Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

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Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation by Zhenni Yang, Minqi Xiong, Minqi Xiong, Xinmiao Tang, Peiwei Wang, Peiwei Wang, Jingang Cui, Jingang Cui, Yu Chen, Yu Chen, Yu Chen, Teng Zhang, Teng Zhang

“…Furthermore, Fto overexpression in endothelial cells partially abolished Rb1-confered attenuation of atherosclerotic pathologies and the aortic expression of Vcam1 in HFD-fed Apoe−/− mice.ConclusionThe work here demonstrates that Rb1 mitigates atherosclerosis in part by suppressing NETs-induced endothelial activation. …”
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Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles by Lizi Zhang, Yishan Qu, Larry J Young, Wenjuan Hou, Limin Liu, Jing Liu, Yuqian Wang, Lu Li, Xing Guo, Yin Li, Caihong Huang, Zijian Lv, Yi-Tong Li, Rui Jia, Ting Lian, Hao Feng, Hui Qiao, Zhixiong He, Fa-Dao Tai

“…This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and lower levels of D2 MSNs activity upon sniffing their partners compared to upon sniffing an unknown female. …”
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Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration by Fernando Cruz-Guilloty, Ali M. Saeed, Jose J. Echegaray, Stephanie Duffort, Asha Ballmick, Yaohong Tan, Michel Betancourt, Eduardo Viteri, Ghansham C. Ramkhellawan, Eric Ewald, William Feuer, DeQiang Huang, Rong Wen, Li Hong, Hua Wang, James M. Laird, Abdoulaye Sene, Rajendra S. Apte, Robert G. Salomon, Joe G. Hollyfield, Victor L. Perez

“…Oxidative stress and inflammation are implicated in AMD, but precise mechanisms remain poorly defined. …”
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Measuring what matters: Building impact pathways to actionable information for the weADAPT platform by S. Bharwani, K. Williamson, R. Butterfield

“…These insights offer practical guidance for knowledge managers and platform developers working to enhance learning and support evidence-based climate adaptation. …”
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A Legal Analysis of Liability for the Loss of the Subject Matter of Sale after Contract Termination: A New Inquiry into Sunni Jurisprudence by Mohammad Hossein Taghipour Darzi Naghibi, Umm al-Banin Ramzan Zadeh, Mostafa Firoozi Rad

“…∴ Research Hypothesis ∴ ‌The working hypothesis suggests that if the possessor of the property did not initiate the contract termination, they are not liable for the loss until the owner demands its return. …”
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Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy by Changhao Hu, Siying Gao, Xinyi Li, Kaiqing Yang, Ye Cheng, Wei Guo, Huijun Wu, Xueqin Cheng, Weiwen Zhao, Yuxuan Kong, Haoyuan Hu, Songyun Wang

“…Among the multifaceted mechanisms implicated in CVDs, autophagy and ferroptosis, two intimately linked cellular processes, emerge as pivotal pathophysiological contributors. …”
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The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development by Baoen Shan, Cong Zhang, Guogui Sun, Hongtao Zhang, Xiaoya Li, Sisi Wei, Suli Dai, Huixia Wang, Lianmei Zhao

“…Clinically, high NR_109 expression was found in CD163+ TAMs from tumor tissues and was positively correlated with poor clinical stages of patients with gastric cancer and breast cancer.Conclusions Our work revealed for the first time that NR_109 exerted a crucial role in regulating the phenotype-remodeling and function of M2-like macrophages via a NR_109/FUBP1/c-Myc positive feedback loop. …”
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A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia by Jarrad M. Scarlett, Eunsang Hwang, Nicole E. Richardson, Caeley L. Bryan, Ingrid Redford, Emily Quah, Erik Tyr R. Odderson, Pique P. Choi, Matthew K. Hwang, Bao Anh Phan, Kelly Kadlec, Kimberly M. Alonge, Gregory J. Morton, Kevin W. Williams, Michael W. Schwartz

“…To investigate the mechanism(s) underlying this anorexic response, the current work focused on a specific neuronal subset located in the external lateral subdivision of the parabrachial nucleus marked by the expression of calcitonin gene-related peptide (elPBNCGRP neurons). …”
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Longitudinal kinetics of the viral infection biomarker 3′-deoxy-3′,4′-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models by Ravi Mehta, Elena Chekmeneva, Stephanie Ascough, Helen Wagstaffe, Loukas Papargyris, Malick Gibani, Ada H. Y. Yuen, Maria Valdivia-Garcia, Caroline Sands, María Gómez-Romero, Ewurabena A. Mills, Vincenzo Sgro, Lydia Slater, Pete Dayananda, Claire Broderick, Jiayun Xu, Myrsini Kaforou, Lynn Maslen, Mahdad Noursadeghi, Andrew J. Pollard, Wendy Barclay, Zoltan Takats, Christopher Chiu, Shiranee Sriskandan

“…Future work should explore ddhC dynamics in natural and experimental infections across varying severities and assess its utility in diverse populations and healthcare settings.…”
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Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study by Zhu X, Yin H, Han J, Zhang X, Han Q, Sun W, Liu Y, Tao W, Liu X, Wang G, Li L

“…The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic biomarker implicated in MASLD pathogenesis. This study aimed to evaluate the association between UHR and MASLD in a T2DM population.Methods: In this cross-sectional study, we analyzed clinical data from 1081 T2DM patients (464 without MASLD, 617 with MASLD). …”
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The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation by Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X

“…Xiang Ren,1,* Zhixian Wang,2,3,* Jing Wang,1 Xing Li,1 Huizhi Wei,4 Chang Liu,5 Shiliang Liu,6 Yunpeng Zhu,7 Chunxiang Feng,8 Yisheng Yin,1 Yiqun Tian,1 Minglong Wu,1 Xiaoyong Zeng1 1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Urology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Urology, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 4School of Pharmacy, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 6Department of Ultrasonography, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 7Department of Thoracic, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 8Department of Urology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Minglong Wu, Email 1924212533@qq.com Xiaoyong Zeng, Email miwai@163.comBackground: Macrophages are highly plastic cells, and macrophage-derived exosomes (M-Exos) have been implicated in inflammation-related pathophysiologies, such as tissue injury and fibrosis repair. …”
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Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer by Liu Y, Li B, Ke L, Luo T, Wu H, Lin J, Deng Y, Huang X, Xu L, Liu Y, Qi J

“…SAPCD2, a cell cycle related gene, has been implicated in tumorigenesis and proposed as a potential therapeutic target in cancer. …”
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Desain Layanan E-Surat untuk Desa Waru Barat, Pamekasan, Madura menggunakan QR-Code by Wahyudi Agustiono, Intan Rofika Putri, Devie Rosa Anamisa

“…Therefore, e-certificate seems to be useful especially for Waru Barat Village authority, Pamekasan District, Madura, whose people mostly work outside or even overseas. Eventually, they often need to obtain certificates from the authority for various purposes. …”
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Serological Markers of Intestinal Barrier Function and Inflammation as Potential Predictors of Recurrent Primary Sclerosing Cholangitis by Hlavaty M, Brezina J, Osadcha T, Fabian O, Vajsova A, Drastich P, Cahova M, Bajer L

“…Mojmir Hlavaty,1 Jan Brezina,1 Tetiana Osadcha,2 Ondrej Fabian,3,4 Andrea Vajsova,3,5 Pavel Drastich,1 Monika Cahova,6,* Lukas Bajer1,7,* 1Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska, Prague, 1958, Czech Republic; 2Department of Data Science, Institute for Clinical and Experimental Medicine, Videnska, Prague, 1958, Czech Republic; 3Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, 14021, Czech Republic; 4Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine, Charles University and Thomayer Hospital, Prague, 14059, Czech Republic; 5Institute of Pathology of the First Faculty of Medicine and General Teaching Hospital, Prague, 12800, Czech Republic; 6Center of Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska, Prague, 1958, Czech Republic; 7Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic*These authors contributed equally to this workCorrespondence: Monika Cahova, Institute for Clinical and Experimental Medicine, Videnska, Prague, 1958/9, Czech Republic, Tel +420775994869, Email monika.cahova@ikem.czAbstract: The impairment of intestinal barrier function is implicated in primary sclerosing cholangitis, but the clinical evidence is scarce. …”
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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. by Benjamin I Perry, Stephen Burgess, Hannah J Jones, Stan Zammit, Rachel Upthegrove, Amy M Mason, Felix R Day, Claudia Langenberg, Nicholas J Wareham, Peter B Jones, Golam M Khandaker

“…Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. …”
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Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism by Tara L. MacDonald, Birgitta Ryback, Jéssica Aparecida da Silva Pereira, Siying Wei, Bryhan Mendez, Erica P. Cai, Yuki Ishikawa, Meagan Arbeau, Gordon Weir, Susan Bonner-Weir, Stephan Kissler, Peng Yi

“…Objective: Renalase (Rnls) is annotated as an oxidase enzyme. It has been implicated in Type 1 diabetes (T1D) risk via genome-wide association studies (GWAS). …”
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Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis by Taruna Sharma, Shaifali Tyagi, Rahul Pal, Jayendrajyoti Kundu, Sonu Kumar Gupta, Vishawjeet Barik, Vaibhav Kumar Nain, Manitosh Pandey, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Ranjan Kumar Nanda, Samrat Chatterjee, Amit Kumar Pandey

“…This work highlights the importance of pgmA in maintaining the metabolic flexibility of Mtb during the nutritional switch. …”
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Impact of rosuvastatin on the memory potential and functionality of CD8+ T cells from people with HIVResearch in context by Federico Perdomo-Celis, Caroline Passaes, Valérie Monceaux, Olivier Lambotte, Dominique Costagliola, Mathieu F. Chevalier, Laurence Weiss, Asier Sáez-Cirión

“…Funding: The CESAR trial was sponsored by IMEA. This work was supported by the NIH (grants UM1AI164562 and R01DK131476).…”
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Potential therapeutic effects of Ferula gummosa Boiss. Extract on Autistic-like behaviors in maternally separated mice: Role of NMDA receptor gene by Forozan Yaghoubi, Hossein Amini-Khoei, Kamal Solati, Antoni Sureda, Zahra Lorigooini

“…The current interest has pointed out anti-inflammatory, antipyretic, and anticonvulsant actions. Thus, the present work aims to evaluate the hydroalcoholic extract from F. gummosa in mouse autism-like behavior caused by early maternal separation and its possible action by the involvement of the NMDA receptors. …”
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