Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial by Jochen Gaedcke, Malte Sahrhage, Marcel Ebeling, Azadeh Azizian, Felix Rühlmann, Markus Bernhardt, Marian Grade, Wolf Otto Bechstein, Christoph-Thomas Germer, Robert Grützmann, Pompiliu Piso, Ralf-Dieter Hofheinz, Ludger Staib, Tim Beißbarth, Rebekka Kosmala, Emmanouil Fokas, Claus Rödel, Michael Ghadimi, The German Rectal Cancer Study Group

“…After 3 years, role functioning (p = 0.019) and physical functioning (p = 0.001) had a slightly poorer outcome in APR patients. The poorer prognosis of patients undergoing APR for locally advanced rectal cancer may be explained by clinicopathological characteristics. …”
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Optimized CO2 Cycloaddition to Epichlorohydrin Catalyzed by Ionic Liquid with Microwave and Ultrasonic Irradiation by Maria Atlaskina, Zakhar Markin, Kirill Smorodin, Sergey Kryuchkov, Nikita Tsivkovsky, Anton Petukhov, Artem Atlaskin, Olga Kazarina, Andrey Vorotyntsev, Ilya Vorotyntsev

“…The 1-(2-hydroxyethyl)-3-methylimidazolium catalyst had stable catalytic activity, with only minimal activity loss observed over five consecutive cycles.…”
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Assessing the accuracy and readability of ChatGPT-4 and Gemini in answering oral cancer queries—an exploratory study by Márcio Diniz-Freitas, Rosa María López-Pintor, Alan Roger Santos-Silva, Saman Warnakulasuriya, Pedro Diz-Dios

“…The Mann-Whitney U test revealed a statistically significant difference between the models’ scores (p = 0.02), with Gemini outperforming ChatGPT-4 in terms of completeness and accuracy. …”
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Bio-Inspired Thin-Walled Straight and Tapered Tubes with Variable Designs Subjected to Multiple Impact Angles for Building Constructions by Quanjin Ma, Nor Hazwani Mohd Yusof, Santosh Kumar Sahu, Yiheng Song, Nabilah Afiqah Mohd Radzuan, Bo Sun, Ahmad Yunus Nasution, Alagesan Praveen Kumar, Mohd Ruzaimi Mat Rejab

“…It was shown that a tapered square thin-walled structure with 2.5 mm thickness had the best crashworthiness performances with energy absorption (EA) of 11.01 kJ and specific energy absorption (SEA) of 20.32 kJ/kg under a 30° impact angle. …”
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Assessing mutation-clinical correlations and treatment outcomes in Vietnamese non-small cell lung cancer patients by Hoang-Bac Nguyen, Bang-Suong Nguyen-Thi, Huu-Huy Nguyen, Minh-Khoi Le, Quoc-Trung Lam, Tuan-Anh Nguyen

“…EGFR-mutant patients treated with TKIs had significantly longer survival (p = 0.027); however, no survival difference was observed between the EGFR- and KRAS-mutated groups. …”
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The impact of bronchoalveolar lavage fluid metagenomics next-generation sequencing on the diagnosis and management of patients with suspected pulmonary infection by Mei Zhou, Shengwen Sun, Long Chen, Huan Xu, Lanlan Liu, Jiaxi Lv, Jianchu Zhang, Xianzhi Xiong

“…Analysis of the rate of positive detection between CMTs and mNGS in various subgroups revealed that mNGS had a significantly higher positive detection rate in patients with pulmonary infections (87.95% vs. 71.06%, p<0.001), in immunocompetent patients (86.91% vs. 68.08%, p<0.001), and in patients with malignant tumors (92.31% vs. 69.23%, p=0.035). …”
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Crop gains induced by diversification exceed crop losses to diseases and weeds in a low-input rice cultivation system by Koloina Rahajaharilaza, Cyrille Violle, Bertrand Muller, Kirsten vom Brocke, Jean Benoît Morel, Rémi Pelissier, Elsa Ballini, Delphine Luquet, Perle Ramavovololona, Florian Fort, Lucie Mahaut

“…The average height of varieties in mixtures as well as their height plasticity had strong predictive power of crop yields, confirming the great potential of trait-based approaches to design innovative cropping system. …”
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Epicardial adipose tissue in patients with and without COVID-19 infection by Alexander J. Küng, Iryna Dykun, Matthias Totzeck, Raluca Mincu, Lars Michel, Clemens Kill, Oliver Witzke, Jan Buer, Tienush Rassaf, Amir A. Mahabadi

“…We aimed to determine whether EAT amount differs in patients with and without acute COVID-19 infection and myocardial injury. …”
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Comparison of Photocatalytic Activity: Impact of Hydrophilic Properties on TiO₂ and ZrO₂ Thin Films by Yuliana de Jesús Acosta-Silva, Misael Ian Lugo-Arredondo, Salvador Gallardo-Hernández, Juan Fernando Garcia-Trejo, Yasuhiro Matsumoto, Sandra Rivas, Ana Angélica Feregrino-Pérez, Luis A. Godínez, Arturo Méndez-López

“…The X-ray diffraction patterns showed that the TiO₂ TFs had an anatase crystalline structure, unlike the ZrO₂ TFs, which showed a tetragonal crystalline structure that was verified by Raman spectroscopy. …”
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Chondroprotective functions of neutrophil-derived extracellular vesicles by promoting the production of secreted frizzled-related protein 5 in cartilage by Keita Kitahara, Taku Ebata, Chen Liyile, Yoshio Nishida, Yuki Ogawa, Taiki Tokuhiro, Junki Shiota, Tatsuya Nagano, Taichi E. Takasuka, Tsutomu Endo, Tomohiro Shimizu, Hend Alhasan, Tsuyoshi Asano, Daisuke Takahashi, Kentaro Homan, Tomohiro Onodera, Ken Kadoya, M. Alaa Terkawi, Norimasa Iwasaki

“…Results Conditioned medium from neutrophils stimulated with TGF-β (N-β) had the greatest inhibitory effect on the expression of catabolic factors in stimulated chondrocytes. …”
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Risk factors for CAR T-cell manufacturing failure and patient outcomes in large B-cell lymphoma: a report from the UK National CAR T Panel by Vaishali Dulobdas, Amy A. Kirkwood, Fabio Serpenti, Brijesh Gautama, Aikaterini Panopoulou, Amrith Mathew, Sumantha Gabriel, Ram Malladi, Jessica Pealing, Denise Bonney, Emma Nicholson, Caroline Besley, Sara Ghorashian, Andrea Kuhnl, Elizabeth Davies, Jackie Chappell, Anne Black, Tobias Menne, Maeve A. O’Reilly, Robin Sanderson, Sridhar Chaganti

“…Of 981 large B-cell lymphoma (LBCL) patients approved for CAR T-cell therapy, 38 (3.87%) had MF. Eleven patients received delayed infusion with a product in-specification (delayed-infused) following 21 remanufacturing attempts. …”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…The research nurses came from a different clinical background and had very little prior knowledge around allergy. …”
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Worst pattern of invasion in oral squamous cell carcinoma is an independent prognostic factor by Aseem Mishra, Abhishek Das, Ipsita Dhal, Ravi Shankar, B.M. Bhavya, Neha Singh, Parul Tripathi, Dipti Daga, Atul Rai, Monika Gupta, Guru Charan Sahu

“…On multivariate analysis, non-cohesive WPOI (IV & V) showed significant association with grade, PNI, DOI (0.002, 0.033 & 0.033 respectively). Non-cohesive WPOI had significantly higher locoregional failures and short DFS. …”
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Impact of Perioperative Antibiotic Prophylaxis Targeting Multidrug-Resistant Gram-Negative Bacteria on Postoperative Infection Rates in Liver Transplant Recipients by Eleni Massa, Dimitrios Agapakis, Kalliopi Tsakiri, Nikolaos Antoniadis, Elena Angeloudi, Georgios Katsanos, Vasiliki Dourliou, Antigoni Champla, Christina Mouratidou, Dafni Stamou, Ioannis Alevroudis, Ariadni Fouza, Konstantina-Eleni Karakasi, Serafeim-Chrysovalantis Kotoulas, Georgios Tsoulfas, Eleni Mouloudi

“…Although overall complication and mortality rates at 30 days and 3 months did not differ significantly between groups, the targeted prophylaxis group had fewer infectious complications (22.8% vs. 68.5%, <i>p</i> = 0.008), particularly bacteremia (<i>p</i> = 0.007). …”
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Incidence and Risk Factors of De Novo Postpartum Hypertension by Ukachi N. Emeruwa, MD, MPH, Ana Çapi, MD, Marni B. Jacobs, PhD, Louise C. Laurent, MD, PhD, Natalie A. Bello, MD, MPH, Cynthia Gyamfi-Bannerman, MD, MS

“…Results: Of 389 included participants, 35 (9.0%) developed dnPPHTN. Of these, 5.7% had pregestational diabetes compared to 0.6% of normotensive individuals (P = 0.042; adjusted OR: 11.3; 95% CI: 1.8-73.1). …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…The broad negative effects of land-use conversion for agriculture on wildlife species are well known, but few studies have evaluated how different land-use types impact spatiotemporal patterns and trophic strategy of large carnivores. …”
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Acaricidal efficacy of fluralaner against Rhipicephalus microplus ticks under laboratory and field conditions in Brazil by Daniel de Castro Rodrigues, Gabriel Webert Gomes, Francisca Leticia Vale, Ana Lúcia Coutinho Teixeira, Isabela Santos Silva, Haile Dean Figueiredo Chagas, Tom Strydom, Siddartha Torres, Rafael Paranhos de Mendonça, Fernando de Almeida Borges, Lívio Costa Junior, Lorena Lopes Ferreira, Welber Daniel Zanetti Lopes, Caio Monteiro

“…Conclusion We observed natural variability in the susceptibility of larvae from the different populations of R. microplus that had never been treated with this compound. …”
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Prevalence and potential impact of human pegivirus-1 on HIV-1 disease progression among Indian PLHIV by Diviya Alex, Runal J Steve, Veena V Ramalingam, John P Demosthenes, Gopinathan Vijayalakshmi, Ben C Ghale, Priscilla Rupali, George M Varghese, Dolly Daniel, Grace Rebekah, Gnanadurai J Fletcher, Priya Abraham, Rajesh Kannangai

“…CD4+ T-cell count (245.5 vs. 240; p = 0.59) and HIV-1 log viral load (4.7 vs. 4.9; p = 0.50) were not significantly different between the HIV-1 mono-infected and coinfected individuals. …”
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Effects of sport and physical recreation on health-related outcomes among children and young people with physical disability: systematic review with meta-analysis by Catherine Sherrington, Juliana S Oliveira, Leanne Hassett, Stephen Gilbert, Amabile B Dario, Kerry West, Jennifer N Baldwin, Heidi Gilchrist, Minke Geerts, Wing S S Kwok, Rae Anderson, Gavin John Robertson

“…Sport and physical recreation had a small positive impact on activity limitations (nine trials, n=271, standardised mean difference (SMD) 0.30, 95% CI 0.02 to 0.57, p=0.018, low certainty evidence) and a medium positive impact on physical impairment (seven trials, n=216, SMD 0.63, 95% CI 0.08 to 1.18, p=0.025, very low certainty evidence) compared with control. …”
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Inbreeding and genetic load in a pair of sibling grouse species: Tetrastes sewersowi and T. bonasia by Kai Song, Tom van der Valk, Bin Gao, Peter Halvarsson, Yun Fang, Wendong Xie, Siegfried Klaus, Zhiming Han, Yue-Hua Sun, Jacob Höglund

“…We found a large range of inbreeding measured as FROH (fraction of runs of homozygosity) in individuals from different populations of Chinese Grouse (Tetrastes sewerzowi) and Hazel Grouse (T. bonasia). …”
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