Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients by Malgorzata Labuda, Sophie Laberge, Julie Brière, Denis Bérubé, Patrick Beaulieu, Tomi Pastinen, Maja Krajinovic

“…The association remained significant with inclusion of age, sex, atopy, and controller medication into multivariate model (P=0.004 and P=0.02, resp.). Our work identifies new genetic variants implicated in modulation of asthma treatment, one of them (rs1544791) previously associated with asthma phenotype.…”
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Challenging the Gaze: The Subject of Attention and a 1915 Montessori Demonstration Classroom (Bilingual edition: English/Portuguese) by Noah W. Sobe

“…Abstract: The child's attention, how this attention is reasoned about, and how attention works as a surface for pedagogical intervention are central to understanding modern schooling. …”
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Explainable artificial intelligence visions on incident duration using eXtreme Gradient Boosting and SHapley Additive exPlanations by Khaled Hamad, Emran Alotaibi, Waleed Zeiada, Ghazi Al-Khateeb, Saleh Abu Dabous, Maher Omar, Bharadwaj R.K. Mantha, Mohamed G. Arab, Tarek Merabtene

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Simulation analysis of path planning for workpiece clamping robots based on digital twin technology by Xin PAN, Min LIANG, Yanchao YIN, Zhong CHEN

“…This approach not only improves operational efficiency but also ensures safety and adaptability in complex working environments. Central to this method is the proposed RRT*-Connect algorithm, which performs dynamic elliptical constraint sampling. …”
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Mechanistic controls on permeability evolution in thermally-upgraded low-maturity oil shales: Application of machine learning outputs by Bo He, Lingzhi Xie, Xin Liu, Jun Liu, Derek Elsworth

“…These descriptions define key factors influencing permeability evolution, in particular the development of anisotropy and its implication for recovery. Heating enhances permeability by increasing both the number and total cross-sectional area (SEM) of pores. …”
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Optimal pathways toward a carbon-neutral power system considering low-carbon technologies in the Yangtze River Delta region by Yaru Zhang, Tieju Ma, Yadong Yu, Hongtao Ren

“…Because of its important role in China, many scholars have addressed the decarbonization of the Yangtze River Delta Region (YRDR). However, little work has been conducted on appropriate ways to transform the YRDR power system into a carbon-neutral system. …”
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Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder by Lingling Cui, Xiaohong Gong, Yanqing Tang, Lingtao Kong, Miao Chang, Haiyang Geng, Ke Xu, Fei Wang

“…However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD. …”
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The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex by Emmanuelle Gruz-Gibelli, Natacha Chessel, Clélia Allioux, Pascale Marin, Françoise Piotton, Geneviève Leuba, François R. Herrmann, Armand Savioz

“…It diminishes, for instance, the production of Aβ peptides and their oligomerisation. In the present work we investigated the possible implication of RA receptor (RAR) in repair of Aβ-induced DSBs. …”
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Causal role of endothelial dysfunction in ischemic stroke and its subtypes: A two-stage analysis by Qian Wu, Jiabo Cui, Yao Jiang, Xiaoxin Li, Chongge You

“…Objective: Endothelial dysfunction is implicated in the pathogenesis of ischemic stroke (IS), but its causal role remains unclear. …”
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Salivary extracellular vesicles isolation methods impact the robustness of downstream biomarkers detection by Jérémy Boulestreau, Laurence Molina, Alimata Ouedraogo, Louën Laramy, Ines Grich, Thi Nhu Ngoc Van, Franck Molina, Malik Kahli

“…Abstract Extracellular vesicles (EVs), crucial mediators in cell-to-cell communication, are implicated in both homeostatic and pathological processes. …”
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Lipid packing defects are necessary and sufficient for membrane binding of α-synuclein by David H. Johnson, Orianna H. Kou, John M. White, Stephanie Y. Ramirez, Antonis Margaritakis, Peter J. Chung, Vance W. Jaeger, Wade F. Zeno

“…Abstract α-Synuclein (αSyn), an intrinsically disordered protein implicated in Parkinson’s disease, is thought to initiate aggregation by binding to cellular membranes. …”
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Statistical Modeling to Improve Time Series Forecasting Using Machine Learning, Time Series, and Hybrid Models: A Case Study of Bitcoin Price Forecasting by Moiz Qureshi, Hasnain Iftikhar, Paulo Canas Rodrigues, Mohd Ziaur Rehman, S. A. Atif Salar

“…Through comparison testing with training data sets consisting of 30%, 20%, and 10%, the present work demonstrated that the suggested hybrid model outperforms the individual approaches in terms of error metrics, such as the MAE, RMSE, MAPE, SMAPE, and direction accuracy, such as correlation and the MDA of BTC. …”
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Nidogen-1 suppresses cell proliferation, migration, and glycolysis via integrin β1-mediated HIF-1α downregulation in triple-negative breast cancer by Joo-hyung Lee, Seogho Son, Yunhyo Ko, Hogeun Lim, Minhyeok Lee, Min-gyeong Kang, Hyungjoo Kim, Kyung-min Lee, Incheol Shin

“…In this work, we found that the expression of NID1 is significantly lower in breast cancer tissue than in normal tissue. …”
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Vascular Graft Impregnation with a Fosfomycin/Oritavancin Combination to Prevent Early Infection by Inês Cruz, Stefano Di Bella, Mario D’Oria, Cristina Lagatolla, M. Cristina L. Martins, Cláudia Monteiro

“…Vascular grafts with impregnated antibiotics are not yet available on the market, and this work represents an important step toward the development of a new class of antimicrobial vascular grafts.…”
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FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity by Annarita Miluzio, Federica De Grossi, Marilena Mancino, Stefano Biffo, Nicola Manfrini

“…In this study, we focused specifically on SphK1, the sphingosine kinase predominantly implicated in cancer and investigated the combinatorial effect of forced FAM46C expression and treatment with PF-543, a selective SphK1 inhibitor. …”
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Effect of fungal microbiota on RANKL and sclerostin in patients with Crohn's disease by Rana Hanan Al-rubaye, Hazima Mossa Alabassi, Anwar Khalil Ismael, Alaa Saad Hasan

“…However, many factors, including a dysregulated immune system, altered microbiota, inheritance, and environmental factors, have been implicated. This work was conducted to estimate the effect of fungal microbiota on two bone mineral density markers, RANKL and sclerostin, in addition to the correlation between these markers and vitamin B12, D3, and zinc in CD patients, along with their potential effect on fungal microbiota and vice versa. …”
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Bridging the digital Divide: The role of educational interventions in enhancing economic growth in Ghana by Joseph Antwi Baafi, Michael Kwame Asiedu, Seyrame Pearl Kumah

“…This supports targeted implementation of Sustainable Development Goals (SDG) 4 (quality education) and SDG 8 (decent work and economic growth), ensuring inclusive and sustainable development.…”
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Gelsolin Facilitates Estrogen Receptor Beta Nuclear Translocation and Transcriptional Repression of Genes Associated with Alzheimer Disease by Yoldas Yildiz, Angela H. S. Fan, Amanda A. Hartoun, Sarah Flury, Yan Ngai, Toni R. Pak

“…<b>Background/Objectives</b>: Gelsolin (GSN) is an actin-binding protein that helps maintain neuronal structure and shape, regulates neuronal growth, and apoptosis. Our previous work demonstrated that GSN associated with estrogen receptor beta (ERβ1) in the brains of female rats, but this association was lost in advanced age. …”
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ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype by Céline Mongaret Kossmann, Maxime Annereau, Audrey Thomas-Schoemann, Carole Nicco-Overney, Christiane Chéreau, Frédéric Batteux, Jérôme Alexandre, François Lemare

“…A disintegrin and metalloproteinase 9 (ADAM9) possesses potent metastasis-inducing capacities and is highly expressed in several cancer cells. Previous work has shown that ADAM9 participates in the adhesive–invasive phenotype in lung cancer cells in vitro. …”
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