Severe paradoxical generalized pustular psoriasis induced by adalimumab biosimilar successfully treated with brodalumab by Angela Fico, Edoardo Mortato, Claudia Paganini, Marina Talamonti, Cosimo Di Raimondo, Dionisio Silvaggio, Luca Bianchi, Marco Galluzzo

“… Paradoxical psoriasis is a rare but increasingly recognized adverse effect of anti-TNF-α therapy, characterized by the onset or exacerbation of psoriatic lesions in patients treated for other immune-mediated conditions. …”
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Bayesian compositional generalized linear mixed models for disease prediction using microbiome data by Li Zhang, Xinyan Zhang, Justin M. Leach, A. K. M. F. Rahman, Carrie R. Howell, Nengjun Yi

“…However, in real-world data, both large and small effects frequently coexist, and acknowledging the contribution of smaller effects can significantly enhance predictive performance. …”
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The general composition of the faecal virome of pigs depends on age, but not on feeding with a probiotic bacterium. by Jana Sachsenröder, Sven O Twardziok, Matthias Scheuch, Reimar Johne

“…Only little is known about factors influencing its general composition. Here, the effect of the probiotic bacterium Enterococcus faecium (E. faecium) NCIMB 10415 on the pig faecal virome composition was analysed in a pig feeding trial with sows and their piglets, which received either the probiotic bacterium or not.…”
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Social support in a large general population sample over the course of six years by Andreas Hinz, Peter Esser, Diana Richter, Antje Schönfelder, Heide Glaesmer, Antje Lehmann-Laue, Svenja Heyne, Katja Leuteritz, Annekathrin Sender, Franziska Springer, Heide Götze, Anja Mehnert-Theuerkauf

“…Abstract Social support is an important resource that is assumed to buffer the effect of stressful events on health. The aims of this study were to test psychometric properties of the ENRICHD Social Support Instrument (ESSI), to investigate the impact of several sociodemographic and behavioral variables on social support, and to analyze changes in social support over a 6-year period. …”
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GENERALIZED ANALYSIS OF MONOCLONAL ANTIBODIES TO IGE IN THE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN IN RUSSIAN FEDERATION by T.V. Kulichenko, A.A. Baranov, M.M. Abelevich, E.V. Balashova, E.A. Vishneva, A.N. Galustyan, S.Yu. Elizarova, I.V. Koroleva, A.G. Manvelyan, L.S. Namazova-Baranova, Yu.V. Peshekhonova, E.V. Timofeeva, R.M. Torshhoeva, N.V. Tursina, T.E. Chashina

“…The article presents a generalized 2-year Russian experience in the application of monoclonal antibodies to IgE in children and adolescents with severe, resistant to standard treatment of bronchial asthma. …”
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Association of serum carotenoids and SII among general people, based on NHANES 2001–2006 by Shao-Hua Yan, Wenqing Nai, LuShan Peng, Junpu Wang

“…Multivariate linear regression analyses were used to evaluate the association between serum carotenoids and SII among general people. The potential non-linear relationship was determined using threshold effect analysis and fitted smoothing curves. …”
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Chelidonic Acid and its Derivates: General Spectrum of Biological Activity and Osteogenic Properties (Review) by L. A. Miroshnichenko, T. Yu. Polyakova, E. Yu. Avdeeva, S. V. Krivoshchekov, I. A. Khlusov, M. V. Belousov

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Does Training and Support of General Practitioners in Intensive Treatment of People with Screen-Detected Diabetes Improve Medication, Morbidity and Mortality in People with Clinically-Diagnosed Diabetes? Investigation of a Spill-Over Effect in a Cluster RCT. by Morten Charles, Mette V Skriver, Simon J Griffin, Rebecca K Simmons, Daniel R Witte, Else-Marie Dalsgaard, Torsten Lauritzen, Annelli Sandbæk

“…<h4>Introduction</h4>Very few studies have examined the potential spill-over effect of a trial intervention in general practice. …”
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Impact of General Anesthesia and Antioxidants on Cognitive, Static and Locomotor Functions During Laparoscopic Cholecystectomy by V. V. Moroz, V. T. Dolgikh, S. A. Karpitskaya

“…We studied the effect of general anesthesia and antioxidants on cognitive, static and locomotor functions during laparoscopic cholecystectomy. …”
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Association Between Hospital Policy on Local Versus General Anesthesia, and Outcomes of Carotid Endarterectomy by Felix Kirchhoff, Christoph Knappich, Michael Kallmayer, Bianca Bohmann, Vanessa Lohe, Pavlos Tsantilas, Shamsun Naher, Hans‐Henning Eckstein, Andreas Kuehnl

“…Stratified multivariable analysis revealed that the beneficial effect of LA was only present in routine LA centers. …”
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A CLINICAL CASE OF THE USE OF AN IMMUNOMODULATORY DRUG IN THE COMPLEX THERAPY OF SEVERE GENERALIZED PERIODONTITIS by G.М. Silenko, H.M. Sylenko

“…The patient’s treatment was done comprehensively, purposefully, individually including local and general therapy, and effective, conservative, surgical and orthopedic measures in the conditions of outpatient supervision of patients were also performed. …”
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Personality and interest in general practice: results from an online survey among medical students by Maike Krauthausen, Tobias Leutritz, Martin J. Koch, Pamina E. Hagen, Sarah König, Anne Simmenroth

“…Results Higher levels of agreeableness and neuroticism predicted greater interest in GPs, whereas higher levels of conscientiousness and openness predicted less interest in GPs. The effects of extraversion were unclear. Age was a significant predictor of interest, with older age associated with greater interest in General Practice. …”
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GENERALIZED TONIC-CLONIC SEIZURES : CLASSIFICATION, ELECTRO-CLINICAL CHARACTERISTICS, AND EFFICACY OF ANTIEPILEPTIC THERAPY by M. B. Mironov, N. V. Chebanenko, S. G. Burd, T. M. Krasilshikova, M. N. Sarzhina, M. M. Gunchenko, G. G. Avakyan, Yu. V. Rubleva, T. T. Batysheva, G. N. Avakyan

“…In 5.3% of cases, the antiepileptic therapy had no effect. In 35 patients (18.4% of cases) in remission, recurrent seizure attacks were observed.Conclusion. …”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…The position of the jaws has an effect on the spatial orientation of the head and this in turn affects the position of other structures of the body. …”
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Knowledge support for optimising antibiotic prescribing for common infections in general practices: evaluation of the effectiveness of periodic feedback, decision support during consultations and peer comparisons in a cluster randomised trial (BRIT2) – study protocol by Tjeerd Van Staa, Darren Ashcroft, Christopher Sutton, Rachel Ann Elliott, Victoria Palin, Edward Tempest, Chris Armitage, William Welfare, Georgina Moulton, Anita Sharma, Natalie Gold, Jung Yin Tsang, Ali Fahmi, Harriet Cant, Xiaomin Zhong, Francine Jury, Philip Couch, Iain Edward Buchan

“…Methods and analysis A pragmatic cluster randomised controlled trial will be conducted, with randomisation of at least 112 general practices in North-West England. General practices participating in the trial will be randomised to the following interventions: periodic practice-level and individual prescriber feedback using dashboards; or the same dashboards plus a KSS. …”
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Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial by Kariem Hussein, Melanie Kistler-Fischbacher, Michèle Mattle, Caroline De Godoi Rezende Costa Molino, Li-Tang Tsai, Reto W. Kressig, E. John Orav, José A.P. Da Sliva, Bruno Vellas, René Rizzoli, Gabriele Armbrecht, Egli Andreas, Bess Dawson-Hughes, Heike A. Bischoff-Ferrari

“…Objectives: Physical function and physical activity (PA) are key drivers of health and autonomy at older age. We examined the effects of supplemental vitamin D3, supplemental marine omega-3 fatty acids (omega-3s), and a simple home exercise program (SHEP), alone or in combination, on change in physical function and PA among generally healthy older adults. …”
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Differences in the force exerted during wrist movements are explained by a general mathematical model by Camilo Leonardo Sandoval Rodriguez, Carlos Julio Arizmendi Pereira, Diana María Reyes Bravo, Omar Lengerke, Ricardo Palacio, Andrés Jiménez Quezada

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Features of teaching thermal injury course for the third-year students at the general surgery department. by V. Nagaichuk, M. Zheliba, R. Chornopyshchuk

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Application of Multistep Generalized Differential Transform Method for the Solutions of the Fractional-Order Chua's System by Asad Freihat, Shaher Momani

“…By utilizing the multistep generalized differential transform method (MSGDTM), we find that the fractional-order Chua's system with “effective dimension” less than three can exhibit chaos as well as other nonlinear behavior. …”
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Corpus callosum stimulation and stereotactic callosotomy in the management of refractory generalized epilepsy: preliminary communication by Raul Marino Jr., Gary Gronich

“…Corpus callosum stimulation produced by chronically implanted electrodes, placed either by craniotomy or stereotactically, failed to control refractory generalized epilepsy in humans and also in experimentally produced penicillin epilepsy in cats. …”
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