PEDV infection downregulates goblet cell differentiation through activating the Notch pathway by Yi Wang, Shanshan Yang, Yongxiang Zhao, Shuo Tian, Qiuxia Cao, Xinmei Geng, Mengdi Yang, Xu Song, Hongqi Shang, Shiyu Liu, Rongli Guo, Yunchuan Li, Min Sun, Mi Hu, Baochao Fan, Bin Li

“…This study reveals that PEDV infection reduces the number of goblet cells and impairs the intestinal barrier integrity in newborn piglets. …”
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice by Yulia Dwi Setia, Yulia Dwi Setia, Mio Kokubo-Tanaka, Ryusei Tanaka, Akemi Yoshida, Eiji Nagayasu, Parnian Ahmadi, Parnian Ahmadi, Parnian Ahmadi, Ayako Yoshida, Ayako Yoshida, Haruhiko Maruyama

“…To elucidate mechanisms of goblet cell dysfunction, we performed RNA sequencing of large intestine tissue to examine host as well as parasite transcriptomes.ResultsFecal oocyst excretion peaked at 8–9 dpi. …”
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Fructose aggravating colon barrier dysfunction by decreasing gut bacteria metabolites indole-3-carboxaldehyde and inhibiting activation of aryl hydrocarbon receptor in vivo and in... by Ge Song, Shaojie Pang, Wenting Peng, Wei Fang, Yong Wang, Rui Liu, Qianyun Gan, Wentao Qi

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Engeletin Targets Mitochondrial Dysfunction to Attenuate Oxidative Stress and Experimental Colitis in Intestinal Epithelial Cells Through AMPK/SIRT1/PGC-1α Signaling by Jing Li, Zhijun Geng, Lixia Yin, Ju Huang, Minzhu Niu, Keni Zhang, Xue Song, Yueyue Wang, Lugen Zuo, Jianguo Hu

“…Eng administration (10, 20, 40 mg/kg) significantly alleviated colitis symptoms, including weight loss, disease activity index (DAI) scores, and colon shortening, while restoring intestinal barrier integrity through the upregulation of tight junction proteins (ZO-1, claudin-1) and goblet cell preservation. Eng suppressed NF-κB-mediated inflammation and activated the Nrf2 antioxidant pathway, as well as reduced oxidative stress markers (MDA, CAT, GSH, and SOD). …”
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Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures by Chengfeng Xing, Guili Liang, Xin Yu, Anxing Zhang, Xiang Luo, Yu Liu, Zengli Tang, Bian Wu, Zhengji Song, Danfeng Lan

“…Here, the crypts were isolated from the small intestine of mice; with the participation of major cytokines (EGF, Noggin, and R-Spondin 1 included), the intestinal organoids were established at a density of 100 crypts per well, containing intestinal stem cells (ISC), Paneth cells, goblet cells, and intestinal endocrine cells. …”
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Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways by Tahmina Yasmin, Sreelakshmi N. Menon, Ajay Pandey, Shahnaz Siddiqua, Syed Abdul Kuddus, Md. Mizanur Rahman, Ferdous Khan, Nazia Hoque, Md. Sohel Rana, Nusrat Subhan, Emran Habibi, Fatemeh Ramezani, Satyajit D. Sarker, Lutfun Nahar, Md. Ashraful Alam, Raquibul Hasan

“…Importantly, it preserved the goblet cell population within both intestinal crypts and villi, thereby maintaining the integrity of the gut-mucus barrier. …”
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Traditional Mongolian Medicine Qiqirigan-8 alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism by Dandan Yang, Dandan Yang, Wuyunsiqin, Wuyunsiqin, YanNiu, Hashentuya, Tana, Anna, Mingxing Ma, Wenhui Zhao, Menggenduxi, Minjie Wang, Minjie Wang

“…MMQ-8 reduced the infiltration of inflammatory cells in the colon epithelium of model mice while restoring the number of goblet cells. MMQ-8 significantly enhanced ZO-1 protein expression in the colon, as well as the mRNA expression of both ZO-1 and Occludin. …”
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