Peptide vaccine targeting mutated GNAS: a potential novel treatment for pseudomyxoma peritonei by Ben Davidson, Kjersti Flatmark, Annette Torgunrud, Karianne G Fleten, Hedvig V Juul, Nadia Mensali, Christin Lund-Andersen, Else Marit Inderberg

“…A large proportion of T cells expressed immune checkpoint molecules, in particular programmed death receptor-1 and T cell immunoreceptor with Ig and ITIM, indicating that these T cells were antigen experienced.Conclusion These findings point to the existence of a pre-existing immunity in patients with PMP towards mutated Gsα, which has been insufficient to control tumor growth, possibly because of inhibition of antitumor T cells by upregulation of immune checkpoint molecules. …”
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Breast screening participation and retention among immigrants and nonimmigrants in British Columbia: A population‐based study by Ryan R. Woods, Kimberlyn M. McGrail, Erich V. Kliewer, Arminee Kazanjian, Colin Mar, Lisa Kan, Janette Sam, John J. Spinelli

“…Abstract Breast cancer screening programs operate across Canada providing mammography to women in target age groups with the goal of reducing breast cancer mortality through early detection of tumors. …”
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Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection by Ruiling Zhou, Kangshuai Sun, Xiao Xie, Fei Yin, Jorge Galindo-Villegas

“…The results revealed tissue- and time-specific significant changes, indicating increased oxidative stress and activation of compensatory antioxidant and mucosal immune defenses. …”
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Molecular biology of glucose-6-phosphate dehydrogenase and UDP-glucuronosyltransferase 1A1 in the development of neonatal unconjugated hyperbilirubinemia by Yi-Li Hung, Pi-Feng Chang, Ching-Shan Huang

“….−53 A(TA)6TAA > A(TA)7TAA nor c.211G > A causes it; (5) in breast-fed East Asian neonates, the TA7 repeat variant of the UGT1A1 gene protects against the development of NUH; (6) G6PD deficiency combined with homozygous c.211G > A variation of the UGT1A1 gene increases the risk of severe NUH; (7) in Pakistani and Caucasian patients with Crigler–Najjar syndrome type 2 (CN-2), point mutations of the UGT1A1 gene are widely distributed and frequently occur with variation at nucleotide −53, whereas in Asian patients with CN-2, compound homozygous variations in the coding region are frequently observed; and (8) records of G6PD deficiency and UGT1A1 variation status for a neonate offer useful pharmacogenomic information that can aid long-term care. These results indicate that timely diagnosis of NUH through molecular tests is crucial and that early initiation of treatment for the neonates and educational programs for their parents improves outcomes.…”
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Childhood exposure to intimate partner violence against women and its association with violence against children in refugee settlements in Uganda by George Odwe, Francis Obare, Stella Muthuri, Peter Kisaakye, Dagim Habteyesus, Gloria Seruwagi, Yohannes Dibaba Wado, Yadeta Dessie, Bonnie Wandera, Caroline W. Kabiru, Chi-Chi Undie

“…Violence prevention and response programs should pay attention to IPVAW as a risk factor for VAC, emphasizing integrated approaches that target both forms of violence within households.…”
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Development and validation of a risk prediction model for abdominal aortic aneurysm: a nationwide population-based cohort study by Hyung-jin Cho, Mi-hyeong Kim, Kyung-Jai Ko, Kang-woong Jun, Kyung-do Han, Jeong-Kye Hwang

“…Although AAA screening programs targeting specific demographics are available, there is room for improvement in terms of inclusivity and cost-effectiveness. …”
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The Influence of Season and Age on Specific Semen Traits and Reproductive Behavior in Carpatina Breed Bucks by Constantin Pascal, Claudia Pânzaru, Răzvan-Mihail Radu-Rusu, Vasile Maciuc, Alexandru Marian Florea, Ionică Nechifor

“…This research has valuable implications for optimizing breeding programs, contributing to genetic advancement, and improving management strategies in goat farming, especially within temperate continental climates.…”
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How far along the future path do individuals recognize the path for stepping on multiple footfall targets? A new evaluation method under virtual reality by Ryotaro Waki, Ryotaro Waki, Kazuyuki Sato, Kazuyuki Sato, Junki Inoue, Junki Inoue, Minoru Yamada, Takahiro Higuchi

“…In three of these conditions, all three colored squares present in the same row—located either one, two, or three rows ahead of the participants—were programmed to change to white (i.e., N + 1, N + 2, and N + 3 conditions). …”
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Prediction of Complications in Gunshot Wounds of the Pelvis in Women Received in Armed Conflict by M. A. Polidanov, V. V. Maslyakov, M. A. Barulina, S. V. Kapralov, A. V. Parshin, S. E. Uryadov, K. A. Volkov, D. T. Tashukhozhaeva

“…Taking into account the fact that the prediction of the development of such a formidable complication as peritonitis and its complications is of great clinical importance, we, using artificial intelligence, analyzed the main indicators influencing the development of complications, which, in turn, made it possible to create two programs: “A system for predicting the likelihood of complications after surgery for patients with peritonitis” and “An Internet service for predicting the likelihood of postoperative complications in patients with peritonitis”, for which patents of the Russian Federation have already been received.…”
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Quality Management Outweighs Pandemic: Retrospective Analysis Shows Improved Quality of Care for <i>Staphylococcus aureus</i> Bacteremia Despite SARS-CoV-2 by Lena Jakoby, Ernst Molitor, Nico T. Mutters, Ruth Weppler, Dominic Rauschning, Manuel Döhla

“…Several studies show that the quality of care and thus the outcome can be positively influenced by the involvement of infectious disease specialists and structured programs like Antimicrobial Stewardship (AMS). In 2020, the SARS-CoV-2 pandemic occurred, which dominated the healthcare system and global events during this time. …”
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Intraspecific Variability of Wormwood (<i>Artemisia absinthium</i> L.) Occurring in Poland in Respect of Developmental and Chemical Traits by Olga Kosakowska, Zenon Węglarz, Agnieszka Żuchowska, Sylwia Styczyńska, Ewa Zaraś, Katarzyna Bączek

“…This diversity may be valuable for future breeding programs and for the selection of populations with desired phytochemical profiles for medicinal, food, and agricultural applications. …”
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Risk factors associated with health literacy among community residents in China based on multiple correspondence analysis and ordinal logistic regression by Mengqian Gao, Shuo Yang, Hongtao Zhang, Ying Huang, Hui Xiao, Zhanming He, Chao Qiu, Jianyun Lu

“…Public health policies should focus on improving educational opportunities and providing tailored health education programs to enhance health literacy, thereby reducing health disparities.…”
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Healthcare practitioners and robotic-assisted rehabilitation: understanding needs and barriers by Giovanna Nicora, Enea Parimbelli, Maria Cristina Mauro, Francesca Falchini, Marco Germanotta, Alessio Fasano, Giuseppina Sgandurra, Elena Beani, Emanuele Gruppioni, Francesca Bugané, Irene Giovanna Aprile, Silvana Quaglini, the Mission 1 Fit4MedRob Consortium

“…The survey highlights the need for enhanced training and education on robotics in rehabilitation programs. Additionally, the limited focus on home rehabilitation is noted. …”
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Bayesian joint-regression analysis of unbalanced series of on-farm trials by Turbet Delof, Michel, Rivière, Pierre, Dawson, Julie C, Gauffreteau, Arnaud, Goldringer, Isabelle, van Frank, Gaëlle, David, Olivier

“…This challenge is not unique to PPB, as many breeding programs use sparse testing or incomplete block designs to evaluate more genotypes, however in PPB genotypes are not always assigned randomly to environments. …”
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Inheritance of Drought Tolerance in a F₃ Biparental Population of Pinto Saltillo (<i>Phaseolus vulgaris</i> L.) × Tepary Cafe (<i>Phaseolus acutifolius</i> A. Gray) by Marcela Cília-García, José Cruz Jiménez-Galindo, Cecilia Beatriz Peña-Valdivia, Ebandro Uscanga-Mortera, Antonio García-Esteva, Daniel Padilla-Chacón

“…The results highlight lines that can be candidates for the registration of new drought-tolerant varieties or used as sources of drought tolerance in future common bean improvement programs. Our results indicate that multiple genetic factors are involved in the drought tolerance response of the F₃.…”
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Skateboarding’s Olympic journey: do the performance profiles of top athletes remain consistent? by Chloé Fouillot, Chloé Fouillot, Guillaume Saulière, Juliana Antero, Adrien Sedeaud, Jean-François Toussaint, Jean-François Toussaint

“…For men, both AUC and age at peak performance increased significantly, indicating a widening of the optimum performance age range.DiscussionThe inclusion of skateboarding into the Olympic programs has expanded career opportunities, lowering peak performance age for women and broadening the optimal age range for men. …”
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Blockade of CLEVER-1 restrains immune evasion and enhances anti-PD-1 immunotherapy in gastric cancer by Tianwei Xu, Jing Qin, Xiaolei Zhang, Zihao Zhang, Xinxin Guo, Yifan Cao, Yichao Gu, Kuan Yu, Leihao Wang, Zhenbin Shen

“…Co-targeting CLEVER-1 and PD-1 synergistically enhanced antitumor responses.Conclusions High infiltration of CLEVER-1+TAMs indicates immune suppression and poor prognosis in GC. …”
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Cross-Disciplinary Rapid Scoping Review of Structural Racial and Caste Discrimination Associated with Population Health Disparities in the 21st Century by Drona P. Rasali, Brendan M. Woodruff, Fatima A. Alzyoud, Daniel Kiel, Katharine T. Schaffzin, William D. Osei, Chandra L. Ford, Shanthi Johnson

“…The evidence from the literature indicates that genetic variations and biological differences (e.g., disease prevalence) occur within and between races/castes for various reasons (e.g., random gene mutations, geographic isolation, and endogamy). …”
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Psychosocial hazards and work-life balance: the role of workplace conflict, rivalry, and harassment in Latvia by Diāna Inga Paegle, Svetlana Lakiša, Linda Matisāne, Monta Matisāne, Linda Paegle, Kristīne Mārtinsone, Daiga Kamerāde, Daiga Kamerāde, Valentīna Krūmiņa, Elīna Akmane, Amanda Ķule, Ivars Vanadziņš

“…Practical implications include prioritizing leadership development programs focusing on conflict resolution and fostering a supportive organizational culture to improve employee WLB.…”
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Realidad virtual inmersiva y su influencia en parámetros fisiológicos de personas sanas (Immersive virtual reality and its influence on physiological parameters in healthy people)... by Gustavo Rodriguez-Fuentes, Pablo Campo-Prieto, Xose Carlos Souto, Jose Maria Cancela Carral

“…Immersive virtual reality (IVR) exercise programs could be compared to traditional training programs. …”
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