Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis by Anup Dey, Matthew Butcher, Anne Gegonne, Ryoji Yagi, Keita Saeki, Eunju Lee, Dinah S. Singer, Jinfang Zhu, Keiko Ozato

“…In contrast, the number of T cells detected in the CNS of Brd4cKO mice was much fewer. …”
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Distribution and abundance of key vectors of Rift Valley fever and other arboviruses in two ecologically distinct counties in Kenya. by Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander

“…Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence. …”
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Peripheral blood basophils are the main source for early interleukin-4 secretion upon in vitro stimulation with Culicoides allergen in allergic horses. by Fahad Raza, Susanna Babasyan, Elisabeth M Larson, Heather S Freer, Christiane L Schnabel, Bettina Wagner

“…Human and mouse studies additionally suggest that basophils have a unique role in the regulation of allergic diseases by providing initial IL-4 to drive T cell development towards the Th2 phenotype. …”
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First Rib Resection Using Videothoracoscopy in Patients With Vascular Thoracic Outlet Syndrome by Agustín Buero, Soledad Olivera Lopez, Gustavo A. Lyons, Leonardo G. Pankl, Pablo Young, Domingo J. Chimondeguy

“…No recurrences were detected during midterm follow up (median of 17.9 months, interquartile range 7.3, 45). …”
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The relationship of physical exercise and suicidal ideation among college students: a moderated chain mediation model by Jinrui Zhou, Feng Sun

“…Gender moderates both the initial segment of the physical exercise → meaning in life → suicidal ideation pathway and the direct effect on suicidal ideation.…”
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Physicochemical Stability of Nab-Paclitaxel (Pazenir) Infusion Dispersions in Original Glass Vials and EVA Infusion Bags by Helen Linxweiler, Judith Thiesen, Irene Krämer

“…Paclitaxel concentrations remained >95% of the initial concentrations for 7 days (RTU 2–8 °C, RTA 25 °C) and for 14 days (RTA 2–8 °C). …”
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Cadonilimab combined with trastuzumab and chemotherapy for HER2-positive gastric cancer with bone marrow metastasis and DIC: a case report and literature review by Meijing Chen, Jiwen Fan, Danyang Zhou, Boran Cheng, Shubin Wang, Gangling Tong

“…Notably, next-generation sequencing (NGS) detected a high plasma HER-2 copy number (34.88). Given her ECOG performance status of 2, initial therapy consisted of trastuzumab combined with docetaxel and fluorouracil, alongside supportive care. …”
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MEGA PROTAC, MEGA DOCK-based PROTAC mediated ternary complex formation pipeline with sequential filtering and rank aggregation by Sadettin Y. Ugurlu, David McDonald, Ramazan Enisoglu, Zexuan Zhu, Shan He

“…The docking establishes an initial exploration area for PPCs. A sequential filtration strategy combined with rank aggregation is employed to choose a subset of PPCs for grid search. …”
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Molecular Characteristics and Antimicrobial Resistance of Linezolid-Resistant Staphylococcus aureus in Osteoarticular Infections: A 11-Year Study From a Hospital in Xi’an by Zhou S, Zhou K, Yang P, Kong M, Liu H, Zhang R, Hou Z, Liu J

“…Among the 797 S. aureus isolates, eight strains were initially identified as LRSA through VITEK2; however, only one isolate was confirmed as LRSA by BMD. …”
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Interannual variability of the Barents Sea branch water in the northeastern part of the Barents Sea and the St. Anna Trough by Zinaida Zabudkina, Zinaida Zabudkina, Alexander Osadchiev, Alexander Osadchiev, Alexander Osadchiev, Vladimir Ivanov, Vladimir Ivanov, Mikhail Makhotin, Viktor Merkulov

“…However, significant warming was detected in the northeast part of the Barents Sea after 2000. …”
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Long-term sequelae of coronavirus disease: long COVID-19 and cardiovascular outcomes (a literature review) by A. V. Hovornyan, T. O. Ilashchuk

“…As a result, in 2021, at the WHO level, the concept of “long-term COVID” was introduced, including more than 100 already described symptoms in patients for at least 3 months after initial recovery. At the same time, the clinical symptoms are not specific, strategies for the treatment of such disorders have not been worked out, and measures to detect and/or prevent the development of these complications have not been organized. …”
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Synergy and competition during the anaerobic degradation of N-acetylglucosamine in a methane-emitting, subarctic, pH-neutral fen by Katharina Kujala, Oliver Schmidt, Marcus A. Horn

“…Supplemental N-acetylglucosamine was fermented to acetate, ethanol, formate, and CO2 during the initial incubation of anoxic peat soil microcosms without preincubation. …”
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Non-uniform temperature fields and debonding of a long-span CFST arch bridge under coupled environmental actions by Qian Zhou, Jiao Wan, Jingzhou Xin, Jiu-qun Mao, Jianting Zhou

“…Experimental and theoretical analyses yielded several significant findings: (1) During the hydration exothermic phase, the temperature field at concrete center exhibited a tri-linear distribution pattern (characterized by rapid initial rise, subsequent decline, and final stabilization), with the ascending rate significantly exceeding the descending rate; temperatures exceeded 50°C between 25 and 73 h post-placement. (2) The external steel tube temperature demonstrated sinusoidal diurnal variations during and post-hydration, closely correlating with ambient temperature fluctuations; after hydration, concrete temperatures also followed sinusoidal diurnal distributions, with amplitudes increasing proportionally to radial distance from the center. (3) A pronounced radial temperature gradient from center to surface manifested during hydration, reaching a maximum differential of 40°C; the temperature gradients substantially decreased to 7°C after hydration. (4) Longitudinal stress differentials between the interface steel tube and concrete measured 42.5 MPa (sun-exposed side) and 74.2 MPa (shadowed side), while radial stress differentials were −1.37 MPa and −0.34 MPa, respectively. (5) The temperature field model demonstrated a tri-linear distribution pattern with an effective influence depth of D/8 to D/4 (where D represents steel tube diameter); the temperature constant exhibited significant temporal dependency on environmental conditions and hydration heat evolution. (6) Although longitudinal relative slip occurred at the steel-concrete interface during placement, no void was detected.…”
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A case of long-term tolerance after kidney transplantation by A. A. Korzhenevsky, N. P. Korzhenevskaya

“…Deforming osteoarthritis of the right hip joint was detected, and the hip replacement surgery was suggested. …”
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Assessment of Meat Quality and Shelf Life from Broilers Fed with Different Sources and Concentrations of Methionine by Antonia Albrecht, Martin Hebel, Céline Heinemann, Ulrike Herbert, Dennis Miskel, Behnam Saremi, Judith Kreyenschmidt

“…The fillets showed a normal initial microbial quality (2.5 log10 cfu/g) and spoilage process with microbial counts of 8.5 log10 cfu/g at the end of storage. …”
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Psychometrical properties of the Turkish translation of the New Knee Society Scoring System by Fatih Özden, Nazan Tuğay, Baki Umut Tuğay, Cem Yalın Kılınç

“…Patients completed WOMAC, KOOS and SF-36 surveys along with the Turkish version of the new KSS. After the initial evaluation, patients were asked to refill the new KSS 1 week later. …”
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The impact of the structural state of the tubulin cytoskeleton on chlorophyll fluorescence indicators and auxin content in Solanum tuberosum by I.Yu. Makeeva, T.I. Puzina

“…Disruption of the structural state of microtubules reduced the initiation of tuberization and the productivity of potato plants. …”

Machine learning-driven development of a stratified CES-D screening system: optimizing depression assessment through adaptive item selection by Ruo-Fei Xu, Zhen-Jing Liu, Shunan Ouyang, Qin Dong, Wen-Jing Yan, Dong-Wu Xu

“…Results The resulting stratified screening system consists of an initial four-item rapid screening layer (encompassing emotional, cognitive, and interpersonal dimensions) for detecting probable depression (AUC = 0.982, sensitivity = 0.945, specificity = 0.926), followed by an enhanced assessment layer with five additional items. …”
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Hydrothermal liquefaction of southern yellow pine with downstream processing for improved fuel grade chemicals production by Tawsif Rahman, Hossein Jahromi, Poulami Roy, Bijoy Biswas, Sushil Adhikari

“…The catalytic and non-catalytic biocrude products were chosen to undergo HYD treatment at 400 °C under high hydrogen pressure (initial 1000 psi) using an alumina-supported cobalt-molybdenum catalyst. …”
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Using contactless methods of diagnostics of high electric fields by A. V. Golenischev-Kutuzov, D. A. Ivanov, A. A. Potapov, V. I. Krotov

“…An analysis of emergencies at substations and open switchgears [1- 2, 4] was carried out, which showed that in most cases the causes of damage to high-voltage insulators are natural aging in an applied electric field, overvoltage, and the presence of initial defects in the manufacture of high-voltage insulators. …”
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