Refractoriness to eltrombopag in adult primary immune thrombocytopenia: utility of next-generation sequencing techniques by Tomás José González-López, Ricardo Sanchez, Carmen Pastoriza, Pavel Olivera, Silvia Bernat, Fernando Fernandez-Fuertes, Isabel Socorro Caparrós-Miranda, Gloria Pérez-Rus, Isidro Jarque, Maria Esperanza Moreno-Beltrán, Emma López-Abadía, Erik De Cabo, Shally Marcellini, Gloria Pérez-Segura, Carmen Fernández-Miñano, María Jesús Peñarrubia, Sergio Matarraz, María Pérez-Caro, Alberto Orfao, Drew Provan, Joaquín Martínez-López

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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

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Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models by Yvonne A. Evrard, Sergio Y. Alcoser, Michael Mullendore, Li Chen, Chih-Jian Lih, Vishnuprabha Rahul Kannan, Vivekananda Datta, Lindsay Dutko, Shahanawaz Jiwani, Lawrence V. Rubinstein, Yingdong Zhao, P. Mickey Williams, Alida Palmisano, Alida Palmisano, Laura Kuhlmann, Mel Simpson, Shivaani Kummar, Biswajit Das, Chris Karlovich, Eric Polley, Ming-Chung Li, Alice P. Chen, Melinda G. Hollingshead, James H. Doroshow, James H. Doroshow

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SBRT for bridging and downstaging HCC before transplant by Zhihao Li, Michael Yan, Marco P.A.W. Claasen, Luckshi Rajendran, Christian T.J. Magyar, Saheli Saha, Cameron Lee, Nazia Selzner, Elmar Jaeckel, Anand Ghanekar, Mark Cattral, Blayne A. Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Grainne M. O’Kane, Arndt Vogel, Robert C. Grant, Tae Kyoung Kim, Catherine Soo-Yee Naidoo, Ali Hosni, Rebecca Wong, Aruz Mesci, Jelena Lukovic, Aisling Barry, John Kim, Laura A. Dawson, Gonzalo Sapisochin

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Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets by Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani

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Prognostic factors and treatment response in HER2-positive gastric cancer patients receiving trastuzumab deruxtecan: secondary analysis of the EN-DEAVOR study by K. Nakanishi, N. Sugimoto, Y. Kodera, H. Kawakami, A. Makiyama, H. Konishi, S. Morita, Y. Narita, K. Minashi, M. Imano, R. Inamoto, T. Nishina, T. Kawakami, M. Hagiwara, H. Kume, K. Yamaguchi, W. Hashimoto, K. Muro

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Correlation of Urinary Soluble CD163 Levels With Disease Activity and Treatment Response in IgA Nephropathy by Jingyi Li, Jicheng Lv, Muh Goet Wong, Sufang Shi, Jincan Zan, Helen Monaghan, Vlado Perkovic, Hong Zhang, Hong Zhang, Vlado Perkovic, Rajiv Agarwal, Sean Barbour, Daniel Cattran, Alan Cass, Tak Mao Chan, John Feehally, Richard Glassock, Michelle A. Hladunewich, Lai Seong Hooi, Meg J. Jardine, Vivekanand Jha, David W. Johnson, Adeera Levin, Zhi-Hong Liu, Jicheng Lv, Helen Monaghan, Heather Reich, Giuseppe Remuzzi, David C. Wheeler, Muh Geot Wong, Mark Woodward, Yangfeng Wu, Minghui Zhao

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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation by Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan

“…However, 6GE pigs showed increased susceptibility to infection compared to other gene-edited pigs, while TKO/hCD55 pigs were considered safe when they were all bred in a general environment.DiscussionHighly expressing hCD55, along with the co-expression of hEPCR and hTM genes, is expected to effectively reduce human complement cytotoxicity and enhance anticoagulant efficacy in genetically modified pigs. …”
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Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates by Kim Stobbelaar, Lotte Jacobs, Francisco I. Serrano-Cano, Axelle Fransen, Winke Van der Gucht, Annemieke Smet, Benedicte Y. De Winter, Paul Cos, Winnok de Vos, Kim Van Hoorenbeeck, Stijn Verhulst, Peter L. Delputte

“…Ongoing monitoring of RSV is critical to ensure current and future vaccines remain effective.…”
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مشكلة المياه في القانون الدولي مع إشارة خاصة إلى العراق by رياض الاسدي, تغريد قاسم ابو تراب

“…These crises have spread over the past decades, leading to serious international problems that have not yet found effective solutions. Food problems are concentrated in East Africa: Somalia, Ethiopia and Kenya in particular. …”
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A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context by Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Amani M. Norling, Afroditi Boulougoura, Theodoros Vichos, Tamara Tchkonia, Aaron Deisinger, Tamar Pirtskhalava, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz

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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

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Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair by Kenichi Shibata, PT, Masanori Yamamoto, MD, Ai Kagase, MD, Takahiro Tokuda, MD, Hiroshi Tsunamoto, MD, Testuro Shimura, MD, Azusa Kurita, MD, Ryo Yamaguchi, MD, Mike Saji, MD, Masahiko Asami, MD, Yusuke Enta, MD, Masaki Nakashima, MD, Shinichi Shirai, MD, Masaki Izumo, MD, Shingo Mizuno, MD, Yusuke Watanabe, MD, Makoto Amaki, MD, Kazuhisa Kodama, MD, Junichi Yamaguchi, MD, Toru Naganuma, MD, Hiroki Bota, MD, Yohei Ohno, MD, Masahiro Yamawaki, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, Kazuki Mizutani, MD, Toshiaki Otsuka, MD, Shunsuke Kubo, MD, Kentaro Hayashida, MD

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Community-engaged curriculum development using racial justice and biomedical lenses to address COVID-19 vaccine hesitancy in black individuals with rheumatologic conditions by Eseosa Olive Osaghae, Greta Sirek, Tonya Roberson, Mia Chandler, Ariel Childs, Monica Crespo-Bosque, Gina Curry, Amar Dhand, Mary Dollear, Alice Eggleston, Nnenna Ezeh, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Muriel Jean-Jacques, Elena Losina, Elena Losina, Holly Milaeger, Lutfiyya Muhammad, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Bisola Ojikutu, Bisola Ojikutu, Neil Pillai, Mary Beth Son, Marie Jacques Toussaint, Ana Valle, Jessica N. Williams, Michael York, Karen Mancera-Cuevas, Candace H. Feldman, Candace H. Feldman, Rosalind Ramsey-Goldman

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Prognostic impact of being underweight in patients undergoing mitral TEER: The OCEAN‐Mitral registry by Ryosuke Higuchi, Masaki Izumo, Yuki Izumi, Mike Saji, Mitsuaki Isobe, Yoshihiro Akashi, Masanori Yamamoto, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Shunsuke Kubo, Toshiaki Otsuka, Kentaro Hayashida, the OCEAN‐Mitral Investigators

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BECN1 regulates ferroptosis induced by 2,4-dichlorophenoxyacetic acid in SH-SY5Y cells by Xiaoqi Luo, Jinyu Luo, Liping Ma, Yixuan Wei, Xiaoning Meng, Yating Yang, Huifang Yang, Jian Zhou

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Transarterial chemoembolization plus apatinib for unresectable hepatocellular carcinoma: a multicenter, randomized, open-label, phase III trial by Xue-Feng Kan, Bin Liang, Xiao-Lin Zhang, Lei Yu, Yao-Chang Luo, Shi Zhou, Rui-Bao Liu, Guo-Hui Xu, Hai-Liang Li, Zheng-Yin Liao, Hua Xiang, Wei Lu, Lin-Feng Xu, Yi-Long Ma, Xiang-Wen Xia, Kun Qian, Xiang-Jun Dong, Fu Xiong, Song-Lin Song, Chang Zhao, Ming Huang, Chuan-Sheng Zheng

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Time to treat the climate and nature crisis as one indivisible global health emergency by Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

“…Damage to one subsystem can create feedback that damages another—for example, drought, wildfires, floods and the other effects of rising global temperatures destroy plant life, and lead to soil erosion and so inhibit carbon storage, which means more global warming.2 Climate change is set to overtake deforestation and other land-use change as the primary driver of nature loss.3 Nature has a remarkable power to restore. …”
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SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study by Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…AbstractThe purpose of this research is the effective factors on the design of the management dashboard framework with an emphasis on the components of human resources productivity. …”
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