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    Maternal plasma cell-free RNA as a predictive test for fetal lung maturation by Sean W. D. Carter, Kay Yi Michelle Seah, Si En Poh, Winston Koh, Haruo Usuda, Erin L. Johnson, Yusaku Kumagai, Tsukasa Takahashi, Lara J. Monteiro, Reyna Peñailillo, Gino Nardocci, Hannah R. S. Watson, Masatoshi Saito, Mahesh A. Choolani, Sebastián E. Illanes, Matthew W. Kemp

    Published 2025-07-01
    “…A Random Forest algorithm identified genes that separated mature from immature fetal lung subgroups and determined AUC values for maternal and fetal cell-free RNA (cfRNA) feature sets to predict fetal lung maturation. Results We demonstrate that the analysis of 21 human cfRNA targets in maternal plasma is highly predictive of fetal lung maturation status across antenatal steroid induced (Dexamethasone AUC = 0.93; Betamethasone AUC = 1) and physiological (AUC = 1) lung development models. …”
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