In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…Strikingly, we detected two mutIDH1-specific TCRβ candidate sequences in three different patients. These three patients had the same human leukocyte antigen (HLA) DQA-DQB alleles. …”
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Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery by Pablo Aja-Macaya, Kelly Conde-Pérez, Noelia Trigo-Tasende, Elena Buetas, Mohammed Nasser-Ali, Paula Nión, Soraya Rumbo-Feal, Susana Ladra, Germán Bou, Álex Mira, Juan A. Vallejo, Margarita Poza

“…Basecalling models broadly resulted in similar taxonomic output, but had significantly higher observed species and different taxonomic identification the lower the basecalling quality (p-value<0.05). …”
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The study on risk assessment of carotid plaques in the Northern Chinese population based on LASSO regression by Kun Yuan, Chongjian Li, Junmin Chu, Yilin Huang, Jiayi Song, Liguang Dong, Ying Yang, Hongyu Wang, Jinbo Liu, Xinhua An, Xiaoyuan Tian, Lin Mu, Ye Tian, Zengwu Wang, Linfeng Zhang

“…The constructed nomogram Risk assessment had an AUC of 0.850 (95% CI: 0.823–0.877) and demonstrated good calibration (χ2 = 13.973, P = 0.08246). …”
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Renal resistive index as an early predictor and discriminator of acute kidney injury in critically ill patients; A prospective observational cohort study. by Jelle L G Haitsma Mulier, Sander Rozemeijer, Jantine G Röttgering, Angelique M E Spoelstra-de Man, Paul W G Elbers, Pieter Roel Tuinman, Monique C de Waard, Heleen M Oudemans-van Straaten

“…Forty-nine patients (49%) developed AKI within the first week. AKI patients had a higher RRI on admission than those without: 0.71 (0.69-0.73) vs. 0.65 (0.63-0.68), p = 0.001. …”
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Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation by Gavin Markey, Joseph McLaughlin, Joseph McLaughlin, Darren McDaid, Seodhna M. Lynch, Andrew English, Andrew English, H. Denis Alexander, Martin Kelly, Manav Bhavsar, Victoria McGilligan, Shu-Dong Zhang, Elaine K. Murray, Taranjit Singh Rai, Colum Walsh, Colum Walsh, Anthony J. Bjourson, Priyank Shukla, David S. Gibson

“…T cell receptor repertoire analysis found that the non-hospitalised subgroup had a much higher number of circulating clonotypes, targeting a wider range of predominantly MHC-I epitopes across the SARS-CoV-2 genome. …”
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Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes by Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries

“…The current study adds to previous data by including pediatric acute liver failure cases during the upsurge, enabling the analyses of inflammation expression profiles in cases with different viruses in relation to pediatric controls. …”
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Efficacy and safety of topical minocycline preparations for papulopustular rosacea: a systematic review and meta-analysis by Awadh Alamri, Awadh Alamri, Abdulrahman H. Alsamadani, Abdulrahman H. Alsamadani, Rose A. Alraddadi, Rose A. Alraddadi, Mulham Kalantan, Mulham Kalantan, Randa Khafaji, Randa Khafaji, Bader Bashrahil, Bader Bashrahil, Hassan Bogari, Hassan Bogari, Athoub Kadasa, Athoub Kadasa, Abdulhadi Jfri, Abdulhadi Jfri, Abdulhadi Jfri

“…FMX103 and minocycline gel 1% and 3% had significant results in absolute change in inflammatory lesion count (RR = 3.49, 95% CI = 2.61–4.36, P &lt; 0.00001). …”
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Mechanism of fumonisin B1 on growth performance and intestinal structural integrity of juvenile grass carp (Ctenopharyngodon idella) by Daiyu Chen, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Xiaoqiu Zhou, Lin Feng

“…A total of 720 juvenile grass carp (10.92 ± 0.02 g) were fed with four different levels of FB1 diets (0, 2.06, 3.94, and 8.05 mg/kg) for 30 d and each group had 3 replicates of 60 fish. …”
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Biomimetic design and integrated biofabrication of an in-vitro three-dimensional multi-scale multilayer cortical model by Ling Wang, Luge Bai, Sen Wang, Jiajia Zhou, Yingjie Liu, Chenrui Zhang, Siqi Yao, Jiankang He, Chaozong Liu, Dichen Li

“…Micrometer-scale (10 μm) cross-layer fibers effectively guided and controlled the extension length and direction of the neurites of surrounding neural cells but had no significant effect on the migration of neurons. …”
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Safety of hepatitis E vaccination for pregnancy: a post-hoc analysis of a randomized, double-blind, controlled phase 3 clinical trial by Guohua Zhong, Chunlan Zhuang, Xiaowen Hu, Qi Chen, Zhaofeng Bi, Xinhua Jia, Siying Peng, Yufei Li, Yue Huang, Qiufen Zhang, Ying Hong, Youlin Qiao, Yingying Su, Huirong Pan, Ting Wu, Lihui Wei, Shoujie Huang, Jun Zhang, Ningshao Xia

“…Among the 140 women who were inadvertently vaccinated during pregnancy, the incidences of adverse reactions had no statistical difference between the two groups (31.8% vs 35.1%, p = 0.6782). …”
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A network meta-analysis of maintenance therapy in chronic lymphocytic leukemia. by Cho-Hao Lee, Po-Huang Chen, Chin Lin, Chieh-Yung Wang, Ching-Liang Ho

“…Lenalidomide, rituximab and ofatumumab had demonstrated some efficacy as a maintenance therapy compared to no intervention for CLL patients. …”
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Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis by Yuanhang Rong, Yuanhang Rong, Yuanhang Rong, Qinqing Li, Qinqing Li, Yuzhong Du, Yuzhong Du, Yuzhong Du, Wenting Wang, Wenting Wang, Wenna Su, Wenna Su, Junlong Zhang, Junlong Zhang, Junlong Zhang, Wenbin He, Wenbin He

“…Risk of bias was evaluated following the Systematic Review Center for Laboratory Animal Experiments. The mean difference (MD) or standard mean difference (SMD) with 95% confidence intervals (CIs) were used to evaluate the effect of Tan ⅡA on cognitive function, neuropathology, neuroinflammation, oxidative stress, apoptosis, and neural/synaptic plasticity, with P &lt; 0.05 considered a significant difference. …”
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16S rDNA sequencing combined with metabolomic probes to investigate the effects of Salmonella Pullorum on gut microbes and metabolites in broilers by Jiongwen Wu, Jiongwen Wu, Jiongwen Wu, Ruixiang Xue, Ruixiang Xue, Ruixiang Xue, Zhexia Fan, Zhexia Fan, Zhexia Fan, Ruina Li, Ruina Li, Ruina Li, Xiaomeng Wang, Xiaomeng Wang, Xiaomeng Wang, Chutian Ye, Chutian Ye, Chutian Ye, Shuya Chen, Shuya Chen, Shuya Chen, Cheng Fang, Cheng Fang, Cheng Fang, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang, Qingbin Luo, Qingbin Luo, Qingbin Luo

“…SP-infected broilers were classified into positive (P) and negative (N) groups using hematoxylin-and-eosin staining, metabolome sequencing, and 16S rDNA to investigate the effects of SP infection on the metabolites and microorganisms in the cecum of broilers. Groups had different degrees of inflammatory cell infiltration in the cecum, spleen, liver, and lung tissues. …”
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The predictive value of Naples prognostic score for patients with locally advanced non-small cell lung cancer undergoing surgery after neoadjuvant chemotherapy by Yanfei Zhang, Yanfei Zhang, Chunyan Tang, Chunyan Tang, Min Yang, Shixuan Li, Fangchao Li, Fangchao Li, Yang Wang, Yang Wang, Li Qi, Jingjing Li, Jingjing Li, Jingjing Li

“…Smoking status (P=0.032) and KPS score (P=0.018) were significantly different among the three NPS groups, but it had no statistical relevance in regards to gender (P=0.849), age (P=0.474), clinical stage (P=0.101), pathology (P=0.819), tumor location (P=0.304), degree of differentiation (P=0.889), surgical method (P=0.436), chemotherapy (P=0.718), postoperative complications (P=0.177) or CEA level (P=0.447). …”
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Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease by Ikechukwu B. Jacob, Ikechukwu B. Jacob, Akinkunmi O. Lawal, Akinkunmi O. Lawal, Salma S. Mahmoud, Emerson M. Kopsack, Erin S. Reynolds, Qinghe Meng, Hongkuan Fan, Paul T. Massa, Paul T. Massa, Saravanan Thangamani, Hongpeng Jia, Guirong Wang, Guirong Wang

“…Here, we elucidated the differential antiviral and immunoregulatory roles of SP-A variants in response to SARS-CoV-2 infection in vivo.MethodsSix genetically-modified mouse lines, expressing both hACE2 (SARS-CoV-2 receptor) and individual SP-A variants: (hACE2/6A2 (6A2), hACE2/6A4 (6A4), hACE2/1A0 (1A0), and hACE2/1A3 (1A3), one SP-A knockout (hACE2/SP-A KO (KO) and one hACE2/mouse SP-A (K18) mice, were challenged intranasally with 103 PFU SARS-CoV-2 or MEM medium (Sham).ResultsInfected KO and 1A0 mice had more weight loss and mortality compared to other mouse lines. …”
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Malnutrition and Disability: A Retrospective Study on 2258 Adult Patients Undergoing Elective Spine Surgery by Matteo Briguglio, Andrea Campagner, Francesco Langella, Riccardo Cecchinato, Marco Damilano, Pablo Bellosta-López, Tiziano Crespi, Elena De Vecchi, Marialetizia Latella, Giuseppe Barone, Laura Scaramuzzo, Roberto Bassani, Andrea Luca, Marco Brayda-Bruno, Thomas W. Wainwright, Robert G. Middleton, Giovanni Lombardi, Federico Cabitza, Giuseppe Banfi, Pedro Berjano

“…Protein malnutrition with acute/chronic inflammation (PMAC) in both adults (adjusted-<i>p</i> < 0.001, η² = 0.04; adjusted-<i>p</i> < 0.001, η² = 0.04) and older adults (adjusted-<i>p</i> = 0.010, η² = 0.04; adjusted-<i>p</i> = 0.009, η² = 0.05) had also a discernible impact in determining the ODI and PH. …”
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Calcium and silicon nanofertilizers improved morphological attributes and fatty acid composition in olive; an insight to synergistic interaction between these elements by Javad Erfani-Moghadam, Abdolkarim Zarei

“…Moreover, this study highlight the synergistic effects between silicon and calcium, as the simultaneous application of these two elements had more beneficial impacts on the olive fruit than their individual utilization.…”
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Valoración perceptiva del rendimiento físico y psicológico en función del tipo de entrenamiento reali-zado y las fases del ciclo menstrual en mujeres deportistas (Perceptual assess... by Carolina Dominguez Muñoz, Juan del Campo Vecino, Alberto García Bataller, Jesus Ramón Llin Más

“…The phase of the menstruation cycle had a significant effect on the perception of strength impairment (p<.001), aerobic capacity (p<.001) and anaerobic capacity (p<.001), being the phase menstruation the most affected and the pre-ovulation phase the least. …”
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Improving type 2 diabetes detection among at-risk individuals – comparing the effectiveness of active opportunistic screening using spot capillary-HbA1c testing and venous HbA1c te... by Linda Chan, Esther Yee Tak Yu, Eric Yuk Fai Wan, Samuel Yeung Shan Wong, David Vai Kiong Chao, Welchie Wai Kit Ko, Catherine Xiao Rui Chen, Paul Po Ling Chan, Emma Victoria Marianne Bilney, Eng Sing Lee, Wei Leik Ng, Cindy Lo Kuen Lam

“…Multilevel logistic regression analyses were employed to evaluate the effect of the intervention on the uptake rate, adjusting for patient characteristics and clinic clustering. Results POC-cHbA1c had a higher uptake rate than vHbA1c (76.0% vs 37.5%; OR = 7.06, 95% CI [2.47–20.18], p < 0.001). …”
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Effect of Chemical and Hand thinning on the Fruit Biochemical Properties of ‘Khadrawi’ Date Palm (Phoenix dactylifera L.) during Fruit Development by M. Jalali, N. Moallemi, E. Khaleghi, S. Zivdar, M. Rahmati-Joneidabad

“…The purpose of this experiment was to investigate the effects of manual and chemical thinning on the qualitative characteristics of date fruit at different stages of development for the Khadrawi cultivar. …”
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