artificial intelligence-enabled non-invasive ubiquitous anemia screening: The HEMO-AI pilot study on pediatric population by Daniel Gordon, Jason Hoffman, Keren Gamrasni, Yotam Barlev, Alex Levine, Tamar Landau, Ronen Shpiegel, Avishai Lahad, Ariel Koren, Carina Levin, Osnat Naor, Hannah Lee, Xin Liu, Shwetak Patel, Gilad Chayen, Michael Brandwein

“…It identifies important sample collection parameters and design, provides critical algorithms for the pre-processing of fingernail data, and reports an initial capability to detect anemia with 87% sensitivity and 84% specificity. …”
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Multidisciplinary intervention for adverse events associated with ATZ + BEV therapy: a case report by Ko Masaki, Motoyasu Miyzaki, Kota Mashima, Yasutaka Sumi, Kohei Noda, Syohei Ueno, Takashi Tanaka, Nobutaka Takahashi, Susumu Kaneshige, Hidetoshi Kamimura

“…ATZ + BEV combination therapy was initiated for unresectable hepatocellular carcinoma on day 0. …”
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Predictors of pre-hospital delay among stroke patients in Yekatit-12 hospital Addis Ababa, Ethiopia: unmatched case-control study by Biniyam Tedla Mamo, Dawit Bekele Tefera, Makida Girma Altaye, Ferehiwot Gebrehiwot Geram, Anteneh Mitiku Dano, Yeteshaw Bekele Sana, Feven Sahle Gebre, Zelalem Tazu Bonger

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Test and treat—impact of microbiological testing on antibiotic prescribing for Legionnaires’ disease in Switzerland: results of the multicentre SwissLEGIO study by Melina Bigler, Florian Zacher, Sarah Dräger, Werner C. Albrich, Daniel Mäusezahl, the SwissLEGIO Hospital Network

“…Conclusion Routine aetiological testing for LD has improved the clinical management of CALD by facilitating rapid detection of CALD cases and timely initiation of appropriate and targeted antibiotic therapy. …”
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Perceptual Response Training for Reduction of Injury Risk Among High School Girls’ Soccer Players by Gary B. Wilkerson, Kyle S. Mether, Zoë A. Perrin, Samuel L. Emberton, Lynette M. Carlson, Jennifer A. Hogg, Shellie N. Acocello

“…<b>Background/Objectives:</b> Neural processes involved in visual detection, decision-making, and motor plan execution are believed to play a key role in the avoidance of sport-related injuries, but very little evidence exists to guide the development of training activities for the optimization of brain function. …”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…A random-effects meta-analysis was employed to assess efficacy differences between drugs with various mechanisms and placebo. Initial Pearson correlation analysis explored the relationships between biomarkers and LFC. …”
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PREGNANCY AND DENTAL HEALTH: NAVIGATING THE COMPLEXITIES OF ORAL CARE, RISKS AND PREVENTIVE APPROACHES FOR EXPECTANT MOTHERS by Ciprian Gavrila Ilea, Irina Liviana Stoian, Alexandra Pangal, Bogdan Doroftei, Adeline Samar Nassouh, Laurian Lucian Francu, Corina Ciupilan, Monica Mihaela Scutariu

“…Additionally, it highlights preventive strategies, including improved oral hygiene practices, early detection, and the integration of dental care into routine prenatal healthcare. …”
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Glacial ring forms on Axel Heiberg Island, Nunavut, Canada by S. M. Hibbard, S. M. Hibbard, G. R. Osinski, E. Godin, C. Andres, A. Kukko, A. Kukko, S. Chartrand, A. Grau Galofre, A. M. Jellinek, W. Boucher

“…This striking landform was initially identified in the Canadian High Arctic on the south coast of Devon Island, Nunavut, Canada. …”
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Lactate, an Essential Metabolic Marker in the Diagnosis and Management of Pediatric Conditions by Alina Belu, Nina Filip, Laura Mihaela Trandafir, Elena Lia Spoială, Elena Țarcă, Diana Zamosteanu, Gabriela Ghiga, Jana Bernic, Alina Jehac, Elena Cojocaru

“…As the role of lactate in pediatric pathology continues to evolve, optimizing measurement protocols and exploring new therapeutic strategies will enhance early detection, intervention, and clinical outcomes for critically ill children.…”
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Distant Metastasis of Merkel Cell Carcinoma: A Descriptive Study by Clara Muntaner-Virgili, Júlia Boronat-Cucarull, Josep Ramon Ferreres, Marta Gamissans, Joaquim Marcoval, Davinia Fernández-Calvo, Rosa María Penín, Josep Bermejo, Lia Huesa-Barceló, Sergio Manzano-Mora, Eric Ruzafa-Martínez, María Teresa Bajén-Lázaro, Ana Benítez-Segura, Paula Cecilia Notta, Laura Jiménez-Colomo, Juan Martín-Liberal, Pablo Araguas-Mora, Marc Juárez-Lozano, Isabel Linares-Galiana

“…The locations of the first metastasis detected were recorded, both at tumor diagnosis and during follow-up after initial treatment. …”
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Approaches to Evaluate Whole Exome Sequencing Data That Incorporate Genetic Intolerance Scores for Congenital Anomalies, Including Intronic Regions Adjacent to Exons by Kosuke Taniguchi, Fuyuki Hasegawa, Yuka Okazaki, Asuka Hori, Hiroko Ogata‐Kawata, Saki Aoto, Ohsuke Migita, Tomoko Kawai, Kazuhiko Nakabayashi, Kohji Okamura, Kana Fukui, Seiji Wada, Katsusuke Ozawa, Yushi Ito, Haruhiko Sago, Kenichiro Hata

“…We aimed to improve diagnostic precision by developing an effective WES‐based strategy for detecting congenital anomalies. Methods Initially, 128 probands with congenital anomalies were assessed using trio‐WES and copy number variation analysis—variant interpretation was for exons and splice sites. …”
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Tearing down inequalities in the healthcare system across Europe: the BEACON project by Chrysanthi Koukoutzeli, Giulia Ferraris, Veronica Coppini, Maria Vittoria Ferrari, Elisa Fragale, Dario Trapani, Dario Trapani, Ida Minchella, Roberto Grasso, Roberto Grasso, Giuseppe Curigliano, Giuseppe Curigliano, Gabriella Pravettoni, Gabriella Pravettoni

“…Although numerous European initiatives address prevention, early diagnosis, and treatment, significant disparities in access to innovative cancer therapies persist. …”
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Reduction with zinc — Impact on the determination of nitrite and nitrate ions using microfluidic paper-based analytical devices by Mika I. Umeda, Kaewta Danchana, Takatoshi Fujii, Eiichi Hino, Yusuke Date, Kaoru Aoki, Takashi Kaneta

“…Initially, the sensitivity to nitrate corresponded to 55% that of nitrite, which implied an incomplete reduction. …”
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