Novel Insight into the Multiple Biological Characteristics of Polyamines in the Gut: From Structure to Function by Xinyi Yu, Shuzi Xin, Xiaohui Liu, Luming Pan, Weikai Shi, Yize Li, Hongli Wang, Xin Lu, Han Gao, Jingdong Xu

“…Furthermore, the connection between polyamines and normal immune cell functions, as well as their roles in autoimmune and antitumor immune cell functions, is significant. …”
Get full text

FUNCTIONAL POLYMORPHISM OF THE PRO-INFLAMMATORY CYTOKINE GENES IN PULMONARY TUBERCULOSIS by E. G. Churina, O. I. Urazova, V. V. Novitsky, A. V. Sitnikova, S. E. Barmina

“…The MBT antigens can cause dysfunction of the receptors and modulate the cytokine secreting function of immunocompetent cells. Polymorphic genes of pro-inflammatory cytokines involved in the mechanisms of defense responses of innate immunity, determine the degree of resistance to individual mycobacterial infection, as well as severity and duration of the disease in cases of clinical manifestations. …”
Get full text

Structural and functional state of blood lymphocytes in patients with infectious mononucleosis with different course by Ya. V. Kolesnyk, T. O. Briukhanova, M. Yu. Sliepchenko, O. A. Nakonechna, O. H. Sorokina

“…From the B-system of immunity in patients with a prolonged course of IM in comparison with the acute course increased content of CD22 was more often determined, as well as low levels of IgA, IgM <1.1 g/l and IgG <10.0 g/l. …”
Get full text

Mechanisms of immune regulation and transplantation immunity in corneal transplants by V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

“…Endothelial rejection causes the most severe affection of visual functions, due to the inability of local endothelial recovery, and water accumulation due to the endothelial dysfunction.Graft rejection is clinically characterized by edema and the presence of inflammatory cells, either circulating in the anterior chamber, or forming precipitates on the graft endothelial cells.A number of factors are associated with an increased risk of corneal graft rejection, including the degree of inflammation and/or vascularization of the transplant bed i.e., location of the donor cornea, repeated keratoplasty, allosensitization due to other cellular transplants, including bone marrow, blood transfusions, pregnancy, etc., as well as allergic and systemic diseases.This review article considers and systematizes the data from the literature concerning studies of the factors determining the immune privileged state of cornea, and the ACAID phenomenon, their role in development of allotolerance in corneal transplantation, highlights the main conditions required for triggering the tissue incompatibility reactions, discusses the mechanisms of allogeneic recognition and effector stage of the immune response, destruction of corneal allografts.…”
Get full text

ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses by Rebecca L. Wallings, Drew A. Gillett, Hannah A. Staley, Savanna Mahn, Julian Mark, Noelle Neighbarger, Holly Kordasiewicz, Warren D. Hirst, Malú Gámez Tansey

“…Grn-deficiency is known to alter peripheral immune cell function, including impaired autophagy and altered cytokine secretion. …”
Get full text

O antigen allows B. parapertussis to evade B. pertussis vaccine-induced immunity by blocking binding and functions of cross-reactive antibodies. by Xuqing Zhang, Maria Eugenia Rodríguez, Eric T Harvill

Get full text

Dietary Puerarin Enhances Growth, Immune Function, Antioxidant Capacity, and Disease Resistance in Farmed Largemouth Bass, <i>Micropterus salmoides</i> by Yi Huang, Wenjing Ma, Disen Zhang, Xi Chen, Zhiqiu Huang, Yuhang Hong

“…Dietary supplementation with moderate doses of puerarin (200 and 500 mg/kg) effectively suppressed inflammation and enhanced immune function, while the highest dose (1000 mg/kg) may mildly activate the immune system. …”
Get full text

iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides by Xiaofei Xu, Xiaofei Liu, Jin Chen, Jingjing Guan, Donghui Luo

Get full text

Mucosal barrier function and microbial community of small intestines in sheep in response to dietary energy concentrations by X.L. Wang, J. Zhou, M.L. Lu, S.P. Zhao, W.J. Li, G.B. Quan, B. Xue

“…To determine the optimal dietary energy concentration for the intestinal health of sheep, we compared microbiota, barrier function, and mucosal immunity in the small intestine of sheep consuming diets with different metabolisable energy (ME) concentrations. …”
Get full text

Inorganic dietary nanoparticles in intestinal barrier function of inflammatory bowel disease: allies or adversaries? by Duo Luo, Guifang Luo, Haoming Xu, Kangbao Li, Zhaotao Li, Cong Zhang

“…Considering that impaired intestinal barrier function plays a central role in the pathogenesis of IBD, this review concentrates on the roles and mechanisms of IDNPs in the intestinal barrier (physical, chemical, biological, and immune barriers) of IBD patients. …”
Get full text

A pan-cancer study of ADAM9’s immunological function and prognostic value particularly in liver cancer by Mandana AmeliMojarad, Melika AmeliMojarad, Jiang Wang, Vahid Tavakolpour, Parvin Shariati

“…Abstract A pan-cancer analysis summarizing the overall changes in mRNA and protein stability of ADM9, as well as its oncogenic function on immune cell line modulation and checkpoints within the tumor microenvironment (TME), is lacking, despite the fact that ADM9 up-regulation is correlated with the progression of many cancers. …”
Get full text

The aging hematopoietic stem cell niche: a mini review by Xin Gao, Jing Zhang, Jing Zhang, Owen J. Tamplin

Get full text

Role of the cellular immunity in the formation of the immune response in coronavirus infections by I. A. Ivanova, N. D. Omelchenko, A. V. Filippenko, A. A. Trufanova, A. K. Noskov

“…The data obtained during previous epidemics caused by coronaviruses, and current pandemic indicate that assessing the role of certain immune interactions between these viruses and the microorganism is the main pre-requisite for development of diagnostic test systems as well as effective medical drugs and preventive measures. …”
Get full text

ISOLYQUIRITIGENIN AFFECTS PHAGOCYTES FUNCTIONS AND INCREASES MICE SURVIVAL RATE IN STAPHYLOCOCCAL INFECTION by E. A. Solenova, S. I. Pavlova

Get full text

Effects of Different Levels of <i>Lycium barbarum</i> Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks by Minhang Tu, Gentan Cai, Longfei Ma, Leyan Yan, Tian Wang, Zhendan Shi, Chao Wang, Zhe Chen

“…This study aimed to explore the effects of different concentrations of LBFs on the growth performance, immune function, intestinal barrier, and antioxidant capacity of meat ducks. …”
Get full text

Enterotoxigenic Escherichia coli heat-labile enterotoxin induces cell death and disrupts effector functions in porcine monocytes by Jinglin Ma, Hans Van der Weken, Leen Hermans, Matthias Dierick, Eric Cox, Bert Devriendt

“…Furthermore, LT triggered the production of the cytokines IL-1β, IL-6 and TNF-α as well as the chemokines CCL-3 and CXCL-8. Together, our results show that, in contrast to STa, LT can cause monocyte death and disrupt monocyte immune effector functions, potentially acting as an immune evasion strategy to establish infection.…”
Get full text

Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice by Natasha A. Trzaskalski, Melissa M. Dann, Antonio Hanson, Branka Vulesevic, Evgenia Fadzeyeva, Natasha Jeraj, Ilka Lorenzen‐Schmidt, Rick Seymour, Erin E. Mulvihill

“…Abstract The association between metabolic dysfunction–associated steatotic liver disease (MASLD) and cardiovascular disease is well characterized; however, the underlying mechanism is incompletely understood. …”
Get full text

Effects of 4-hydroxyphenylacetic acid, a phenolic acid compound from Yucca schidigera extract, on immune function and intestinal health in meat pigeons by Yuxin Shao, Yipu Li, Shuxian Xie, Bo Zhang, Jing Li, Yalei Wang, Yusheng Gao, Jianyuan Ma, Asmaa Taha Yaseen Kishawy, Lihong Gu, Tenghe Ma, Zheng Wang

“…In conclusion, 600 μM 4-HPAA exhibits anti-inflammatory activity in Caco-2 cells, and 2000 mg/kg 4-HPAA promotes immune function and intestinal barrier integrity while inhibiting glycolytic gene expression and the production of related serum metabolites in meat pigeons.…”
Get full text

Optimistic effects of dual nano-encapsulated probiotics on breeders laying performance, intestinal barrier functions, immunity and resistance against Salmonella Typhimurium challen... by Mohamed Tharwat Elabbasy, Asmaa T. Y. Kishawy, Walaa S. Abdelaziz, Ahmed Abdelfattah Hassan, Hend S. Nada, Reham A. Elbhnsawy, Amany M. Shosha, Dina Ibrahim, Fatma Eldemery, Shimaa A. E. Atwa, Wafaa R. I. A. Sherief, Eman S. El-Shetry, Ayman A. Saleh, Doaa Ibrahim

Get full text

CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS... by Yu. V. Zhukova, A. A. Alshevskaya, F. D. Kireev, O. A. Chumasova, N. S. Shkaruba, A. E. Sizikov, Yu. A. Lopatnikova, D. V. Demina, A. V. Karaulov, A. N. Silkov, S. V. Sennikov

“…These findings indicate that the coexpression profile of TNFR1 and TNFR2 receptors in patients with RA and BA differ within these groups as well as compared to that in healthy subjects. These immune cell populations are actively involved in the pathogenesis of both rheumatoid arthritis and bronchial asthma, so the results may indicate that these cells might show different responses to TNFα as the percentage and the number of receptors on their surface vary.…”
Get full text