Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition by Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller

“…Furthermore, statin treatment influenced the Th1 prenylome, altering protein prenylation in a prenyltransferase-dependent manner, underscoring distinct enzymatic specificities and potential off-target effects. Conclusions Our findings confirm that prenylation plays a key role in Th1 cell function, with more proteins undergoing prenylation than previously known, some of which exhibit activation-dependent changes. …”
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Chemical Versus Enzymatic Nucleic Acid Modifications and Genomic Stability by Jonathan R. Cortez, Marie E. Migaud

“…Enzymatic DNA modifications also present a degree of sequence specificity and are often reversible. However, both types of DNA modifications contribute to cellular aging when poorly repaired and, as a result, remain incompletely understood. …”
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The cardiac phospho-proteome during pressure overload in mice by Rhys Wardman, Steve Grein, Jennifer Schwartz, Frank Stein, Joerg Heineke

“…Our analysis highlights significant changes in hypertrophic signalling, metabolic remodelling, contractile function, and the stress response pathways. We present proteomic data from the main cardiac cell types (endothelial cells, fibroblasts and cardiomyocytes) to reveal the cellular localisation of the detected phospho-proteins, offering insights into temporal and site-specific phosphorylation events, facilitating the potential discovery of novel therapeutic targets and biomarkers. …”
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OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning by Christopher Schmied, Michael Ebner, Paula Samsó, Rozemarijn Van Der Veen, Volker Haucke, Martin Lehmann

“…Abstract Background Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for their function. …”
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The exocyst in ciliogenesis by Brennan Winkler, Kasey Lerner, Joshua H. Lipschutz

“…The mechanisms of how primary cilia work remain incompletely understood. One particular axis of ciliary function that is especially unclear is the role of the highly-conserved eight-subunit exocyst trafficking complex, which is critically involved in transporting proteins from the trans-Golgi network to the cilium. …”
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Global Grin2a loss causes divergent impairments to PV+ and SST+ interneurons and alters gamma oscillations in prefrontal cortex by Hassan Hosseini, Sky Evans-Martin, Kevin S. Jones

“…Although GluN2A is expressed in multiple interneuron subtypes, its role in inhibitory circuit function remains incompletely understood. Recent genetic and transcriptomic studies implicate somatostatin-positive (SST+) interneurons in SCZ pathophysiology, raising the question of whether Grin2a deletion differentially affects SST+ and parvalbumin-positive (PV+) cells. …”
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Growth Failure in Children with Congenital Heart Disease by Jihye Lee, Teresa Marshall, Harleah Buck, Mulder Pamela, Sandra Daack-Hirsch

“…However, children with complex conditions, such as single-ventricle physiology or multiple heart defects, may experience persistent growth impairment due to chronic disease effects. Specific features of CHD—cyanosis, pulmonary hypertension, and low cardiac output—can further hinder growth by disrupting endocrine function and impairing musculoskeletal development. …”
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Retrograde Ret signaling controls sensory pioneer axon outgrowth by Adam Tuttle, Catherine M Drerup, Molly Marra, Hillary McGraw, Alex V Nechiporuk

“…Ret receptor was highly enriched in sensory pioneer neurons and Ret51 isoform was required for pioneer axon outgrowth. Loss-of-function of a cargo adaptor, Jip3, partially phenocopied Ret axonal defects, led to accumulation of activated Ret in pioneer growth cones, and reduced retrograde Ret51 transport. …”
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Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes by Yue Guo, Jing Zhang, Luyu Gong, Na Liu, Qiaoqiao Liu, Zhaojun Liu, Baosheng Guo, Jingping Yang

“…The results showed that mechanical loading enhanced NRF2 protein stability, promoted its nuclear translocation, and activated osteocyte-specific transcriptional programs. In contrast, pharmacological stabilization of NRF2 failed to fully replicate these effects, underscoring the unique role of mechanical stimuli in modulating NRF2 activity and antioxidant function. …”
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MicroRNA‐9 exerts antitumor effects on hepatocellular carcinoma progression by targeting HMGA2 by Xiangang Xu, Haibo Zou, Lanyun Luo, Xiankui Wang, Guan Wang

“…Accumulating evidence has demonstrated that the aberrant expression of microRNAs (miRs or miRNAs) may contribute to the initiation and progression of various types of human cancer and may also constitute biomarkers for cancer diagnosis and therapy. However, the specific function of miR‐9 in hepatocellular carcinoma (HCC) remains unclear, and the mechanisms that underlie HCC are incompletely understood. …”
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Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury. by Kimberly A Thomas, Rassam M G Rassam, Ronit Kar, Devin M Dishong, Katelin C Rahn, Ricardo Fonseca, Melissa Canas, Jose Aldana, Hussain Afzal, Kelly Bochicchio, Matthew D Neal, Grant V Bochicchio, Philip C Spinella, Susan M Shea

“…Alterations in platelet function are a critical component of trauma-induced coagulopathy (TIC), yet these changes and the potential resulting dysfunction is incompletely understood. …”
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Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives by Suzan Al-Gburi, Pia Moinzadeh, Thomas Krieg

“…There have been considerable advancements in understanding the pathophysiology of the disease during the last few years and this has already resulted in the improvement of the therapeutic approaches used to control organ-specific manifestations. However, the underlying cause of the disease still remains incompletely elucidated. …”
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Spoken words affect visual object recognition via the modulation of alpha and beta oscillations by Piermatteo Morucci, Piermatteo Morucci, Francesco Giannelli, Francesco Giannelli, Craig G. Richter, Nicola Molinaro, Nicola Molinaro

“…Yet, the mechanisms that underpin this facilitation are incompletely understood. Recent proposals suggest that words can alter visual processes by activating category-specific representations in sensory regions. …”
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RETRACTED: In Vivo Clearance of Apoptotic Debris From Tumor Xenografts Exposed to Chemically Modified Tetrac: Is There a Role for Thyroid Hormone Analogues in Efferocytosis? by Kavitha Godugu, Shaker A. Mousa, Gennadi V. Glinsky, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Paul J. Davis, Paul J. Davis

“…The molecular basis for efferocytosis linked to tetrac is incompletely understood, but several factors are proposed to play roles. …”
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The mammalian longevity associated acetylome by S. Feldman-Trabelsi, N. Touitou, R. Nagar, Z. Schwartz, A. Michelson, S. Shaki, M. Y. Avivi, B. Lerrer, S. Snir, H. Y. Cohen

“…Likewise, replacing the human ubiquitin-specific peptidase 10 acetylated lysine 714 with arginine as in short-lived mammals, reduces its anti-neoplastic function. …”
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Estimating total species richness: Fitting rarefaction by asymptotic approximation by Yi Zou, Peng Zhao, Jan Christoph Axmacher

“…The function also enables users to visualize the estimation. …”
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Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Abstract Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. …”
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Truncated NTRK2 is induced in CAP1 endothelial cells during mouse lung injury-repair by Celine Shuet Lin Kong, Mitheera V, Jezreel Pantaleón-García, Scott E. Evans, Jichao Chen

“…Summary: Pulmonary capillary endothelial cells (ECs) consist of two populations, CAP1 and CAP2; how each population reacts to diverse tissue injury is incompletely understood. Using single-cell multiome and mouse genetics, we characterize the induction and function of a truncated isoform of Ntrk2, Ntrk2-T1, in multiple lung injury models. …”
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Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. by Leo Goodstadt, Chris P Ponting

“…Accurate predictions of orthology and paralogy relationships are necessary to infer human molecular function from experiments in model organisms. Previous genome-scale approaches to predicting these relationships have been limited by their use of protein similarity and their failure to take into account multiple splicing events and gene prediction errors. …”
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Influence of aging on dermal elastin fiber architecture and skin firmness assessed by finite element modeling by Fei Jiang, Takeshi Tohgasaki, Mayuko Kami, Ryota Sanuki, Yuya Nakata, Shinya Kondo, Xian Chen

“…This study provides quantitative, mechanistic insights into how specific architectural alterations in elastin fibers directly impact the mechanical properties of aging skin. …”
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