A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment by Disen Nie, Yao Jiang, Hui Li, Keying Zhang, Zhengxuan Li, Tong Lu, Yu Li, Donghui Han, Changhong Shi, Nianzeng Xing, Fa Yang, Weihong Wen, Weijun Qin

Get full text

Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

Get full text

Does Deltoid Ligament Repair Reduce Complications and Improve Functional Outcomes Measured by PROMIS Scores Following Ankle Fracture Surgery? by Steven M. Hadley BA, Rachel Bergman MD, John J. Peabody MD, Sarah J. Westvold MPH, Ryan Filler MD, Milap Patel DO, Anish R. Kadakia MD

Get full text

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

Get full text

Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the... by Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He

Get full text

A systematic review of impact of person-centred interventions for serious physical illness in terms of outcomes and costs by Richard Harding, Sridhar Venkatapuram, Alessandra Giusti, Ruwayda Petrus, Liz Gwyther, Lindsay Farrant, I Petersen, Amelia Cook, Kennedy Bashan Nkhoma

Get full text

The association between china’s primary health care reform and inequalities in primary care utilisation and maternal mortality: a quasi-experimental longitudinal study from 2010 to... by Chang Cai, Christopher Millett, Jin Xu, Yanshang Wang, Thomas Hone

Get full text

Long COVID and Biomarker Dysregulation—A Shift Toward Immune Exhaustion? by Anne Kallaste, Kalle Kisand, Agnes Aart, Ahto Salumets, Kai Kisand, Pärt Peterson, Margus Lember

Get full text

THE FUTURE OF SERBIAN FRUIT EXPORTS TO EGYPT: OPPORTUNITIES UNDER THE NEW FREE TRADE AGREEMENT by Nataša Stanojevic

Get full text

Exploring Medical Students’ Self-Reported Confidence and Willingness Administering Basic Life Support (BLS) Following Peer-Led Training in the Context of COVID-19 by Sarah Allsop

Get full text

Using Music to Promote Hong Kong Young People’s Emotion Regulation and Reduce Their Mood Symptoms and Loneliness: Protocol for a Pilot Randomized Controlled Trial by Yuan Cao, Yuanxin Shi, Debbie Chi Wing Low, Daniel T L Shek, David H K Shum, Radhika Tanksale, Genevieve Dingle

“…The intervention is grounded in Russell’s emotion circumplex model and music psychology, and program content included: The 2D model and characteristics of emotions from different quadrants (session 1); happiness and loneliness (session 2); high-arousal and negative-valence emotions, for example, stress and anxiety (sessions 3); and anxiety, perfectionism, and a celebration of achievement (session 4). …”
Get full text

Sesame oil improves biomarkers of glycemic control in women with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, controlled clinical trial by Masoumeh Atefi, Hamid Vahedi, Mina Darand, Mohammad Hassan Entezari

“…Serum fasting blood glucose (FBG), fasting serum insulin (FSI), homeostatic model assessment for insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), serum high-sensitivity C-reactive protein (hs-CRP), and serum malondialdehyde (MDA) were measured at the pre- and post-intervention phases. …”
Get full text

Modified Alliance-Focused Training with Doubling as an integrative approach to improve therapists’ competencies in dealing with alliance ruptures and prevent negative outcomes in p... by Anne Daubmann, Antonia Zapf, Antje Gumz, Frank Jacobi, Denise Kästner, Laurence Reuter, Carmen Martinez Moura, Klarissa Ehlers, Catherine F Eubanks, John Christopher Muran, Timothy Anderson, Ramona Stöckl, Georg Schwanitz, Lena Stegemann, Lana Rohr, Ulrike Willutzki

“…The two hierarchically ordered primary hypotheses are: In MAFT-D compared with TAU, a stronger reduction of depressive symptoms and a lower rate of patient dropout is expected from baseline to 20 weeks after baseline. …”
Get full text

Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

Get full text

Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome by Tae-Yeon Eom, J. Eric Schmitt, Yiran Li, Christopher M. Davenport, Jeffrey Steinberg, Audrey Bonnan, Shahinur Alam, Young Sang Ryu, Leena Paul, Baranda S. Hansen, Khaled Khairy, Stephane Pelletier, Shondra M. Pruett-Miller, David R. Roalf, Raquel E. Gur, Beverly S. Emanuel, Donna M. McDonald-McGinn, Jesse N. Smith, Cai Li, Jason M. Christie, Paul A. Northcott, Stanislav S. Zakharenko

Get full text

A Hf(IV)‐Coordinated NIR‐II Fluorescence “Turn‐On” Nanoprobe for Precise Imaging‐Guided Surgery in Breast Cancer by Yueyang He, Jinyan Lin, Jingwen Bai, Xiao Shen, Kangliang Lou, Yuanyuan Zhu, Zishan Qiao, Weiling Chen, Yang Li, Xiaolong Liu, Guojun Zhang

Get full text

Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Get full text

Short-term PM1 exposure and sleep duration: a nationwide study using consumer-grade wearable devices by Jiajun Liu, Mintao Su, Junxiong Ma, Qinfeng Zhou, Hanxu Shi, Yujie Shi, Shuyu Huang, Yuchuan Tang, Peining Zhou, Kunyao Yu, Rui Su, Rui Zhou, Jing Wei, Jing Ma, Zhenyu Zhang

Get full text

The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…The PROSPERO Registration: CRD420250649970 (https://www.crd.york.ac.uk/PROSPERO/view/CRD420250649970).…”
Get full text

Cigarette smoke modulates methylation levels of LEF1-AS1 and impedes its expression: An experimental study by Bader O. Almutairi, Ahmed Rady, Bashayer S. Aljuhani, Mikhlid H. Almutairi

Get full text