Cloning and function prediction of full-length cDNA for cathepsin E derived from medaka (Oryzias latipes) by WANG Jiaqing, DONG Huiming, LI Zhengang, LI Shaoming, WANG Ruonan, FU Yujie

“…A total of 22 CtpE proteins in different fish species had the active sites of conserved aspartate protease, which were “VIFDTGSSDLWV”(amino acids 98-109) and “AIVDTGTSLIAG”(amino acids 284-295) by homology analysis. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…The VAS overall score was notably higher at baseline (mean ± SD: 82 ± 10) compared to the paired score before RT (79 ± 14, p = 0.02), although this difference was not clinically significant. No statistically or clinically significant changes were observed in any of the five individual items.ConclusionThe use of neoadjuvant relugolix prior to prostate radiation therapy had no clinically significant impact on patient-reported health-related quality of life. …”
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A Comparison of Retinoblastoma Cases in the Philippines by Roland Joseph D. Tan, MD, MS, MIH, Aldous Dominic C. Cabanlas, MD, Benedicto Juan E. Aguilar, MD, Gabrielle S. Evangelista, MD, John Michael Maniwan, MD, Andrei P. Martin, MD, Calvin Y. Martinez, MD, John Alfred A. Lim, MD, Rena Ivy Bascuna, MD, Rachel M. Ng, MD, MPH, Kevin B. Agsaoay, MD, Kris Zana A. Arao, MD, Ellaine Rose V. Apostol, MD, Mara Augustine S. Galang, MD, Josemaria M. Castro, MD, Kimberley Amanda K. Comia, MD, Gary John V. Mercado, MD, Patricia E. Cabrera, MD, Paulita Pamela P. Astudillo, MD, Rolando Enrique D. Domingo, MD, Josept Mari S. Poblete, MD, PhD, Charmaine Grace M. Cabebe, MD, Adriel Vincent R. Te, MD, Melissa Anne S. Gonzales, MD, Jocelyn G. Sy, MD, Beltran Alexis A. Aclan, MD, Jayson T. So, MD, Fatima G. Regala, MD, Beatriz M. Prieto, MD

“…Patients had significantly different distributions of intraocular grades (p<0.0001) and systemic staging (p<0.0001) between the two time periods. …”
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Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany by Sophie Diexer, Jonas Frost, Peter Ahnert, Till W. Baernighausen, Hermann Brenner, Julia Fricke, Sabine Gabrysch, Karin Halina Greiser, Volker Harth, Jana-Kristin Heise, Rudolf Kaaks, André Karch, Thomas Keil, Bianca Klee, Carolina J. Klett-Tammen, Lilian Krist, Benedikt M. J. Lampl, Michael F. Leitzmann, Wolfgang Lieb, Claudia Meinke-Franze, Karin B. Michels, Ilais Moreno Velásquez, Nadia Obi, Annette Peters, Laura R. Pfrommer, Tobias Pischon, Oliver Purschke, Nicole Rübsamen, Tamara Schikowski, Börge Schmidt, Sigrid Thierry, Henry Völzke, Marvin N Wright, Hajo Zeeb, Rafael Mikolajczyk

“…After adjusting for the number of current symptoms related to PCC, this difference disappeared, suggesting that the symptoms collected explain the impairment of self-perceived health in the PCC group.…”
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Soil quality improvement on Qinghai-Tibet Plateau induced by soil hydrothermal changes from 1980s to 2020s by Kuan Chen, Jingyao Suo, Xiaodong Song, Yiyao Liu, Xiang Xiang, Yingping Pan, Jiarui Wang, Liang Ren, Xiaodong Ge, Xia Xu, Xiuchen Wu, Lei Duan, Yongmei Huang

“…However, whether the soil quality had changed over recent decades on QTP remains unclear. …”
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Effect of High-Dose Oral Rabeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers by Hyung-Keun Kim, Jin-Soo Kim, Tae-Ho Kim, Chang-Whan Kim, Young-Seok Cho, Sung-Soo Kim, Hiun-Suk Chae, Sok-Won Han, Yong-Wan Park, Hye-Suk Son, Jeong-Yo Min, Guen-Jong Cho, Jung-Sun Bag, Son-Ook Choi

“…Patients with a high-risk bleeding peptic ulcer had endoscopic hemostasis and were randomly assigned to the high-dose oral rabeprazole group (20 mg twice daily for 72 hours) or the high-dose IV omeprazole group (80 mg as a bolus injection followed by continuous infusion at 8 mg/h for 72 hours). …”
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The Impact of Rotational Malalignment Following Intramedullary Nailing for Intertrochanteric Fractures on Patients’ Functional Outcomes: A Prospective Study by Michail Vavourakis, Athanasios Galanis, Dimitrios Zachariou, Evangelos Sakellariou, Christos Patilas, Panagiotis Karampinas, Angelos Kaspiris, Meletis Rozis, John Vlamis, Elias Vasiliadis, Spiros Pneumaticos

“…Results: The mean femoral anteversion difference was 12.3° with a standard deviation of 10.3°. …”
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Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…We compared these ‘cost-effectiveness’ estimates for different ways of avoiding low staffing and for different patient groups. …”
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Phylodynamic of Tomato Brown Rugose Fruit Virus and Tomato Chlorosis Virus, Two Emergent Viruses in Mixed Infections in Argentina by Julia M. Ibañez, Romina Zambrana, Pamela Carreras, Verónica Obregón, José M. Irazoqui, Pablo A. Vera, Tatiana E. Lattar, María D. Blanco Fernández, Andrea F. Puebla, Ariel F. Amadio, Carolina Torres, Paola M. López Lambertini

“…Phylodynamic analysis indicated that both viruses had a recent, single introduction in Argentina but predicted different times for ancestral diversification. …”
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Reducing the Social Gradient in Uptake of the NHS Colorectal Cancer Screening Programme Using a Narrative-Based Information Leaflet: A Cluster-Randomised Trial by Lesley M. McGregor, Christian von Wagner, Wendy Atkin, Ines Kralj-Hans, Stephen P. Halloran, Graham Handley, Richard F. Logan, Sandra Rainbow, Steve Smith, Julia Snowball, Mary C. Thomas, Samuel G. Smith, Gemma Vart, Rosemary Howe, Nicholas Counsell, Allan Hackshaw, Stephen Morris, Stephen W. Duffy, Rosalind Raine, Jane Wardle

“…The control arm received the standard NHS CRC screening information material (SI) and the intervention arm received the standard information plus a supplementary narrative leaflet, which had previously been shown to increase screening intentions (SI + N). …”
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Characteristics of the first confirmed case of human infection with mpox virus clade Ib in China by Jimin Sun, Lei Zhou, Beibei Wu, Zhongwen Chen, Yedong He, Xiaoxiao Wang, Jun Lu, Dan Li, Li Zhao, Xinhui Guo, Ruiqi Ren, Wenqing Bai, Chao Li, Guoying Zhu, Wei Jiang, Wenqin Zhang, Ying Liu, Haiyan Mao, Yi Sun, Rui Ge, Xuguang Shi, Hangjie Zhang, Jun Han, Jibo He, Yan Li, Qun Li, Jianmin Jiang, Guoqing Shi

“…The case was a 28-year-old woman from South Africa who had sexual contact with an asymptomatic man from the Democratic Republic of the Congo. …”
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Impact of Metastasectomy on Survival Outcomes in Colorectal Cancer: A Single Center Retrospective Study by Oğuzcan Kınıkoğlu, Yunus Emre Altıntaş, Goncagül Akdağ, Sedat Yıldırım, Hacer Şahika Yıldız, Akif Doğan, Uğur Özkerim, Sıla Öksüz, Alper Topal, Deniz Işık, Tuğba Başoğlu, Heves Sürmeli, Seval Ay, Hatice Odabaş, Nedim Turan

“…R0 resections were associated with improved OS (median: 69.6 months), while non-R0 resections had poorer outcomes. Synchronous metastases were linked to shorter OS than metachronous metastases, although the difference was not statistically significant (p=0.09). …”
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Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemias with Hyperdiploid Karyotype by TL Gindina, NN Mamaev, ES Nikolaeva, SN Bondarenko, OA Slesarchuk, AS Borovkova, SV Razumova, OV Pirogova, AL Alyanskii, LS Zubarovskaya, BV Afanas’ev

“…In univariate analysis, the OS and EFS after allo-HSCT differed in patients with different clinical status (remission vs. active disease; p = 0.003 and p = 0.002, respectively), different chromosomal abnormalities in hyperdiploid karyotype (ACA– vs. …”
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Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD by Lanlan Liu, Mei Zhou, Shengwen Sun, Long Chen, Dehu Li, Dehu Li, Jiaxi Lv, Rui Cheng, Rui Cheng, Jianchu Zhang, Jianghua Wu, Jianghua Wu, Xianzhi Xiong

“…Especially, we identified two distinct exhausted CD8+ T cell clusters (CD8Tex_PDCD1 and CD8Trm_LAG3) originating from different developmental trajectories. Regulatory T cells had a reduced proportion and regulatory capacity in COPD airways, while CD4+ tissue-resident memory T cells displayed excessive Th2 responses and diminished Th1 responses. …”
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Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases by Kosuke Fujimoto, Fumikazu Koyama, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yukihide Kanemitsu, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Kimihiko Funahashi, Heita Ozawa, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka

“…Additionally, the GPS0 or 1 group with total resection of peritoneal metastases had a significantly better prognosis than the non‐resection group (p < 0.001); however, there was no difference between the GPS2 group with total peritoneal resection and the non‐resection group (p = 0.713). …”
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Synergistic Antibacterial Interaction of Geraniol and Biogenic Silver Nanoparticles on Methicillin-Resistant <i>Staphylococcus aureus</i> by Isabela Madeira de Castro, Camila Antunes, Camila Cristina Valentim, Laís Fernanda de Almeida Spoladori, Helena Tiemi Suzukawa, Guilherme Ferreira Correia, Gislaine Silva-Rodrigues, Paulo Henrique Guilherme Borges, Guilherme Bartolomeu-Gonçalves, Mariana Luiza Silva, Marcelle de Lima Ferreira Bispo, Rayanne Regina Beltrame Machado, Celso Vataru Nakamura, Gerson Nakazato, Phileno Pinge-Filho, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta

“…Since ancient times, plants have been used in folk medicine to treat different diseases. Plants offer exceptional chemical diversity with a wide range of biological activities, and have therefore been the most promising sources for the discovery and development of drugs, including antimicrobial agents. …”
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Deep learning based detection of enlarged perivascular spaces on brain MRI by Tanweer Rashid, Hangfan Liu, Jeffrey B. Ware, Karl Li, Jose Rafael Romero, Elyas Fadaee, Ilya M. Nasrallah, Saima Hilal, R. Nick Bryan, Timothy M. Hughes, Christos Davatzikos, Lenore Launer, Sudha Seshadri, Susan R. Heckbert, Mohamad Habes

“…We implemented an effective lightweight U-Net adapted for ePVS detection and comprehensively investigated different combinations of information from SWI, FLAIR, T1-weighted (T1w), and T2-weighted (T2w) MRI sequences. …”
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Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis by Pierre-Louis Batrow, Sylvie Caspar-Bauguil, Nathalie Rochet, Nadine Gautier, Anne-Sophie Rousseau, Marielle Maret, Samah Rekima, Etienne Mouisel, Emmanuel Van Obberghen, Christian H. Roux, Hervé Guillou, Catherine Postic, Christian Wolfrum, Dominique Langin, Ez-Zoubir Amri, Isabelle Mothe-Satney

“…Indeed, when treated with CL316,243, both male and female mice had increased De Novo Lipogenesis (DNL), reflected by an increased expression of ChREBPβ and lipogenic enzymes ACLY, ACC1, FASN and SCD1. …”
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Parker Solar Probe Observations of a Highly Energetic and Asymmetric Reconnecting Heliospheric Current Sheet during Encounter 13 by T. D. Phan, O. M. Romeo, J. F. Drake, D. Larson, M. Øieroset, S. Eriksson, B. Lavraud, S. D. Bale, A. Rahmati, R. Livi, P. Whittlesey, M. Pulupa, J. Huang, J. Halekas, M. L. Stevens, A. Szabo, N. Raouafi

“…These escaping electrons are distinguishable from solar strahl electrons observed further away from the HCS, which had lower energies.…”
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Whole-genome amplification as a tool to improve bacterial detection by PCR in microbiological samples after endodontic treatment by Gabriela Ceccon Chianca, Gabriela Ceccon Chianca, Caroline Corrêa Fendeler, Caroline Corrêa Fendeler, Sérgio Pinto Chaves Junior, Sérgio Pinto Chaves Junior, Gabriella Lorena Dias Pereira, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio

“…After CMP, however, bacterial detection differed in the assays performed (p = 0.0198). The presence of bacteria was detected in 70% (7 of 10) of the samples by WGA followed by PCR, where only 10% (1 of 10) had demonstrated bacterial growth in the culture method.ConclusionThe combination of WGA followed by PCR increased the detection of microorganisms from root canal samples after endodontic treatment using NaOCl as a CMP irrigant. …”
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