Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omics and experimental va... by Rui Hou, Wei Song, Yi Nan, Yiyi Gong, Jieying Liu, Jialin Liu

“…Crucially, in-vitro experiments demonstrated that GCT directly promoted the proliferation of Akkermansia muciniphila, a key probiotic implicated in AD amelioration.ConclusionThis work uncovers a novel “gut microbiota-fatty acid metabolism-neuroinflammation” axis as the primary mechanism underlying GCT’s anti-AD effects. …”
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ATR regulates OCT4 phosphorylation and safeguards human naïve pluripotency by Xudong Ma, Cheng Chen, Xinyu Chen, Songsong Dan, Jianqiong Li, Xiaobing Zhang, Shiqi She, Jianwen Hu, Yan-Wen Zhou, Bo Kang, Ying-Jie Wang, Wenjie Chen

“…Ablating cellular ATR activity significantly halted the induction of naïve hESCs from their primed counterparts, and increased early apoptotic death of naïve hESCs upon UV and CPT treatment. Thus, our work reveals the importance of ATR activity in safeguarding human naïve pluripotency, and implicates a potential association of OCT4 phosphorylation, DNA damage sensing and repairing system in regulating different states of pluripotency during early development.…”
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Evaluation of Screening Tool of Older People’s Prescriptions (STOPP) Criteria in an Urban Cohort of Older People with HIV by Lauren F. O’Connor, Jenna B. Resnik, Sam Simmens, Vinay Bhandaru, Debra Benator, La’Marcus Wingate, Amanda D. Castel, Anne K. Monroe

“…The most common systems implicated were musculoskeletal (23%), analgesic drugs (16%), and the central nervous system (13%). …”
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Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…By elucidating the TSG-6/NLRP3 regulatory axis, this work provides a novel framework for developing exosome-engineered treatments for IBD and other pyroptosis-related inflammatory disorders.…”
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Plasma proteomic and polygenic profiling improve risk stratification and personalized screening for colorectal cancer by Jing Sun, Yue Liu, Jianhui Zhao, Bin Lu, Siyun Zhou, Wei Lu, Jingsun Wei, Yeting Hu, Xiangxing Kong, Junshun Gao, Hong Guan, Junli Gao, Qian Xiao, Xue Li

“…Participants with high ProS, PRS, or combined risk score are proposed to start screening at age 46, 41, or before 40 years old. In this work, the integration of blood proteomics with PRS and QCancer-15 demonstrates improved performance for risk stratification and clinical implication for the derivation of risk-adapted starting ages of CRC screening, which may contribute to the decision-making process for CRC screening.…”
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An unconventional T cell nexus drives HCK-mediated chronic obstructive pulmonary disease in miceResearch in context by Amy T. Hsu, Robert J.J. O'Donoghue, Evelyn Tsantikos, Timothy A. Gottschalk, Jessica G. Borger, Nicholas A. Gherardin, Calvin Xu, Hui-Fern Koay, Dale I. Godfrey, Matthias Ernst, Gary P. Anderson, Margaret L. Hibbs

“…Haematopoietic cell kinase (HCK) is a druggable SRC-family non-receptor protein tyrosine kinase and COPD candidate gene. It is implicated in the chronic and non-resolving inflammation that causes mucosecretory bronchitis and destruction of small airways and alveoli, but how it drives pathophysiology remains obscure. …”
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance by Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z

“…Bioinformatics analysis identified 19 DEIRGs, with PPI networks implicating immune regulation (PPI enrichment p=3.35× 10-6). …”
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Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study by Chen HB, Li L, Sun YK, Liu Y, Chen W, Liu P, Liao YH, Xie A

“…At 2-month follow-up, decreased FC implicated in emotion regulation, executive function, and memory; increased FC in semantics, attention, and auditory-visual processing. …”
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Genome-wide identification and analysis of Rop GTPase family members reveal their potential functions in biotic stress in potato (Solanum tuberosum L.) by Zhida Liu, Guochao Xuanyuan, Shuqing Yang, Miru Du, Xiaoluo Zhang, Tingting Bao, Zhiwei Zhang, Wenbing Zhang, Jun Zhao

“…Although the function of Rops has been well studied in many plant species, the research conducting on Rops in potato is limited. Results In this work, a total of 11 Rop members were identified in the potato (Solanum tuberosum) genome. …”
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cGAS-STING Targeting Offers Novel Therapeutic Opportunities in Liver Diseases by Wang Y, Yang R, Cao Y, Li Y, Zhu Y, Zhang Z, Fleishman JS, Chen J, Ding M

“…However, sustained abnormal activation of this signaling axis is implicated in the pathogenesis of chronic inflammatory and autoimmune conditions. …”
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Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures by Andrew J. Annalora, Jacki L. Coburn, Antony Jozic, Patrick L. Iversen, Craig B. Marcus

“…By identifying regulatory mechanisms, including AHR activation, epitranscriptomic modulation, and crosstalk within SR protein networks, that shape adaptive responses to xenobiotic stress, this work offers insights into the splicing and transcriptional networks that maintain cellular homeostasis. …”
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Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis by Qiao S, Wu B, Chen L, Ma L, Wang Y, Xu B, Gu R

“…MiRNA-sequencing of KLF2-EXO implicated that miRNA-486-5p (miR-486-5p) was a potent candidate mediator that inhibited myocardiocyte apoptosis, and the miR-486-5p antagomir reversed the effect. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…Anwaier Apizi,* Jian Li,* Paiheriding Kamilijiang, Chun-Bo Yang, Zheng-Kai Wang, Rui-Feng Chai, Zhao-Xia Yu Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhao-Xia Yu, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13899858397, Email zhaoxia_yu01@126.com Rui-Feng Chai, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13999819217, Email chairuifeng_chai@126.comObjective: This study aimed to evaluate the extent of organ damage associated with sepsis and to identify key genes implicated in its pathogenesis.Methods: Eighteen rats were randomized into experimental and control groups. …”
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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

“…Shaohua Yang,1– 3,* Hejie Liu,4,* Youbin Zheng,5,* Hongyu Chu,6 Zhuming Lu,4 Jie Yuan,1,2 Shengshan Xu4 1Department of General Surgery, Foshan Clinical Medical School, Guangzhou University of Chinese Medicine, Foshan, Guangdong, People’s Republic of China; 2Department of General Surgery, Foshan Fosun Chancheng Hospital, Foshan, Guangdong, People’s Republic of China; 3Institute of Gastroenterology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 4Department of Thoracic Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, People’s Republic of China; 5Department of Radiology, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen, Guangdong, People’s Republic of China; 6Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Yuan, Email yuanj1282024@163.com Shengshan Xu, Email xushengshan97@163.comBackground: Nucleolar and spindle-associated protein 1 (PLIN3), a member of the perilipin family, plays a critical role in lipid droplet dynamics and is implicated in promoting tumor progression across several cancers. …”
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Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study by Zhang X, Yang M, Duan X, Feng X, Fang Y

“…Proteomics revealed 27 differentially expressed proteins (DEPs) (FDR < 0.05), including MPO, IL-17, MMP2, C3 and COL1A1, implicating coagulation cascades and neutrophil extracellular trap (NET) formation. …”
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Clonorchis sinensis infection remodels chromatin accessibility in hepatocellular carcinoma by Weilong Yang, Caibiao Wei, Junxian Chen, Qiumei Lin, Yuling Qin, Taijun Huang, Xueling Deng, Mulin Jun Li, Zeli Tang, Min Fang

“…Clonorchis sinensis (C. sinensis) infection, a recognized carcinogen, has been implicated in the progression of liver diseases, including HCC. …”
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Serum Soluble Asialoglycoprotein Receptor 1: A Potential Predictor Marker Linked to Type 2 Diabetes Mellitus, Demonstrating Positive Correlation With High Sensitive C-Reactive Prot... by Zhu H, Zhong Z, Zhao G, Cao Y, Liu W, Guo Y, Jin J

“…Haifeng Zhu,1,* Ziyi Zhong,2,* Gaonian Zhao,1,* Yuan Cao,1 Wei Liu,1 Yawen Guo,1 Jing Jin1 1Rehabilitation Medicine Center, Taizhou People’s Hospital, Taizhou City, Jiangsu Province, People’s Republic of China; 2Endocrinology Department, Nanjing First Hospital, Nanjing City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Jin, Email try15063@163.comBackground: Asialoglycoprotein receptor 1 (ASGR1) deficiency has been implicated in enhancing liver insulin sensitivity and reducing systemic insulin resistance, thus highlighting its pivotal role in glucose metabolism. …”
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Knowledge management in higher education: a meta-synthesis of success factors, challenges, and implementation strategies by Mohammad Hossein Zerafati, Reza Hosseinpour

“…It serves as a valuable resource for academic leaders, administrators, and researchers working to enhance knowledge management practices in higher education institutions.The findings underscore the importance of adopting a systemic, long-term approach to knowledge management implementation, recognizing that success requires careful attention to cultural, structural, and technological factors. …”
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Amyloid precursor-like protein 2 expression in macrophages: differentiation and M1/M2 macrophage dynamics by Gabrielle L. Brumfield, Gabrielle L. Brumfield, Shelby M. Knoche, Shelby M. Knoche, Kenadie R. Doty, Kenadie R. Doty, Alaina C. Larson, Alaina C. Larson, Brittany J. Poelaert, Brittany J. Poelaert, Don W. Coulter, Don W. Coulter, Don W. Coulter, Joyce C. Solheim, Joyce C. Solheim

“…This suggests that APLP2 influences macrophage polarization dynamics between M0/unpolarized and pro- and anti-inflammatory states, and populations altered by APLP2 KO resemble the macrophage profiles altered with NB-conditioned media treatment. In total, our work implicates APLP2 as a mediator of macrophage status, namely in the M0/unpolarized macrophage and the M1/pro-inflammatory and M2/anti-inflammatory axis.…”
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Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder by Sujung Yoon, Woojin Won, Suji Lee, Kayoung Han, Eunji Ha, Juheon Lee, Seung Jae Hyeon, Yoonji Joo, Haejin Hong, Hyangwon Lee, Yumi Song, Ki Duk Park, Bertrand R. Huber, Junghee Lee, Richard A. E. Edden, Minah Suh, Hoon Ryu, C. Justin Lee, In Kyoon Lyoo

“…By bridging human and animal studies with translational clinical trials, this work positions KDS2010 as a promising first-in-class therapy, offering a novel paradigm for PTSD treatment.…”
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