Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types by Yangyong Sun, Zhi Li, Jianchao Liu, Ying Xiao, Yaqiang Pan, Benbo Lv, Xufeng Wang, Zhiqiang Lin

“…Emerging evidence suggests that BCAP31 may play a role in cancer development and progression, although its specific effects across different cancer types remain incompletely understood.MethodsThe raw data on BCAP31 expression in tumor and adjacent non-tumor (paracancerous) samples were obtained from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) and UCSC databases. …”
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Nerve growth factor: what can surgeons and oncologists learn from a neurological and psychological biomarker? by Fei Xiong, Ben-li Xiao, Qi Wang, Kun Liu, Hong-wei Wu, Chao Jing, Kui-nan Tong, Zhong-tao Zhang, Wei Guo

“…The exact molecular mechanisms exhibit malignancy-specific differences and remain incompletely characterized. …”
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IRAK4 Targeting: A Breakthrough Approach to Combat Hidradenitis Suppurativa by Zhang H, Liu Z, Qin B, Cheng D, Chen P, Bi X

“…This paper comprehensively reviews IRAK4 and its family members’ physiological functions, systematically examines the IRAK family’s roles in the IL-1R/TLR pathway, with a focus on IRAK4, analyzes IRAK4’s specific role in HS, strengthening the theoretical basis for using IRAK4-targeted drugs. …”
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UPP1 and AHSA1 as emerging biomarkers and targets in pancreatic cancer: A proteomic approach by Kongfan Zhu, Hua Hu, Yuanfa Tao, Zhijian Yang, Hanjun Li

“… The specific protein targets involved in pancreatic cancer (PC) pathogenesis and its varying levels of differentiation remain incompletely understood. …”
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Macrophages in rosacea: pathogenesis and therapeutic potential by Xiaolin Wang, Huanyu Shi, Xueli Li, Yanyan Feng

“…Macrophages, as innate immune cells in the human body, play a crucial role in inflammatory responses. However, the specific mechanistic role of macrophages in rosacea remains incompletely understood. …”
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Rho-GTPases subfamily: cellular defectors orchestrating viral infection by Beibei Zhang, Shuli Li, Juntao Ding, Jingxia Guo, Zhenghai Ma, Hong Duan

“…Despite these insights, the molecular mechanisms underlying Rho-GTPase regulation during viral infections remain incompletely understood. Future research should focus on delineating the precise roles of Rho-GTPases in distinct viral life cycles, uncovering novel regulatory mechanisms, and developing targeted antiviral therapies that selectively inhibit Rho-GTPase signaling without compromising host cell functions. …”
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Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. by Alberto Montalbano, Renato Corradetti, Boris Mlinar

“…Whole-cell voltage-clamp recording in brainstem slices were used to determine concentration-response relationships for the selected GIRK channel blockers on 5-HT1A autoreceptor-activated inwardly rectifying K+ conductance in rat dorsal raphe 5-HT neurons. 5-HT1A autoreceptor-activated GIRK conductance was completely blocked by the nonselective inwardly rectifying potassium channels blocker Ba2+ (EC50 = 9.4 μM, full block with 100 μM) and by SCH23390 (EC50 = 1.95 μM, full block with 30 μM). GIRK-specific blocker tertiapin-Q blocked 5-HT1A autoreceptor-activated GIRK conductance with high potency (EC50 = 33.6 nM), but incompletely, i.e. ~16% of total conductance resulted to be tertiapin-Q-resistant. …”
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The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies by Diana Sabina Radaschin, Alin Tatu, Alina Viorica Iancu, Cristina Beiu, Liliana Gabriela Popa

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Programmed cell death-driven remodeling of the melanoma microenvironment enables prognostic stratification and therapeutic prediction by Bo Hu, Shengnan Chai, Xuan Li, Qiang Zhang, Mei Jin, Long Zhang

“…Cell-type–specific analyses examined heterogeneity, metabolic dependencies, and pathway correlations. …”
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The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis by Erik Hellbacher, Erik Hellbacher, Vincent van Hoef, Alina Johansson, Ann Knight, Ann Knight, Iva Gunnarsson, Iva Gunnarsson, Annette Bruchfeld, Annette Bruchfeld, Per Eriksson, Sophie Ohlsson, Solbritt Rantapää-Dahlqvist, Johanna Dahlqvist, Johanna Dahlqvist

“…MMP-1, MMP-9, HGF, and OSM were uniquely upregulated in PR3-AAV, while TNF, TNF-R1/R2, TNFRSF14, and TNFRSF9 were prominent in MPO-AAV. Functional enrichment analyses underscored STAT3 signaling in PR3-AAV and TNF signaling in MPO-AAV.ConclusionsThis study identifies distinct and shared signaling pathways in PR3-AAV and MPO-AAV, highlighting STAT3 and TNF pathways as potential subtype-specific mechanisms. …”
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Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. by Stephen T Gee, Sharon L Milgram, Kenneth L Kramer, Frank L Conlon, Sally A Moody

“…YAP morpholino (MO)-mediated loss-of-function in both frog and fish resulted in incomplete epiboly at gastrulation and impaired axis formation, similar to the mouse phenotype. …”
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Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion by Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen

“…Conversely, hippocampus‐specific activation of mTOR reverses these effects, highlighting the crucial role of mTOR in mediating the positive effects of exercise. …”
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Epitranscriptomic Analysis of the Ventral Hippocampus in a Mouse Model of Post-Traumatic Stress Disorder Following Deep Brain Stimulation Treatment of the Basolateral Amygdala by Mingxi Ma, Hao Fan, Hui Zhang, Yao Yin, Yizheng Wang, Yan Gao

“…Background: Basolateral amygdala (BLA) deep brain stimulation (DBS) has been shown to alleviate the symptoms of post-traumatic stress disorder (PTSD), but the specific mechanisms remain incompletely understood. …”
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GPx3 marks adipocyte lineage commitment in bone marrow stromal cells by Zhongxiang Wang, Yangyang Hu, Mao Li, Xiaojun Chen, Chengyu Zhou, Zhiyang Xu, Kai Chen, Lichuang Wu

“…Functional assays using RNA interference were carried out to investigate the role of glutathione peroxidase 3 (GPx3) in adipogenesis. …”
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N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression by Hongyu Wang, Bozhi Zhao, Jiayu Zhang, Qunyu Hu, Linlin Zhou, Yinghui Zhang, Yixin Cai, Yuansong Qu, Tao Jiang, Dongwei Zhang

“…Abstract Long noncoding RNAs (lncRNAs) play critical roles in the initiation and progression of breast cancer. However, the specific mechanisms and biological functions of lncRNAs in breast cancer remain incompletely understood. …”
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Systematic proteomic and small RNA profiling of extracellular vesicles from cattle infected with a naturally occurring buparvaquone-resistant strain of Theileria annulata and from... by Yijun Chai, Jin Che, Jinming Wang, Guiquan Guan, Hong Yin

“…Additionally, EVs were isolated from T. annulata-infected bovine immune cells to determine the protein and microRNA (miRNA) compositions of EVs secreted by specific immune cell types. Label-free liquid chromatography–tandem mass spectrometry proteomics and small RNA sequencing were employed to identify EV-associated proteins and miRNAs, followed by functional enrichment analysis to explore key host-parasite regulatory pathways. …”
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KDM4B enhances immune surveillance via demethylating cGAS by Qiao Peng, Huimin Zhuo, Minkang Wu, Yun Hao, Yiyi Zhang, Yuying Zheng, Lei Yu, Lin Han, Hui Ren, Yingcong Wang, Zhijie Gao, Leilei Wu, Qi Lin, Chunhua Lu, Jinghua Li, Ping Wang, Lan Fang, Haihong Yu, Meiling Lu

“…Collectively, this study demonstrated that KDM4B functions as a specific demethylase for cGAS, controlling its chromatin dissociation and subsequent activation, thereby providing a therapeutic rationale for targeting cGAS methylation in human diseases.…”
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TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension by Wenhan Lu, Yu Wang, Wei Hu, Xinyi Lin, Xiaoyu Tong, Yi Tian, Yuning Chen, Yicong Wang, Yan Xiao, Hongfang Yang, Yi Feng, Xinghuai Sun

“…Abstract Acute ocular hypertension (AOH), a major cause of progressive irreversible vision loss, showed significant retinal ganglion cell (RGC) degeneration as well as selective RGC vulnerability upon functional tests, yet the underlyding mechanisms remain incompletely understood. …”
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Prodynorphin-expressing neurons in the ventromedial hypothalamus respond to the predatory odor and modulate defensive behaviors by Ting He

“…Furthermore, optogenetic activation of these PDYN-expressing neurons induced escape-like behaviors and place aversion in male mice, highlighting their functional involvement in threat processing. These findings indicate that PDYN-expressing neurons in the VMH are specifically tuned to detect threat stimuli and play a role in modulating defensive behaviors.…”
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USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation by Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang

“…This cascade reduces DNA damage and apoptosis in NPCs and enhances their functional activity. Overall, our findings reveal a previously unrecognized mechanism by which apoptotic donor MSCs exert therapeutic effects through intercellular communication, specifically by modulating recipient NPCs apoptosis and DDR pathways. …”
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