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    Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method by Tao Huang, Yuanyuan Li, Simin Wang, Shijie Qiao, Xiujuan Zheng, Wenhui Xiong, Menghan Yang, Xirui Huang, Bizhen Gao

    Published 2025-12-01
    “…Furthermore, the model combining conventional risk factors and GRS exhibited excellent discriminative performance (AUC = 0.962) and outstanding robustness (mean ROC-AUC = 0.959).Conclusion This study established a reliable XGBoost-based GRS model and a GRS prediction platform (https://metabolicsyndromeapps.shinyapps.io/geneticriskscore/) to assess individual genetic susceptibility to MetS. …”
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