Advances in the roles and molecular mechanisms of exosomal circular RNAs in regulating the pre-metastatic niche of tumors by Wei Xu, Luyu Zhu, Shiqi Zhang, Xiaoyan Wang, Dandan Gong, Yu Fan

“…Circular RNAs (circRNAs), a class of single-stranded closed non-coding RNAs, exhibit high stability, evolutionary conservation, and cell-type specificity. Exosomes, as natural carriers of circRNAs, mediate intercellular communication and contribute to the formation of the pre-metastatic niche; however, the mechanisms by which they do so remain incompletely understood. …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…In a mouse model, cardiac function deteriorated and ventricular structural changes were observed 14 days post-myocardial infarction relative to controls. …”
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Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway by Yanyu Pang, Lei Tian, Yufei Liu, Yifan Guo, Jingwen Zhao, Yutong Wang, Mengdi Wang, Wenjing Zhao

“…A group of m/m mice served as the control. Renal function, urinary albumin-to-creatinine ratio (UACR), histopathological analysis, apoptotic, and mitophagy-related protein levels were evaluated. …”
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Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism by Hyejin Choi, Min-Jin Kwak, Youbin Choi, An Na Kang, Daye Mun, Ju Young Eor, Mi Ri Park, Sangnam Oh, Younghoon Kim

“…Gene ontology (GO) and pathway analysis classified LF216EV proteins into biological processes, molecular functions, and cellular components. Importantly, specific abundance in linoleic, oleic, palmitic, sebacic, and stearic acids indicating upregulated fatty acid metabolism were observed by metabolomic analysis. …”
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On the Extension of the Burr XII Distribution: Applications and Regression by SELASI KWAKU OCLOO, LEWIS BREW, SULEMAN NASIRU, BENJAMIN ODOI

“…The proposed model can be used to model data which exhibit bimodal shapes or are heavy-tailed. Specific properties like non-central and incomplete moments, quantile function, entropy, mean and median deviation, mean residual life, moment generating function, and stress-strength reliability are derived. …”
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RIGHTS AND OBLIGATIONS OF THE STATE AS A PARTICIPANT OF CRIMINAL LAW RELATIONS by GUZEEVA O.S.

“…In modern conditions of diversification of methodological approaches to the organization of legal research, it is important to rethink and re-discover the epistemological possibilities of the methods of classical legal science, among which a special place is occupied by documentary analysis and generalization of judicial practice. Research results. Specific rights, duties and responsibilities of the state as a subject of criminal law relations are textually defined in the Constitution of the Russian Federation incompletely, abstractly and implicitly. …”
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Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation by Sheng Chen, Haijian Wu, Damon Klebe, Yuan Hong, Jianmin Zhang, Jiping Tang

“…Stroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. …”
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lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss by Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang

“…BackgroundWeightless bone loss is a common pathological phenomenon in weightless environments, yet its specific molecular mechanism remain incompletely elucidated. …”
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Association of Mobile Stroke Unit Care and Spending, Utilization, and Death in New York City by Dhruv Khullar, Babak B. Navi, Saad Mir, Matthew E. Fink, Luisa Tinapay, Glenn Asaeda, Rainu Kaushal, Eshani Pareek, Amelia M. Bond

“…Background Transport by mobile stroke units (MSUs), which provide access to computed tomography scanning and intravenous blood pressure medications and thrombolytics, reduces time to treatment and may improve short‐term functional outcomes for patients with acute stroke. …”
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Optimizing Screening Performance for the Risk of Hyperoxaluria and Urolithiasis Using the Urinary Oxalate/Creatinine Ratio: A Retrospective Analysis by Pierre Letourneau, Lara Cabezas, Aurélie De Mul, Nadia Abid, Christelle Machon, Cécile Poussineau, Cécile Acquaviva, Justine Bacchetta, Laurence Derain-Dubourg, Sandrine Lemoine

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Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease by Viktor H. Mebus, Larissa M. Busch, Morten Børre, Tobias K. Nielsen, Martin Saxtorph Bojer, Camilla Henriksen, Maria D. Barbuti, Danae M. Angeles, Kamilla Brejndal, Stephan Michalik, Manuela Gesell Salazar, Morten Kjos, Uwe Völker, Birgitte H. Kallipolitis, Dorte Frees

“…The mechanisms allowing bacteria to control these deadly enzymes in response to environmental changes remain incompletely understood. Here, we find that in Staphylococcus aureus, temperature-dependent regulation of such hydrolases occurs by the coordinated action of a CHAP domain-specific regulatory RNA and the ClpXP protease. …”
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Multiplex imaging reveals novel patterns of MRTFA/B activation in the breast cancer microenvironment by Stephanie M. Wilk, Kihak Lee, Caitlyn C. Castillo, Mohamed Haloul, Alexa M. Gajda, Virgilia Macias, Elizabeth L. Wiley, Zhengjia Chen, Xinyi Liu, Xiaowei Wang, Maria Sverdlov, Kent F. Hoskins, Ekrem Emrah Er

“…Furthermore, MRTFA was specifically expressed in the perivascular antigen-presenting cells (APCs), which has been previously associated with immune suppression and breast cancer progression. …”
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Prediction of Milk Yield and Lactation Curve of Dairy Cows: A Comparative Analysis of Three Mathematical Models in Tropical Smallholder Dairy Farm by Aswah Ridhowi, Trianti Djoharjani, Sucik Maylinda

“…This study aimed to evaluate the predictive performance of three mathematical models, i.e incomplete gamma function model , orthogonal polynomial contrast model , and non-linear regression model for estimating total milk production during lactation in dairy cows. …”
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Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling by Nikole J. Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner, Günter Roth, Michael M. Hoffmann, Katja E. Odening, Hauke Horstmann, Luke A. Potter, Christoph Bode, Dennis Wolf, Harald Sourij, Senka Ljubojevic-Holzer, Markus Wallner, Peter P. Rainer, Simon Sedej, Daniel Scherr, Dirk von Lewinski, Adam R. Wende, Andreas Zirlik, Heiko Bugger

“…Cardiac structure, function and energy metabolism were assessed by echocardiography and working heart perfusions. …”
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The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interf... by Binghua Chen, Binghua Chen, Yunyan Luo, Yongjie Chen, Jingxing Wang, Jiecong Yan, Zhan He, Fangfang Li, Chunhe Guo

“…PRRSV infection induced the upregulation of endogenous DDX27 mRNA without affecting protein levels in Marc-145 cells. Functional studies revealed that overexpression of DDX27 significantly inhibited PRRSV N protein and mRNA accumulations, while silencing DDX27 enhanced viral replication. …”
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The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets involved in motor neuron development by Catarina Catela, Stavroula Assimacopoulos, Yihan Chen, Konstantinos Tsioras, Weidong Feng, Paschalis Kratsios

“…Despite their link to various congenital conditions in humans, our understanding of Iro/Irx gene expression, function, and regulation remains incomplete. Here, we conducted a systematic expression analysis of all six mouse Irx genes in the embryonic spinal cord. …”
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A novel asymmetric form of the power half-logistic distribution with statistical inference and real data analysis by Amal S. Hassan, Najwan Alsadat, Mohammed Elgarhy, Laxmi Prasad Sapkota, Oluwafemi Samson Balogun, Ahmed M. Gemeay

“…Furthermore, the SPHLD's hazard rate plots displayed both monotonic increases and decreases. The quantile function, moments, incomplete moment, and stress-strength reliability were among the statistical characteristics of the SPHLD that were computed. …”
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A New Extention of the Odd Inverse Weibull-G Family of Distributions: Bayesian and Non-Bayesian Estimation with Engineering Applications by Yassmen Y. Abdelall, Amal Soliman Hassan, Ehab M. Almetwally

“…The statistical features of the proposed family are analyzed, including quantile function, moments, incomplete moments, mean deviation, density function expansion, order statistics and entropy measures. …”
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Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition by Chengyu Li, Chen Fu, Wenhan Zhou, Hongmin Li, Zhaojun Liu, Gang Wu, Tong He, Ming Shen, Honglin Liu

“…Although prolyl hydroxylation-mediated degradation via the von Hippel–Lindau (VHL) ubiquitination complex is a well-established regulatory mechanism, the role of lactate-induced posttranslational modifications in HIF-1α stabilization remains incompletely understood. Here, we demonstrate that lactate induces lysine lactylation of HIF-1α at distinct residues across species—specifically, K644 in mice and K12 in humans and pigs—to increase protein stability by impairing VHL recognition. …”
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Students’ understanding of two-variable calculus concepts in mathematics and physics contexts. II. The gradient and the Laplacian by Maria Al Dehaybes, Johan Deprez, Paul van Kampen, Mieke De Cock

“…Student difficulties with interpreting the gradient may be related to an incomplete understanding of steepness in graphical representations of functions of two independent variables. …”
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