Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Targeted therapies against key targets in GC, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR), have shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. …”
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Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth by Ghulam Murtaza, Najmaldin Ezaldin Hassan, Muhammad Usman, Gang Deng, Zeeshan Ahmed, Javed Iqbal, Mohamed S. Elshikh, Humaira Rizwana, Basharat Ali, Rashid Iqbal, Maximilian Lackner

“…Lead (Pb), a toxic metal, causes severe health hazards to both humans and plants due to environmental pollution. …”
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Beef cattle performance and hair cortisol accumulation in silvopastoral and pastoral systems: a 2-year assessment by A. Ripamonti, G. Foggi, A. Mantino, L. Turini, J. Goracci, A. Silvi, M. Finocchi, M. Mele

“…Additionally, we monitored microclimate conditions in both systems via the black globe humidity index (BGHI) as a heat stress proxy for outdoor-reared animals. …”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…Series of the population studies, confirming association of HLA antigens with human diseases were carried out. Main histocompatibility complex (MHC) plays the leading role in immune response as well as in development of CD, therefore occurrence of disease is related to changes at genetic level. …”
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Calm ocean, stormy sea: atmospheric and oceanographic observations of the Atlantic during the Atlantic References and Convection (ARC) ship campaign by L. Köhler, L. Köhler, J. Windmiller, D. Baranowski, M. Brennek, M. Ciuryło, L. Hayo, D. Kȩpski, S. Kinne, B. Latos, B. Lobo, T. Marke, T. Nischik, D. Paul, P. Stammes, A. Szkop, O. Tuinder

“…We present data from the integrated ship sensors (DSHIP); a humidity and temperature profiler (HATPRO); a ceilometer; aerosol instruments (DustTrak, Microtops, and Calitoo); radiosondes; uncrewed aircraft vehicles (UAVs); and conductivity, temperature, and depth (CTD) profiles of the upper ocean. …”
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COVID-19 in patients with severe mental illness: An analysis of in-patients at a psychiatric hospital in Cape Town by Haseena B. Sablay, Qhama Z. Cossie, Deirdre I. Pieterse

“…Reported comorbidities included nicotine use (71%, n = 181), hypertension (11%, n = 28) and human immunodeficiency virus (7%, n = 18). Most patients (62%, n = 156) were symptomatic for COVID-19. …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…While the toxicological effects of 3-ADON on human and animal health are well-documented, its specific impact on the reproductive system remains underexplored. …”
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Disparities in well-being outcomes among medical students: a comparative study between medical students with and without disability by Henry J. Seaborne, Lara Z. Chehab, Nikhil Rajapuram, Amanda Sammann

“…Trial registration This study does not report the results of a health care intervention on human participants, so trial registration is not required.…”
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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati... by Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang

“…Our results found that melatonin administration effectively inhibited BDE-47-induced ferroptosis in mice hippocampi and murine hippocampal neuronal HT-22 cells. Acyl-CoA synthetase long-chain family member 4 (ACSL4), a key lipid metabolism enzyme dictating ferroptosis sensitivity, accompanied by higher MDA and lipid reactive oxygen species (ROS), was remarkably increased under BDE-47 stress, while melatonin supplementation could suppress the elevated ACSL4 in vivo and in vitro. …”
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Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

“…In this study, we demonstrate that ES outperforms BDNF in promoting neuronal maturation in human neuroblastoma SH-SY5Y. Additionally, we address the question regarding which ES parameters regulate biological responses. …”
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Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome by Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev

“…The area of interaction of intestinal bacteria and the human body is not limited to the intestines. Intestinal bacteria demonstrate a significant humoral effect due to signalling molecules, some of which exhibit neurotransmitter properties. …”
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Causes of the exceptionally high number of fatalities in the Ahr valley, Germany, during the 2021 flood by B. Rhein, B. Rhein, H. Kreibich

“…Specific recommendations for disaster management are (1) that in the event of such extreme flash floods, the warning messages must focus on saving human lives – i.e. those at risk must be advised to move to safe places, e.g. to the upper floors, instead of trying to save belongings – and (2) evacuations must be initiated in good time, especially where flooding of the ground floor with high water levels is to be expected, paying particular attention to the safety of the elderly and people with limited mobility.…”
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Behavioural Response To Self-Medication Practice Before and During Covid-19 Pandemic in Western Uganda by Samuel Sunday, Dare, Ejike, Daniel Eze, Isaac, Echoru, Ibe Michael, Usman, Fred, Ssempijja, Edmund Eriya, Bukenya, Robinson, Ssebuufu

“…This may be partly because of the absence of a recognized treatment for the disease, however, the differing prevalence and nature from country to country may influence human behavioral responses. Purpose: This study aimed to investigate the behavioral response to self-medication practices during the COVID-19 pandemic and lockdown in comparison to the pre-COVID period in Western Uganda. …”
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Quantification of Lead and Zinc in Ground, Surface and Tap Drinking Water Sources in Kabale Municipality. by Mongusho, Ivan

“…Water is a dynamic source, essential for all aspects of human and ecosystem for existence and health. Apparently drinking water sources are affected by anthropogenic activities. …”
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Employees Team Work and Performance of Organizations in Kabale District: A Case Study of Kabale District Local Government. by Akansasira, Mathius

“…The study findings concluded showing the benefits of employee teamwork of organization in Kabale district include; team exists to achieve a shred goal, boundedness means the team has an identifiable membership, members of group usually do not take responsibility for any result other than their own, productivity, satisfaction and individual well being is achieved, organizations can be successful if they use all of their human resource capacity, compensation can be removed as an obstacle to effective teamwork.…”
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The Role of Donations and Education Services in Kabale Municipality Kabale District. by Ampaire, Bronia

“…The study recommends that for the success of donor-funded projects, contextualizing them to the societal and humane capital framework in which delivery is essential. …”
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Procurement Auditing and Service Delivery in Procuring Entities in Uganda: A Case Study of Kabale Regional Referral Hospital. by Aijuka, Jacob

“…The study targeted a population of 59 respondents, including 1 in-charge, 2 human resource officers, 2 procurement officers, and 54 staff members. …”
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Impact of Effective Recruitment and Selection Practices on Organizational Performance: A Case Study of Kabale District Local Government. by Nyakiti, Deborah

“…These included the 1 CAO and 2 human resource management officers, 2 accounting and 2 finance officers, and 4 from procurement departments and 39 clients. …”
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Investigating the Performance of Epoxy Concentrations in the Self-Healing of Concrete. by Manzi, Evans Evalist

“…Traditional methods of repair often involve human intervention and significant costs. In recent years, the concept of self-healing concrete has gained traction as a potential solution to mitigate the impact of cracks and enhance the longevity of structures. …”
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Impact of Climate Variability on Coffee Production in Kambuga Sub-County Kanungu District. by Tumutegyerize, Vicent

“…The findings showed that climatic factors that have affected coffee production in Kambuga sub-county, Kanungu district include; Temperature, Rainfall Patterns, Pests and Diseases, Rainfall, Humidity, and Climate Extremes. The study revealed the impact of climate variability on Coffee Production in Kambuga sub-county, Kanungu district, and these include; climate change as a reason for the rapid spread of leaf rust, hotter temperatures have caused plants to lose several growing days in their usual harvest cycle, coffee plants need a terrain with rich soil, rainfall and temperature changes are likely to reduce yields of desirable crops, temperature increases may cause changes in runoff and groundwater recharge rates. …”
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