Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging by Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga

“…New in vitro binding data is also made available for (-)-FEOBV with human-sourced σ1 receptors, revealing a 300-fold stronger affinity for VAChT compared to σ receptors. …”
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Physical Activity and Gallstone Disease by I. N. Grigor’eva, T. E. Notova, T. I. Romanova

“…PA favorably affects almost all mechanisms of gallstone formation: improves cholesterol metabolism in bile, increases serum HDL cholesterol, bile acid synthesis, stimulates the release of cholecystokinin, reduces mucin hypersecretion, increases the diversity and richness of the intestinal microbiota. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. Here, we investigated whether the duodenal epithelium of MASH patients could exhibit intrinsic dysfunctions. …”
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CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Abstract Background Colorectal cancer (CRC) stands as one of the most serious threats to human health, with its mortality rate increase during the past years. …”
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A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication by Jane Loftus, Bradley S. Miller, Craig S. Parzynski, Jose Alvir, Yong Chen, Priti Jhingran, Anu Gupta, Mitch DeKoven, Victoria Divino, Jenny Tse, Jing He, Michael Wajnrajch

“…Somatropin - a type of human growth hormone that can be made in a laboratory and used to treat growth hormone deficiency.…”
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Level of fecal neopterin and calprotectin in asymptomatic and symptomatic norovirus-infected children with malnutrition in Indonesia by Anisa Lailatul Fitria, Zayyin Dinana, Aussie Tahta Maharani, Alinda Syifa Fumizuki, Faiz Nabila Mumtazya, Dominikus Raditya Atmaka, Laura Navika Yamani, Juniastuti, Maria Inge Lusida, Soetjipto, Septa Indra Puspikawati

“…We assessed the fecal neopterin and calprotectin from the stools samples collected during viral diarrhea surveillance in Surabaya, East Java, Indonesia, using commercially ELISA kit from BT Lab (Zhejiang, China) for human neopterin and calprotectin. The statistical differences were tested using Kruskal-Wallis nonparametric test. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Abstract Mammography is the recommended imaging modality for breast cancer screening. Expressions of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), and progesterone receptor (PR) are critical to the development of therapeutic strategies for breast cancer. …”
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Damage symptoms, development, and reproductive performance of the fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) on fodder maize and cob by Hend O. Mohamed, Hassan F. Dahi, Azza A. Awad, Walaa E. Gamil, Bassam F. Fahmy

“…The results exhibited that the FAW larvae were able to feed on and infest both fodder maize and corn cobs, causing significant damage particularly to the cobs making them unsuitable for marketing and human consumption. Moreover, the larvae and pupae from the corn cobs had the greatest weight and were significantly affected by food items. …”
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The Effect of Implementing Self-Compassion Program on Moral Injury of Nursing Students by Hanie Dahmardeh

“… Background: Self-compassion can have a significant role and impact on moral damage, and the positive components of self-compassion (self-kindness, common human sense, and mindfulness) reduce the negative effects of moral damage, so using self-compassion methods can reduce the moral damage caused to nursing students during their studies. …”
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Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic arsenic exposure on prostate cancer metastasis still unclear. …”
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Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Materials and methods Human cholangiocarcinoma cell lines QBC939 and RBE were purchased for in vitro studies. …”
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The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics by Szonja Polett Pósa, Éva Saskői, Lili Bársony, Lőrinc Pongor, Fanni Fekete, János Papp, Anikó Bozsik, Attila Patócs, Henriett Butz

“…Based on data from 1085 human breast cancer specimens, GR pathway expression correlated with migratory, extracellular matrix, and angiogenesis gene signatures. …”
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International Experience of Innovative Development of the Forest Industry in the Post-War Period and Its Adaptation for Ukraine by Petrashchuk Mykola V.

“…Also, one of the most common factors of negative impact on the forest ecosystem is human activity, which, in particular, consists in the use of forest resources for economic purposes by logging without appropriate permission. …”
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Evaluation of the penetration depth of Guttaflow bioseal and Bioceramic sealers using scanning electron microscope (in vitro study). by Razawa Kareem Saeed

“…Methods: Twenty extracted single-rooted human teeth (mandibular first premolar) were used in this study, teeth were decornated leaving 10 mm root length. …”
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Validation of the factor structure of the Experiences Questionnaire using Exploratory Graph Analysis by Lena Rader, Barbara Drueke, Saskia Doreen Forster, Siegfried Gauggel, Verena Mainz

“…The two dimensions of the EQ-D showed a high internal consistency (DP: ω = 0.74; AS: ω = 0.86) and discriminant validity with the rumination items of the EQ. Furthermore, a high convergent validity of the EQ was established, as the AS factor exhibited a significantly stronger correlation with self-esteem than the DP factor (z = 7.98, p < 0.001), which aligns with theoretical considerations suggesting that the AS factor encompasses aspects of self-compassion alongside decentering. …”
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Measurement the Physiological Properties of Water Pipe Smokers in Shekhan Distract by Abdullah. M. Al-Saiegh, Turki Sabri Haji, Jihan Saado Ahmed, Alaa Azzo Aslo, Firas Faris Khalaf

“…Smoking is one of the old habits used by humans before 400 years ago, where this custom was exclusively used in males with the development of time, tools, ingredients and flavors that used in hookah the women also started smoking, which led to an increase in the prevalence of use in many countries of the world Smoking is one of the reasons that lead to an increase in the percentage incidence of lung cancer, chronic lung disease ,mouth disease ,teeth deformation and gingivitis. …”
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Design of a Mechanized Road Sweeper by Asiimwe Dianah

“…Street sweeping has become an important service used to remove debris deposited on roadways to keep them dean to ensure the health and safety of human beings. The objective of this research was to design a mechanized road sweeper in order to ease and improve the street sweeping process. …”
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Investigation of the Content and Dynamics of Nutrients In The Surface Water of Lake Mulehe In Kisoro District, South-Western Uganda. by Saturday, Alex

“…The recorded overall WQI value places Lake Mulehe’s water quality into the ‘poor’ category in terms of worthiness for human consumption. The study, therefore, recommends continuous pollution monitoring and enforcement of local regulations to reduce pollution in the lake as a result of anthropogenic activities.…”
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Records Utilization and Service Delivery in The Central Registry at Kabale District Local Government. by Namanya, Ovet

“…The findings from the study revealed that there are challenges faced in the Utilization of records at the Central Registry at Kabale District Local Government such as high relative humidity, abuse, mishandling, and lack of enough funds to support the management of records. …”
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Improved estimates for extinction probabilities and times to extinction for populations of tsetse (Glossina spp) by Damian, Kajunguri, Elisha B., Are, John W., Hargrove

“…These mortality levels can be achieved for some species using insecticide-treated targets or cattle— providing thereby a simple, effective and cost-effective method of controlling and eradicating tsetse, and also human and animal trypanosomiasis. Our results are of further interest in the modern situation where increases in temperature are seeing the real possibility that tsetse will go extinct in some areas, without the need for intervention, but have an increased chance of surviving in other areas where they were previously unsustainable due to low temperatures.…”
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