Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer by Gerhard Rogler, Arndt Hartmann, Marianne Rebecca Spalinger, Michael Scharl, Elisabeth Naschberger, Jesus Francisco Glaus Garzon, Silvia Lang, Kirstin Atrott, Philipp Busenhart, Ana Montalban-Arques, Egle Katkeviciute, Yasser Morsy, Chiara Van Passen, Larissa Hering, Michael Stürzl

“…Antibody-mediated inhibition of integrin αvβ6 sparked a potent cytotoxic T-cell response and overcame resistance to programmed cell death protein 1 (PD-1) blockade therapy in ITGB6 expressing tumors, provoking a drastic increase in anti-PD-1 treatment efficacy. …”
Get full text

Intensive and critical care nurses’ compliance, barriers, and challenges with ventilator-associated pneumonia prevention: a cross-sectional study by Hazel Novela Villagracia, Tahani Nasser Alhejaili, Bushra Alshammari, Salwa Abd El Gawad Sallam, Awatif Mansour Alrasheeday, Lea L. Dando, Odeta A. Nacubuan, Habib Alrashedi, Shaimaa Mohamed Nageeb, Larry Terence O. Cornejo, Rico William A. Villagracia, Soha Kamel Mosbah Mahmoud, Ingrid Jacinto-Caspillo, Rizal Angelo N. Grande, Daniel Joseph E. Berdida, Bahia Galal Abd Elrazik Siam

“…As a result, nurse managers could create comprehensive programs like long-term VAP prevention training and interdisciplinary collaboration in the ICU. …”
Get full text

Neck pain burden in China and G20 countries: an analysis of 1990–2021 with a 30-year forecast for China by Huale Li, Huale Li, Zhichun Chang, Zhichun Chang, Ting Qin, Ting Qin, Yanfang Li, Yanfang Li, Mingren Hu, Xinjing Yang, Jun Li, Jun Li, Yufeng Xie, Yufeng Xie

“…The analysis is conducted via the R programming language, with joinpoint regression employed to calculate the APC and AAPC. …”
Get full text

Heat stress-induced genomic instability in neural stem cells and its association with neuronal developmental deficits by Zeze Wang, Zhen Luo, Yulong Tan, Xue Luo, Xuesen Yang

“…The ''first hit'' is an acute disruption of developmental programming via a p53-p21-mediated response to DNA damage. …”
Get full text

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages by Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue

“…Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM. …”
Get full text

Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…Biacore-based binding data indicate that both vibostolimab and tiragolumab bind on TIGIT with comparable binding affinity (KD), but different binding kinetics characterized by faster on and off rates, which may contribute to enhanced T-cell activation with vibostolimab, as evidenced by greater IL-2 production in an in vitro cell-based assay. …”
Get full text

Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…Countries were categorized into Eastern (EEC), Mediterranean (MEC), and Northern European (NEC). We analyzed LT indications, recipient and donor age, transplant type, and WL outcomes from 2012 to 2022. …”
Get full text

Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity by Xingbin Hu, Wenhao Ouyang, Haizhu Chen, Zhihong Liu, Zijia Lai, Herui Yao

“…Background: Gastric cancer (GC) is a common malignancy characterized by the absence of reliable prognostic indicators and effective therapeutic targets. Claudin-9 (CLDN9) has been demonstrated to be upregulated in various cancers. …”
Get full text

Knowledge, attitudes and strategies on contraceptive utilization among adolescents: views from beneficiaries and parents in City of Kigali by Jean Baptiste Hategekimana, Adolphe Ndikubwimana, Justin Ndayisenga, Fidele Niyitegeka, Daniel Ukwishatse, Serieux Cyubahiro, Bivegete Kenny Ntwali, Absolomon Gashaija, Alice Nyirazigama, Noel Korukire, Felix K. Rubuga, Patrick Karakwende, Celestin Banamwana, Pierre Dukuziyaturemye, Jean Muhire, Marie Josee Mwiseneza, Theoneste Ntakirutimana, Deborah Oluwaseun Shomuyiwa, Don Eliseo Lucero-Prisno III

“…Improved education and awareness programs for both adolescents and parents, along with supportive community strategies, may enhance contraceptive utilization. …”
Get full text

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…The therapeutic use of these Nb-Fc fusion proteins was evaluated, either as monotherapy or as combination therapy with anti-programmed cell death protein-1 (anti-PD-1), in both the LLC-OVA and MC38 mouse models.Results We were able to discern two ti-Treg populations, one of which is characterized by the unique expression of Ccr8 in conjunction with Treg activation markers. …”
Get full text

Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment by Yan Li, Haiting Sun, Yufen Huang, Anqi Yin, Linjuan Zhang, Jiao Han, Yixuan Lyu, Xiangzhao Xu, Yifang Zhai, Huan Sun, Ping Wang, Jinyang Zhao, Silong Sun, Hailong Dong, Feng Zhu, Qiang Wang, Luis Augusto Rohde, Xuefeng Xie, Xin Sun, Lize Xiong

Get full text

Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Results obtained in this study permit to elucidate some variables which could be used as indicators for monitoring programs with emphasis on this resource. …”
Get full text

The triple-helix model as foundation of innovative entrepreneurial ecosystems by Klaus Bruno Schebesch, Horațiu Florin Șoim, Radu Lucian Blaga

“…This study aims at leveraging the city-based view on entrepreneurial ecosystems, to enable new ways of boosting the functionality of triple-helix minded programs, especially so for emerging economies and their cross-border regions. …”
Get full text

Autopercepción del nivel de logro de los Estándares Disciplinarios y Pedagógicos en estudiantes de educa-ción física de dos universidades de Santiago de Chile (Self-perception of t... by Elizabeth Flores Ferro, Fernando Maureira Cid, Francisca Pauvif Cárcamo, Elvira Palma Gajardo, Jessica Ibarra-Mora, Claudia Muñoz Vargas, Bruno Quilodrán Muñoz

“…These variables should be investigated and their relationship with educational models, programs and curricula according to study house. …”
Get full text

Association of self-efficacy, risk attitudes, and time preferences with health-related quality of life and functioning after total hip or knee replacement – Results of the MobilE-T... by Sebastian Fuchs, Lars Schwettmann, Benedict Katzenberger, Alexander Paulus, Boris Michael Holzapfel, Johanna Theresia Biebl, Martin Weigl

“…If these findings can be confirmed in further research, strategies to improve self-efficacy should be considered in prehabilitation programs. Trial registration Not applicable.…”
Get full text

Point prevalence survey of antibiotic use in Mexican secondary care hospitals. by Federico A Zumaya-Estrada, Celia M Alpuche-Aranda, Hilda Ivonne Huerta Icelo, Felipe D Neri-Estrada, Verónica M Calixto Silva, Haydee E Quiroz Escoriza, Jesus Ulises Garza-Ramos, Pedro J Saturno-Hernandez

“…Point prevalence surveys (PPSs) enable the surveillance of antibiotic prescribing at the patient level in small hospitals that lack the resources to establish antimicrobial stewardship programs (ASP). In this study, we analyzed antibiotic use at two public secondary care hospitals in Mexico using PPSs.…”
Get full text

Dynamics of c-kit immunopositive pancreatic beta cells influenced by exogenous factors or endogenous pathology by T. V. Ivanenko, Yu. M. Kolesnyk, A. V. Abramov

“…Results. The quantitative indicator of beta cells was almost 6 times decreased in rats with diabetes mellitus. …”
Get full text

L’ITALIANO L2 TRA LAVORO DI CURA E PLURALITÀ IDENTITARIA: UN’INDAGINE SUI BISOGNI FORMATIVI DELLE ASSISTENTI FAMILIARI DALL’EST EUROPA ATTRAVERSO L’AUTOBIOGRAFIA LINGUISTICA... by Edith Cognigni, Tatiana Borisova, Elena Michelini

“…Thematic analysis reveals that most participants articulate a “sought” or “balanced” identity, indicative of conscious efforts toward social and professional integration. …”
Get full text

CHARACTERISTICS OF PSYCHOLOGICAL MATURITY AS A SOFT-SKILL OF A MODERN PERSONALIT by Mitchenko Kateryna

“…The author determines that modern research and the experience of leaders in various fields of work indicate an increase in the role of soft skills in occupational programs and requirements for candidates for employment, which in turn leads to an improvement in positive emotional integrity in terms of increasing the team’s performance, the effectiveness of training and mutual development, a positive perception of any challenges and solving urgent problems of the enterprise, and the way to use one’s own creativity, flexibility, responsibility and independence. …”
Get full text

Current status of nurses’ public health emergency response capacity for emerging infectious disease: a cross-sectional study by Qin Qiu, Qin Qiu, Yuntong Liu, Fanping Meng, Fanping Meng, Xinhua Wang, Chunxiang Su

“…Future initiatives should prioritize strengthening theoretical reinforcement training and cognitive transformation programs for nurses, while accelerating the development of EID specialty nurses and inter-hospital collaboration. …”
Get full text