Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study by Imene Deneche, Camille Couffignal, Nassima Si Mohammed, Anette Arbjerg Højen, Carme Font, Stavros Konstantinides, Marieke Kruip, Luigi Maiorana, Sebastian Szmit, Denise Abbel, Laurent Bertoletti, Susanne Cannegieter, Adrian Edwards, Michelle Edwards, Alessandra Gava, Jacobijn Gussekloo, Miriam J. Johnson, Rashmi Kumar, Johan Langendoen, Kate Lifford, Ellen Ligtenberg, Simon Mooijaart, Mark Pearson, Johanneke Portielje, Kathy Seddon, Stella Trompet, Frederikus A. Klok, Simon Noble, Isabelle Mahé

“…The WP4 steering committee had two objectives. (1) to build a representative expert panel comprising physicians, pharmacists, nurses and psychologists from eight European countries; and (2) to advise on the content of the Delphi form, divided into four sections: context, content, SDST design and trial outcomes. …”
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Superior diagnostic performance of Grocott methenamine silver staining in pulmonary cryptococcosis: a multicenter, large-sample cohort study by Suijing Wang, Suijing Wang, Jieyi Lai, Jieyi Lai, Chengyou Zheng, Chengyou Zheng, Pengfei Yang, Zhengyi Zhou, Zhengyi Zhou, Haibo Wu, Haibo Wu, Mayan Huang, Mayan Huang, Xinke Zhang, Xinke Zhang, Yongbo Xiao, Yongbo Xiao, Jierong Chen, Jierong Chen, Chao Ma, Chao Ma, Keming Chen, Keming Chen, Liyan Lin, Huanyu Liu, Yubo Cai, Xiaolei Xue, Zizi Li, Jiewei Chen, Jiewei Chen

“…IntroductionIn the histopathological diagnosis of pulmonary fungal infections, particularly pulmonary cryptococcosis, the diagnostic performance of different staining techniques varies significantly, often confounding pathologists. …”
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Plasmidome analyses of Klebsiella pneumoniae co-producing blaKPC-2 and blaNDM-1 in Southern Brazil: characterisation of mobile genetic elements by Mayana Kieling Hernandez Berdichevski, Rafaela R. Guerra, Dariane C. Pereira, Camila M. Wilhelm, Patricia O. Barth, Melise C. Silveira, Fabiana C.Z. Volpato, Claudio Rocha-de-Souza, Richard M. Carrassai, Ana Paula Carvalho-Assef, Andreza F. Martins, Afonso Luís Barth

“…Significantly, isolates obtained since 2020 showed the blaNDM-1 gene carried by IncA/C in an IS26-flanked pseudo-composite transposon containing ISCR1, which also had genes that conferred resistance to sulfonamides, aminoglycosides, macrolides, quinolones, amphenicols, tetracyclines, rifampicin, sulfonamide, and trimethoprim. …”
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Pathogenic variation underlying rare diseases in an Arab population: Implications for screening programs by Ruchi Jain, Sami Bizzari, Sathishkumar Ramaswamy, Khaleem F. Hasham, Shruti Sinha, Ikram Chekroun, Fatma Rabea, Eman Abuijlan, Maha El Naofal, Massomeh Sheikh Hassani, Shruti Shenbagam, Alan Taylor, Mohammed Uddin, Mohamed Almarri, Omer Alkhnbashi, Hamda Khansaheb, Hanan Al Suwaidi, Stefan S. Du Plessis, Stephany El-Hayek, Alawi Alsheikh-Ali, Ahmad Abou Tayoun

“…Results: Among the 1333 families, 1060 had 701 variants meeting the American College of Medical Genetics and Genomics/Association for Molecular Pathology criteria for pathogenicity, with 52% and 30% being absent from the Genome Aggregation Database and ClinVar databases, respectively. …”
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Lower pain, less itching, and faster healing after ultrasound scalpel-assisted hemorrhoidectomy using an intimate cleaner containing chlorhexidine, acid hyaluronic acid, and natura... by Antonio Brillantino, Luigi Marano, Maurizio Grillo, Alessio Palumbo, Fabrizio Foroni, Luciano Vicenzo, Alessio Antropoli, Michele Lanza, Maria Laura Sandoval Sotelo, Nicola Sangiuliano, Mauro Maglio, Rosanna Filosa, Lucia Abbatiello, Maria Preziosa Romano, Luana Passariello, Pasquale Talento, Giovanna Ioia, Corrado Rispoli, Mariano Fortunato Armellino, Vincenzo Bottino, Adolfo Renzi, Carlo Bartone, Luigi Monaco, Paolino Mauro, Stefano Picardi, Maria Paola Menna, Elisa Palladino, Mario Massimo Mensorio, Vinicio Mosca, Claudio Gambardella, Luigi Brusciano, Ludovico Docimo

“…This study aimed to evaluate the impact of an intimate cleansing gel containing chlorhexidine, hyaluronic acid, and other anti-inflammatory agents (Antroclean Fisioderm) on postoperative pain, itching, and wound healing in patients who had undergone this procedure. Methods This multicenter observational case-control study involved a cohort of consecutive adult patients who underwent hemorrhoidectomy using an ultrasound device. …”
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A Revolutionary Device for Endovascular Aortic Repair of Abdominal Aortic Aneurysm: A Pilot Study [version 2; peer review: 2 approved] by Bambang Widyantoro, Yoga Yuniadi, Muhammad Rafli Iqbal, Macmilliac Lam, Melani Limenco Benly, Renan Sukmawan, Rendra Mahardika Putra, Bagus Herlambang, Ruth Grace Aurora, Sung Gwon Kang, Bagas Adhimurda Marsudi, Suci Indriani, Suko Adiarto, Iwan Dakota, Taofan Taofan

“…Result T&K B-EVAR pilot procedures proved successful in various cases, from simple to complex anatomy, and even with varied graft stent deployment strategies. None of the patients had complications or prolonged length of stay (LOS). …”
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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…For the 60-day follow-up there was no difference in risk of AA/AD between FQ and TMP (absolute rate difference [ARD], 0.21 per 1000 person-year; calibrated HR, 0.91 [95% CI 0.73–1.10]). …”
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Outcomes in frail patients receiving BCMA-directed bispecific antibodies for relapsed/refractory multiple myeloma by Benjamin Adegbite, Carlyn Rose Tan, Tala Shekarkhand, Ross S. Firestone, Eric M. Jurgens, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Sridevi Rajeeve, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H. Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Andriy Derkach, David Nemirovsky, Sergio A. Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi

“…Of 102 patients analyzed (age range, 40-88 years), 40 (39%) were considered frail. The frail group had more patients aged ≥70 years (73% vs 29%; P < .001), with ECOG PS ≥2 (36% vs 0%; P < .001), and worse median CCI (2 vs 1; P < .001). …”
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Pulmonary arterial hypertension with cardiopulmonary comorbidities: is it a unique phenotype? by Meng Zhang, Xueran Guo, Wei Guo, Yan Wang, Yao Xiao, Jiancheng Han, Ye Li, Tingting Man, Jie Li, Yong Chen, Shengchen Duan, Wenmei Zhang, Hui Li, Ao Yin, Jiafei Peng, Chunrong An, Wanmu Xie, Qian Gao, Shuai Zhang, Yunxia Zhang, Zhenguo Zhai, Jun Wan

“…According to whether they had cardiopulmonary diseases or not, they were classified into two groups: comorbidities group and non-comorbidities group. …”
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Implementation of a cascade training model to enhance emergency care capacity of healthcare workers during the COVID-19 outbreak in Uganda by Sulaiman Bugosera Wasukira, Carl Trevor Kambugu, Judith Nanyondo S, Emmanuel Candia, Stephen Emmanuel Aporu, Patricia Ikwaru, Racheal Kwagala, Andrew Kwiringira, Peter Mukiibi, Costance Murungi, Marek Ma, Celine Jacobs, Cliff Asher Aliga, Afizi Kibuuka, Dathan M. Byonanebye, Sylvia Natukunda, Kenneth Bagonza, Rose Muhindo, Prisca Kizito, Benard Toliva Opar, Nathan Kenya-Mugisha, Wilson Etolu, Paska Apiyo, Mohammed Larmode, Joseph Oumo, Rony Bahatungire, John Baptist Waniaye, Annet Alenyo-Ngabirano

“…Only 31.3% (36/115) of the health facilities had a formal triage system. 53.5% (54/101) of general hospitals lacked non-rotating staff in the emergency unit. …”
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A Randomized Controlled Trial of a Biodegradable Polymer, Microcrystalline Sirolimus-Eluting Stent (MiStent) versus Another Biodegradable Polymer Sirolimus-Eluting Stent (TIVOLI):... by Bin Wang, Sicong Ma, Zhiyong Wang, Li Zhang, Hanjun Pei, Yang Zheng, Yuejin Yang, Zheng Zhang, Xinqun Hu, Ziwen Ren, Feng Zhang, Changqian Wang, Renqiang Yang, Zhiming Yang, Yuexi Wang, Guosheng Fu, Yu Cao, Zuyi Yuan, Kai Xu, Xin Zhao, Bo Xu, Miaohan Qiu, Quanmin Jing

“…Compared with TIVOLI BP-SES, the MiStent system was superior in in-stent LLL at 9 months and had a comparable clinical benefit at 1 year in de novo coronary lesions.…”
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Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair by Kenichi Shibata, PT, Masanori Yamamoto, MD, Ai Kagase, MD, Takahiro Tokuda, MD, Hiroshi Tsunamoto, MD, Testuro Shimura, MD, Azusa Kurita, MD, Ryo Yamaguchi, MD, Mike Saji, MD, Masahiko Asami, MD, Yusuke Enta, MD, Masaki Nakashima, MD, Shinichi Shirai, MD, Masaki Izumo, MD, Shingo Mizuno, MD, Yusuke Watanabe, MD, Makoto Amaki, MD, Kazuhisa Kodama, MD, Junichi Yamaguchi, MD, Toru Naganuma, MD, Hiroki Bota, MD, Yohei Ohno, MD, Masahiro Yamawaki, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, Kazuki Mizutani, MD, Toshiaki Otsuka, MD, Shunsuke Kubo, MD, Kentaro Hayashida, MD

“…Thirty-day mortality occurred in 51 patients (1.4%), and the GNRI <82 group had the highest 30-day mortality rate. Kaplan–Meier curves showed significantly better prognoses for the entire cohort, functional MR, and degenerative MR across the 4 groups (P < 0.001). …”
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Prolonged Edoxaban in Patients With Low Body Weight and Cancer-Associated Isolated Distal Deep Vein Thrombosis by Tomoyuki Nagai, MD, Naohiko Nakanishi, MD, Yugo Yamashita, MD, Takeshi Morimoto, MPH, MD, Nao Muraoka, MD, Michihisa Umetsu, MD, Yuji Nishimoto, MD, Takuma Takada, MD, Yoshito Ogihara, MD, Tatsuya Nishikawa, MD, Nobutaka Ikeda, MD, Kazunori Otsui, MD, Daisuke Sueta, MD, Yukari Tsubata, MD, Masaaki Shoji, MD, Ayumi Shikama, MD, Yutaka Hosoi, MD, Yasuhiro Tanabe, MD, Ryuki Chatani, MD, Kengo Tsukahara, MD, Kitae Kim, MD, Satoshi Ikeda, MD, Takeshi Kimura, MD, Satoaki Matoba, MD

“…Results: Of the 601 participants, 426 had low body weight, 99% receiving a reduced dose of edoxaban. …”
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Profiling type I and II interferon responses reveals distinct subgroups of pediatric patients with autoinflammatory disorders by Anaïs Nombel, PharmD, Magali Perret, MSc, Sophie Trouillet-Assant, PhD, Marine Villard, PhD, Christine Lombard, PharmD, Lorna Garnier, PharmD, Anne-Perrine Foray, MD, PhD, Sarah Benezech, MD, Remi Pescarmona, PharmD, Samira Khaldi-Plassart, PhD, Thierry Walzer, PhD, Alexandre Belot, MD, PhD, Sébastien Viel, PharmD, PhD

“…We identified IFI27, IFI44L, and SIGLEC1 as the ISGs most closely related to IFN-α2 concentration. Nineteen samples had a positive IFN-I score but undetectable IFN-α2. …”
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Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke by Jaeseob Yun, Jae Wook Jung, Kwang Hyun Kim, Hyo Suk Nam, Hyo Suk Nam, JoonNyung Heo, Hyungwoo Lee, Byung Moon Kim, Dong Joon Kim, Minyoul Baik, Joonsang Yoo, Jinkwon Kim, Hyungjong Park, Sung-Il Sohn, Jeong-Ho Hong, Tae-Jin Song, Yoonkyung Chang, Jung Hwa Seo, Gyu Sik Kim, Kwon-Duk Seo, Seong Hwan Ahn, Jang-Hyun Baek, Han-Jin Cho, Jin Kyo Choi, Yo Han Jung, Bang-Hoon Cho, Il Kwon, Ji Hoe Heo, Young Dae Kim, Young Dae Kim

“…We investigated whether ischemic stroke thrombus composition and spatial distribution patterns differed with thrombus volume.MethodsWe enrolled patients with thrombi undergoing endovascular therapy (EVT) between July 2017 and July 2023. …”
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Comparative genomic and transmission analysis of Clostridioides difficile between environmental, animal, and clinical sources in China by Yanzi Zhou, Wangxiao Zhou, Tingting Xiao, Yunbo Chen, Tao Lv, Yuan Wang, Shuntian Zhang, Hongliu Cai, Xiaohui Chi, Xiaoyang Kong, Kai Zhou, Ping Shen, Tongling Shan, Yonghong Xiao

“…The number of virulence genes was not statistically different between strains from different sources. Multi-source strains in the same CG carried identical virulence gene sequences, including pathogenicity genes at the pathogenicity locus and adhesion-related genes at S-layer cassette. …”
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Measurement of myocardial blood flow in atrial fibrillation using high-resolution, free-breathing in-line quantitative cardiovascular magnetic resonance by Richard J. Crawley, Karl-Philipp Kunze, Anmol Kaushal, Xenios Milidonis, Jack Highton, Blanca Domenech-Ximenos, Irum D. Kotadia, Can Karamanli, Nathan C.K. Wong, Robbie Murphy, Ebraham Alskaf, Radhouene Neji, Mark O’Neill, Steven E. Williams, Cian M. Scannell, Sven Plein, Amedeo Chiribiri

“…Results: Around 442 patients were analyzed; 63 of whom had a history of AF and were in AF during the scan. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Motor functions and body weight improved mostly in female mice with sustained estrogen levels, whereas males had to compensate for the ongoing, disease-related testis atrophy and the loss of androgen production.Our study underscores the beneficial therapeutic effects of FTY on HD involving endogenous steroid hormones and their important anabolic effects. …”
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Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort by Yanjie Hao, Dylan Hansen, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Lanlan Ji, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Kristine (Pek Ling) Ng, B. M. D. B. Basnayake, Nicola Tugnet, Naoaki Ohkubo, Yoshiya Tanaka, Cherica Tee, Michael Tee, C. S. Lau, Ning Li, Vera Golder, Alberta Hoi, Rangi Kandane‐Rathnayake, Eric Morand, Shereen Oon, Mandana Nikpour, for the Asia Pacific Lupus Collaboration

“…Results Among 3,811 patients over 2.8 (interquartile range 1.0–5.3) years of follow‐up, 2,142 (56.2%) experienced flare and 1,786 (46.9%) had PAD, with 368 (9.7%) experiencing PAD but not flare. …”
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Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine‐125 Plaque Radiotherapy Using a Novel Structural‐Functional Imaging Analysis System by Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren, Wenbin Wei

“…However, there was no significant difference in SO2 and CO2 compared with healthy controls. …”
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