Antiviral effectiveness and safety of azvudine in hospitalized SARS‐CoV‐2 patients with pre‐existing chronic respiratory diseases: A multicenter, retrospective cohort study by Junyi Sun, Mengzhao Yang, Daoke Yao, Yongjian Zhou, Xiaobo Hu, Guowu Qian, Yiqiang Yuan, Silin Li, Hong Luo, Shixi Zhang, Guangming Li, Donghua Zhang, Guotao Li, Yanyang Zhang, Xinjun Hu, Zujiang Yu, Guangying Cui, Zhigang Ren

“…Azvudine could be effective in reducing all‐cause death among inpatients with COVID‐19 and CRDs and had few serious adverse events.…”
Get full text

Artificial Intelligence–Enabled ECG Screening for LVSD in LBBB by Hak Seung Lee, MD, Sooyeon Lee, MD, Sora Kang, MS, Ga In Han, MS, Ah-Hyun Yoo, MS, Jong-Hwan Jang, PhD, Yong-Yeon Jo, PhD, Jeong Min Son, MD, Min Sung Lee, MD, MS, Joon-myoung Kwon, MD, MS, Kyung-Hee Kim, MD, PhD

“…Results: In external validation, the transfer learning model achieved the highest AUROC (0.903; 95% CI: 0.887-0.918), closely followed by the general model (0.899; 95% CI: 0.883-0.915); the difference was not significant. Models using automated or expert-based LBBB extraction had lower AUROCs (0.879 and 0.841, respectively). …”
Get full text

Phylogenetic analysis and virulence characteristics of methicillin-resistant Staphylococcus aureus ST764-SCCmec II: an emerging hypervirulent clone ST764-t1084 in China by Yanghua Xiao, Weihua Han, Bingjie Wang, Yanlei Xu, Huilin Zhao, Xinyi Wang, Lulin Rao, Jiao Zhang, Li Shen, Hui Zhou, Long Hu, Junhong Shi, Jingyi Yu, Yinjuan Guo, Han Xia, Fangyou Yu

“…Virulence assays showed that ST764-t1084 isolates had high haemolytic activity and α-toxin levels. …”
Get full text

Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein O-GlcNAcylation by Zhen Wang, Fujia Chen, Yun Li, Chaoying Liu, Lizhen Wang, Weilun Shao, Zhen Lu, Li Hu, Longxuan Li, Yue Wang, Jinyang Lin, Yaxuan Yu, Shengjun Sun, Yurong Yang, Zhijian Zhu, Siqiang Li, Enzhong Li

“…After five weeks of treatment, evaluations based on organ coefficients, sperm count detection, testicular pathology analysis, and hormone level assessments determined the most effective curcumin dosage.Results and disccusionThe findings indicated that cryptorchidism had a detrimental impact on reproductive function, evident by decreased testicular coefficient, cessation of sperm production, abnormal testicular tissue morphology, and hormonal imbalances. …”
Get full text

Effects of the replacement of fishmeal with defatted black soldier fly (Hermetia illucens) larvae meal in high lipid diets on growth, serum liver antioxidant and disease resistance... by Weibin Huang, Wanting Huang, Wenshan Cai, Hao Liu, Menglong Zhou, Beiping Tan, Hengyang Song, Xiaohui Dong

“…And there was no significant difference in SOD. In liver, DSM40 group had the highest T-AOC content, which was higher than other group (P < 0.05). …”
Get full text

Soil porosity as a key factor of soil aggregate stability: insights from restricted grazing by Yi Yang, Yi Yang, Yi Yang, Zhongju Meng, Zhongju Meng, Zhongju Meng, Haonian Li, Haonian Li, Haonian Li, Yue Gao, Yue Gao, Yue Gao, Tianyang Li, Tianyang Li, Tianyang Li, Lei Qin

“…GE significantly increased soil organic carbon in the 0–10 cm and 10–20 cm layers by 7.02 g/kg and 7.45 g/kg, respectively. In addition, SG had no significant effect on soil organic carbon. …”
Get full text

Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…Rising by >10-fold in at least one cross were 455 genes, and 182 in all three crosses. Most genes had elevated expression in a self-fertile strain. …”
Get full text

Rock dust-based potting media enhances agronomic performance and nutritional quality of horticultural crops by Abraham Arma, Linda Alrayes, Thu Huong Pham, Muhammad Nadeem, Charles Manful, Owen Bartlett, Eric Fordjour, Mumtaz Cheema, Lakshman Galagedara, Lord Abbey, Raymond Thomas

“…Lettuce crops grown in RB had the highest consumer preference based on size and overall appearance. …”
Get full text

A novel strategy for promoting corrosion and wear resistance of Mg-Li alloys: Gradient eutectic high-entropy alloy coating induced by in-situ bidirectional diffusion by Xin Wen, Xiufang Cui, Yufei Liu, Ye Zhang, Haoliang Tian, Simin Wan, Lipeng Jiang, Guo Jin

“…TEM analysis indicated that Cu2Mg and Cu3Al2 phases were well matched with the β-Li matrix phase. The EHEA coating had a nano-lamellar eutectic microstructure with relatively small lamellar-spacing (< 100 nm). …”
Get full text

Dynamic monitoring of Staphylococcus epidermidis biofilm formation using a microfluidic approach by Sahra Fonseca, Jonathan Robidoux, Marie-Pierre Cayer, Jolianne Matte, Steve J. Charette, Danny Brouard

“…This study evaluated the performance of different methods for assessing biofilm formation under various growth conditions, using Staphylococcus epidermidis as a model bacterium. …”
Get full text

Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions by Guan-Hua Chen, Yu-Ching Dai, Szu-Chia Hsieh, Jih-Jin Tsai, Ava Kristy Sy, Mario Jiz, Celia Pedroso, Carlos Brites, Eduardo Martins Netto, Phyllis J. Kanki, Danielle R. D. Saunders, Dana L. Vanlandingham, Stephen Higgs, Yan-Jang S. Huang, Wei-Kung Wang

“…Due to cross-reactivities of antibodies recognizing the envelope protein of different flaviviruses, serosurveillance remains a challenge. …”
Get full text

Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons fr... by David Saadoun, Eric Vicaut, Valérie Touitou, Jacques Lagier, Frédéric Mouriaux, Pierre-Yves Robert, Antoine Rousseau, Nicolas Schleinitz, Jean-Marie Michot, Loic Guillevin, Matthieu Groh, Antoine Martin, Philippe Blanche, Sébastien Abad, Robin Dhote, Felix Ackermann, Boris Bienvenu, Olivier Galatoire, Sophie Coffin-Pichonnet, Pierre Aucouturier, Françoise Heran, Bertrand Vabres, Ambre La Rosa, Stéphane Tran Ba, Nahla Cucherousset, Neila Sedira, Emmanuel Héron, Aïcha Abbas, Mboup Bassirou, Isabelle Badelon, Mathieu Zmuda, Alain Ducasse, Isabelle Larré, Amélie Brabant-Viau, Jean Luc George, Jean Maalouf, Anne-Laure Fisch, Nathalie Tieulé, Juliette Delmas, Alexandre Vallon, Natahlie Massart, Marie Alexandra Alyanakian, Pierre Olivier Schischmanoff, Nabila Pizzi, Nathalie Kingue-Elessa, Jad Abou Ghantous, Solohaja-Faniaha Dimby

“…Among the 35 patients with histologically proven orbital inflammation who had previously been studied for their IgG4 immunostaining status, we selected those with a negative IgG4 status (ie, pIOIS) who received corticosteroids as single first-line treatment. …”
Get full text

Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…As expected, infection had a major impact on cattle blood transcriptome regardless of the breed. …”
Get full text

Computed tomography angiography in the diagnosis of non-ST-elevation myocardial infarction: redefining our first line of defense by Yvonne J.M. van Cauteren, Marie-Julie D.K. Lemmens, Sebastiaan C.A.M. Bekkers, Bas L.J.H. Kietselaer, Jordi Heijman, Ralph A.L.J. Theunissen, Braim Rahel, Talitha Voorn, Sander M.J. van Kuijk, Robin Nijveldt, Kevin Vernooy, Joachim E. Wildberger, Casper Mihl, Martijn W. Smulders

“…CAD-RADS ≥ 3 (i.e. stenosis ≥50%) had a sensitivity of 95% (95%CI 83–99%), a specificity of 65% (95%CI 44–83%) and an overall accuracy of 83% (95%CI 72–91%). …”
Get full text

Evaluation of the effects of Keratinase-treated feather meal as a replacement for fishmeal on growth performance, liver function, and intestinal health in juvenile largemouth bass... by Yi-Huan Xu, Li-Han Zhang, Min Liu, Mei-Yan Li, Xue-Dan Fang, Hui Xia, Ran Guo, Fazhan Hanafiah, Waiho Khor, Guang Chen, Xin Hao

“…According to analysis on weight gain rate (WGR), specific growth rate (SGR) and feed conversion ratio (FCR), we found that the largemouth bass had the best growth performance when dietary KFM replaced 25.19 %-26.25 % of FM, and the highest feed utilization when replacing 9.38 % of FM. …”
Get full text

A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years by Bo Yu, Haiyu Wang, Guangming Li, Junyi Sun, Hong Luo, Mengzhao Yang, Yanyang Zhang, Ruihan Liu, Ming Cheng, Shixi Zhang, Guotao Li, Ling Wang, Guowu Qian, Donghua Zhang, Silin Li, Quancheng Kan, Jiandong Jiang, Zhigang Ren

“…Safety analysis revealed that azvudine treatment had a lower incidence of adverse events and higher lymphocyte levels than Paxlovid treatment. …”
Get full text

Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…Additionally, we assessed whether DFI had a potential impact on long-term maternal and neonatal complications.MethodsA total of 5,271 women who underwent IVF treatment for the first time between October 1, 2020, and July 31, 2023, were included from an academic fertility center. …”
Get full text

Expression patterns of immune checkpoint proteins and Plasmodium falciparum‐induced cytokines in chronic hepatitis B virus‐infected and uninfected individuals: A cross‐sectional st... by Selorm P. Segbefia, Diana A. Asandem, Abigail Pobee, Bright Asare, Ahu Diana Prah, Rawdat Baba‐Adam, Jones Amo Amponsah, Eric Kyei‐Baafour, William van derPuije, Frank Osei, Doreen Teye‐Adjei, Seth Agyemang, Theophilus Brenko, Lutterodt Bentum‐Ennin, John K. A. Tetteh, Kofi J. H. Bonney, Samuel Asamoah Sakyi, Linda E. Amoah, Kwadwo A. Kusi

“…Results HBV‐negative and CHB individuals had comparable levels of CD4+ and CD8+ T cells. …”
Get full text

In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extrac... by Diana Laura Clark-Pérez, César Iván Romo-Sáenz, Jesica María Ramírez-Villalobos, Patricia Tamez-Guerra, Diana Caballero-Hernández, Ana Laura Delgado-Miranda, Andrés García, Joel Horacio Elizondo-Luevano, Cristina Rodríguez-Padilla, Ricardo Gomez-Flores

“…The search for new effective treatments for cancer has led to the discovery of different molecules from plants, bacteria, and fungi with pharmacological use. …”
Get full text

Impact of the fishing ban on fish diversity and population structure in the middle reaches of the Yangtze River, China by Juan Du, Juan Du, Huiwu Tian, Zhiyuan Xiang, Kangshun Zhao, Kangshun Zhao, Lixiong Yu, Xinbin Duan, Daqing Chen, Jun Xu, Jun Xu, Mingdian Liu

“…These findings suggest that while the fishing ban has had a positive initial impact on fish populations and ecological conditions, continued and long-term conservation measures are essential for fully recovering the river’s biodiversity and restoring its fishery resources. …”
Get full text