Multistakeholder scientific advice for medicinal products used in combination with a medical device or a companion diagnostic in the EU—summary of a Focus group discussion by Stiina Aarum, Claudia Popp, Alexa Hunter, Miha Skvarc, Ilona Reischl, Hilke Zander, Joerg Zinserling, Petra van Leeuwen, Jonathan Sutch, Tim Chesworth, Elisabeth Kapeller, Andreas Emmendoerffer, Iordanis Gravanis, Christelle Bouygues, Claudia Vincenzi, Michael Berntgen

“…A multistakeholder platform would allow for an opportunity to discuss the scientific expectations of the different decision makers involved and guide the identification of an appropriate development path for both medicine and medical device/IVD (including CDx). …”
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Metabarcoding-based characterization of soil nematode communities to assess soil health in viticulture by Rubén Blanco-Pérez, María de Toro, Sergio Álvarez-Ortega, Alícia Pou, Sara Sánchez-Moreno, Raquel Campos-Herrera

“…In contrast, tillage and cover cropping had limited effects on nematode community structure and soil health indices, suggesting a weaker influence on nematode-mediated soil functions under the studied conditions. …”
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Changes in unhealthy food consumption among vulnerable elementary-aged children in the United States during the COVID-19 pandemic: a serial cross-sectional analysis by Nivedhitha Parthasarathy, Nalini Ranjit, Ru-Jye Chuang, Christine Markham, Mike Pomeroy, Jacqueline Noyola, Deepali K. Ernest, Shreela V. Sharma

“…Secondary data analysis included 5,384 surveys from families who had complete data: 3422 pre-pandemic, 944 from the early pandemic, and 1,018 mid-pandemic. …”
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Stepwise improvement in intracerebral haematoma expansion prediction with advanced imaging: a comprehensive comparison of existing scores by Mayank Goyal, Nishita Singh, Johanna Ospel, Koji Tanaka, David Rodriguez-Luna, Andrew Demchuk, Bijoy Menon, MacKenzie Horn, Umberto Pensato, Wu Qiu, Chitapa Kaveeta, Ankur Banerjee, Sanchea Wasyliw, Kennedy Horn, Amy Bobyn, Anneliese Neweduk

“…A statistically significant difference favouring mCTA over other imaging modalities in predicting both HE and severe HE was observed.Conclusions Advanced imaging demonstrated a stepwise improvement in the predictive performance of HE scores. …”
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Clinical outcomes of nephroureterectomy with bladder cuff excision or radical cystectomy for distal ureteral carcinoma invaded muscle of the ureteral orifice by Pan Li, Suoshi Jing, Yindong Kang, Bin Feng, Yunxin Zhang, Hui Ding, Juan Wang, Yingru Wang, Li Yang, Zhilong Dong, Junqiang Tian, Zhiping Wang, Zizhen Hou

“…Conclusions Patients who underwent NU-RC had better RFS and CSS than NU-BCE, but there was little difference in OS due to the higher mortality rate of postoperative complications in the NU-RC.…”
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FBXO42 promotes hepatocellular carcinoma progression via mediating p57Kip2 ubiquitination and degradation by Bing Zhou, Shasha Wu, Shengqian Hong, Han Li, Zhi Jiang, Yong Sun, Jiannan Qiu, Lei Qin

“…The studies on the role of FBXO42 in different diseases are inadequate, especially in HCC. …”
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Construction and evaluation of a nomogram model for predicting the risk of hospital-acquired pneumonia in elderly patients with acute ischemic stroke by Man Huang, Wan Wang, Wu-lin Li, Yan-qing Chen, Xian-ting Chen, Ye Liu, Yan Li, Dong-mei Ren, Fei Wang

“…The model can also help clinicians make personalized treatment decisions for patients at different risk levels. Clinical trial number Not applicable.…”
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Unveiling Resmetirom: A systematic review and meta‐analysis on its impact on liver function and safety in non‐alcoholic steatohepatitis treatment by Hashim Talib Hashim, Ahmed Qasim Mohammed Alhatemi, Sania Riaz, Mohammedbaqer Ali Al‐Ghuraibawi, Arwa S. Alabide, Humza Saeed, Fatimah Abdullah Sulaiman, Mustafa Ali Abd Alhussain, Maythum Ali Shallan, Ahmed Dheyaa Al‐Obaidi, Omar Saab, Hasan Al‐Obaidi, Ali Talib Hashim, Nooraldin Merza

“…Results The study showed that patients who were treated with Resmetirom had significantly lower low‐density lipoprotein‐cholesterol (LDL‐C) levels (mean difference [MD] −10.45; 95% confidence interval [CI] −15.86 to −5.83; P < 0.001) and alanine aminotransferase (ALT) levels (MD −7.18; 95% CI −12.67 to −1.68; P = 0.01) as compared with those in the placebo group. …”
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Predicting the prognosis of epithelial ovarian cancer patients based on deep learning models by Zihan Li, Jiao Wang, Yixin Zhang, Zhen Yang, Fanchen Zhou, Xueting Bai, Qian Zhang, Wenchong Zhen, Rongxuan Xu, Wei Wu, Zhihan Yao, Xiaofeng Li, Yiming Yang

“…Survival outcomes were compared between different risk subgroups based on Kaplan-Meier analysis. …”
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Comparison of blended e-learning and face-to-face-only education for resuscitation training in German schools – A cluster randomized-controlled prospective study by Wolfgang A. Wetsch, Nikolas Link, Niels Rahe-Meyer, Rico Dumcke, Jan M. Stock, Bernd W. Böttiger, Sabine Wingen

“…Results: Overall, 375 students participated; 33 of which had to be excluded. 342 participants were included in statistical analysis (instructor-led group n = 109; e-learning group n = 233). …”
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Weight-adjusted-waist index is associated with increased risk of sleep disturbances in the U.S. adult population: an analysis of NHANES 2007–2012 by Haiping Xie, Chuhui Chen, Ting Li, Lizhen Xu, Jixing Liang, Junping Wen, Gang Chen, Liangchun Cai

“…; (2) if they reported trouble sleeping; and (3) if they had physician-diagnosed sleep disorders. Regression models assessed the association between WWI and sleep outcomes across the entire population and within subgroups. …”
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Internet-based cognitive behavioral therapy for psychological symptoms during the final phase of the COVID-19 pandemic: a feasibility study by Victoria Aminoff, My Björklund, Elina Ekström, Andrea Stenback, Uzma Yousafzai, Matilda Berg, Mikael Ludvigsson, Mikael Ludvigsson, Mikael Ludvigsson, Gerhard Andersson, Gerhard Andersson, Gerhard Andersson

“…IntroductionSARS-CoV-2 and the accompanying COVID-19 pandemic had a great impact on people's well-being, both physically and mentally. …”
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Climate Change: A Major Factor in the Spread of <i>Aedes aegypti</i> (Diptera: Culicidae) and Its Associated Dengue Virus by Shahid Majeed, Waseem Akram, Muhammad Sufyan, Asim Abbasi, Sidra Riaz, Shahla Faisal, Muhammad Binyameen, Muhammad I. Bashir, Shahzad Hassan, Saba Zafar, Oksana Kucher, Elena A. Piven, Olga D. Kucher

“…The current study was conducted to evaluate the impact of different temperature and relative humidity regimes on the developmental stages of the yellow fever mosquito, <i>Aedes aegypti</i> (Diptera: Culicidae). …”
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Parathyroid Hormone Reduction Predicts Transient Hypocalcemia after Total Thyroidectomy: A Single-Center Prospective Study by Kangnan Mo, Jinbiao Shang, Kejing Wang, Jialei Gu, Peng Wang, Xilin Nie, Wendong Wang

“…The ROC curve analysis illustrated that 65.58%, 71.00%, and 71.00% PTH level reduction had high accuracy in predicting transient hypocalcemia in the whole cohort, bilateral group, and female patients, respectively (AUC = 0.986, 0.987, and 0.987). …”
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What motivates participants: a qualitative analysis of gamification and financial incentives to increase physical activity by Eric Ryu, David Farraday, Alexander C. Fanaroff, Samantha Coratti, Neel P. Chokshi, Jingsan Zhu, Julia E. Szymczak, Louise B. Russell, Laurie Norton, Dylan Small, Kevin G. Volpp, Tamar Klaiman

“…Thematic analysis was conducted inductively and deductively, and identified themes were mapped onto the COM-B Framework to understand the interaction between different themes. Results We achieved saturation after conducting interviews with 55 participants (30 high performers and 25 low performers); 19 in the gamification arm, 19 in the financial incentives arm, and 17 in the gamification plus financial incentives arm. …”
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Evolution of mobility, pain/discomfort, self-care, and mental health in patients with alpha-mannosidosis: an international caregiver and patient survey by Karolina M. Stepien, Sophie Thomas, Julia B. Hennermann, Christina Lampe, Nicole M. Muschol, Maria Juliana Ballesta-Martínez, Jordi Cruz, Mónica López-Rodríguez, Anneliese Barth, Martin Magner, Allan M. Lund, Vasilica Plaiasu, Andrea Ballabeni, Francesca Donà, Heather M. Morgan, Nathalie Guffon

“…Results Analyses include 51 responses from 18 countries: 26 patients were on velmanase alfa enzyme replacement therapy (ERT), seven had been treated with hematopoietic stem cell transplantation (HSCT) and 18 were untreated patients (UP). …”
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Sociodemographic and clinical predictors of quality-of-life outcome in children and young people with primary brain tumour in Karachi, Pakistan: a prospective cohort study by Nick Brown, Sadaf Altaf, Salman Kirmani, Nida Zahid, Iqbal Azam, Faiza Kausar, Syed Ather Enam, Thomas Mårtensson, Naureen Mushtaq, Mariya Moochhala, Aneesa Hassan, Saqib Bakhshi, Lal Rehman, Farrukh Javeed, Muhammad Nouman Mughal

“…There was no significant difference in mean global QoL scores of patients at 12 months post-treatment. …”
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Long-term Outcomes of Infant Ear Molding: A 10-year Single-Surgeon Experience by Meagan Wu, MA, Ashley E. Chang, BA, Alana M. Platukus, BS, Benjamin B. Massenburg, MD, China N. Byrns, MS, PhD, Dominic J. Romeo, MA, Jinggang J. Ng, MA, Jordan W. Swanson, MD, MSc, Jesse A. Taylor, MD, Scott P. Bartlett, MD

“…Thirty patients with 47 deformities had photographs at T1 = 0.2 ± 2.8 years and T2 = 6.5 ± 2.8 years after treatment, which were evaluated by 236 laypeople. …”
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Fatal disseminated mucormycosis due to Cunninghamella bertholletiae infection after ABO-incompatible living donor liver transplantation: a case report by Atsuyoshi Mita, Shohei Hirano, Takeshi Uehara, Kai Uehara, Yasunari Ohno, Koji Kubota, Yuichi Masuda, Tsuyoshi Notake, Kazuki Yoshizawa, Akira Shimizu, Yuji Soejima

“…Case presentation A 47-year-old man with decompensated liver cirrhosis and hepatocellular carcinoma underwent an ABO-incompatible LDLT using a graft procured from his son, who had a different blood type. Rituximab and mycophenolate mofetil were administered 3 weeks before LDLT as immunosuppressive therapy. …”
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What activities do patients hope to perform following anatomic total shoulder arthroplasty but are unable to? Looking beyond patient-reported outcome measures by Alexander E. White, MD, Nicolas Pascual-Leone, MD, Anthony Finocchiaro, BS, Christopher M. Brusalis, MD, David M. Dines, MD, Joshua S. Dines, MD, Andreas Kontaxis, PhD, Samuel A. Taylor, MD, Lawrence V. Gulotta, MD, Michael C. Fu, MD, MHS

“…The majority of patients had no difficulty managing toileting (93.7%), driving a car (92.4%), washing their hair (91.9%), and putting on a seatbelt (90.7%). …”
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