Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…Subtypes and risk subgroups differed in ROS metabolism and the p53 signaling pathway. …”
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Persistent Symptoms (Lasting Longer than 1 Year) in Children Hospitalized with Acute COVID-19 Versus Other Conditions by Marta Conde, Irati Gastesi, Lucía de Pablo, Sara Villanueva-Medina, David Aguilera-Alonso, Ana Esteban, Cristina Epalza, María López, Sara Domínguez-Rodríguez, Pablo Gómez, Álvaro Ballesteros, Carlota Pinto, Marisa Navarro, Carlo Giaquinto, Cinta Moraleda, Alfredo Tagarro

“…We also selected a comparison group of patients hospitalized for other, unrelated conditions within the same month. Eligible participants had no history of COVID-19 at recruitment or during follow-up. …”
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Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1–Coated Gut Bacteria by Micaela Gentile, Nina Goerlich, I-Ju Lo, N. Eric Olson, Mark McConnell, Johannes Pospiech, Tobias Bohnenpoll, Philipp Skroblin, Olivier Radresa, Uwe Andag, Kirk N. Campbell, Kristin Meliambro, Luis Sanchez-Russo, Alberto Verlato, Enrico Fiaccadori, Seunghee Kim-Schulze, Maria Lanau, M. Loreto Fernandez-Lorente, Miguel Fribourg, Joaquin Manrique, Paolo Cravedi

“…Results: Patients with IgAN had higher circulating levels of total IgA, gd-IgA1, and APRIL, and higher IgA and gd-IgA1-coated gut bacteria than controls, whereas serum levels of SIgA and BAFF did not differ between groups. …”
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Sustaining forest biodiversity: Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems by Rhiannon Gloor, Marek Svitok, Martin Mikoláš, Jeňýk Hofmeister, Josef Halda, Pavel Janda, Francesco Maria Sabatini, Lucie Zemanová, Arne Buechling, Daniel Kozák, Matej Ferenčík, Michal Frankovič, Martin Dušátko, Miroslav Svoboda

“…Mixed modelling revealed that natural historical disturbance processes have decades-long effects on forest structural attributes, which had both congruent and divergent impacts on lichen community richness and composition. …”
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Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system by Jatinder Saini, Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Matt Ruth, Sunan Cui, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Ning Cao, Eric C. Ford, Eric C. Ford, Juergen Meyer, Juergen Meyer, Charles Bloch, Charles Bloch, Tony Wong, Tony Wong, Clemens Grassberger, Ramesh Rengan, Ramesh Rengan, Jing Zeng, Jing Zeng, Marco Schwarz, Marco Schwarz

“…The pre-clinical field for mice irradiation consisted of different dose levels to deliver uniform doses in transmission mode. …”
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Prominence of Mycobacterium tuberculosis biomarkers among sputum culture-negative clinic attendees, independent of Ultra status by Yingda L. Xie, Nisha Modi, Kattya Lopez, Robert Reiss, Jorge Robledo, Christie Eichberg, Nchimunya Hapeela, Elizabeth Nakabugo, Irene Anyango, Kiranjot Arora, Ronald Odero, Judi Van Heerden, Widaad Zemanay, Vaishnavi S. Kaipilyawar, Samuel Kennedy, Padmapriya Banada, Lydia Nakiyingi, Moses L. Joloba, Chad Centner, Kimberly McCarthy, Jerrold Ellner, Padmini Salgame, David Alland, Susan E. Dorman

“…Longitudinally, 26.5 % of untreated sputum-discordant versus 41.7 % of untreated sputum-negative participants had Mtb biomarkers (p = 0.17) despite most reporting symptom improvement. …”
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Costs of biomarker testing in advanced non‐small cell lung cancer: a global study comparing next‐generation sequencing and single‐gene testing by Umberto Malapelle, Chien‐Chin Chen, Enrique deÁlava, Paul Hofman, Daniel Kazdal, Tae‐Jung Kim, Tony Kiat Hon Lim, Aleš Ryška, Angelica A Saetta, Ed Schuuring, Giancarlo Troncone, Michele Biscuola, Yi‐Lin Chen, Gek San Tan, Charles Hugo Marquette, Maria Michelli, Arja terElst, Hana Vošmiková, Joshua Kapp, Sebastian Gonzalez‐McQuire, Andromachi Giannopoulou, Jean Marie Franzini, Victoria Lucia Rabsiun Aramburu, Anna Baggi, Albrecht Stenzinger

“…In the standardized model, the tipping point for the minimum number of biomarkers required for NGS to result in cost savings (per patient) was 10 and 12 in the SP and CP scenarios, respectively. Retesting had a negligible impact on cost analyses, and results were robust to variation in cost parameters. …”
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Induction immunochemotherapy followed by definitive chemoradiotherapy and consolidation immunotherapy for unresectable stage III non-small cell lung cancer: a multi-institutional r... by Zhixue Fu, Zhixue Fu, Xin Dong, Jiawen Sun, Wei Deng, Yuting Zhao, Dan Yang, Leilei Jiang, Xiao Chang, Rong Yu, Anhui Shi, Huiming Yu, Jidong Wang, Wei Jiang, Jiawei Lu, Dongjie Chen, Jun Liang, Weihu Wang

“…The median OS in the I-CRT-I group was not reached, with 1-, 2-, and 3-year OS rates of 91.3%, 80.0%, and 72.9%, respectively; the CRT-I group had a median OS of 39.3 months, with survival rates of 91.1%, 69.3%, and 52.0%, respectively. …”
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Post-myocardial infarction patient pathways in Portugal by Ricardo Fontes-Carvalho, Ana Abreu, Luísa Bento, Eduardo Infante de Oliveira, Hélder Pereira, João Freitas, Hugo Pedrosa, Filipe Macedo

“…This study aims to characterize the path taken by AMI patients in Portugal after hospital treatment, at the different hospital levels. Subsequently, it aims to propose recommendations for improvements. …”
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Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages by Jingyun Yang, Xuemei He, Huashan Shi, Cai He, Hong Lei, Heng He, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhenling Wang, Guangwen Lu, Jiong Li, Yuquan Wei

“…In this study, serum samples were collected from adult participants including those who had gone through the BA.5/BF.7, EG.5/HK.3 and XBB/JN.1 infection waves, characterized by different infection and vaccination histories. …”
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Serial Optical Coherence Tomography Assessment of Coronary Atherosclerosis and Long‐Term Clinical Outcomes by Kyohei Yamaji, Kenji Kanenawa, Toru Morofuji, Ryusuke Nishikawa, Kazuaki Imada, Hirohiko Kohjitani, Hiroki Watanabe, Junichi Tazaki, Masanori Taniwaki, Seiji Koga, Ryohei Akashi, Shunsuke Kubo, Masanobu Ohya, Tatsuo Kikuchi, Hiroshi Ohira, Yohei Numasawa, Masaya Arikawa, Makoto Iwama, Takeshi Kitai, Yohei Kobayashi, Hiroki Shiomi, Tomohisa Tada, Yuhei Yamaji, Hyuma Daidoji, Hayato Ohtani, Yutaka Furukawa, Kazushige Kadota, Mamoru Toyofuku, Kenji Ando, Koh Ono, Takeshi Kimura

“…Patients with thin‐cap fibroatheroma had a significantly higher 3‐year risk of ischemia‐driven nontarget vessel revascularization (hazard ratio, 2.42 [95% CI, 1.03–5.71]; P=0.04), primarily due to revascularization in the imaged region. …”
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Effects of dietary metabolizable energy and crude protein levels on production performance, meat quality and cecal microbiota of Taihe Silky Fowl during growing period by Yutian Shen, Wentao Li, Lixia Kai, Yuqing Fan, Youping Wu, Fengqin Wang, Yizhen Wang, Zeqing Lu

“…The dressing percentage and half-eviscerated yield rate were significantly increased (P < 0.01), with no significant difference between 12.1 and 12.6 MJ/kg groups. Dietary CP level and the interaction between ME and CP had no significant effects on growth performance, slaughter performance, organ index, serum biochemical indexes and meat quality of Taihe Silky Fowl during growing period. …”
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Building a DNA Reference for Madagascar’s Marine Fishes: Expanding the COI Barcode Library and Establishing the First 12S Dataset for eDNA Monitoring by Jean Jubrice Anissa Volanandiana, Dominique Ponton, Eliot Ruiz, Andriamahazosoa Elisé Marcel Fiadanamiarinjato, Fabien Rieuvilleneuve, Daniel Raberinary, Adeline Collet, Faustinato Behivoke, Henitsoa Jaonalison, Sandra Ranaivomanana, Marc Leopold, Roddy Michel Randriatsara, Jovial Mbony, Jamal Mahafina, Aaron Hartmann, Gildas Todinanahary, Jean-Dominique Durand

“…Of the 1689 species listed in 2018, only 22% had accessible cytochrome oxidase I (<i>COI)</i> sequences in public databases. …”
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A radiomics-based model for predicting lymph nodes metastasis of pancreatic ductal adenocarcinoma: a multicenter study by Liwen Zhu, Ben Zhao, Tianyi Xia, Di Chang, Cong Xia, Mengqiu Liu, Ridong Li, Buyue Cao, Yue Qiu, Yaoyao Yu, Shuwei Zhou, Huayu Chen, Wu Cai, Zhimin Ding, Chunqiang Lu, Tianyu Tang, Yang Song, Yuancheng Wang, Jing Ye, Ying Liu, Shenghong Ju

“…Kaplan–Meier analysis revealed that patients with a higher risk of LNM also had worse outcomes (all p < 0.05). Additionally, among the high-risk subgroup identified by the radiomics model in the clinical utilization cohort, patients who underwent dissection of ≥ 15 lymph nodes exhibited better overall survival compared to those with fewer lymph nodes dissected (p = 0.002). …”
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Athletic pseudonephritis in male cross-country ultra-marathoners: a comparative observational study by Kai-Hung Chen, Cheng-Hsun Lee, Pang-Yen Chen, Pang-Yen Chen, Pang-Yen Chen, Pang-Yen Chen, Li-Hua Li, Li-Hua Li, Chorng-Kuang How, Chorng-Kuang How, Yen-Kuang Lin, Yu-Hui Chiu, Yu-Hui Chiu, Yu-Hui Chiu, Feng-Lin Wang, Wei-Fong Kao, Ming-Kun Huang, Ming-Kun Huang, Ming-Kun Huang, Ding-Kuo Chien, Ding-Kuo Chien, Wen-Han Chang, Wen-Han Chang

“…Additionally, 10 (50%) post-race specimens had albumin-to-creatinine ratios &gt;30 mg/g, and 9 (45%) specimens showed protein-to-creatinine ratios &gt;0.2 mg/mg. …”
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Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis by Philippe J Guérin, Kavitha Saravu, Julie A Simpson, Bipin Adhikari, Komal Raj Rijal, Prakash Ghimire, Mark Rowland, Sasithon Pukrittayakamee, Amit Sharma, Manju Rahi, Praveen K Bharti, Ric N Price, Megha Rajasekhar, Toby Leslie, Reena Verma, Rishikesh Kumar, Sauman Singh-Phulgenda, Robert J Commons, Apoorv Gupta, Nitika, Kamala Thriemer, Mohammad Shafiul Alam, Wasif A Khan, Benedikt Ley, Alejandro Llanos-Cuentas

“…We investigated the efficacy and safety of different primaquine regimens to prevent P. vivax relapse.Methods A systematic review identified P. vivax efficacy studies from South Asia published between 1 January 2000 and 23 August 2021. …”
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Transcriptional insights on the incomplete cytoplasmic maturation and developmental potential of oocytes cultured without granulosa cells in mice by Yibo Wang, Yichuan Zhang, Tianjie Li, Yun Ren, Ping Zhou, Lin Fu, Chenxi Xiao, Ziying Huang, Hanji Huang, Wenfeng Xie, Yuxin Luo, Yanan Qi, Hongcui Zhao, Yang Yu, Yong Fan, Heng Pan

“…Of note, oocytes with immature and mature cytoplasm had distinct transcriptional profiles. In the immature oocytes, we observed a deficient mRNA restoration of genes in crucial regulatory pathways of cellular growth and division, potentially affecting embryonic development. …”
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Immunogenicity of SARS-CoV-2 Vaccination Schedules Including a Booster Dose in Patients with Systemic Lupus Erythematosus: Data from a Prospective Multicenter Study by Natália Sarzi Sartori, Ketty Lysie Libardi Lira Machado, Samira Tatiyama Miyamoto, Flávia Zon Pretti, Maria da Penha Gomes Gouveia, Yasmin Gurtler Pinheiro de Oliveira, Vanezia Gonçalves da Silva, Filipe Faé, Ana Paula Neves Burian, Karina Rosemarie Lallemand Tapia, Anna Carolina Simões Moulin, Luiza Lorenzoni Grillo, Paula dos Santos Athayde, Helena da Silva Corona, Sabrina de Souza Ramos, Flávia Maria Matos Melo Campos Peixoto, Priscila Dias Cardoso Ribeiro, Vanessa de Oliveira Magalhães, Mariana Freitas de Aguiar, Erika Biegelmeyer, Cristiane Kayser, Alexandre Wagner Silva de Souza, Charlles Heldan de Moura Castro, Juliana Bühring, Sandra Lúcia Euzébio Ribeiro, Sérgio Henrique Oliveira dos Santos, Clara Pinheiro Martins, Jonathan Willian da Silva Rodrigues, Marcos Mavignier Sousa Dias, Bruna Guimarães Dutra, Camila Maria Paiva França Telles, Samuel Elias Basualto Dias, Rodrigo Poubel Vieira de Rezende, Katia Lino Baptista, Rodrigo Cutrim Gaudio, Ana Karla Guedes de Melo, Valéria Bezerra da Silva, Vitor Alves Cruz, Jozelia Rêgo, Rejane Maria Rodrigues de Abreu Vieira, Adah Sophia Rodrigues Vieira, Adriana Maria Kakehasi, Anna Carolina Faria Moreira Gomes Tavares, Victória Dornelas Paz Carvalho, Renata Henriques de Azevedo, Valderilio Feijó Azevedo, Olindo Assis Martins-Filho, Vanessa Peruhype-Magalhães, Andrese Aline Gasparin, Vanessa Hax, Valéria Valim, Gilda Aparecida Ferreira, Andréa Teixeira-Carvalho, Edgard Torres dos Reis-Neto, Emília Inoue Sato, Marcelo de Medeiros Pinheiro, Viviane Angelina de Souza, Ricardo Machado Xavier, Gecilmara Salviato Pileggi, Odirlei André Monticielo

“…Results: Two hundred and thirty-five patients with SLE who had completed their vaccination schedules (two doses + booster dose) were included in this study. …”
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Exploring voluntary sector specialist services for victim-survivors of sexual violence in England: the PROSPER co-production study by Caroline Bradbury-Jones, Sarah Damery, Kirsten Fruin, Clare Gunby, Jenny Harlock, Lucy Hebberts, Louise Isham, Anne-Marie Jones, Fay Maxted, Amelia Mighty, Priti Parmar, Laura Patterson, Jason Schaub, Fee Scott, Harriet Smailes, Debs Smith, Julie Taylor

“…Explore the usefulness of different approaches to service delivery and different therapy models. …”
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Investigating the knowledge attitude and practice of evidence based medicine education in Sudanese medical students: a cross sectional study by Mohammed Hammad Jaber Amin, Mohammed Haydar Awad, Elmontasirbillah Salah Mohamed Ginawi, Amjed Siddig Khalid Mohammed, Eltayep Hasab Elrasoul Noureldaiem Ibrahim, Ola Yaser Mohammed Yassen, Leina Elfatih Salah Mohamed Ali Elomeiri, Aseel Hisham Mohamed Abdelhalim Hakim Hussain, Tasneem Abdelrahman Eltahir, Fatima Saif Alyazal Ahmed Mohmmed, Rayan Abdalla Elawad Wedatalla, Khaild Hayder Awad, Rayan Kamal eldin Mahgoub, Abdalazez Mohamed Ali Karar, Ayat Yousif Mohammed Saeed, Asma Eltayeb Abdalla Mohamed, Rawan Salah Mohamed Ginawi, Fatin Mohamed Kaidan Sidar, Reham Rrdwan Abdalrab Saifalsorori, Othman Ibrahim Abdullah Osman, Mohammed Adil Ibrahim Nouri, Manasik Adam Ahmed Mohamed, Nadreen Babikir Mohammad Ibrahim, Maha Mujtaba Mahmoud Mohamed, Abd Elrahman Ahmed Bashir Mohamed, Faris Mohamed AbdAllah MohamedAhmed, Mohammad Rabie Mohammad Hassan, Shahd Abdelkhalig Abdelrahman Mohamed, Hafiz Elhadi Bashar Hadi, Hanan Mohamed Naeim Gandour Gandour, Nirmeen Ali Farah Ahmed, Noon Mohamed El-Fatih Ahmed, Maria Mohammed AlMogtaba AbdElaziz Osman, Sara Elmuntasir Ibrahim Elhadi

“…The majority were fourth-year students (25.4%). Over half (51.3%) had attended previous EBM training, with 71.4% having taken research methodology courses. …”
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