Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR by Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal

“…To identify the binding site of M5-selective PAMs, we implement an integrated approach combining mutagenesis, pharmacological assays, structural biology, and molecular dynamics simulations. …”
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An Intelligent Agent-Based Resilient Framework for Marine Vessel Mission Adaptations by Nikos Kougiatsos, Evelien L. Scheffers, Marcel C. van Benten, Dingena L. Schott, Peter de Vos, Rudy R. Negenborn, Vasso Reppa

“…During operation, switching between hardware and virtual sensors as well as switching between energy management controllers is implemented to handle the effects of sensor faults. …”
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Classification of Individuals With COVID-19 and Post–COVID-19 Condition and Healthy Controls Using Heart Rate Variability: Machine Learning Study With a Near–Real-Time Monitoring C... by Carlos Alberto Sanches, Andre Felipe Henriques Librantz, Luciana Maria Malosá Sampaio, Peterson Adriano Belan

“… BackgroundHeart rate variability (HRV) is a validated biomarker of autonomic and inflammatory regulation and has been associated with both acute COVID-19 and post–COVID-19 condition. …”
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Evaluation of the physicochemical and microbiological quality of raw milk in the dairy industry of Napo, Ecuador by José Alberto de la Torres–Moreira, Milton Andrés Montalvo–Lozada, Joel Oswaldo Meza–Barrezueta, Verónica Gabriela Rivadeneyra–Espín, Kleber Alejandro Gallegos–Guerra, Kimberley Katiusca Villamarin

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Assessment of feasibility of actigraphy as a measure of clinical change in response to an experimental interventional treatment in adolescents and adults with autism spectrum disor... by Matthew Boice, Svetlana Bryant, Matthew Klein, Martine Meyer, Abi Bangerter, Srinivasan Vairavan, Gahan Pandina

“…Additional significant correlations were observed between caregiver reported outcomes of self-regulation and actigraphy features measuring daytime physical activity. …”
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The value-added model of the supply chain of petrochemical industries with a sustainable development approach by ali amiri, seyed abbas heydari, vahidreza Mirabi

“…Legal factors: following up and complying with local and international laws and regulations, creating solutions to adapt to legal changes, and maintaining compliance with standards and regulations can be efficient.…”
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LEGAL STATUS AND COST-EFFECTIVENESS OF SUPERVISORY BODIES IN PREVENTING OFFENSES IN THE CONSTRUCTION SECTOR by Volodymyr Buha, Valentyn Tulinov, Valerii Kosse

“…The coordination of activities across different sectors, and the degree to which these sectors influence one another, directly impact the overall efficiency of economic growth. …”
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Pesticide Exposure and Hypertension Risk in Indonesian Agricultural Workers: A Systematic Review and Meta-Analysis by Suratman, Khaidar Ali, Muhammad Addin Rizaldi

“…The findings highlight the urgent need for stricter environmental health regulations, the implementation of integrated pest management, and improved education on pesticide safety. …”
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Scientific and methodological tools of cost management of enterprises: the main approaches and proposals by M. S. Dikunova

“…However, there are problems of its implementation with regard to the current economic situation in the state.The law regulates supply and marketing policy of the companies. …”
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Legal aspects of protecting the Ukrainian population against emergencies under martial law by O. A. Lukianykhina, S. A. Petrovska

“…The introduction of martial law on the territory of Ukraine affects the civil defence system in terms of the legal framework and the process of organising disaster protection, which is manifested in the following 1) in addition to the Civil Protection Code of Ukraine No. 5403-VI of 2 October 2012 and departmental by-laws in the field of civil protection of the population from emergencies, an extra legal basis appears in the form of the Decree of the President of Ukraine on the introduction of martial law, the provisions of which may define additional tasks in the field of civil defence; ensure the implementation of functions on protection of the population from emergencies; 2) the structure of public administration is changed, which provides for the establishment of military administrations, which, in cooperation with the military command, ensure coordination of public authorities, in particular those responsible for the protection of the population from emergencies; 3) during the legal regime of martial law, it is allowed to involve citizens of Ukraine in socially useful works carried out to eliminate man-made, natural and military emergencies that occurred during martial law and their consequences It is noted that the procedure for engaging representatives of the categories specified in the Resolution of the Cabinet of Ministers of Ukraine “On Approval of the Procedure for Engaging Able-bodied Persons in Socially Useful Work under Martial Law” needs to be clarified at the level of individual by-laws and regulations at the level of peculiarities of their collection, notification, management of their activities, disciplinary liability and the system of payment of remuneration in cash or in kind, non-material incentives, their institutionalisation and methodological basis for organising and conducting such work.…”
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Taxation of personal income in the context of issues of social fairness by N. M. Artemov, K. A. Ponomareva

“…Second, income tax allows to maximize the implementation of the basic principles of taxation - universality and uniformity. …”
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Spatial revitalization and renewal strategies of historic neighborhoods in poor places based on Depthmap–taking Zhengyangguan township neighborhood in Shou County, Huainan City, Ch... by Li Hong, Liwen Sun, Shuowen Feng, Meiling Miao, Xinran Zhu, Aoxue Wang

“…Additionally, highly accessible streets are prohibited from centralized stall activities, and low-cost operational space is under centralized regulation. …”
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Roman law and modern national systems of civil procedure: metamorphoses of harmonization of the civil process within the framework of European and Eurasian integration by Nadezhda V. Sukhova

“…The author also tries to synthesize some trends in the development and convergence of civil procedural law in Europe and in post-Soviet space making attempts to find some unity in the diversity of transformations.Methodological bases of research are General scientific methods (dialectics, analysis, synthesis, comparison); private and scientific methods (interpretation, formal-logical, comparative-legal, based on the actual approach).The aims of the article are: to analyze the reasons and factors that influence the convergence of the civil process in the framework of European and Eurasian integration; to identify gaps in legal regulation, difficulties encountered in the activities of courts in the implementation of justice; to identify trends in the further development of the civil process within the framework of European and Eurasian integration.The main scientific results. …”
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The diagnostic and predictive potential of lncRNA CASC2 targeting miR-155 in systemic lupus erythematosus patients with nephritis complication by Nada R. Mohamed, Abeer l. Abd El-Fattah, Olfat Shaker, Ghadir A Sayed

“…Quantification of lncRNA CASC2 and miR-155 in serum samples from the Egyptian population was carried out with real-time polymerase chain reaction (RT-PCR). The disease activity index (SLEDAI) for SLE was evaluated, and the analysis of the receiver operating characteristic (ROC) curve was implemented. …”
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Current issues of digitalization of criminal proceedings: a look into the future by G. M. Meretukov, S. I. Gritsaev, V. V. Pomazanov

“…Which rest on the need to reform the entire system of the branch of law, as the digitalization of any sphere of activity requires changes in formal and constitutional institutions, culture, as well as the creation and use of AI artificial intelligence systems, the creation of technological capabilities to analyze huge amounts of Big Data and the protection of personal data. …”
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Characteristics of neutron fields at pool-type research nuclear reactors by M. D. Pyshkina, M. V. Zhukovsky, A. V. Vasilyev, A. A. Ekidin, E. I. Nazarov, M. A. Romanova, M. N. Anikin

“…The performed studies allow to improve the system of individual dosimetric control based on the cycle of improvements: new knowledge – experimental studies – implementation of research results – regulation of activities to reduce the exposure of workers – analysis of the data obtained – new knowledge. …”
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Analysing the Influence of Augmented Reality on Organization Performance via Supply and Logistics Value Chain Functions: A Hybrid ANN-PLS Model Assessment in the Gulf Cooperation C... by Ahmad Aburayya

“…<i>Results</i>: The current paper’s statistical evidence demonstrates that AR implementation has a positive impact on the supply and logistics value chain activities and organizational performance of furniture suppliers in the GCC region. …”
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Information transparency in research funding organizations: a case study of the Supreme Council of Ataf and the Iran National Science Foundation by Reza Hesan, Amir Hossein Seddighi

“…There is also a need to pursue and implement transparency in the organizations involved in the science and technology system that use public budgets. …”
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Smart Tourism in ASEAN: Leveraging Technology for Sustainable Development and Enhanced Visitor Experiences by Wai Yie Leong, Yuan Zhi Leong, Wai San Leong

“…The adoption of sustainable practices through incentives and regulations promotes eco-friendly accommodations, sustainable transportation options, and responsible tourism activities, which enhances ASEAN Smart Tourism initiatives.…”
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Responsible Consumption – Source of Competitive Advantages and Solution for Tourist Protection by Gheorghe Epuran, Bianca Tescașiu, Raluca Dania Todor, Karin-Andreea Sasu, Nicoleta Cristache

“…With no connection with the area of activity, the XXIst century companies make real efforts to obtain competitive advantages by a consequent implementation of social responsibility, by assuring a responsible consumption in all the processes, and by protecting the consumer interests and rights. …”
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