Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection. by Johannes Nemeth, Gregory S Olson, Alissa C Rothchild, Ana N Jahn, Dat Mai, Fergal J Duffy, Jared L Delahaye, Sanjay Srivatsan, Courtney R Plumlee, Kevin B Urdahl, Elizabeth S Gold, Alan Aderem, Alan H Diercks

“…Protection is associated with elevated activation of alveolar macrophages, the first cells that respond to inhaled Mtb, and accelerated recruitment of Mtb-specific T cells to the lung parenchyma. Systems approaches, as well as ex vivo functional assays and in vivo infection experiments, demonstrate that CMTB reconfigures tissue resident alveolar macrophages via low grade interferon-γ exposure. …”
Get full text

The European Union in a New Emerging Global Order by Bogdan J. Góralczyk

“…The European Union (EU) is a very specific sui generis entity in the international arena as it neither a classical international organisation nor state. …”
Get full text

Types of Argumentation in Editorials by E. A. Nikonova

“…The dominance of weak argumentation can be attributed to the specific nature of editorials, which aim to present the editorial board’s opinion and influence readers. …”
Get full text

PTPN11 in cartilage development, adult homeostasis, and diseases by Wentian Yang, Véronique Lefebvre

“…Moreover, SHP2 inhibition was found to mitigate osteoarthritis pathogenesis in mice, and abundant but incomplete evidence suggests that SHP2 is crucial for cartilage development and adult homeostasis, during which its expression and activity are tightly regulated transcriptionally and posttranslationally, and by varying sets of functional partners. …”
Get full text

Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks. by Kristien J M Zaal, Ericka Reid, Kambiz Mousavi, Tan Zhang, Amisha Mehta, Elisabeth Bugnard, Vittorio Sartorelli, Evelyn Ralston

“…The mechanism of these changes and their functional implications are still poorly understood, in large part because all changes occur seemingly simultaneously. …”
Get full text

A Rotation Target Detection Network Based on Multi-Kernel Interaction and Hierarchical Expansion by Qi Wang, Guanghu Xu, Donglin Jing

“…Additionally, the Midpoint Offset Loss Function is employed to mitigate the impact of gradual scale changes on target direction perception, enabling precise regression for targets across various scales. …”
Get full text

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. by Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn

“…TLF resistance mechanisms of T. b. gambiense and T. b. rhodesiense are now known to arise through either gain or loss-of-function, but our understanding of factors that render T. b. brucei susceptible to lysis by human serum remains incomplete. …”
Get full text

Structure of the EphB6 receptor ectodomain. by Emilia O Mason, Yehuda Goldgur, Dorothea Robev, Andrew Freywald, Dimitar B Nikolov, Juha P Himanen

“…EphB6 has important functions in both normal physiology and human malignancies and is especially interesting because this atypical receptor innately lacks kinase activity and our understanding of the mechanism of action is still incomplete. …”
Get full text

RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium... by Gerard Badia-Bringué, Marta Alonso-Hearn

“…Although RNA-Seq enables AS analysis, most transcriptomic studies still emphasize gene-level expression due to the complexity of AS workflows, the need for deeper sequencing, and incomplete transcript annotations, even in humans. Nevertheless, interest in AS is growing, driven by its recognized role in tissue-specific functions and disease mechanisms. …”
Get full text

Methods of Administrative and Legal Protection of Tax Relations: Theoretical and Legal Study by K. S. Rohozinnikova

“…The author has indicated generic and specific features of the methods of administrative and legal protection of tax relations, where the latter will depend on the peculiarities of the means and methods of influence used by the public administration for the purpose of exercising security functions. …”
Get full text

A Fortran–Python interface for integrating machine learning parameterization into earth system models by T. Zhang, C. Morcrette, C. Morcrette, M. Zhang, W. Lin, S. Xie, Y. Liu, K. Van Weverberg, K. Van Weverberg, J. Rodrigues

“…<p>Parameterizations in earth system models (ESMs) are subject to biases and uncertainties arising from subjective empirical assumptions and incomplete understanding of the underlying physical processes. …”
Get full text

Generating diversity and securing completeness in algorithmic retrosynthesis by Florian Mrugalla, Christopher Franz, Yannic Alber, Georg Mogk, Martín Villalba, Thomas Mrziglod, Kevin Schewior

“…In this work we focus on algorithms for assembling such predictions to a full synthesis plan that, starting from simple building blocks, produces a given target molecule, a procedure known as retrosynthesis. Objective functions for this task are hard to define and context-specific. …”
Get full text

Probiotic supplementation for optimizing athletic performance: current evidence and future perspectives for microbiome-based strategies by Timea Teglas, Zsolt Radak, Zsolt Radak

“…While existing research highlights the promising potential of probiotics, our understanding of how they benefit highly active individuals remains incomplete. Nonetheless, it appears that probiotics have a beneficial effect on mental health, cognitive functions, sleep, gastrointestinal, and upper respiratory symptoms in adult humans. …”
Get full text

Incomes and Expenses of Single-Parent Families of Farmers of Sverdlovsk Region (according to Budget Surveys of 1960) by V. N. Mamyachenkov

“…It is noted that every family, including incomplete, is a specific legal institution, having a number of important socio-economic functions. …”
Get full text

Antibody-dependent cellular cytotoxicity, infected cell binding and neutralization by antibodies to the SIV envelope glycoprotein. by Michael W Grunst, Ruby A Ladd, Natasha M Clark, Hwi Min Gil, Vadim A Klenchin, Rosemarie Mason, Genoveffa Franchini, Mario Roederer, David T Evans

“…Antibodies specific for diverse epitopes of the simian immunodeficiency virus envelope glycoprotein (SIV Env) have been isolated from rhesus macaques to provide physiologically relevant reagents for investigating antibody-mediated protection in this species as a nonhuman primate model for HIV/AIDS. …”
Get full text

Transfer learning and the early estimation of single-photon source quality using machine learning methods by David Jacob Kedziora, Anna Musiał, Wojciech Rudno-Rudziński, Bogdan Gabrys

“…Such a process is typically slow and costly, which has motivated growing research into whether SPS quality can be more rapidly inferred from incomplete emission statistics. Hence, this study is a sequel to previous work that demonstrated significant uncertainty in the standard method of quality estimation, i.e. the least-squares fitting of a physically motivated function, and asks: can machine learning (ML) do better? …”
Get full text

Neurological Recovery Following Surgical Intervention in Patients with Traumatic Spinal Cord Injury at the University Teaching Hospital in Zambia by Munosiya Mulemwa, Joseph Lupenga, Martha Banda-Chalwe

“… Introduction Traumatic spinal cord injuries cause long-term disability and functional impairment. Timely and proper surgical treatment improves neurological recovery and functional outcomes. …”
Get full text

Quality of aerobic training description and its relation to intervention efficacy in chronic obstructive pulmonary disease trials: study protocol for a systematic review, meta-anal... by André Nyberg, Peter Klijn, Anouk A F Stoffels, Jana de Brandt, Hieronymus W H van Hees, Johan Jakobsson

“…Introduction Chronic obstructive pulmonary disease (COPD) is a major global health concern, characterised by ventilatory constraints, decreased cardiovascular fitness and reduced limb muscle function, profoundly affecting patients’ quality of life. …”
Get full text

Cytotoxic lesions of the corpus callosum due to FOLFIRINOX chemotherapy by Mafalda Soares, Sara Rosa, Sofia Bettencourt, Rita Ferreira, Mariana Sardinha, Margarida Dias, Bruno Cunha

“…Neurological examination identified an incomplete wall-eyed bilateral internuclear ophthalmoplegia – a rare finding. …”
Get full text

Multifaceted Role of Specialized Neuropeptide-Intensive Neurons on the Selective Vulnerability to Alzheimer’s Disease in the Human Brain by Manci Li, Nicole Flack, Peter A. Larsen

“…However, progress in this area is currently hindered by the incomplete understanding of the intricate functional and spatial diversity of neuronal subtypes in the human brain. …”
Get full text