Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo by Natasha M. Nesbitt, Gian Luca Araldi, Lisa Pennacchia, Natalia Marchenko, Zahra Assar, Kendall M. Muzzarelli, Rahul Raghavan Thekke Veedu, Brian Medel-Lacruz, Eunjeong Lee, Elan Z. Eisenmesser, Dale F. Kreitler, Wadie F. Bahou

“…Abstract Biliverdin IXβ reductase (BLVRB) is an NADPH-dependent enzyme previously implicated in a redox-regulated mechanism of thrombopoiesis distinct from the thrombopoietin (TPO)/c-MPL axis. …”
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Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models by Vivian W. C. Lau, Gracie J. Mead, Zofia Varyova, Julie M. Mazet, Anagha Krishnan, Edward W. Roberts, Gennaro Prota, Uzi Gileadi, Kim S. Midwood, Vincenzo Cerundolo, Audrey Gérard

“…Importantly, analysis of transcriptomic datasets suggests that similar immune remodelling occurs in human tumours carrying mutations in the IFNγ pathway. Our work thus serves mechanistic insight for the crosstalk between tumour IFNγ resistance and anti-tumour immunity, and implicates this regulation for future cancer therapy.…”
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Improving consumer awareness for reducing food waste using partial least squares structural equation modelling (PLS-SEM) approach by Ismat Jahan, Kazi Tamzid Kamal, Prattusha Bhattacharjee, Hasin Md. Muhtasim Taqi, Syed Mithun Ali

“…In the explicative model, improper meal storage emerged as the factor with the highest correlation with the generation of FW. The implication of this research encourages stakeholders to share research findings to work toward a sustainable and food-secure future.…”
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Bacterial profiling of colorectal cancer biopsies: a culture-based study in Indian patients by Manish Kushwaha, Manish Kushwaha, Shubham Chaudhary, Akhilesh Kumar Singh, Govind K. Makharia, Anil Kumar

“…However, further investigation is required to elucidate the precise mechanisms by which the microbial community or specific bacteria contribute to carcinogenesis. The present work deals with the isolation and identification of bacteria from nine CRC biopsy samples and nine adjacent normal biopsy samples. …”
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In and out: factors influencing two decades of straying and homing by Pacific salmon within the Columbia River basin by Peter A. H. Westley, Andrew H. Dittman, Benjamin W. Nelson, Morgan H. Bond, Molly Payne, Thomas P. Quinn

“…Additionally, water temperature was positively associated with both immigration into and emigration out of hatcheries, increasing by approximately 0.5% for every degree of warming, suggesting consequences for both donor and recipient populations. This work suggests that dispersal rates may increase in a warming world, which in turn has implication for the flow of both individuals and, potentially, beneficial or deleterious genes.…”
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Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation by Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz

“…Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell behaviors. …”
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Targeting interleukin-1 signaling for renoprotection by Daria Bogdanova, Daria Bogdanova, Mikhail Y. Samsonov, Svetlana Lebedeva, Darya Bukhanova, Maria Materenchuk, Kerim Mutig

“…Sterile inflammation with ensuing immune-mediated kidney damage has been implicated in pathophysiology of acute and chronic kidney diseases. …”
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Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies by Katie Facecchia, Lee-Anne Fochesato, Sidhartha D. Ray, Sidney J. Stohs, Siyaram Pandey

“…This review discusses recent work related to oxidative toxicity in the central nervous system and strategies to treat neurodegenerative diseases.…”
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Lamiaceae honey: polyphenol profile, vitamin C content, antioxidant and in vitro anti-inflammatory, cholinesterase and tyrosinase inhibitory activity by Florinda Fratianni, Maria Neve Ombra, Beatrice De Giulio, Antonio d’Acierno, Filomena Nazzaro

“…The present work aimed to study some biochemical characteristics and in vitro health properties of Lamiaceae (mint, basil, oregano, rosemary, savory, and thyme) honey. …”
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Inefficiency of Financial Markets and Paths to the Development of a Modern Financial Theory by Miloudi Kobiyh, Adil El Amri

“…The purpose of this work is to examine new avenues for developing financial theory, including the role of ethics and cognitive psychology. …”
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Cuerpo y movimiento en las guías docentes de Didáctica de las Ciencias Sociales de Educación Infantil: un estudio de caso (Body and movement in the teaching guides of Social Scienc... by Alberto San Martín, Ana Garrido Aroz

“…Spatial-temporal notions are a fundamental objective in the teaching of Social Sciences, with important bodily and motor implications for their learning in Early Childhood Education. …”
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A Comparative Study of the Relationship Between Rights and Good in Rawlsian Perspective on the Protests Against the Murder of George Floyd (2020) and the Protests Against the Pales... by Maysam Baharloo, Mohamed Sadiq Nosratpanah

“…These concepts are then compared with Rawls’s later works and with the ideas of other political philosophers, especially Immanuel Kant, in order to clarify their role within political theory. …”
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Assessing Dynamic Cognitive Function in the Daily Lives of Youths With and Without Type 1 Diabetes: Usability Study by Mary Katherine Ray, Jorie Fleming, Andrew Aschenbrenner, Jason Hassenstab, Brooke Redwine, Carissa Burns, Ana Maria Arbelaez, Mary Ellen Vajravelu, Tamara Hershey

“…For all studies, youths were asked to complete cognitive tests on the Ambulatory Research in Cognition (ARC) smartphone app that measured processing speed, associative memory, and working memory. For the in-laboratory study, youths completed testing 4 times during 1 session. …”
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SEPLINE: Socioeconomic Position in Epidemiological Research—A National Guideline on Danish Registry Data by Hjorth CF, Kjærulff TM, Thomsen MK, Cronin-Fenton D, Dalton SO, Olsen MH

“…Insights from these workshops were integrated into iterative refinements of the guideline.Conclusions and Implications: The guideline provides a structured framework for conducting socioeconomic epidemiological research using Danish registry data, offering specific information on data sources and recommendations about variable selection, measurement timing, and data handling. …”
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The oxidation of Fe in riebeckite at 0.7 GPa by G. Della Ventura, G. Della Ventura, G. Della Ventura, R. Oberti, V. Misiti, F. Radica, G. J. Redhammer, S. Bernardini, M. Boiocchi, B. Mihailova

“…</p> <p>In this work, we address the effect of pressure on the oxidation of Fe in riebeckite, a process that is irreversible for temperatures above <span class="inline-formula">∼</span> 377 °C at 1 atm pressure, under oxidizing conditions. …”
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Benchmark soils on alluvial, fluvial and fluvio-glacial formations of the upper-Segre valley Suelos de referencia en formaciones aluviales, fluviales y fluvio-glaciales de la cabec... by Rosa María Poch Claret, Iolanda Simó, Jaume Boixadera

“…The objective of this work is to widen the knowledge about the main characteristics and formation processes of some benchmark soils developed on fluvio-glacial, alluvial-fan and terrace materials of Pleistocene and Holocene age related to the Segre river, either siliceous or carbonatic. …”
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A Virtual Mixture Approach to the Study of Multistate Equilibrium: Application to Constant pH Simulation in Explicit Water. by Xiongwu Wu, Bernard R Brooks

“…Chemical and thermodynamic equilibrium of multiple states is a fundamental phenomenon in biology systems and has been the focus of many experimental and computational studies. This work presents a simulation method to directly study the equilibrium of multiple states. …”
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Interação de atributos atrativos e obrigatórios de um serviço na satisfação do cliente Interaction of basic and excitement service attributes in customer satisfaction by Gérson Tontini, André José Sant'Ana

“…<br>Kano Model distinguishes service attributes in three types: basic, excitement and performance attributes. This work has as objective to verify how these attributes interact to proportionate satisfaction to customers. …”
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The Study the relationship between TGF-β gene expression and TH17 in influencing recurrent miscarriages in women with autoimmune thyroid disease. by Nadia M. Nageeb, Saria N. Mohsen, Hadeel A. Omear

“…Conclusion: Through this study, it was found that the presence of the TGF-β gene and its high levels maintain pregnancy and work to suppress the cytokines secreted by Th17, which stimulate miscarriage. …”
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Overcoming constraints of scaling: Critical and empirical perspectives on agricultural innovation scaling. by Million Gebreyes, Kindu Mekonnen, Peter Thorne, Melkamu Derseh, Aberra Adie, Annet Mulema, Seid Ahmed Kemal, Lulseged Tamene, Tilahun Amede, Amare Haileslassie, Aster Gebrekirstos, Walter Tamuka Mupangwa, Mohammed Ebrahim, Temesgen Alene, Addisu Asfaw, Workneh Dubale, Simret Yasabu

“…The data for the paper came from a qualitative assessment using focus group discussions, key informant interviews, and document analysis on scaling work done in Ethiopia by a USAID-funded research for development project. …”
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