The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis by Iriscilla Ayala, Skanda K. Hebbale, Juho Mononen, Madelaine C. Brearley-Sholto, Christopher E. Shannon, Ivan Valdez, Marcel Fourcaudot, Terry M. Bakewell, Anna Zagorska, Giovanna Romero, Mara Asmis, Fatima A. Musa, Jonah T. Sily, Annie A. Smelter, Edgar A. Hinostroza, Leandro C. Freitas Lima, Thomas Q. de Aguiar Vallim, Sami Heikkinen, Luke Norton

“…Abstract The molecular mechanisms regulating the zonal distribution of metabolism in liver are incompletely understood. Here we use single nuclei genomics techniques to examine the spatial transcriptional function of transcription factor 7-like 2 (TCF7L2) in mouse liver, and determine the consequences of TCF7L2 transcriptional inactivation on the metabolic architecture of the liver and the function of zonated metabolic pathways. …”
Get full text

Dissecting the Cellular Heterogeneity Underlying Liver Diseases Through the Integration of GWASs and Single-Cell RNA Sequencing by Miao Zhou, Meng Liu, Chao Xue

“…Liver diseases encompass a wide range of etiologies and involve highly heterogeneous cellular environments, yet the specific cellular states through which genetic risk contributes to disease remain incompletely understood. …”
Get full text

Proteostasis signatures in human diseases. by Christine M Lim, Michele Vendruscolo

“…The protein homeostasis (proteostasis) network maintains the proteome in a functional state. Although this network has been comprehensively mapped, its perturbations in disease remain incompletely characterised. …”
Get full text

Delayed diagnosis of the full triad autoimmune polyendocrine syndrome type 2 with adrenal crisis: a case report and literature review by Zihong Yao, Zihong Yao, Hui Chen, Xuejian Hu, Dan Ge, Xiangyu Xu, Danxia Xu

“…An adrenocorticotropic hormone stimulation test confirmed non-responsive adrenal function, indicating PAI. Together with her medical history and positive antibody profile, APS-2 with AC was diagnosed. …”
Get full text

Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. by Farhoud Faraji, Yanli Pang, Renard C Walker, Rosan Nieves Borges, Li Yang, Kent W Hunter

“…We demonstrate that Cadm1 can specifically suppress metastasis without affecting primary tumor growth. …”
Get full text

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanisms. Using sibling-matched cell lines with/without T21, we investigated Mediator kinase function in the context of hyperactive IFN in DS over a 75 min to 24 hr timeframe. …”
Get full text

Frizzled receptors: gatekeepers of Wnt signaling in development and disease by Dalia Martinez-Marin, Grace C. Stroman, Camryn J. Fulton, Kevin Pruitt

“…Despite their significance, FZD signaling remains incompletely understood, particularly in distinguishing receptor-specific roles across canonical and non-canonical Wnt pathways. …”
Get full text

PRDM16 acts as a homeostasis regulation factor to suppress the transition of AKI to CKD via upregulation of eukaryotic initiation factor 6 by Xiaozhou Li, Yang Xia, Xingjin Li, Yong Guo, Shuangfa Qiu, Huiling Li, Yijian Li, Lidong Wu, Dongshan Zhang

“…Our recent works indicated that PR domain-containing 16 (PRDM16) impedes the progression of AKI and DKD. Nonetheless, the specific function and regulatory mechanism of PRDM16 during the AKI to CKD transition remain incompletely understood. …”
Get full text

Microstructural asymmetry in the human cortex by Bin Wan, Amin Saberi, Casey Paquola, H. Lina Schaare, Meike D. Hettwer, Jessica Royer, Alexandra John, Lena Dorfschmidt, Şeyma Bayrak, Richard A. I. Bethlehem, Simon B. Eickhoff, Boris C. Bernhardt, Sofie L. Valk

“…Abstract The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. …”
Get full text

Why Are Cytomegalovirus-Encoded G-Protein-Coupled Receptors Essential for Infection but Only Variably Conserved? by Suzan Fares, Benjamin A. Krishna

“…Different CMVs appear to have evolved vGPCRs with functions specific to infection of their respective host. …”
Get full text

Comparative transcriptome analysis of pectoralis major muscles affected by white striping, wooden breast and spaghetti meat in male and female broiler chickens by Marija Bošković Cabrol, Marianna Pauletto, Mery Giantin, Mauro Dacasto, Gerolamo Xiccato, Angela Trocino

“…Although these myopathies share some histological features, their molecular mechanisms remain incompletely understood, particularly regarding sex-specific differences. …”
Get full text

Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction by Keyur Thummar, Chozha Vendan Rathinam

“…Even though pioneering studies have established indispensable roles for specific catalytic subunits (p110δ and p110γ) in immune cells, functions of the regulatory subunits, particularly of Class I PI3K, within the hematopoietic system remain incompletely understood. …”
Get full text

Role of Hippo/ACSL4 axis in ferroptosis-induced pericyte loss and vascular dysfunction in sepsis by Yiyan Liu, Daiqin Bao, Han She, Zisen Zhang, Shifeng Shao, Zhengbin Wu, Yue Wu, Qinghui Li, Li Wang, Tao Li, Liangming Liu

“…In vivo studies with pericyte-specific ACSL4 knockout mice showed a marked decrease in pericyte loss and enhanced vascular barrier function following sepsis induction. …”
Get full text

Diabetes and brain: omics approaches to study diabetic encephalopathy by Nicoletta Lionetti, Maria Grazia Di Lago, Tania Brescia, Federica Bevilacqua, Antonio Gnoni

“…DE is a severe neurological condition characterized by a progressive decline in cognitive and motor functions, significantly impacting patients’ quality of life. …”
Get full text

The thymic microenvironment gradually modulates the phenotype of thymus‐homing peripheral conventional dendritic cells by Susanne Herppich, Michael Beckstette, Jochen Huehn

“…So far, it is only incompletely understood which impact the thymic microenvironment has on thymus‑homing conventional DCs (cDCs), which phenotypic changes occur after the entry of peripheral cDCs into the thymus and which functional properties these modulated cells acquire. …”
Get full text

A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC by Zhipeng Wang, Yan Wu, Ziqi Ding, Xinru Xiao, Yanhua Huang, Zhiguang Liu, Qian Zhang

“…Results Sanger sequencing analysis identified an increased A-to-I RNA editing ratio of CYP1A1 in NSCLC specimens. This specific RNA editing, regulated by ADAR1, resulted in gain-of-function phenotypes characterized by enhanced tumor progression and more aggressive behavior. …”
Get full text

Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. by Marta M Gaglia, Dae-Eun Jeong, Eun-A Ryu, Dongyeop Lee, Cynthia Kenyon, Seung-Jae Lee

“…However, the mechanisms underlying these effects are incompletely understood. Using whole-genome microarray analysis, we identified transcripts whose levels are altered by mutations in the intraflagellar transport protein daf-10, which result in impaired development and function of many sensory neurons in C. elegans. …”
Get full text

Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning by Jiasi Zhang, Yichen Lei, Yaqin Wang, Wen Yu, Xiaoyan Zhao, Yongbing Zhu, Dedong Zhang, Siying Liu, Aiguo Liu

“…However, the underlying mechanisms remain incompletely understood. Elucidating these pathways is critical for advancing personalized treatments for MYCN‐driven NB. …”
Get full text

Integration of canonical and noncanonical Wnt signaling pathways patterns the neuroectoderm along the anterior-posterior axis of sea urchin embryos. by Ryan C Range, Robert C Angerer, Lynne M Angerer

“…However, the mechanisms that regulate the specification and patterning of the neuroectoderm are incompletely understood. …”
Get full text

Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. by Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan

“…During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known as chromocenters. …”
Get full text