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    Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance by Xin Zhang, Huan Liu, Yu Li, Yanlong Wen, Tianxin Xu, Chen Chen, Shuxia Hao, Jielun Hu, Shaoping Nie, Fei Gao, Gengjie Jia

    Published 2025-02-01
    “…., inflammatory bowel disease and irritable bowel syndrome); (3) designed a body‐site‐specific microbiota disturbance scoring scheme, computing a disturbance score (DS) for each disease and highlighting the pronounced capacity of Crohn's disease to disturb gut microbiota (DS = 14.01) in contrast with food allergy's minimal capacity (DS = 0.74); (4) identified 1659 fiber‐disease associations, predicting the potential of dietary fiber to modulate specific microbiota changes associated with diseases of interest; (5) established murine models of inflammatory bowel disease to validate the preventive and therapeutic effects of arabinoxylan that notably perturbed the Bacteroidetes and Firmicutes phyla, as well as the Bacteroidetes and Lactobacillus genera, aligning with our model predictions. …”
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