Choosing health facilities and impact factors of the choice in context of tiered medical system: A questionnaire survey of opinions of patients with multi-morbidity by Yuqin Zhu, Hua Jin, Dehua Yu

“…A self-designed questionnaire was used to collect general data from patients with multi-morbidity, to understand their awareness and actual compliance with the tiered medical system policy, their willingness to first visit community health centers under different disease control conditions, and the factors they consider when choosing healthcare facilities. …”
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CLINICAL AND LABORATORY EFFICIENCY OF TREATMENT OF WOMEN WITH PERIODONTAL DISEASES ON THE BACKGROUND OF BACTERIAL VAGINOSIS by A.D. Shulzhenko, T.O. Petrushanko, M.V. Mykytiuk

“…None of the 54 patients had clinically intact periodontal disease. The PMA and Leish KPI indices in women of the 1st group after the treatment did not have a significant difference with the initial results, while the rates of patients in the second group decreased significantly, indicating a decrease in inflammation in the periodontal tissues. …”
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Optimal Period of Calcium Propionate Supplementation in Arrival High-Risk Bull Calves: Growth Performance, Body Fat Reserves, and Serum Metabolites by Daniel Rodríguez-Cordero, Octavio Carrillo-Muro, Pedro Hernández-Briano, Paola Isaira Correa-Aguado, Alejandro Rivera-Villegas, Alberto Barreras, Rosalba Lazalde-Cruz, Richard A. Zinn, Alejandro Plascencia

“…Compared with the other treatments, the calves receiving CaPr during the initial 42 d had a greater average daily weight gain (<i>p</i> ≤ 0.035) without affecting the dry matter intake (<i>p</i> ≥ 0.24). …”
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Skeletal muscle lncRNA profile associated with fatty acids in Nellore beef cattle by Bruna Maria Salatta, Maria Malane Magalhães Muniz, Larissa Fernanda Simielli Fonseca, Lucio Flavio Macedo Mota, Caio de Souza Teixeira, Gabriela Bonfá Frezarim, Marta Serna-García, Danielly Beraldo dos Santos Silva, Angélica Simone Cravo Pereira, Fernando Baldi, Lucia Galvão de Albuquerque

“…DE analyses were performed on three different comparisons, C1 vs. C2, C1 vs. C3 and C2 vs. …”
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Global burden of periodontal diseases among the working-age population from 1990–2021: results from the Global Burden of Disease Study 2021 by Haojie Fu, Xinyu Li, Ruhong Zhang, Jiaxue Zhu, Xudong Wang

“…At the national level, Sierra Leone, Gambia, and Cabo Verde had the highest disease burden. Males consistently showed higher prevalence rates than females, with peak rates observed in the 50–59 age group. …”
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DESIGNING THE SOVIET IDENTITY (THROUGH THE EXAMPLE OF ELYOR ISHMUKHAMEDOV’S FILMS TENDERNESS AND LOVERS) / КОНСТРУИРОВАНИЕ СОВЕТСКОЙ ИДЕНТИЧНОСТИ (НА ПРИМЕРЕ ФИЛЬМОВ Э. ИШМУХАМЕДОВ... by SHCHEBROVA SVETLANA Ya. / ЩЕБРОВА СВЕТЛАНА ЯКОВЛЕВНА

“…Ishmukhamedov’s films were studied as a semiotic system, in which the main myths and archetypes were revealed that had a manipulative and mobilizing influence on the viewer, thereby creating an image of a Soviet person which is attractive to the masses. …”
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Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation:... by Trifunović Zoran, Obradović Slobodan, Balint Bela, Ilić Radoje, Vukić Zoran, Šišić Marija, Kostić Jelena, Rusović Siniša, Dobrić Milan, Ostojić Gordana

“…The group with BMMNC and CABG had the average of 17.5 ± 3.8 injections of BMMNC suspension with the average number of injected bone marrow mononuclear cells of 70.7 ± 32.4 × 106 in the total average volume of 5.7 ± 1.5 mL. …”
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Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosisResearch in context by Luoshiyuan Zuo, Maryam Kavousi, Julie A.E. Van Oortmerssen, Trudy Voortman, M Kamran Ikram, Daniel Bos

“…The funder of the study had no role in study design, data collection, data analysis, data interpretation, writing, or submission of the report.…”
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High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo by Margarita Pustovalova, Rita Mohammad, Yuzhe Wang, Wenyu Xue, Philipp Malakhov, Viktor Nekrasov, Elizaveta Kontareva, Zain Nofal, Vyacheslav Saburov, Dmitry Kolesov, Andreyan Osipov, Sergey Leonov

“…Both PBI-survived cell lines had greater capability for 2D collective migration, but their metastatic potential was significantly reduced. …”
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Identification of sex linked molecular markers in Indonesian giant freshwater prawn Macrobrachium rosenbergii by Novi Megawati, Alimuddin, Ratu Siti Aliah

“…Based on the PCR analysis with MrMKn primers, 30 samples of female prawns had 100 % occurred DNA bands, while no DNA bands were obtained in all-male prawns from Solo. …”
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Chemical composition of aerosol in the atmospheric surface layer of the East Antarctica coastal zone by L. P. Golobokova, V. V. Polkin, N. A. Onischuk, O. I. Khuriganova, A. B. Tikhomirov, S. A. Terpugova, V. V. Polkin, U. S. Turchinovich, V. F. Radionov

“…Fractional relation between the element concentrations changed in different phases from 16 to 98%. High enrichment of the aerosol particles by Zn, Cu, Cr, Ba, Pb, Ni,Se, As, Cd (the enrichment factors = 27÷26 445) had been revealed. …”
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Evaluating the Efficacy and Safety of 48-Week Low-Dose Dienogest Administration in Patients With Dysmenorrhea Caused by Endometriosis: Protocol for a Randomized, Open-Label, Parall... by Kyoko Kikuno, Ryuta Asada, Takuma Ishihara, Yoshimasa Bomoto, Saki Murase, Yoko Ueda, Tomomi Shiga, Yoh Hayasaki, Tatsuro Furui, Satoko Matsuzaki, Masahiko Takemura, Kazutoshi Matsunami, Makoto Kubo, Naoki Ito, Masanori Isobe, Ken-ichirou Morishige

“…As of March 22, 2025, a total of 88 participants had been enrolled in this clinical trial. …”
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Upgrading intrathecal morphine for postoperative pain mitigation in abdominal surgery: an exploratory multiple regression analysis of observational data addressing co-administered... by Brian A. Williams, Brian A. Williams, Brian A. Williams, Ridhi Choragudi, Christopher A. Schumacher, Kelly E. Garbelotti, Catalin S. Ezaru, Catalin S. Ezaru, Catalin S. Ezaru, Monique Y. Boudreaux-Kelly, Luca La Colla, Luca La Colla, John M. Ludden

“…PONV on days 0–1 (vs. day 2) appears to have differing predictor patterns, warranting both 5-MMAEPPx preoperatively, and future antiemetic upgrade from 2-drug booster prophylaxis (perphenazine/aprepitant) to also include palonosetron every 40 h. …”
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Blood type susceptibility to SARS-CoV-2 at a tertiary hospital in Accra, Ghana by Prince N. Odoom, Olayinka S. Okoh, Yaa Y. Asare, Clara O. Mac-Arthur, Judith D. Azumah, Albert Mensah, Akua K. Yalley, Kwamena W. Sagoe, Nicholas I. Nii-Trebi

“…Antigen A participants had a higher probability of symptomatic infection than non-antigen A individuals. …”
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Dual pH- and Temperature-Responsive Performance and Cytotoxicity of N-Isopropylacrylamide and Acrylic Acid Functionalized Bimodal Mesoporous Silicas with Core–Shell Structure and F... by Huijie Ge, Xiaoli Wang, Shiyang Bai, Yuhua Bi, Fei Liu, Jihong Sun, Wenliang Fu, Donggang Xu

“…Specially, P_0.2AN@M-BMMs had a superior cellular uptake and fluorescence properties via the time-dependent uptake experiments, and exhibited the highest silicon content via the cellular internalization analysis, as compared to other carriers. …”
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Effects of judo-specific intermittent training on lower-limb impulse and specific performance in judokas by Pi-Yen Ho, Hung-Chih Yeh, Fang Li, Chia-An Ho, Cheng-Pang Yang, Ying-Chen Kuo, Chih-Wen Hsu, Chin-Shan Ho

“…Additionally, the Uke group, while serving as sparring partners, had no negative impact on any variables examined in this study. …”
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Impact of a Heating Voucher on Health Outcomes in COPD Patients: A Randomised Controlled Trial by Viggers HE, Ingham TR, Chapman RB, Crane J, Currie AB, Davies C, Keall M, Howden-Chapman PL

“…We enrolled people aged over 55 who had COPD before winter. We gave half of the participants a voucher to help with electricity bills in their first winter in the study. …”
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Plasma ctDNA TP53 Mutation and Breast Cancer Prognosis: A Systematic Review and Meta-Analysis by FAN Hao, LIANG Annan, ZOU Wei, GAO Guangxi, LIU Lijin, LIU Fei, ZHAO Lina, WU Zhihong

“…ObjectiveTo analyze the association between plasma circulating tumor DNA (ctDNA) TP53 mutation status and survival outcomes in breast cancer patients.MethodsPubMed, Embase, and the Cochrane Library were searched for relevant literature published between 2000 and 2025, examining the impact of plasma ctDNA TP53 mutations on survival outcomes in breast cancer patients, including overall survival (OS), progression-free survival (PFS), or disease-free survival (DFS).Two researchers independently screened the literature according to predefined inclusion and exclusion criteria and extracted relevant data.The Newcastle-Ottawa scale and Cochrane Risk of Bias Assessment Tool were used to evaluate study quality.Meta-analysis, publication bias assessment, and sensitivity analysis were performed using Review Manager 5.3 and STATA 18.0 software.ResultsA total of 14 studies (13 cohort studies and 1 randomized controlled trial) involving 3521 breast cancer patients were included, among whom 921 had TP53 mutations.All studies were assessed as high-quality or low-risk.The random-effects model demonstrated that TP53 mutations were significantly associated with poorer OS (I2=77%, HR=1.82, 95% CI: 1.15-2.88, P=0.010), PFS (I2=63%, HR=1.68, 95% CI: 1.30-2.17, P < 0.001), and DFS (I2=85%, HR=1.98, 95% CI: 1.05-3.75, P=0.040).Funnel plots indicated no significant publication bias, and sensitivity analysis confirmed the stability and reliability of the results.Subgroup analyses based on study design, breast cancer stage and molecular subtype revealed that TP53 mutations were associated with worse prognosis in prospective studies (OS: HR=2.32, 95% CI: 1.84-2.92, P < 0.001;PFS: HR=1.83, 95% CI: 1.47-2.27, P < 0.001), metastatic/advanced breast cancer (OS: HR=2.03, 95% CI: 1.44-2.87, P < 0.001;PFS: HR=1.90, 95% CI: 1.57-2.31, P < 0.001), and hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+HER2-) patients (OS: HR=2.11, 95% CI: 1.56-2.85, P < 0.001;PFS: HR=1.94, 95% CI: 1.62-2.33, P < 0.001).Among different treatment regimens, patients with TP53 mutations receiving trastuzumab combined with paclitaxel exhibited relatively better prognosis (PFS: HR=0.08, 95% CI: 0.02-0.30, P < 0.001).ConclusionPlasma ctDNA TP53 mutations are closely associated with survival outcomes in breast cancer patients and may serve as a potential predictor of poor prognosis, providing support for clinical management and prognostic assessment.…”
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The role of geriatric nutritional risk index in predicting survival of type B aortic dissection patients after thoracic endovascular aortic repair by Kaiwen Zhao, Jinzhu Niu, Yuzhen He, Lingxu Kong, Wenyao Zhao, Qingsheng Lu, Shuangshuang Li, Jian Zhou

“…However, there was no significant difference in 1-year and 5-year ARAEs and MACCEs (all P > 0.05). …”
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Predictive value of Tpeak-Tend interval of supine and orthostatic electrocardiogram in the diagnosis between psychogenic pseudosyncope and vasovagal syncope in children by Zifeng Huang, Yi Xu, Shuo Wang, Miao Wang, Hong Cai, Yuwen Wang, Runmei Zou, Cheng Wang

“…There was no significant difference in Tp-Te between PPS group and control group (P > 0.05). ② The Tp-Te in VVS group was significantly higher than that in control group in aVR, aVF, and V4 lead (P < 0.05). …”
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