Social isolation in relation to the incidence and dynamic progression of frailty in the oldest old: a trajectory analysis of a nationwide cohort by Junyi Wang, Yafu Yu, Lang Xu, Xinyan Xie, Xiaochang Liu, Juan Zhou, Guirong Cheng, Feifei Hu, Dan Liu, Linya Huang, Gangbin Han, Shiyue Li, Dan Song, Jing Liu, Qianqian Nie, Cheng Cai, Yuyang Cui, Wei Tan, Yan Zeng

“…Socially isolated persons had a greater cumulative transition probability to prefrailty and frailty. …”
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Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now by S. A. Shalnova, A. E Imaeva, Yu. A Balanova, V. A Kutsenko, A. V Kapustina, V. A Metelskaya, N. A Imaeva, B. M Nazarov, O. E Ivlev, E. B Yarovaya, O. M Drapkina

“…Men with non-HDL-C levels ≥4.5 mmol/L in the LRC study and ≥4.2 mmol/L in the ESSE-RF study had a significantly increased risk of fatal and non-fatal CVDs (63% and 27%, respectively) and decreased risk of cancer mortality (28% and 50%, respectively). …”
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Lnc-MEG8 regulates yak myoblast differentiation via the miR-22-3p/RTL1 axis by Xiaoming Ma, Yongfu La, Tong Wang, Chun Huang, Fen Feng, Xian Guo, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan

“…Functional experiments showed that Lnc-MEG8 promotes cell proliferation and inhibits differentiation, while its silencing had the opposite effect. Further analysis revealed that both Lnc-MEG8 and the gene RTL1 share miR-22-3p as a common target. …”
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Endogenous endophthalmitis due to Klebsiella pneumoniae liver abscess: a retrospective study of clinical course, treatment pattern, and prognosis by Gyu Chul Chung, Dong Sun Kim, Ji Eun Lee, Iksoo Byon, Sung Who Park, Han Jo Kwon, EunAh Kim

“…Although all but three patients had systemic disease such as diabetes or hypertension, visual prognosis after treatment did not appear to depend significantly on underlying comorbidities. …”
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Gaps in knowledge regarding the diagnostic criteria and management of PCOS in Germany: An anonymous web-based survey by Konstantin Hofmann, Melody Oehler, Christian Ruckes, Anna Dionysopoulou, Kathrin Stewen, Lina Judit Schiestl, Yaman Degirmenci, Susanne Theis, Christine Skala, Annette Hasenburg, Roxana Schwab

“…The preferred general treatments and fertility treatments for PCOS patients also differed significantly between the two groups (p = 0.002, p < 0.001). …”
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Survival outcomes in hormone receptor-negative breast cancer among BRCA carriers versus noncarriers in western Sweden by Anna-Karin Tzikas, Erik Holmberg, Toshima Z. Parris, Anikó Kovács, Lovisa Lovmar, Per Karlsson

“…Results: Among the 106 BRCA carriers, 101 (95%) had a BRCA1 and 5 (5%) a BRCA2 PV. Most of the BRCA-carriers (89/106, 84%) were diagnosed with BC prior to genetic screening. …”
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Influence of age, time of day, and environmental changes on vocalization patterns in broiler chickens by Patricia Soster de Carvalho, Tomasz Grzywalski, Kobe Buyse, Pieter Thomas, Camila Lopes Carvalho, Imad Khan, Bassem Khalfi, Frank Tuyttens, Maarten De Gussem, Paul Devos, Dick Botteldooren, Gunther Antonissen

“…Throughout the starter, grower, and finisher phases, all treatments exhibited similar vocalization patterns across age and time of the day, highlighting the strong influence of daily periods on vocalizations. SP had the highest frequency in the evening and the lowest at night. …”
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Lower rate of mpox vaccination hesitancy and medical consultation among Chinese men who have sex with men living with HIV in comparison with those living without HIV: A national ob... by Min Zheng, Min Du, Guanghong Yang, Yongming Yao, Xiaohan Qian, Yuan Zhi, Lin Ma, Rui Tao, Zhilin Zhu, Feng Zhou, Siqi Dai, Jie Yang, Min Liu, Jue Liu

“…Compared with PLWoH, PLWH had lower odds ratios of vaccination hesitation (aOR = 0.70; 95%CI = 0.53, 0.92; P = .011) and consultation hesitation (aOR = 0.74; 95%CI = 0.60, 0.90; P = .003) among MSM. …”
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Intensive care unit admission and associated factors in patients hospitalised for COVID-19: A national retrospective cohort study in Iran by Fatemeh Shahbazi, Mohammad Reza Taherian, Seyed Saeed Hashemi Nazari, Neda Izadi, Yaser Mokhayeri, Arash Seifi, Niloufar Taherpour, Ahmad Mehri, Saeid Fallah, Sahar Sotoodeh Ghorbani, Kosar Farhadi-Babadi, Elham Rahimi, Koorosh Etemed

“…The association between different variables and ICU admission was assessed by forward Logistic regression and restricted cubic spline method.Results The mean age of the 1 469 620 patients with COVID-19 was 54.49±20.58 years old, and 51.32% of the patients were male. …”
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Ergothioneine attenuates psoriasis symptoms through modulation of M1/M2 macrophage polarisation via the NF-κB/JAK-STAT3 pathway by Ang Li, Yanjie Liu, Peiling Yu, Zhiyuan Zhang, Tengxiao Huang, Hang Li, Songzhi Wu, Xiaoyu Rong, Wensheng Liao, Hongqiang Wang, Yanzheng Gao

“…EGT was also observed to markedly suppress the LPS-induced phosphorylation of JAK/STAT3 and NF-κB, offering a novel insight into the anti-inflammatory mechanism of EGT.DiscussionIn conclusion, the findings of the present study consistently demonstrated that ergothioneine had a significant ameliorative effect on the imiquimod-induced psoriasis model by modulating the NF-κB/JAK-STAT3 signalling pathway. …”
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Comprehensive assessment of fatty acid profiles of meat products to develop action plan strategies for healthier products by Sakineh Yazdanparast, Fatemeh Mohammadi-Nasrabadi, Ali Hashmati, Roghayeh Rezazadeh, Mehdi Taheri, Barbod Alhouei, Fatemeh Esfarjani

“…Beef hamburger (50.38%) and German sausage (20.79%) had the highest and lowest saturated fatty acid (SFA) contents, respectively. …”
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Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study) by Alexia Giovanazzi, Lorenzo Gios, Maria Adalgisa Gentilini, Marina Mastellaro, Patrizia Bartolotta, Lucrezia Nicolussi Giacomaz, Claudio Eccher, Sandro Inchiostro

“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”
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Serum detection of blood brain barrier injury in subjects with a history of stroke and transient ischemic attack by Scott French, Juan Arias, MD, Ikeoluwapo Bolakale-Rufai, MD, Summan Zahra, MD, Kaneez Zahra Rubab Khakwani, MD, Edward J. Bedrick, PhD, Geidy E. Serrano, PhD, Thomas G. Beach, MD, PhD, Eric Reiman, MD, Craig Weinkauf, MD, PhD

“…Results: Serum PDGFRẞ, a putative biomarker of BBB injury, was significantly increased in subjects with vs without a history of CVA who had similar cardiovascular risk factors (P < .01). …”
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18F-NaF PET/CT in Presumed Aseptic Pseudarthrosis after Spinal Fusion: Correlation with Findings at Revision Surgery and Intraoperative Cultures by Yacine El Yaagoubi, Jean-Edouard Loret, Eric Lioret, Clément Thomas, Adrien Simonneau, Laurent Vinikoff, Caroline Prunier-Aesch, Alain Chetanneau, Laurent Philippe, Maja Ogielska, Louis Bernard

“…There was a statistically significant difference in standardized uptake values and uptake ratios between the revision surgery and control groups (p=5.3× 10−6 and p=0.0002, respectively). …”
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Can synthetic data be a proxy for real clinical trial data? A validation study by Monica Parry, Karolina Kublickiene, Valeria Raparelli, Peter Klimek, Alexandra Kautzky-Willer, Louise Pilote, Michal Abrahamowicz, Colleen M. Norris, Maria Trinidad Herrero, Khaled El Emam, Ruth Sapir-Pichhadze, Simon Bacon, Jennifer Fishman, Zahra Azizi, Chaoyi Zheng, Lucy Mosquera, Karin Humphries, Khaled El Emam

“…The univariate distributions were within 1% of difference on an information theoretic metric. All of the bivariate relationships had CI overlap on the tau statistic above 50%. …”
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Twenty‐Four‐Month Outcomes of Heparin‐Bonded Covered Stents and Drug‐Coated Balloon Angioplasty in Femoropopliteal Artery Occlusion by Yuhao Lin, Yaowen Chang, Jing Wang, Huijun Yuan, Feng Zhang, Ruipeng Zhang, Jianjun Quan, Jian Dong, Yang Han, Longlong Cong, Lin Yang

“…Results Compared with the patients in the DCB group, those in the CS group had a lower prevalence of smoking (54.3% versus 74.0%, P=0.004) and diabetes (38.3% versus 66.0%, P<0.001) before propensity score matching. …”
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Prolonged Hospital Stay in Hypertensive Patients: Retrospective Analysis of Risk Factors and Interactions by Stanisław Surma, Michał Czapla, Izabella Uchmanowicz, Raúl Juárez-Vela, Łukasz Pietrzykowski, Bartosz Uchmanowicz, Marcin Leśkiewicz, Krzysztof Griesmann, Michał Burzyński, Jacek Smereka, Łukasz Lewandowski

“…Female patients with HF had 3.995-fold higher odds of prolonged LOHS compared to females without HF (<i>p</i> < 0.001), while no significant difference was found among male patients with or without HF (<i>p</i> = 0.890). …”
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An ecological study on the association between early childhood caries and intimate partner violence in 20 low- and middle-income countries: 2007-2017 [version 3; peer review: 2 app... by Morenike Oluwatoyin Folayan, Maha El Tantawi, Mary O. Obiyan, Ola B. Al-Batayneh, Arthur Kemoli, Robert J. Schroth, Balgis Gaffar

“…The Democratic Republic of Congo had the highest prevalence of physical violence (45.8%), sexual violence (25.4%), and ECC (80.0%). …”
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Characteristics and mechanisms of sea (salt) water intrusion in Laizhou City, Shandong Province, China by Linghao Kong, Linghao Kong, Linghao Kong, Linghao Kong, Hongxian Chu, Guohua Hou, Jiao Zeng, Liyuan Zhao, Xiangcai Han, Yachao Li, Faqiao Zhou, Meiling Yin, Xuzhen Zhang

“…The sea (salt) water intrusion had a strip-sheet distribution. From land to sea, groundwater gradually transitioned from the HCO3·SO4·Cl-Ca type to SO4·Cl-Na·Ca and SO4·Cl-Na types and then evolved to the Cl-Na type. …”
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Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention by Andressa Feitosa Bezerra de Oliveira, Bianne Maria de Melo Costa, Anderson Gomes Forte, Elizabeth Barreto Galvão de Sousa, Vitória Régia Rolim Nunes, Arthur Felipe de Brito Andrade, Juliellen Luiz da Cunha, Nayanna Lana Soares Fernandes, Ana Maria Barros Chaves Pereira, Fabiano Vieira Vilhena, Paulo Henrique Perlatti D’Alpino, Fábio Correia Sampaio

“…This in vitro study evaluated the protective effect of an Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of the demineralized lesions in dentin after cariogenic pH cycling. …”
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