Key organisational barriers to effective knowledge risk management in South African public sector enterprises by Malefetjane Phaladi

“…The improved KRM can enhance public service delivery efficiency, transparency and the accountability of PSEs by addressing socio-economic developmental issues in developing economies. …”
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Prediction of one-year recurrence among breast cancer patients undergone surgery using artificial intelligence-based algorithms: a retrospective study on prognostic factors by Raoof Nopour

“…The discrimination, calibration, and clinical utility were leveraged to assess the algorithms’ performance efficiency. The SHapley Additive exPlanations plot was generated to identify the prominent prognostic factors affecting the one-year recurrence of breast cancer. …”
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Exploring the liposomal encapsulation and enhanced cytotoxicity of selenium nanoparticles against lung cancer cells by Dipti Chirakara, Shriya Lotlikar, Mahalakshmi Nannan, Nageswara Rao Dunna, Sivaramakrishnan Venkatabalasubramanian

“…The augmented results obtained from DLS (homogenous size distribution), Zeta potential (higher negative charge), XRD (no other element interference), and SEM-EDS (53 % selenium encapsulation and negligible agglomeration) further strengthened the stability of the generated Lip-SeNPs compared to liposome-free SeNPs. …”
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Postimplementation Evaluation in Assisted Living Facilities of an eHealth Medical Device Developed to Predict and Avoid Unplanned Hospitalizations: Pragmatic Trial by Jacques-Henri Veyron, François Deparis, Marie Noel Al Zayat, Joël Belmin, Charlotte Havreng-Théry

“…The primary outcomes were the acceptability and feasibility of the monitoring system in the context and confirmation of the effectiveness and efficiency of AI in risk prevention and detection in practical, real-life scenarios. …”
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Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A? by Mohammad Mamun Alam, Asma Salauddin, Sayra Moni, Md Belayet Hasan Limon, Raisha Musarrat, Sagar Bosu, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mustafizur Rahman

“…Subsequent in-silico analysis revealed that most efficient binding (>8 kcal/mol) was found between the antibodies of SARS-CoV-2 delta variant (ΔG) with influenza A/H1N1 HA (Hemagglutinin), A/H3N2 HA, A/H1N1 NA (Neuraminidase), and A/H3N2 NA glycoproteins with −12.4, −9.3, −10.1, and −11.7 kcal/mol, respectively. …”
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Patient Transfer Process From Pre‐Hospital to the Hospital Emergency Department: A Grounded Theory Study by Maryam Jamsahar, Fazlollah Ahmadi, Mitra Khoobi, Mojtaba Vaismoradi

“…While successful strategies can inform practical guidelines, negative consequences highlight the need for more efficient and effective approaches. …”
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Turning Waste into Treasure: Functionalized Biomass‐Derived Carbon Dots for Superselective Visualization and Eradication of Gram‐Positive Bacteria by Ke‐Fei Xu, Zihao Wang, Macheng Cui, Yuhan Jiang, Chengcheng Li, Zi‐Xi Wang, Ling‐Yi Li, Chenyang Jia, Lijie Zhang, Fu‐Gen Wu

“…Strikingly, CDFs achieve superselective visualization of Gram‐positive bacteria even in the presence of mammalian cells and Gram‐negative bacteria. Furthermore, protoporphyrin (PpIX) molecules are conjugated onto BCDs to yield PpIX‐modified BCDs (termed CDPs), which can induce bacterial aggregation and in situ generate singlet oxygen for realizing enhanced antibacterial photodynamic therapy (PDT). …”
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An integrated solution to mitigate climate change through direct air capture and diabatic compressed air energy storage by Yide Han, Yurong Liu, Xin Peng, Bo-Yu Peng, Yuxing Ding, Wenli Du, Weimin Zhong, Feng Qian

“…Results show a D-CAES round-trip efficiency of 59.27% and a levelized cost of electricity of $0.53/kWh. …”
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Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study by Kui Sun, Rongchao Shi, Xinxin Yu, Ying Wang, Wei Zhang, Xiaoxia Yang, Mei Zhang, Jian Wang, Shu Jiang, Haiou Li, Bing Kang, Tong Li, Shuying Zhao, Yu Ai, Jianfeng Qiu, Haiyan Wang, Ximing Wang

“…However, receiving a negative result was reported by radiologists according to the NCCT images. …”
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New understanding and research directions of oil and gas accumulation in Paleozoic buried hills， Jiyang Depression by WANG Yongshi, ZHANG Pengfei, WANG Xuejun, MA Shuai, LUO Xia, ZHANG Yunyin, XIONG Wei, WANG Yong, TIAN Wen, LIU Ruijuan

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Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

“…Consequently, TLK deficiency induces PARPi resistance in triple-negative breast cancer (TNBC) and ovarian cancer (OVCA) cell lines with BRCA1 deficiency, as TLK deficiency in BRCA1-depleted cells, impairs 53BP1 recruitment to DSBs and reduces NHEJ efficiency, while restoring HR. …”
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Modelado predictivo de actitudes y comportamientos ético-profesionales en médicos latinoamericanos mediante redes neuronales by Alberto Guevara Tirado, Raul Emilio Real Delor

“…Conclusions: The multilayer perceptron neural network was efficient for analyzing ethical and professional attitudes and behaviors in medical practice.…”
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Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…Compared to other natural alternatives, saffron by-products offer distinct advantages, including a unique combination of phenolic compounds (e.g., ellagic acid, rutin) and carotenoids (e.g., crocin) that act synergistically against both Gram-positive and Gram-negative bacteria, as well as fungi. Additionally, these by-products represent a sustainable solution, with approximately 63 kg of agricultural waste generated per kg of saffron spice. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The tumor suppressor TP53 is frequently mutated in hormone receptor-negative, HER2-positive breast cancer (BC), contributing to tumor aggressiveness. …”
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CFD-DEM simulation on flow behavior and heat transfer characteristics in a zigzag moving bed for soil disinfection by Huanguang Zhu, Chao He, Gang Li, Xinxin Liu, Youzhou Jiao

“…Utilizing the high-temperature smoke generated from the combustion of crop stubble for heat exchange with the soil can deactivate soil-borne diseases. …”
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STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice by Jochen Utikal, Verena Müller, Viktor Umansky, Peter Altevogt, Rebekka Bitsch, Annina Kurzay, Feyza Özbay Kurt, Carolina De La Torre, Samantha Lasser, Alisa Lepper, Alina Siebenmorgen

“…Background Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. …”
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Comprehensive Performance Analysis for the Rotating Detonation-Based Turboshaft Engine by Zifei Ji, Ruize Duan, Renshuai Zhang, Huiqiang Zhang, Bing Wang

“…The critical compressor pressure ratio corresponding to the disappearance of specific power improvement is higher than that corresponding to the disappearance of thermal efficiency and specific fuel consumption. These critical compressor pressure ratios are positively correlated with flight altitude and negatively correlated with flight velocity. …”
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Feasible and Rapid Screening of <i>IDH1/2</i> and <i>FLT3-TKD2</i> Mutations by High-Resolution Melting for Patients with Acute Myeloid Leukemia by José Vicente Gil, Sandra de las Heras, Alberto Miralles, Claudia Sargas, Marta Llop, Rebeca Rodríguez-Veiga, Laura Torres-Miñana, Blanca Boluda, Isabel Cano-Ferri, Evelyn Acuña-Cruz, Irene Navarro, Pilar Lloret-Madrid, Pau Montesinos, Eva Barragán

“…The method was applied to a cohort of 1363 AML patients, and its performance, including turnaround time, was evaluated through comparison with next-generation sequencing (NGS) results. <b>Results</b>: The PCR-HRM method demonstrated a positive percent agreement of 98%, 98%, and 92% for <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3-TKD2</i>, respectively, and a negative percent agreement of 100% for all three genes compared to NGS. …”
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Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer by Lin Shen, Xiaochen Zhao, Zhenghang Wang, Yuezong Bai, Feilong Zhao, Zhi Peng, Jinping Cai, Tong Xie, Shuang Tong, Xiaofan Wei

“…There were nearly significant differences in tumor mutational burden (TMB) level and SMARCA4 mutation frequency between the ICB response and non-response group.Conclusions We developed an efficient NGS-based EBV detection strategy, and this strategy-identified EBV infection was as effective as dMMR in predicting ICB efficacy in GC. …”
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Reliability and Quality of Complex Systems by B.S. Beysembaeva, V.D. Ezhizhanskiy, A.E. Yarkin, E.A. Aseev, N.S. Reuta

“…The problem of heat sink is one of the main difficulties in ensuring the reliability and quality of complex electronic systems. The heat generated during the operation of electronic devices negatively affects its characteristics, reduces the service life of the device and increases the number of failures. …”