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    A robust multi-scale clustering framework for single-cell RNA-seq data analysis by Songrun Jiang, Chunyan Wang, Qiucheng Sun, Zhi Zhang

    Published 2025-05-01
    “…To address these challenges, we introduce a new method, single-cell Multi-Scale Clustering Framework (scMSCF), which combines multi-dimensional PCA for dimensionality reduction, K-means clustering, and a weighted ensemble meta-clustering approach, enhanced by a self-attention-driven Transformer model to optimize clustering performance. scMSCF constructs an initial clustering framework using a multi-layer dimensionality reduction strategy to establish a robust consensus on clustering structure. …”
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