Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos by Lihong Liu, Siyao Ha, Dan Cao, MingQing Li, Zhiling Li

“…To further explore its function, antisense nucleotides (ASO) targeting MERVL were constructed to knockdown the expression in early embryos. …”
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Integrating isotopic niche metrics and gut microbiota assembly reveals coexistence mechanisms in subtropical riverine fish by Yaqiu Liu, Xinhui Li, Konstantinos Ar. Kormas, Chunni Kou, Huifeng Li, Yuefei Li, Jie Li

“…Our results showed that host phylogenetic specificity primarily reflected the similarity in deterministic selection processes (host filtering) mediated by host phylogenetic conservatism. …”
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Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…Abstract Background The tumor microenvironment (TME) plays a pivotal role in the development and progression of colorectal cancer (CRC), yet the complex crosstalk among its components remains incompletely understood. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) have emerged as key regulators of CRC progression, but their specific contributions, particularly given their heterogeneity, are not fully elucidated. …”
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Integrated lncRNA and mRNA analysis reveals the immune modulatory mechanisms of antimicrobial peptide BSN-37 in mouse peritoneal macrophages by Huihui Zhang, Yanhe Lv, Jingjing Li, Bingze Jiao, Jiahui Fu, Xujie Zhao, Likun Cheng, Yilin Bai, Lei Wang, Yanwei Li, Bolin Hang, Xiaobing Wei, Mingcheng Liu, Zhanwei Teng, Meinan Chang, Chengshui Liao, Yueyu Bai, Xiaojing Xia, Ke Ding, Jianhe Hu

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Emerging biomarkers and frontier therapies: unveiling the role of endothelial dysfunction in cerebral small vessel disease by Kedi Sun, Hui Liu

“…Despite its clinical significance, the underlying mechanisms of cSVD remain incompletely understood, and therapeutic options are limited. …”
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A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish. by Samuel J Capon, Anastasia Maroufidou, McKenna Feltes, Yanli Xu, Darpan Kaur Matharoo, Dörthe Jülich, Scott A Holley, Steven A Farber, Didier Y R Stainier

“…Fibronectin mutants in both mouse and zebrafish fail to form a functional cardiovascular system, although the penetrance and expressivity of this phenotype vary depending on the genetic background. …”
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Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes by Frédéric Destaillats, Manuel Oliveira, Walter Rakitsky, Xiaoying Zhou, Leon Parker

“…This review explores the potential of NA fortification in infant nutrition products and its impact on neurodevelopment, with a specific focus on two populations: premature infants, who are at higher risk of neurodevelopmental impairments due to incomplete in utero myelination, and healthy term infants, who may experience enhanced cognitive development with improved dietary NA intake when consuming infant formula. …”
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HIV alters the landscape of alveolar macrophages subpopulations in the human lung by Dr David Mhango, Ms Christine Mandalasi, Mr Leonard Mvaya, Associate Professor Kondwani Jambo, Professor David Dockrell, Professor Henry Mwandumba

“…On the other hand, there is an expansion of the MSC and NPC high subsets in the HIV-infected individuals contrarily to the HIV-uninfected group.The impact of HIV on the transcriptome of BAL cellssnRNA-Seq unveiled several clusters of AMs expressing specific gene signatures associated with origin and function. …”
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"Each bishop wears the violet of suffering on his face more than the violet of robes" – Review of the joint work "Prymas Stefan Wyszyński i Episkopat Polski", edited by R. Łatka an... by Sebastian Graniczkowski

“…The individual chapters of the work were discussed, presenting the most important themes covered in them, such as the complexities associated with the nomination of Cardinal Wyszyński as Primate of Poland, in accordance with the will of his predecessor—Cardinal August Hlond; the Primate’s concern about new bishop nominations; Cardinal Wyszyński’s skillful combination of the primate’s office with the function of the chairman of the episcopate; the Primate’s unifying openness to cooperation with individual bishops, especially with his own secretary, and then the Metropolitan of Poznań, Archbishop Antoni Baraniak, or the Metropolitan of Kraków, Karol Wojtyła; the Primate’s relations with hierarchs representing specific entities. …”
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Tissue-Engineered Tracheal Reconstruction by Se Hyun Yeou, Yoo Seob Shin

“…Innovations in biomaterial science, three-dimensional printing, and scaffold-free fabrication approaches have broadened the prospects for patient-specific airway reconstruction. However, persistent challenges, including incomplete epithelial regeneration and mechanical instability, have hindered its clinical translation. …”
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Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation by Hana Najahi, Nicola Alessio, Massimo Venditti, Ida Lettiero, Domenico Aprile, Gea Oliveri Conti, Tiziana Cappello, Giovanni Di Bernardo, Umberto Galderisi, Sergio Minucci, Margherita Ferrante, Mohamed Banni

“…Until now, the assessment of the harmful impact of polyethylene (PE) and polyethylene terephthalate (PET) on HepG2 has been incomplete and lacks certain essential data points. …”
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Leveraging Whole-Genome Resequencing to Uncover Genetic Diversity and Promote Conservation Strategies for Ruminants in Asia by Qinqian Wang, Ying Lu, Mengfei Li, Zhendong Gao, Dongfang Li, Yuyang Gao, Weidong Deng, Jiao Wu

“…However, WGS still faces several challenges, such as incomplete and inaccurate genome assembly, as well as the incomplete annotation of numerous unknown genes or gene functions. …”
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FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep by Deping Han, Yuanyuan Zhang, Weidong Deng, Xue Yang, Jianfei Chen, Guoying Hua, Hesham Y.A. Darwish, Huaming Mao, Xiao Gou, Jiankui Wang, Kai Cui, Yuhao Ma, Yurong Tai, Xianggui Dong, Yanzhu Yao, Zu Yang, Suying Cao, Zhengquan Yu, Wansheng Liu, Xuemei Deng

“…Although these disorders are often of genetic origin, the specific genes and mechanisms remain incompletely understood. …”
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The Relationship Between Digital Transformation and Organisational Efficiency in China: The Mediating Role of Information Disclosure by Fengyuan Li

“…Following the exclusion of incomplete and outlier responses, 300 completed questionnaires were analysed. …”
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Vaccinations in Paediatric Solid Organ Transplant Candidates and Recipients by Valeria Casotti, Paola Stroppa, Michela Bravi, Alessandra Tebaldi, Alessandro Loglio, Mauro Viganò, Stefano Fagiuoli, Lorenzo D’Antiga

“…The best intervention to guarantee efficient prevention of infections, with optimal cost–benefit ratio, is represented by vaccination programs; however, the response to vaccines needs that the immune system maintains a good function. This is even more relevant at paediatric age, when specific immunological conditions make transplant candidates and recipients particularly vulnerable. …”
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UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells by Ambre Bender, Marion Morel, Michael Dumas, Muriel Klopfenstein, Naël Osmani, Maxim V. C. Greenberg, Déborah Bourc’his, Norbert B. Ghyselinck, Michael Weber

“…Subsequently, Uhrf2-deficient mice show impaired oocyte development and female-specific reduced fertility, as well as incomplete remethylation of retrotransposons during spermatogenesis. …”
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Interstitial Lung Disease in Rheumatoid Arthritis in the Era of Biologics by A. Picchianti Diamanti, V. Germano, E. Bizzi, B. Laganà, A. Migliore

“…Some reports suggest a causative role for TNFα inhibitors in RA-ILD development/worsening, anyway, no definitive statement can be drawn thus data are incomplete and affected by several variables. A tight control (pulmonary function tests and/or HRCT) is mandatory in patients with preexisting ILD, but it should be also performed in those presenting risk factors for ILD and mild respiratory symptoms. …”
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Closing the multichannel gap through computational reconstruction of interaction in super-resolution microscopy by Ben Cardoen, Hanene Ben Yedder, Ivan Robert Nabi, Ghassan Hamarneh

“…Summary: Cellular function is defined by pathways that, in turn, are determined by distance-mediated interactions between and within subcellular organelles, protein complexes, and macromolecular structures. …”
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Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation by Andrew Kristof, Krithika Karunakaran, Christopher Allen, Paula Mizote, Sophie Briggs, Zixin Jian, Patrick Nash, John Blazeck

“…Abstract Background CRISPR interference (CRISPRi), the repurposing of the RNA-guided endonuclease dCas9 as a programmable transcriptional repressor, allows highly specific repression (knockdown) of gene expression. …”
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CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly by Hanna Schwaemmle, Hadrien Soldati, Nikolaos M. R. Lykoskoufis, Mylène Docquier, Alexandre Hainard, Simon M. G. Braun

“…These are often heterozygous loss-of-function mutations, indicating a dosage-sensitive role for SWI/SNF subunits. …”
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