Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration by Lei Yu, Wentao Wang, Chang Lv, Qian Chen, Peng Yang, Zhenrong Qi, Haomiao Yu, Ruiqi Cao, Wenhao Li, Yi Qin, Gaoran Ge, Peilai Liu, Lixin Zhu, Houyi Sun, Dechun Geng, Liang Zhang

“…This dual-action system synergistically regulates osteoblast and osteoclast activity, optimizing the pathological microenvironment of osteoporosis and facilitating the repair of osteoporotic bone defects. MBG@D5-Gel holds great potential as an effective organic-inorganic hybrid biomimetic implant material for the treatment of osteoporotic bone defects.…”
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Weighted EHR-based prevalence estimates for hypertension at the state and local levels in Louisiana by Wenjun Li, Meng Zhang, Jie Cheng, Sandra L. Jackson, Adam S. Vaughan, Michael Klompas, Thomas W. Carton, Elizabeth Nauman, Lee Mendoza, Arun Adhikari, Jeanie Donovan, Katherine H. Hohman

“…Although electronic health record (EHR) data have great potential for surveillance, population coverage is non-random, which may result in biased estimates. …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…This implies that slow drifts or fluctuations in pumping power can directly affect the long-term stability of the comagnetometer, which is critical for applications requiring minimal drift over time. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Performance Evaluation of Dual-Drive Mach-Zehnder Modulator and Optomechanical Crystal Cavity Comb Generation for All-Optical Band Conversion in 5G-Advanced Cellular Systems by Vicente Fito, Raul Ortiz, Maria Morant, Laura Mercade, Alejandro Martinez, Roberto Llorente

“…Their effectiveness in all-optical frequency conversion depends on their stability in terms of frequency drift, phase noise, and power distribution across the comb lines. …”
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Temporal and Spatial Patterns of Wind Erosion Climate Indices and Their Responses to Atmospheric and Oceanic Circulation Patterns in the Chinese Mollisol Region over the Past 61 Ye... by HU Wentao, ZHENG Fenli, GAO Xiaoyu, ZHENG Runhe, FU Jinxia, LI Zhi, ZHANG Jiaqiong

“…[Objective] A study on the spatial and temporal patterns of wind erosion climate indices and their responses to atmospheric and oceanic circulation patterns in the Chinese Mollisol region is of great significance for the early warning and prevention of wind erosion. …”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

“…At the same time, these images of gardens with great detail content have formed a strong set of garden narratives, which in turn influence the perspective of garden research — a spatially compressed perspective with multiple details superimposed on each other, and a perspective that transforms spatial protagonists and garden narratives, which has begun to subconsciously influence the direction of garden research. …”
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Construction of Multi-level Ecological Corridor System for National Parks: A Case Study of the Proposed Nanling National Park by Yi DENG, Zeyu HUANG, Ziyi MAO, Jinling HUANG

“…However, the current construction of ecological corridors faces challenges, such as not being able to adapt to future environmental changes, not being able to correspond to the multi-layered structure of ecosystems, and not being able to clarify the specific content of construction control. Therefore, it is of great significance to explore the ecological corridor system of national parks that can adapt to future environmental changes, correspond to the multi-level attributes of ecosystems, and implement differentiated construction control.MethodsThis research establishes a framework for the construction of a multi-level ecological corridor system. …”
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Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future by Chundi Liu, Mouyuan Sun, Lining Lin, Yaxian Luo, Lianjie Peng, Jingyu Zhang, Tao Qiu, Zhichao Liu, Jun Yin, Mengfei Yu

“…Peripheral nerve injuries are a prevalent global issue that has garnered great concern. Although autografts remain the preferred clinical approach to repair, their efficacy is hampered by factors like donor scarcity. …”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…Therefore, the research on carbon sequestration capacity of common landscaping tree species in Beijing is of great importance, especially considering that relevant research is still not sufficient and complete at present.MethodsAccording to the principles of ecological adaptability and representativeness, this research mainly considers tree species seldom involved in the current research (Vitex negundo var. heterophylla, etc.), while highly recommended in Beijing in recent years (Chionanthus retusus, etc.), and then takes 30 common landscaping tree species in Beijing urban green space as the research object. …”
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Editorial by Thomas Duve

“…Eine ausführliche Rezension gilt einer Quellensammlung zur portugiesischen Rechtsgeschichte, eine andere der Webseite Slavery, Law & Power in the British Empire and Early America (SLP). …”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…At each site, 100 DUs were placed systematically 2.5-m apart on 50-m x 10-m grids and monitored with still and video cameras. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Consequently, the detection of thousands of additional SNPs not detectable in pre-SWGA samples was facilitated after SWGA, allowing more substantial downstream population genomics analysis, particularly for the polymorphic and antimalarial genes of great interest for all the species. Furthermore, leveraging the long DNA fragments generated by SWGA, we achieved high-quality genome assemblies for P. malariae and P. ovale using PacBio long reads sequencing technology. …”
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A key technology for synergistic backfilling of coal-based solid waste and high-salinity wastewater by Shuning DONG, Shujiang YU, Xingling DONG, Buqin ZHANG, Xiaoming GUO, Xiaodong WANG, Kai WANG, Shibin ZHU, Boqiang WU, Lei LIU

“…However, existing technologies for high-salinity wastewater treatment are generally confronted with issues such as great initial investment and high operation costs of the treatment engineering. …”
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ADMINISTRATIVE PREREQUISITES FOR FINANCIAL MANAGEMENT AND MARKETING OF SMALL BUSINESSES AT THE REGIONAL LEVEL by Natalia Koval, Oksana Kubai, Natalia Germaniuk

“…A small business is often characterised by a lack of resources, which presents a serious challenge: the choice of marketing tools must be made responsibly and with great care. The likelihood of making mistakes must be minimised, as the consequences can have a significant impact on the company's financial health. …”
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Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

“…Background Chimeric antigen receptor natural killer (CAR-NK) therapy holds great promise for treating hematologic tumors, but its efficacy in solid tumors is limited owing to the lack of suitable targets and poor infiltration of engineered NK cells. …”
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Research on Characteristics and Influencing Factors of High Temperature Disaster Risk in Wuhan Based on Local Climate Zone by Shujing GUO, Li ZHANG

“…ObjectiveAgainst the background of rapid urbanization and global warming, Wuhan is frequently hit by extreme heat events, which not only poses a serious threat to the health status of local residents, but also brings great losses to socio-economic development. Mapping the high temperature disaster risk in the urban development area of Wuhan and analyzing the high temperature disaster risk and influencing factors thereof at the local scale can provide an important basis for the prevention of high temperature disasters in the city.MethodsBased on the “hazard – exposure – vulnerability” high temperature disaster risk assessment framework proposed by the Intergovernmental Panel on Climate Change, this research constructed an assessment system by utilizing multi-source data, and then pre-processes all relevant indicators to make them dimensionless. …”
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations by Lucas Tricoli, Sunetra Sase, Julia L. Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife Roche, John Everett, Frederic Bushman, Peter Kurre, Rebecca Ahrens-Nicklas, Laura A. Adang, Adeline L. Vanderver, Stefano Rivella

“…Combined autologous hematopoietic stem cell transplantion (HSCT) with lentiviral (LV)-based gene therapy has great potential to treat MLD. Achieving the optimal balance between high enzyme production for therapeutic efficacy and maintaining a low vector copy number (VCN) is crucial. …”
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Research on Carbon Sequestration Capacity of Urban Park Green Space in the Central Urban Area of Beijing and Driving Factors Thereof by Xiuping LIU, Songting ZHAO, Xinyu LI, Jiale LI, Xing WANG

“…Quantifying the carbon sequestration capacity of urban green spaces is of great significance for achieving carbon peaking and carbon neutrality goals and addressing climate change.MethodsBased on Carnegie-Ames-Stanford approach (CASA) model, Landsat 8 TM remote sensing data and meteorological data from 2014, 2017, and 2020 are used to estimate the net primary productivity (NPP) and carbon sequestration capacity of parks in the central urban area of Beijing, and explore the spatial and temporal distribution pattern and change characteristics of carbon sequestration capacity of parks in the central urban area of Beijing. …”
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Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Abstract Although the efficacy of pharmacy in the treatment of attention deficit/hyperactivity disorder (ADHD) has been well established, the lack of predictors of treatment response poses great challenges for personalized treatment. The current study employed a comprehensive approach, combining genome-wide association analyses (GWAS) and deep learning (DL) methods, to elucidate the genetic underpinnings of pharmacological treatment response in ADHD. …”
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