Divergent mechanisms driving microbial necromass in topsoil and subsoil along an altitudinal gradient on the Loess Plateau by Yuqian Li, Xuyang Wang, Xiaoming Mou, Bin Jia, Jie Lian, Yayi Niu, Xiangwen Gong, Yuqiang Li

“…Soil microbial biomass and soil ecological stoichiometry directly affected the accumulation of soil microbial necromass, and had different effects on fungal and bacterial necromass. …”
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Multi-omics insights implicate the remodeling of the intestinal structure and microbiome in aging by Shaohua Chen, Shaohua Chen, Chengbang Wang, Xiong Zou, Hanwen Li, Guanglin Yang, Guanglin Yang, Xiaotao Su, Xiaotao Su, Zengnan Mo, Zengnan Mo

“…Furthermore, old group had lower levels of various anti-inflammatory or beneficial metabolites. …”
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Long-term follow-up of an IgA nephropathy cohort: outcomes and risk factors by Liliana Gadola, María Jimena Cabrera, Mariela Garau, Ruben Coitiño, María Haydée Aunchayna, Oscar Noboa, María Asunción Alvarez, Sylvia Balardini, Graciela Desiderio, Nelson Dibello, Alejandro Ferreiro, Soledad Giró, Leonella Luzardo, Alfredo Maino, Lucía Orihuela, María Gabriela Ottati, Andrés Urrestarazú

“…In the multivariate Cox analysis, proteinuria in the NoIS group, crescents in the IS group and tubule interstitial damage in both groups were independent risk factors.Conclusion The IS group had more severe risk factors than the NoIS group but attained a similar outcome.…”
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Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model by Ying Chu, Ying Chu, Ying Chu, Hua Shen, Hua Shen, Hua Shen, Qiu Li, Qiu Li, Bo Shen, Yan Zhang, Deqiang Wang, Wei Zhu, Wei Zhu, Shengjun Wang, Jie Ma, Jie Ma

“…BackgroundLactate has been shown to play an important immunosuppressive role in the tumor microenvironment (TME) and promote tumor progression through a variety of different mechanisms of action. Myeloid-derived suppressor cells (MDSCs) are important cells that play an immunosuppressive role in the TME. …”
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Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use by Maria do Céu Costa, Ana Patrícia Gomes, Iva Vinhas, Joana Rosa, Filipe Pereira, Sara Moniz, Elsa M. Gonçalves, Miguel Pestana, Mafalda Silva, Luís Monteiro Rodrigues, Anthony DeMeo, Logan Marynissen, António Marques da Costa, Patrícia Rijo, Michael Sassano

“…<b>Conclusions:</b> According to sensory analysis, purified FECO was more accepted than crude FECO, which had a stronger and more polarizing taste, and received higher ratings for color and overall acceptance. …”
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Asymptomatic carotid artery stenosis and stroke risk in patients undergoing CABG by Nikolaos Bonaros, Clemens Engler, Axel Bauer, Rudolf Kirchmair, Michael Knoflach, Markus Theurl, Michael Grimm, Felix Nägele, Leo Pölzl, Ronja Lohmann, Christian Sutter, Michael Graber, Jakob Hirsch, Jonas Eder, Maria Ioannou-Nikolaidou, Antonia Lutz, Franziska Hübner, Maria Noflatscher, Elfriede Ruttmann, Sebastian Reinstadler, Johannes Holfeld, C Gollmann-Tepeköylü

“…Patients with a carotid stenosis&gt;90% had a higher 30-day mortality (p&lt;0.001) and higher incidence of postoperative stroke within 30 days (p=0.005). …”
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Extraction and Purification of the FrHb1 Fraction from Commercial Natural Latex of <i>Hevea brasiliensis</i> for Biomedical Applications by Ana Karoline Almeida da Silva, Gustavo Adolfo Marcelino de Almeida Nunes, Rafael Mendes Faria, Ana Luiza Coutinho Favilla, Jéssica Dornelas, Marcos Augusto Mountinho Fonseca, Angie Daniela Ibarra Benavides, Lindemberg Barreto Mota da Costa, Mário Fabrício Fleury Rosa, Adson Ferreira da Rocha, Suelia de Siqueira Rodrigues Fleury Rosa

“…Biomaterials interact with biological systems, influencing their responses. Different types of polymers—both natural and synthetic—are widely used in biomedical engineering, among a plethora of healthcare applications, to promote tissue regeneration. …”
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“Awake” Cannulation of Patients for Venovenous Extracorporeal Membrane Oxygen: An Analysis of the Extracorporeal Life Support Organization Registry by Amira Mohamed, MD, Omar Saeed, MD, MSc, Melissa Fazzari, PhD, MS, Michelle Gong, MD, MPH, Mayuko Uehara, MD, Stephen Forest, MD, Anthony Carlese, MD, Marjan Rahmanian, MD, Sammar Alsunaid, MD, Ali Mansour, MD, Matthew Levitus, MD, Deborah Orsi, MD, David Furfaro, MD, MPH, Annette Ilg, MD, Anthony Manasia, MD, MPH, Ari Moskowitz, MD, MPH

“…Patients undergoing awake cannulation were older (52.2 vs. 47.8 yr), had greater prevalence of chronic lung diseases (50.6% vs. 48.9%), and ischemic heart disease (4.3% vs. 2.7%) compared with those cannulated while receiving mechanical ventilation. …”
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Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation by Jianhan He, Huihui Yue, Shufei Zhang, Ruihan Dong, Fengqin Zhang, Xuewen Wang, Ke Wang, Huilan Zhang, Danlei Yang, Zhaoxing Dong, Huiguo Liu

“…Purpose To evaluate the therapeutical efficacy of DHC in different PF models and elucidate its underlying mechanism. …”
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Distinguishing very high-risk patients among high-risk gastrointestinal stromal tumor cases: development and validation of a nomogram based on a multicenter population-based retros... by Qi Jiang, Yang Fu, Xinhua Zhang, Peng Zhang, Zhidong Gao, Jun Zhang, Xuefeng Zhao, Haibo Qiu, Zilong Zhang, Yingfeng Fu, Jian Liu, Zhenhua Yang, Bo Zhang, Xiaodong Gao, Kaixiong Tao

“…Among the general high-risk group, no significant difference in RFS was observed between patients who received adjuvant imatinib for 2.5 years or longer. …”
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Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies by Francesco Muratore, Carlo Salvarani, Luca Cimino, Luigi Boiardi, Nicolò Pipitone, Stefania Croci, Alessandro Zerbini, Alberto Cavazza, Alessandra Bisagni, Alessandro Rossi, Maria Nicastro, Ilaria Ferrigno, Martina Bonacini, Angelo Ghidini, Giuseppe Malchiodi

“…Genes encoding TNF superfamily members, immune checkpoints, chemokine and chemokine receptors, toll-like receptors, complement molecules, Fc receptors for IgG antibodies, signalling lymphocytic activation molecules, JAK3, STAT1 and STAT4 resulted upregulated in TMI.Conclusions TABs with TMI had a distinct transcriptome compared with normal TABs and TABs with ILA. …”
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Clinical characteristics and early identification of augmented renal clearance in PICU patients with severe sepsis associated with MRSA infection by Haonan Wang, Jiaqing Li, Xian Li, Han Li, Yinglang He, Rui Tan, Xuejian Mei, Haoyu Zha, Mingxing Fan, Shuangshuang Peng, Nan Hou, Zhe Li, Yue Wang, Chen Ji, Yao Liu, Hongjun Miao

“…Among them, the best performer had an AUC of 0.746 and a high application prospect.ConclusionARC is a phenomenon significantly underestimated in pediatric patients with severe sepsis associated with MRSA infection, which can affect 74.9% of these patients and affects the process of anti-infection treatment and clinical outcomes. …”
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Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma by Haiyang Zhao, Haiyang Zhao, Haiyang Zhao, Haiyang Zhao, Kexin Luo, Kexin Luo, Kexin Luo, Kexin Luo, Meihan Liu, Meihan Liu, Meihan Liu, Meihan Liu, Yuanze Cai, Siman Liu, Shijuan Li, Yongsheng Zhao, Yongsheng Zhao, Yongsheng Zhao, Hongpan Zhang, Hongpan Zhang, Hongpan Zhang, Hongpan Zhang

“…Recent research has indicated that proteasome 20S subunit 6 (PSMB6) may be closely associated with anti-apoptotic pathways, and proliferation transduction signals in tumor cells of different tumors. However, the precise role of PSMB6 in the immunoregulatory processes within lung adenocarcinoma (LUAD) is yet to be elucidated. …”
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Wearable cardioverter defibrillator after ICD-system explantation: data from a multicenter registry by Ibrahim El-Battrawy, Thomas Beiert, Katharina Koepsel, Boldizsar Kovacs, Tobias C. Dreher, Christian Blockhaus, David Tenbrink, Norbert Klein, Thomas Kuntz, Hendrik Lapp, Dong-In Shin, Mohammad Abumayyaleh, Ardan Muammer Saguner, Mido Hijazi, Julia W. Erath, Firat Duru, Andreas Mügge, Ibrahim Akin, Assem Aweimer

“…Accordingly, several guidelines give a different recommendation regarding WCD indication in this cohort. …”
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Household food insecurity and novel complementary feeding methods in New Zealand families by Ioanna Katiforis, Claire Smith, Jillian J. Haszard, Sara E. Styles, Claudia Leong, Rachael W. Taylor, Cathryn A. Conlon, Kathryn L. Beck, Pamela R. vonHurst, Lisa A. Te Morenga, Lisa Daniels, Kimberley J. Brown, Madeleine Rowan, Maria Casale, Neve H. McLean, Alice M. Cox, Emily A. Jones, Bailey R. Bruckner, Rosario Jupiterwala, Andrea Wei, Anne‐Louise M. Heath

“…Mothers experiencing severe food insecurity had 5.70 times the odds of currently using commercial baby food pouches frequently (≥5 times/week) compared to food secure mothers (95% CI [1.54, 21.01]), reporting that pouches were ‘easy to use’ (89%) and made it ‘easy to get fruits and vegetables in’ (64%). …”
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The Prevalence of Headache and Associated Factors in Al-Kharj, Saudi Arabia: A Cross-Sectional Study by Daifallah Almalki, Mamdouh M. Shubair, Badr F Al-Khateeb, Rawan Abdullah Obaid Alshammari, Saeed Mastour Alshahrani, Raed Aldahash, Khadijah Angawi, Majid Alsalamah, Jamaan Al-Zahrani, Sameer Al-Ghamdi, Hayat Saleh Al-Zahrani, Ashraf El-Metwally, Khaled K. Aldossari

“…Participants who were overweight had a significantly higher risk of headache (OR = 1.631, 95% CI = 1.48–1.854; P=0.037). …”
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Surgical complications of vagus nerve stimulation surgery: A 14-years single-center experience by Jouke van Schooten, Jacco Smeets, Sander MJ. van Kuijk, Sylvia Klinkenberg, Olaf E.M.G. Schijns, Jeske Nelissen, Louis G.L. Wagner, Rob P.W. Rouhl, Marian H.J.M. Majoie, Kim Rijkers

“…Materials and methods: Retrospective cohort study using patient files of DRE-patients who had undergone primary implantation of a VNS-system, replacement of the VNS pulse generator, replacement of the lead, replacement of both pulse generator and lead, or VNS removal surgery in the Maastricht UMC+. …”
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Association between phenotypic age and in-hospital outcomes in patients with acute myocardial infarction: A retrospective observational study by Yajie Gao, Ke Gao, Ruijuan Shi, Xiaorui Huang, Peizhu Dang, Hui Liu, Xiaopu Zheng, Yanbo Xue

“…Results: Overall, patients with high PhenoAge had a higher Gensini score and a higher likelihood of receiving supportive care, as well as worse clinical outcomes. …”
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Unveiling the hidden threat to human health: groundwater contamination in the largest mining enclave of southwestern Ghana by Daniel Senne, Solomon Agyire, Fosu Yaw, Muhammed Abdullah Bello, Emmanuel Daanoba Sunkari

“…In addition, hand-dug wells in the Akoon and Benso communities had high concentrations of nitrate (NO _3 ^− ). …”
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Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain metastasis by Sama I. Sayin, Sama I. Sayin, Ella A. Eklund, Ella A. Eklund, Ella A. Eklund, Kevin X. Ali, Kevin X. Ali, Jozefina J. Dzanan, Jozefina J. Dzanan, Moe Xylander, Martin Dankis, Martin Dankis, Per Lindahl, Per Lindahl, Volkan I. Sayin, Volkan I. Sayin, Andreas Hallqvist, Andreas Hallqvist, Clotilde Wiel

“…Our primary study outcome was the distribution of specific metastatic sites and its impact on Overall Survival (OS).ResultsOut of 913 stage IV LUAD patients, 23.4% had BM. These patients exhibited markedly different metastatic patterns compared to those without BM, and median survival was significantly shorter (6 months) than those without BM (7.8 months) (p = 0.021). …”
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