Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer’s disease by Briana K. Chen, Holly C. Hunsberger, Alicia Whye, Louise C. Matthews, Alyson Yook, Moshe J. Willner, Ryan W. Logan, Stefanie Johns, Eric Weisblum, Christine A. Denny

“…Conclusions Our results indicate that combined administration of (R,S)-ketamine + prucalopride is a novel multimodal therapeutic strategy to treat cognitive decline in AD. Future work will further characterize these interactions with the goal of clinical development.…”
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Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG by Benjamin Hébert-Seropian, Olivier Boucher, Daphné Citherlet, Manon Robert, François Richer, Dang Khoa Nguyen

“…<b>Background/Objectives</b>: The human insula is a key structure implicated in integrating internal states and external food cues, yet its precise role remains unclear, in part due to the temporal limitations of neuroimaging techniques like fMRI. …”
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Consenso sobre el diagnóstico, tratamiento y seguimiento de niñas, niños y adolescentes con sobrepeso y obesidad de la Sociedad Latinoamericana de Gastroenterología, Hepatología y... by Y. Rivera-Suazo, J. Alberto-Meléndez, J.E. Alfaro-Bolaños, F.J. Álvarez-Chávez, A.G. Ayala-Germán, M.J. Galaviz-Ballesteros, M. Higuera-Carillo, C.L. Taquez-Castro, A.L. Villa-Gómez, B.N. Villaroel-Ibarra, B.A. Alvarado-Cárcamo, F.A. Reynoso-Zarzosa, Y.B. Quiñones-Pacheco, C.M. Timossi-Baldi, R. Vázquez-Frias

“…Material and methods: The LASPGHAN Obesity Working Group organized 6 working panels to formulate statements on diagnostic approach, treatment, and follow-up. …”
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Ubiquitination and ALL: Identifying FBXO8 as a prognostic biomarker and therapeutic target by Wei Xian, Yinting Chen, Shuiqing Yu, Zhitao Ye, Zhitao Ye, Yu Zhang, Danlin Yao

“…In FBXO8-knockdown mouse models, in vivo investigations demonstrated increased tumor growth, reduced apoptosis, and diminished survival rates.ConclusionThis work identifies FBXO8 as a crucial therapeutic target and prognostic biomarker for ALL. …”
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Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts by Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu

“…Herein, this work finds that although almost all MSCs undergo in situ apoptosis within 24 h post‐subcutaneous administration, MSC‐derived apoptotic bodies (ABs) mediated potent anti‐fibrotic effects. …”
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Unveiling the molecular mechanism of sepal curvature in Dendrobium Section Spatulata through full-length transcriptome and RNA-seq analysis by Xuefeng Qu, Na Li, Cong Xu, Zifeng Huang, Chunyan Li, Yang Jiang, Guizhao Zheng, Haiping Fu, Guangyan Zhang, Chuan Liu

“…Notably, myosin II filament organization was implicated in generating the mechanical forces responsible for curling, while metabolic pathways provided the energy necessary for these developmental processes. …”
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Phenology and foraging bias contribute to sex‐specific foraging patterns in the rare declining butterfly Argynnis idalia idalia by Matthew W. Chmielewski, Skyler Naya, Monica Borghi, Jen Cortese, Alisdair R. Fernie, Mark T. Swartz, Konstantina Zografou, Brent J. Sewall, Rachel B. Spigler

“…Further work can test whether nutritional differences are a cause of visitation patterns or consequence, reflecting seasonal shifts in the nutritional landscape encountered by male and female A. i. idalia. …”
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Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease by Wenxuan Wang, Sarah J. Myers, Nikita Ollen-Bittle, Shawn N. Whitehead

“…Ganglioside dysregulation has been implicated in various neurodegenerative diseases, including AD, but the spatial distribution of ganglioside dysregulation with respect to amyloid-beta (Aβ) deposition is not well understood. …”
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YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis by Bole Zhou, Xinzhe Feng, Changhao Han, Yang Wu, Junjie Qiao, Wenwen Tong, Weidong Xu

“…Abstract Background As a member of the family of the YTH domain and a an m6A reader, YTHDF3 is implicated in cancer and inflammatory diseases. However, its function in ankylosing spondylitis (AS)—a chronic inflammatory disease marked by aberrant bone formation—is still mysterious. …”
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LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer by Deepak Verma, Sumit Siddharth, Ashutosh S. Yende, Qitong Wu, Dipali Sharma

“…Indeed, LUCAT1 silencing led to mitigated cell growth, migration, and stem-like features in TNBC. This work sheds light on the LUCAT1 ceRNA network in TNBC and implies its involvement in TNBC growth and progression.…”
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Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn&amp;rsquo;s Disease by D'Amico F, Bencardino S, Magro F, Dignass A, Gutiérrez Casbas A, Verstockt B, Hart A, Armuzzi A, Peyrin-Biroulet L, Danese S

“…Unlike conventional therapies, guselkumab offers a different mechanism of action by selectively inhibiting IL-23, a key cytokine implicated in the pathogenesis of CD. IL-23 drives intestinal inflammation through activation of the Th17 cell pathway and other immune processes, positioning IL-23 inhibition as a critical therapeutic approach. …”
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Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology by Zhang N, Zhang H, Guo J, Ma Y, Bai X, Ma N, Ji X, Meng Y, Li H, Sangwanit T, Shi Y, Zhao J, Li X, Lin J, Cui X

“…UPLC-MS/MS identified 44 active ingredients and 123 targets; proteomics revealed 28 differentially expressed proteins. GO/KEGG analysis implicated that the PI3K/AKT/mTOR pathway may be the molecular target. …”
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Identification of ZNF652 as a Diagnostic and Therapeutic Target in Osteoarthritis Using Machine Learning by Chen Y, Liang R, Zheng X, Fang D, Lu WW, Chen Y

“…Zinc Finger Protein 652 (ZNF652) is a transcription factor implicated in various biological processes. Nevertheless, its role in OA has not been elucidated.Methods: The search term “osteoarthritis” was utilized to procure transcriptome data relating to OA patients and healthy people from the Gene Expression Omnibus (GEO) database. …”
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Generación Z y gamificación: el dibujo pedagógico de una nueva sociedad educativa / Generation Z and gamification: the pedagogical drawing of a new educational society by Juan Carlos Manzanares Triquet

“…Furthermore, it contextualizes the role of technology and digital tools within current teaching methods. Lastly, this work examines in detail gamification as an innovation technique by scrutinizing the elements who shape it, their typology and the different phases that link their process in order to enable a learning experience in line with the particularities of nowadays students.…”
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Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics by Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y

“…Although UMI-77 has demonstrated efficacy in mitigating lung injury in sepsis, the molecular mechanisms underlying its action have not yet been fully elucidated.Methods: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomic and metabolomic analyses.Results: UMI-77 significantly ameliorated histopathological changes in the lungs of mice with sepsis-induced ALI Transcriptomic analysis revealed that 124 differentially expressed genes were modulated by UMI-77 and were predominantly implicated in chemokine-mediated signaling pathways, apoptosis regulation, and inflammatory responses. …”
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Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1 by Daiana Alvarez-Olmedo, Claire Kamaliddin, Theodore B. Verhey, May Ho, Rebekah De Vinney, George Chaconas

“…These are the first two host proteins implicated in B. burgdorferi transmigration across endothelial cells.IMPORTANCELyme borreliosis is caused by Borrelia burgdorferi and related bacteria. …”
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The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma by Benjamin B. Gyau, Junyan Wang, Xiang Chen, Margaret A. Clement, Zoe D. Man, Angela M. Major, Mathew C. Weiser, Jun Xu, John Hicks, Tsz-Kwong Man

“…Yet, its roles in osteosarcoma (OS), the predominant pediatric malignant bone tumor, are not fully defined. Our prior work has shown that elevated serum CXCL10 levels correlate with poor OS prognosis. …”
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Stress adaptation under in vitro evolution influences survival and metabolic phenotypes of clinical and environmental strains of Vibrio cholerae El-Tor by Nana Eghele Adade, Stephen Dela Ahator, Inmaculada García-Romero, Macarena Algarañás, Vincent Appiah, Miguel A. Valvano, Samuel Duodu

“…ABSTRACT Bacterial adaptation to stress can lead to phenotypic variants with diverse levels of niche competitiveness, pathogenicity, and antimicrobial resistance. In this work, we employed experimental evolution to investigate whether exposure to various stress conditions results in new phenotypic and metabolic properties in clinical and environmental strains of Vibrio cholerae. …”
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Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury by Arthur D. Stem, Stephen Brindley, Keegan L. Rogers, Adil Salih, Carlos A. Roncal-Jimenez, Richard J. Johnson, Lee S. Newman, Jaime Butler-Dawson, Lyndsay Krisher, Jared M. Brown

“…Such occupational exposures present health risks and have been implicated in a high rate of kidney disease seen in these workers. …”
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Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma by Kaibo Yang, Xing Zhang, Kun Yang, Sinan Liu, Jingyao Zhang, Yunong Fu, Tong Liu, Kunjin Wu, Jing Li, Chang Liu, Qichao Huang, Kai Qu

“…By investigating mitochondrial dynamics as central regulators of cabozantinib resistance, this work specifically aims to discover actionable targets for restoring drug sensitivity in treatment-refractory HCC cells. …”
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