From microbes to molecules: unveiling host-microbe interactions with spatial metabolomics by Malin Stüwe, Lars-Erik Petersen, Manuel Liebeke

“…This commentary explores important aspects in microbial spatial metabolomics, underscores the need for activity and time-resolved studies, and advocates for a deeper exploration of microbial systems to advance chemical ecological concepts, host–microbe interactions, and metabolic mechanisms in microbial communities.…”
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Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans by Liwei Chen, Tingting Zheng, Yifan Yang, Prem Prashant Chaudhary, Jean Pui Yi Teh, Bobby K. Cheon, Daniela Moses, Stephan C. Schuster, Joergen Schlundt, Jun Li, Patricia L. Conway

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Integrated analysis of microbiome and host transcriptome revealed correlations between tissue microbiota and tumor progression in early-stage papillary thyroid carcinoma by Xiuwen Tong, Xiuwen Tong, Xipei Chen, Chen Shen, Jiahao Pan, Xinyu Wang, Xinyun Xu, Sheng Liu

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Protocol for predicting host-microbe interactions and their downstream effect on host cells using MicrobioLink by Lejla Gul, Anna Julia Elias, Tanvi Tambaku, Marton Olbei, Emily Watters, Balazs Bohar, Dezso Modos, Matthew Madgwick, Tamas Korcsmaros

“…Summary: Analyzing host-microbe interactions is essential for understanding how microbiota changes disrupt host homeostasis. …”
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An anaerobic in vitro flow model for studying interactions at the gastrointestinal host–microbe interface by L. L. Bang, J. S. Pettersen, N. Høiland, A. M. Rojek, D. R. Tornby, J. Møller-Jensen, U. S. Justesen, R. M. Pedersen, T. E. Andersen

“…Abstract In vitro research on host–microbe interactions in the human gut has been challenging due to the differing oxygen requirements of mammalian cells and intestinal microbiota. …”
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Stool multi-omics for the study of host–microbe interactions in inflammatory bowel disease by Consuelo Sauceda, Charlie Bayne, Khadijeh Sudqi, Antonio Gonzalez, Parambir S. Dulai, Rob Knight, David J. Gonzalez, Carlos G. Gonzalez

“…Inflammatory Bowel Disease (IBD) is a chronic immune-mediated inflammatory disease of the gastrointestinal tract that is a growing public burden. Gut microbes and their interactions with hosts play a crucial role in disease pathogenesis and progression. …”
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Race-related host and microbe transcriptomic signatures in triple-negative breast cancer by Roshan Kumar, Susan Duyar-Ayerdi, Aishwarya Sundaresan, Vinodh Srinivasasainagendra, Chandra Sekhar Pedamallu, Michael Behring, Darshan Shimoga Chandrashekar, Isam-Eldin Eltoum, Sooryanarayana Varambally, Hemant K. Tiwari, Sadeep Shrestha, Paul L. Auer, Lubna N. Chaudhary, John R. Kirby, Clayton Yates, Upender Manne, Akinyemi I. Ojesina

“…Nonetheless, AA women with high M2 abundance experienced poorer disease-free survival (DFS) than EA women. Integrative analyses revealed that high expression of human SPDYE2B gene was associated with Hafnia abundance and decreased DFS, highlighting complex host-microbe interactions in TNBC patients.…”
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An interactive art activity to promote student reflection and learning about host-microbe interactions by Camila Souza Beraldo

“…ABSTRACT The use of art in science teaching can effectively help students understand complex and abstract concepts, particularly in the fields of Microbiology and Microbial Ecology, where the study objects—the microbes—are invisible to human eyes. To explore how different factors shape host–microbe interactions, I developed the activity MicrobiART, which uses mixed art materials to create analogies that illustrate the dynamic relationships between hosts, microbes, and their environments. …”
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Host genome drives the microbiota enrichment of beneficial microbes in shrimp: exploring the hologenome perspective by Fernanda Cornejo-Granados, Luigui Gallardo-Becerra, Sandra Romero-Hidalgo, Alonso A. Lopez-Zavala, Andrés Cota-Huízar, Melany Cervantes-Echeverría, Rogerio R. Sotelo-Mundo, Adrian Ochoa-Leyva

“…Conclusions This study highlights the importance of exploring the hologenome perspective, where integrating host genetics and microbiome composition can enhance breeding programs and farming practices.…”
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Global spillover of land-derived microbes to Ocean hosts: Sources, transmission pathways, and one health threats by Hai-Chao Song, Hany Elsheikha, Tao Yang, Wei Cong

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Comparative Analysis of Microbial–Short-Chain Fatty Acids–Epithelial Transport Axis in the Rumen Ecosystem Between Tarim Wapiti (<i>Cervus elaphus yarkandensis</i>) and Karakul She... by Jianzhi Huang, Yueyun Sheng, Xiaowei Jia, Wenxi Qian, Zhipeng Li

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Cross-matrix multi-omics profiling identifies host–microbe interactions and diagnostic signatures in bovine subclinical mastitis by Yuqiong Li, Xiulan Xie, Youli Yu, Song Hua, ZhuMing Zhang, Zhengwei Zhao, Haihui Gao, Chenglian Zhang, Meizhou Huang

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Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites by Baikui Wang, Xianqi Peng, Xiao Zhou, Xiuyan Jin, Abubakar Siddique, Jiayun Yao, Haiqi Zhang, Weifen Li, Yan Li, Min Yue

“…Deterministic processes determined the gut microbial community assembly of P118-pretreated mice. Integrated omics further demonstrated that P118 probiotic activities in enhancing host tolerance to Salmonella infection were mediated by microbe-derived tryptophan/indole metabolites (e.g., indole-3-acrylic acid, indole, tryptophan, 5-methoxyindoleacetic acid, and 5-hydroxytryptophan). …”
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Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor by Sita N. Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A.J. Hardy, David W. Randall, Kieran McCafferty, Muhammad M. Yaqoob, Egle Solito, Michael Müller, Andrew V. Stachulski, Robert C. Glen, David Vauzour, Lesley Hoyles, Simon McArthur

“…Accumulating evidence indicates the involvement of gut microbe-derived metabolites. Circulating levels of the gut microbe/host co-metabolite p-cresol sulfate (pCS) correlate with cerebrovascular event risk in individuals with chronic kidney disease (CKD), but whether this relationship is mechanistic is unclear. …”
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Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals by Yanmin Liu, Qinwei Qiu, Yang Chen, Yusheng Deng, Wei Huang, Chen Sun, Xiaoxiao Shang, Xinyan Chen, Chengrui Wang, Lijuan Han, Shiyan Chen, Jiamin Yuan, Fuping Xu, Zhimin Yang, Xiaodong Fang, Li Huang

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mSphere of Influence: The integral art of resolving host-virus interactions by Elliott D. SoRelle

“…-F. Chiu et al. (Cell Host Microbe 14:607–618, 2013, 10.1016/j.chom.2013.11.009), and “Comprehensive integration of single-cell data” by T. …”
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Disrupted host-microbiota crosstalk promotes nonalcoholic fatty liver disease progression by impaired mitophagy by Wenjing Yin, Wenxing Gao, Yuwei Yang, Weili Lin, Wanning Chen, Xinyue Zhu, Ruixin Zhu, Lixin Zhu, Na Jiao

“…ABSTRACT The intricate interplay between host genes and intrahepatic microbes is vital in shaping the hepatic microenvironment. …”
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Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease by Fengyuan Su, Meng Su, Wenting Wei, Jiayun Wu, Leyan Chen, Xiqiao Sun, Moyan Liu, Shiqiang Sun, Ren Mao, Arno R. Bourgonje, Shixian Hu

“…However, the precise mechanisms behind host-microbe cross-talk remain largely undefined, due to the complexity of the human intestinal ecosystem and multiple external factors. …”
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Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome by Hsiao-Wen Huang, Tzu-Chien Kuo, Tzu-Chien Kuo, Ya-Jane Lee, Ya-Jane Lee, Ming-Ju Chen, Ming-Ju Chen

“…In this pilot study, we aimed to evaluate the potential effects of an 8-week Lm intervention in cats with stage 2–3 CKD and to investigate the underlying host-microbiota interactions through integrated multi-omics analysis. …”
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Evolutionary history and association with seaweeds shape the genomes and metabolisms of marine bacteria by Catherine A. Pfister, Johanna Berlinghof, Maximiliana Bogan, Ulisse Cardini, Angélique Gobet, Pauline Hamon-Giraud, Jessica Hart, Natalia Jimenez, Anne Siegel, Emma Stanfield, Marine Vallet, Catherine Leblanc, Coralie Rousseau, François Thomas, Willem Stock, Simon M. Dittami

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