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81
hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke
Published 2025-08-01“…Mechanistically, hUMSC-Exos attenuated NF-κB/p38 MAPK signaling, with TREM1 functioning upstream of p38 (validated by overexpression/reversal). …”
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82
New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research
Published 2025-02-01“…This article reviews the applications of hydrogels in the treatment of RA under different functions and the situation of hydrogels as carriers in the treatment of RA through different drug delivery routes and confirms the outstanding potential of hydrogels as drug carriers in the treatment of RA, which has great research significance.…”
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83
On identification of interconnected systems
Published 2024-10-01“…The adaptive system identification and Lyapunov vector function methods are used along with implicit identification representation for the model.Results. …”
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84
Anatomical heterogeneity in low-grade and high-grade gliomas: A multiscale perspective
Published 2025-07-01“…Background: Low-grade gliomas (LGGs) and high-grade gliomas (HGGs) often exhibit distinct spatial distributions, a phenomenon that remains incompletely understood. Based on previous research, we hypothesized that functional networks, neurotransmitters, and isocitrate dehydrogenase-1 (IDH-1) status characterize the spatial patterns of LGG and HGG. …”
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85
A global study on the Life Cycle Assessment (LCA) of the modern cow leather industry
Published 2025-02-01Get full text
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86
Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impair...
Published 2024-09-01“…Our results revealed a number of new insights into brain function impairment specific to each syndrome group. …”
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87
Indirect Measurement of Tensile Strength of Materials by Grey Prediction Models GMC(1,n) and GM(1,n)
Published 2025-04-01“…However, for the first-order grey prediction model with n variables, specifically the traditional GM(1,n) model, modelling values are derived using a rough approximation method. …”
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88
Research Progress on the Potential Pathogenesis of Persistent Postural–Perceptual Dizziness
Published 2025-01-01“…The pathogenesis of PPPD remains incompletely understood, and it cannot be attributed to any specific anatomical defect within the vestibular system. …”
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89
青少年數位裝置使用時間、媒體多工與認知功能及心理適應間的關聯性 The Relationship Between Screen Time, Media Multitasking and Executive Functions in Adolescents...
Published 2025-03-01“…This study aims to address this gap by investigating digital device usage and media multitasking among Taiwanese adolescents and their effects on cognitive functions and psychological health. Specifically, the study aims to: 1. …”
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90
Quantum chemical modeling of the structure and properties of SnO<sub>2</sub> nanoclusters
Published 2021-11-01“… By the method of density functional theory with exchange-correlation functional B3LYP and basis set 3?…”
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91
Loss of Coral Trait Diversity and Impacts on Reef Fish Assemblages on Recovering Reefs
Published 2024-11-01“…Shifts in the total cover and species composition of habitat‐forming corals can have far‐reaching consequences, including shifts in coral functional traits and impacts on local fish assemblages. …”
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92
Intelligent City 3D Modeling Model Based on Multisource Data Point Cloud Algorithm
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93
L’intuition dans l’apprentissage et l’emploi d’une langue étrangère : pourquoi la notion est-elle importante ?
Published 2024-07-01“…While intuition plays a crucial role in various cognitive processes, its specific implications in linguistics and foreign language pedagogy remain incompletely understood. …”
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94
How does a small molecule bind at a cryptic binding site?
Published 2022-03-01“…Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to virtually all aspects of cellular function. Identifying small molecules that modulate specific disease-related PPIs is a strategy with enormous promise for drug discovery. …”
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95
Retroelement co-option disrupts the cancer transcriptional programme
Published 2025-05-01“…Results We report that cancer-specific transcriptional activation of RTEs causes frequent reduction or loss of gene function. …”
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96
In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons
Published 2024-10-01“…Despite extensive research, the specific functions and mechanisms of microglia-neuron interactions remain incompletely understood. …”
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97
MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity
Published 2025-02-01“…MCU is uniquely enriched in hippocampal CA2 distal dendrites compared to proximal dendrites, however, the functional significance of this layer-specific enrichment is not clear. …”
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98
Genomic identification of recipient-derived hepatocytes in liver transplantation: a hypothesis linking graft repopulation to immune tolerance
Published 2025-07-01“…BackgroundOperational tolerance, defined as stable liver graft function without immunosuppression, has been observed in select transplant recipients. …”
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99
Mitochondrial Quality Control in Health and Disease
Published 2025-08-01“…While the core components of MQC have been characterized, the mechanistic interplay among its modules and their disease‐specific alterations remain incompletely defined. This review provides an integrated overview of the molecular pathways governing mitochondrial biogenesis, dynamics, and mitophagy, with a focus on their cross‐talk in maintaining mitochondrial homeostasis. …”
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100
Inherited disorders of neonatal lung diseases
Published 2004-04-01“… Although genetic factors are assumed to have a role in the etiology of respiratory distress syndrome (RDS), specific genes underlying this susceptibility are incompletely known. …”
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