Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell DeathSummary by Megha Lal, Caitlin M. Burk, Ravi Gautam, Zoe Mrozek, Karina E. Canziani, Tina Trachsel, Jarad Beers, Margaret C. Carroll, Duncan M. Morgan, Amanda B. Muir, Wayne G. Shreffler, Melanie A. Ruffner

“…Prior research has revealed the upregulation of interferon (IFN) response signature genes (ISGs) in biopsy tissue from patients with EoE, but the specific cell types that contribute to this IFN response and the effect of interferons on the esophageal epithelium remain incompletely understood. …”
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Multimodal Alzheimer’s disease classification through ensemble deep random vector functional link neural network by Pablo A. Henríquez, Nicolás Araya

“…This study addresses this gap by integrating multimodal data—including clinical and genetic information—using deep learning (DL) models, with a specific focus on random vector functional link (RVFL) networks, to enhance early detection of AD and mild cognitive impairment (MCI). …”
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IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence. by Ellen J Wehrens, Kurt A Wong, Ankan Gupta, Ayesha Khan, Chris A Benedict, Elina I Zuniga

“…Together, these data show that IL-27 regulates the number and effector functions of MCMV-specific CD4 T cells and could be targeted to enhance control of persistent/latent infection.…”
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Germline PARN Variants in Telomere Biology Disorders and Challenges in Variant Curation by Hasset T. Nurelegne, Mone't B. Thompson, Kelvin C. deAndrade, Ashley S. Thompson, Lisa J. McReynolds, Marena R. Niewisch, Sharon A. Savage

“…Conclusion The extent to which specific PARN variants can be associated with TBD etiology is limited due to incomplete literature, clinical data, lack of robust functional assays, and high frequency of rare variants.…”
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Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury by Almir Aljović, Anne Jacobi, Maite Marcantoni, Fritz Kagerer, Kristina Loy, Arek Kendirli, Jonas Bräutigam, Luca Fabbio, Valérie Van Steenbergen, Katarzyna Pleśniar, Martin Kerschensteiner, Florence M Bareyre

“…Abstract Functional recovery following incomplete spinal cord injury (SCI) depends on the rewiring of motor circuits during which supraspinal connections form new contacts onto spinal relay neurons. …”
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Differential neuronal functions of LNX1 and LNX2 revealed by behavioural analysis in single and double knockout mice by Laura Cioccarelli, Joan A. Lenihan, Leah G. Erwin, Paul W. Young

“…Despite the identification of many LNX interacting proteins and substrates, our understanding of the distinct in vivo functions of LNX1 and LNX2 remains very incomplete. …”
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Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission by Shinichi Kumagai, Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Kensuke Kawai, Hirokazu Takahashi

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Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. by Liqun Wang, Haihua Luo, Xiaohuan Chen, Yong Jiang, Qiaobing Huang

“…But the pathophysiological roles of S100A8, S100A9 and S100A8/A9 in cardiovascular diseases are incompletely explained. In this present study, the effects of homo S100A8, S100A9 and their hetero-complex S100A8/A9 on endothelial barrier function were tested respectively in cultured human umbilical venous endothelial cells (HUVECs). …”
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Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination by Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin

“…Abstract Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates the role and mechanism of deubiquitinating enzyme (DUB) ubiquitin‐specific protease 20 (USP20) in cardiac hypertrophy. …”
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Cetylpyridinium chloride disrupts maternal-to-zygotic transition during early embryonic development by impairing mitochondrial function and histone modification by Caiyun Wu, Zhiming Ding, Xuanxi Li, Yan Xu, Huilei Chen, Hongzhen Ruan, Ping Zhou, Zuying Xu, Huifen Xiang

“…Previous studies have highlighted its toxic effects across various cell types, including reproductive toxicity. However, the specific impacts of CPC on female reproduction, particularly on early embryonic development, as well as the underlying mechanisms, remain incompletely understood. …”
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VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation by Baoji Hu, Baoji Hu, Baoji Hu, Chun-Shiang Chung, Chyna Gray, Yaping Chen, Jihong Jiang, Jihong Jiang, Jianrong Guo, Jianrong Guo, Alfred Ayala

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Ultrasound features and thyroid function of patients with papillary thyroid carcinoma for predicting metastatic cervical lymph nodes with atypical ultrasound features by Shuting Li, Wen Tang, Mengjuan Feng, Zonghui Zhang, Zhongping Tang, Yuanyuan Yue

“…Patients with typical ultrasound features of metastatic cervical lymph nodes or incomplete data were excluded, and 158 PTC patients with atypical ultrasound features were included in the study. …”
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Novel dual gland GAN architecture improves human protein localization classification using salivary and pituitary gland inspired loss functions by Hanaa Salem Marie, Moatasem M. Draz, Waleed Abd Elkhalik, Mostafa Elbaz

“…Our method introduces the “Salivary Gland” loss function (SG-Loss), which addresses missing pixel imputation through a unique computational mechanism that models the graded secretion patterns of acinar cells, incorporating multi-scale contextual information to reconstruct incomplete cellular features. …”
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Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation by Cheng-ting Xie, Hui-lian Zhang, Yi Li, Qian Li, Yi-xian Wen, Jin-yi Liu, Fei Han

“…However, the precise roles of Sox30 in the testis remain largely unclear. Here, the specific functions of Sox30 in testicular cells were determined by single-cell sequencing and confirmed via pathological analyses. …”
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Characteristics of Physical Exercise Programs and Their Effects on Quality of Life and Functional Capacity in Individuals with Chronic Obstructive Pulmonary Disease: A Scoping Revi... by Rafael Oliveira, João Paulo Brito, Halil İbrahim Ceylan, Maria de Brito Soares, Alexandre Duarte Martins, Tiago Vasconcelos, João Moutão, Susana Alves

“…However, the methodologies of the training protocols varied widely, and detailed descriptions of FITT components were often incomplete or lacking clarity, especially regarding the specific exercises used. …”
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Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice by Natasha A. Trzaskalski, Melissa M. Dann, Antonio Hanson, Branka Vulesevic, Evgenia Fadzeyeva, Natasha Jeraj, Ilka Lorenzen‐Schmidt, Rick Seymour, Erin E. Mulvihill

“…Despite these molecular changes, cardiac hypertrophy and systolic and diastolic function were unchanged with systemic and organ‐specific loss of Dpp4.…”
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Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort by Chang Liu, Yao Ma, Shiyuan Qiao, Kexin Li, Mengyao Qi, Chunyu Gu, Chunyu Gu, Lanxin Zhang, Lanxin Zhang, Jia Wei, Dengfeng Gao

“…BackgroundSARS-CoV-2 antibody positivity, whether due to natural infection or vaccination, is known to be associated with specific cardiac and vascular damage, yet its impact on cardiac structure and function in prospective cohorts remains incompletely understood.ObjectiveWe aimed to assess cardiac changes in the UK Biobank cohort among individuals with self-reported seropositive results for SARS-CoV-2 antibodies.MethodsUK Biobank participants with self-reported serological results for SARS-CoV-2 antibodies, who underwent their first cardiac magnetic resonance (CMR) scan after 2019 were included. …”
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Unravelling the genetic and molecular basis of low-frequency rTMS induced changes in functional connectivity density in schizophrenia patients with auditory verbal hallucinations by Yuanjun Xie, Muzhen Guan, Tian Zhang, Chaozong Ma, Chenxi Li, Lingling Wang, Xinxin Lin, Yijun Li, Zhongheng Wang, Ma Zhujing, Huaning Wang, Peng Fang

“…Low-frequency repetitive transcranial magnetic stimulation (rTMS) has demonstrated potential in reducing AVH, yet the underlying neurobiological mechanisms remain incompletely understood. This study investigated the genetic and molecular processes associated with functional connectivity density (FCD) changes induced by 1 Hz rTMS in schizophrenia patients with AVH. …”
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NAF-MEEF: A Nonlinear Activation-Free Network Based on Multi-Scale Edge Enhancement and Fusion for Railway Freight Car Image Denoising by Jiawei Chen, Jianhai Yue, Hang Zhou, Zhunqing Hu

“…To ensure consistency in image details and structure, this paper introduces a fusion loss function. The experimental results show that compared with recent advanced methods, the proposed algorithm has better noise suppression and edge preservation performance. …”
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Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection. by Takahiro Asatsuma, Marcela L Moreira, Hyun J Lee, Brooke J Wanrooy, Oliver P Skinner, Shihan Li, Ivana Rea, Taidhgin Harkin, Saba Asad, Cameron G Williams, Lynette Beattie, Ashraful Haque

“…Plasmodium-specific CD4+ T cells differentiate into effector and memory subsets during experimental malaria, via mechanisms that remain incompletely characterised. …”
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