Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity by Weiwei Chen, Yaya Ji, Rui Wang, Ruijie Ji, Yujian Lin, Yuhang Wu, Lehan Liu, Tianle Sha, Wen Li, Lei Zhang, Longfei Yang, Xinhua Zhang, Jianxiang Song

“…This study aims to assess the prognostic value of POU3F4 in thirty-three cancers and explore its immune-related functions. Based on data from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression (GTE), and Gene Set Cancer Analysis (GSCA), we employed various bioinformatics approaches to investigate the potential carcinogenic effects of POU3F4. …”
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The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without se... by Ayesha Shah, Seungha Kang, Nicholas J Talley, Anh Do, Marjorie M Walker, Erin R Shanahan, Natasha A Koloski, Michael P Jones, Simon Keely, Mark Morrison, Gerald J Holtmann

“…We compared gastrointestinal symptoms, sensory function, psychiatric comorbidities, gut-homing immune cells, and duodenal mucosa-associated microbiome (d-MAM) in FGID patients and controls with and without self-reported wheat sensitivity (SR-NCWS). …”
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Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer by Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher, Christina Plattner, Baharak Hosseinkhani, Zlatko Trajanoski, Dominik Wolf, Peter Carmeliet, Andreas Pircher

“…Understanding the multifaceted roles of TECs as well as assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development of therapeutic interventions, particularly in the context of advanced immunotherapy and anti-angiogenic treatments. …”
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Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). by Tolunay Beker Aydemir, Shou-Mei Chang, Gregory J Guthrie, Alyssa B Maki, Moon-Suhn Ryu, Afife Karabiyik, Robert J Cousins

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High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironmentResearch in context by Jiachen Liu, Zhen Shi, Yajian Li, Jie Ma, Jiaying Yao, Zan Yuan, Yuanhao Wang, Chunyuan Yang, Xiao Li, Nianzeng Xing, Yunping Zhu, Jianhong Zhang, Li Wu

“…Furthermore, our study demonstrates that TREM2 and APP function as immune-modulating molecules, with potential therapeutic implications in the context of bladder cancer. …”
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Effect of freeze-dried powder of lactic acid bacteria treatment of pediatric bacterial peritonitis on immune function and nutritional status by Yang Xue, YuTing Zhang

“…Conclusions Freeze-dried powder of lactic acid bacteria can improve immune function and nutritional status, as well as reduce inflammatory response and intestinal flora dysbiosis in pediatric bacterial peritonitis.…”
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Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells by Nibedita Mitra, Prosanto Chowdhury, Anupam Basu

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The role of TLR-4 gene in the functioning of the natural human immune system and the immunopathogenesis of chronic hepatitis C (literature review) by T.I. Koval, L.M. Syzova, N.O. Pryimenko, A.Н. Sydorenko, M.V. Kulіsh, V.I. Ilchenko, N.P. Lymarenko

“…The article analyzes and summarizes the data of professional scientific sources on the role of the TLR-4 gene in the functioning of the natural human immune system, as well as Asp299Gly polymorphism of this gene in the immunopathogenesis of CHC. …”
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Drug functional remapping: a new promise for tumor immunotherapy by Jiayi Dong, Jiayi Dong, Jiayi Dong, Ting Su, Ting Su, Ting Su, Ting Su, Jiexiong Wu, Yu Xiang, Yu Xiang, Yu Xiang, Yu Xiang, Minghan Song, Minghan Song, Minghan Song, Canfeng He, Canfeng He, Canfeng He, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Yubin Yang, Yubin Yang, Size Chen, Size Chen, Size Chen, Size Chen

“…A study suggests that drug repositioning has the potential to modulate immune cell activity or alter the tumor microenvironment, thereby circumventing the resistance mechanisms associated with immune checkpoint blockade. …”
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Association between pan-immune-inflammation value and Serum Klotho levels: a cross-sectional analysis of renal function mediation by Mingjie Liu, Xuan Zhou, Han Xu, Yan Wang, Yuting Duan, Xiangru Guo, Bai Wei

“…Cancer survivors exhibited significantly lower Klotho levels than non-cancer participants (813.74 ± 8.55 vs. 849.69 ± 5.08 pg/mL; P < 0.0001), as well as higher PIV values (320.07 ± 6.58 vs. 299.07 ± 3.44; P = 0.0059).ConclusionElevated PIV was found to be significantly associated with lower klotho levels, with renal function indicators playing a mediating role.…”
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Identification of TAPBPL as a novel negative regulator of T‐cell function by Yujun Lin, Cheng Cui, Min Su, Lawrence K Silbart, Haiyan Liu, Jin Zhao, Lang He, Yuanmao Huang, Dexin Xu, Xiaodan Wei, Qian Du, Laijun Lai

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Assessing hand motor function in chronic immune-mediated neuropathies: a proof-of-concept study using a data glove by Elisa Gilliam, Pascal Achenbach, Gernot J. Suemmermann, Manuel N. Wessely, Peter Rossmanith, Maike F. Dohrn, Jörg B. Schulz, Anne Waschbisch, Robert Brunkhorst

“…Additionally, the data glove proved to be a valid tool, as we demonstrated moderate to strong, significant correlations between the glove and established clinical parameters (especially Vigorimeter), as well as PROMs (especially R-ODS). Conclusions This data glove allowed for a non-invasive assessment of the hand motor function and yielded investigator-independent results that reliably reflected individual functional deficits with relevance to everyday life. …”
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Identification of a Novel Antibacterial Function of Mammalian Calreticulin by Yichao Ma, Jiachen Liu, Xinming Qin, Xiaojing Cui, Qian Yang

“…Calreticulin is a highly conserved and multifunctional molecular chaperone ubiquitously expressed in humans and animals. Beyond its well-established roles in calcium homeostasis, protein folding, and immune regulation, recent studies in aquatic species have suggested a previously unrecognized antimicrobial function of calreticulin. …”
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Effect of dietary Clostridium butyricum supplementation on growth performance, immune function, and intestinal health of hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus l... by Weijun Chen, Tao Song, Dong Li, Mingfan Chen, Pan Wang, Jidan Ye

“…Supplementation with C. butyricum also altered the composition of the gut microbiota, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria, thereby further enhancing ZO-1 expression and intestinal barrier function.DiscussionThis study suggests that supplementing C. butyricum has a significant immunomodulatory effect on hybrid grouper, enhancing serum immune parameters, alleviating intestinal inflammation and oxidative stress, and promoting intestinal health. …”
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Anti-viral immune enhancer properties of some micro-nutrients and functional Herbs with the potential to augment the treatment of COVID-19 patients by yaseen galali, Simon Davies, Holem Balaky, Ahmad Jabbar

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A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer by Chunmei Lin, Zhiqiao Xu, XinLiang, Hong Wei, Xiaoping Wang

“…Abstract Background The purpose of this study is to evaluate the effect of oxycodone and sufentanil on postoperative analgesia and immune function in patients with laparoscopic resection of colorectal cancer (CRC), as well as the serum level of inflammatory cytokine. …”
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The impact of Toll-like receptors on the immune system functioning and on the immunopathogenesis of chronic hepatitis C: a modern view (literature review) by L. M. Syzova, T. I. Koval, V. I. Ilchenko, I. M. Zviaholska, О. M. Iziumska

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<i>Artemisia annua</i> Residue Regulates Immunity, Antioxidant Ability, Intestinal Barrier Function, and Microbial Structure in Weaned Piglets by Jinjie Hu, Miaomiao Bai, Yueyao Xing, Junhong Liu, Kang Xu, Xia Xiong, Hongnan Liu, Yulong Yin

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The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day” by Lana McClements, Alexandra Kautzky-Willer, Georgios Kararigas, Sofia B. Ahmed, John N. Stallone

“…This article clearly reveals the striking importance of sex differences in cardiovascular, metabolic, and immune system functions in health and in the pathogenesis of disease processes, which likely involve a combination of effects of the sex chromosomes as well as the gonadal steroid hormones. …”
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Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

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