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    Noradrenaline for progressive supranuclear palsy syndromes (NORAPS): a randomised, double-blind, placebo-controlled, crossover Phase IIb clinical trial evaluating the efficacy and... by Robert Durcan, Christopher Kobylecki, Lee Shepstone, James B Rowe, Alistair Church, Duncan Street, Vicky Marshall, Charlotte Russell, Luca Passamonti, Juliet High, Christopher T Rodgers, Boyd C P Ghosh, Kelly Grant, Natalia Igosheva, Hugo Paula, Colin McAlister, Simon P Jones, Rong Ye, Chrystalina Antoniades

    Published 2025-07-01
    “…Apathy and impulsivity are very common, often coexistent in PSP, and negatively predict survival. In preclinical models and other diseases, apathy and impulsivity are associated with noradrenergic deficits, which can be severe in PSP.Methods and analysis Noradrenaline for Progressive Supranuclear Palsy Syndromes trial is a randomised, double-blind, placebo-controlled, crossover design, Phase IIb clinical trial to evaluate the efficacy and safety of oral atomoxetine for the treatment of cognitive and behavioural changes in PSP. …”
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