ATRX, OLIG2, MGMT, and IDH2 in Glioblastoma: Essential Molecular Mechanisms and Therapeutic Significance by Andrea Pop-Crisan, Radu Pirlog, Lavinia-Lorena Pruteanu, Constantin Busuioc, Ovidiu-Laurean Pop, Deo Prakash Pandey, Cornelia Braicu, Ioana Berindan-Neagoe

“…<i>Materials and methods</i>: Key molecular regulators, including ATRX, OLIG2, MGMT, and IDH2, play critical roles in chromatin remodeling, transcriptional reprogramming, DNA repair, and metabolic adaptation. However, their specific expression patterns and functional roles in GBM remain incompletely understood. …”
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Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response by Miaomiao Yan, Ang Su, Suvarin Pavasutthipaisit, Rebecca Spriewald, Guntram A. Graßl, Andreas Beineke, Doris Hoeltig, Georg Herrler, Paul Becher

“…Intestinal epithelial cell interactions with enteric pathogens have been incompletely elucidated owing to the lack of model systems that recapitulate the cellular diversity, architecture and functionality of the intestine. …”
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Regulatory mechanisms and clinical implications of PIWI-interacting RNAs (piRNAs) in major digestive tract cancers by Penghui Li, Yuan Xue, Xinyu Gu

“…Notably, piRNAs exhibit complex and multifaceted roles in these tumors, functioning as both tumor suppressors and oncogenes. …”
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A Neutrosophic β-Generalized α-Closed and d-Ideal-Based Framework for Cross-Border Digital Marketing Optimization in Fashion E-Commerce by Nuo Chen

“…Together, these tools help marketers evaluate which international markets are most suitable for specific campaigns, even when data is incomplete or unclear. …”
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Analysis and Control of the Complex Dynamics of a Multimarket Cournot Investment Game with Bounded Rationality by LiuWei Zhao

“…A dynamic multimarket Cournot model is introduced based on a specific inverse demand function. Puu’s incomplete information approach, as a realistic method, is used to contract the corresponding dynamical model under this function. …”
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METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA by Tian-Hao Lan, Wei Li, Xin Wang, Yan-Jie Geng, Bo Pang, Long-Fei Kang, Dong-Yun Li, Li-Yun Pang, Xin-Xin Zhang, Chen-Qi Zhang, Gui-Qi Wang, Zhong-Xin Li, Chuan-Min Zhou, Xia Jiang, Zeng-Ren Zhao

“…Methyltransferase-like 3 (METTL3) promoted the progression of CRC whereas its function in peritoneal metastasis was incompletely understood. …”
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WFDC3 identified as a prognostic and immune biomarker in pancreatic cancer by Bohan Liu, Xuqing Shi, Tianqi Liu, Huanwen Wu, Zhiyong Liang

“… The whey acidic protein four-disulfide core (WFDC) family comprises key modulators of tumor initiation and progression, offering significant potential for diagnostic, prognostic, and therapeutic applications. However, the specific role of WFDCs in the oncogenesis of pancreatic cancer (pancreatic adenocarcinoma [PAAD]) remains incompletely understood. …”
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Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT by Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye

“…However, the primary mechanism deteriorating the brain functions to regulate the aging process remains incompletely understood. …”
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Identification of USP39 as a prognostic and predictive biomarker for determining the response to immunotherapy in pancreatic cancer by Jiahui Yuan, Beibei Xu, Yongcheng Su, Pingping Zhang, Xianbin Zhang, Peng Gong

“…Abstract Ubiquitin-Specific Protease 39 (USP39) has been implicated in numerous malignancies, however, its pathogenic mechanisms and impact on the tumor immune microenvironment (TIME) remain incompletely characterized. …”
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Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery by Angyang Cao, Angyang Cao, Rui Zhao, Rui Zhao, Chunqu Chen, Chunqu Chen, Can Wu, Can Wu, Yiwei Zhang, Yiwei Zhang, Changshun Huang, Changshun Huang, Binbin Zhu, Binbin Zhu

“…BackgroundPostoperative delirium (POD) is a serious neuropsychiatric complication in elderly surgical patients, yet its pathogenesis remains incompletely understood. Transfer RNA-derived small RNAs (tsRNAs) have emerged as crucial regulators in neurological disorders. …”
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Autobiographical memory in Alzheimer’s disease: a systematic review by Chiara Stramba-Badiale, Fabio Frisone, Fabio Frisone, Fabio Frisone, Fabio Frisone, Diana Biondi, Giuseppe Riva, Giuseppe Riva

“…While this impairment has been extensively studied, its aspects and manifestations remain incompletely synthesized in the literature regarding the relationship between memory specificity, temporal gradients, and emotional processing.MethodsWe conducted a systematic review following PRISMA guidelines, searching across PubMed, Scopus, ScienceDirect, and Web of Science databases. …”
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From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment by Shengkun Peng, MinHong Cai, Hongyu Kuang, Anqi Lin, Qinghua Ma, Xiaoqin Dai, Peng Luo, Yijun Liu, Guo Zhang, Yifeng Bai

“…Furthermore, we performed a retrospective analysis of cardiac function parameters in patients undergoing VEGF(R)i treatment at local hospitals. …”
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The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation by Olena Rogulska, Eliska Vavrinova, Irena Vackova, Jarmila Havelkova, Klara Gotvaldova, Pavel Abaffy, Sarka Kubinova, Michal Sima, Pavel Rossner, Lucie Bacakova, Pavla Jendelova, Katarina Smolkova, Yuriy Petrenko

“…While licensing has demonstrated benefits for immunomodulation, its effects on other key MSC functions, including differentiation and paracrine activity, remain incompletely explored. …”
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Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker by Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

“…Single-cell dataset analysis highlighted significant expression of CHD5 in specific cell populations, suggesting its potential as a marker gene for neuroblastoma. …”
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Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism by Susan Lin, Aravind R Gade, Hong-Gang Wang, James E Niemeyer, Allison Galante, Isabella DiStefano, Patrick Towers, Jorge Nunez, Maiko Matsui, Theodore H Schwartz, Anjali Rajadhyaksha, Geoffrey S Pitt

“…Disruption of, or variants in, FGF13 were implicated as causal for a set of DEEs, but the underlying mechanisms were clouded because FGF13 is expressed in both excitatory and inhibitory neurons, FGF13 undergoes extensive alternative splicing producing multiple isoforms with distinct functions, and the overall roles of FGF13 in neurons are incompletely cataloged. …”
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Risk factors for postoperative complications in patients with pulmonary tuberculosis by Bing Wang, Li Yao, Jian Sheng, Xiaoyu Liu, Yuhui Jiang, Lei Shen, Feng Xu, Qibin Liu, Sheng Bao, Chao Gao, Xiyong Dai

“…Abstract Background The risk factors associated with postoperative complications following pulmonary resection in individuals with tuberculosis remain incompletely understood. Methods We conducted a retrospective analysis of baseline data—including sex, age, BMI, comorbidities, previous COVID-19 status, smoking history, respiratory function, ASA grade, affected lung lobe, and operative factors—in patients who underwent surgical treatment at Wuhan Pulmonary Hospital between January 2018 and September 2022. …”
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Analysis of ferritinophagy-related genes associated with the prognosis and regulatory mechanisms in non-small cell lung cancer by Yuan Hao, Xin Wang, Zerong Ni, Yuhui Ma, Jing Wang, Wen Su

“…Ferritinophagy, a pivotal autophagic process in ferroptosis, plays an essential role in tumor initiation and progression. However, the specific contributions of ferritinophagy-related genes (FRGs) to NSCLC pathogenesis remain incompletely understood. …”
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Drug-Induced Interstitial Lung Disease by Wei-I Lee, Pravin Hissaria

“…However, sometimes, the underlying diseases (e.g., rheumatoid arthritis) and the drugs used to treat the disease (e.g., methotrexate) can both cause ILD; it is often difficult to tease out causality especially if baseline pulmonary assessment (respiratory function test and imaging) is incomplete prior to the commencement of the drug therapy. …”
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Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4−related op... by Yu Yang, Yu Yang, Yujiao Wang, Xuelian Jin, Weimin He

“…IntroductionThe molecular pathogenesis of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) remains incompletely understood. Differentiating between the two diseases is vital given that the diagnostic evaluation and treatment approaches can vary significantly; this difficulty in distinction is exacerbated by the absence of specific biomarkers. …”
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Immune Regulation and Disulfidptosis in Atherosclerosis Influence Disease Progression and Therapy by Wei Lu, Zhidong Zhang, Gang Qiao, Gangqiang Zou, Guangfeng Li

“…A diagnostic risk score model was developed and rigorously tested through Receiver Operating Characteristic analysis. To illustrate the functional impact of CTSC on the regulation of plaque formation and SMC viability, both in vitro and in vivo experimental investigations were conducted. …”
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