Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024 by Siyu Lou, Huayou Chen, Zhiwei Cui, Xiyuan Zhang, Chengyu Zhu, Linmei Zhou, Yingyong Ou, Fan Zou

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Unequal ageing: the quality of life of senior citizens in the EU before and after COVID-19. A multidimensional approach by Elżbieta Roszko-Wójtowicz, Klaudia Przybysz, Agnieszka Stanimir

“…In particular:Northern and Western Europe: seniors in these regions generally experienced improved overall life quality over the observed period. …”
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Characterization and evaluation of tamarind (Tamarindus indica L.) germplasm: implications for tree improvement strategies by A. K. Singh, Vikas Yadav, V. V. Appa Rao, Daya Shankar Mishra, Lalu Prasad Yadav, K. Gangadhara, Jagadish Rane, A. Sahil, Prakashbhai Ravat, P. Janani, Prashant Kaushik, Ali Khadivi, Yazgan Tunç

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Spatial pattern of Trees in the Riparian Forests (Case Study: Wildlife Refuge of Karkhe) by Shaieste Gholami

“…A current challenge in ecology is underestimating how patterns and processes vary with scale and searching for general principles (assembly rules) which determine the species composition of communities. …”
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Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression by Shau-Hsuan Li, Wan-Ting Huang, Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Hsin-Ting Tsai, Chang-Han Chen

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Specific features of psychopathological manifestations in criminal clozapine intoxications by D. G. Slyundin, A. S. Livanov, V. V. Anuchin, A. G. Merkin, I. G. Bobrinskaya, E. V. Gutova

“…The specific features of the course of criminal clozapine intoxications seem to lie in the combined effects of clozapine and ethanol on the central nervous system and their synchronous metabolism.…”
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Status and influencing factors of readiness for hospital discharge in patients undergoing radiofrequency ablation for atrial fibrillation (心房颤动射频消融术后患者出院准备度现状及影响因素分析)... by LIU Weiwei (刘微微), HUANG Shuping (黄淑萍), ZHONG Bing (钟冰)

“…Medical workers should take effective intervention to improve quality of hospital discharge teaching and quality of life after hospital discharge (目的 探讨心房颤动患者射频消融术后出院准备度及出院指导的现状及其相关影响因素。…”
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Development and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms by Yicheng Wang, Yicheng Wang, Yicheng Wang, Chuan-Yang Wu, Hui-Xian Fu, Jian-Cheng Zhang, Jian-Cheng Zhang, Jian-Cheng Zhang

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Evaluating the Impact of Smart Infusion Pump Interoperability on Reducing Medication Administration Errors: A Systematic Literature Review by Borrelli EP, Lucaci JD, Wilson NS, Taneja A, Weiss M, Beer I

“…The secondary outcome assessed the cumulative reduction in medication administration errors.Results: Three studies met the inclusion criteria, spanning general community hospitals, pediatric facilities, and intensive care units (ICUs). …”
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Detection of carbapenemase-producing carbapenem resistant Enterobacterales (CP-CRE): A preliminary data from a tertiary hospital in Malaysia by Dr Fairuz Abdul Rashid, Dr Noraziah Sahlan, Associate Professor Dr Navindra Kumari Palanisamy, Dr Siti Farah Nawi, Associate Professor Dr Fadzilah Mohd Nor

“…Introduction: Infection with carbapenem resistant Enterobacterales (CRE) is a public health concern associated with significant morbidity and mortality rates due to limited effective antibiotics available. Production of carbapenemase is the principal mechanism of carbapenem resistance in Enterobacterales. …”
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Towards a Safer Future: The Imperative of the New Pandemic Agreement by Faiza Bashir, Muhammad Kashif Munir

“… s the dust settles from the global disruption of COVID-19, one lesson stands above all: no country can respond effectively in isolation. In a hope step forward, the World Health Organization (WHO) announced on April 16, 2025, that its Member States had concluded negotiations on a draft pandemic agreement. …”
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Efficacy and safety of rapid dose escalation of methotrexate in rheumatoid arthritis. Results of the multicenter “METEOR” study by V. N. Amirjanova, E. Yu. Polishchuk, O. N. Anoshenkova, I. B. Vinogradova, E. V. Zonova, L. V. Ivanova, R. R. Samigullina, T. S. Salnikova, E. L. Shakhramanova, E. I. Shmidt, S. P. Yakupova, A. M. Lila, E. L. Nasonov

“…The aim of the study – to analyze the effectiveness and tolerability of subcutaneous methotrexate (sc MTX) (Metorthrit; S.C. …”
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The sedation efficacy of different doses of remimazolam in elderly patients with regional nerve block anaesthesia by Wan-jun Yang, Zhi-long Geng, Zheng-ze Chen, Chao-yuan Cui, Zi-wei Tian, Xi-lin Guo, Ya-nan Zhang, Lu Wang, Rui Huo, Chen-wei Ma, Yuan-yuan Gao

“…Aim The aim of this study was to evaluate the effects of different doses of remimazolam in elderly patients when specifically related to regional nerve block anaesthesia. …”
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Energy Consumption and Transportation in Developing Countries: Need for Local Scenario-Based Energy Efficiency Plans by Houshmand Masoumi

“…The benefits of policymaking based on empirical transportation / energy research do not remain limited to energy efficiency; it also has positive effects on environmental pollution control. Moreover, transportation [1] and urban planning [2,3,4] policies can limit both energy use and air pollution, however such efficiency improvements may be most effective when they are derived from the vernacular conditions. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…Since entrepreneurship is a broad field in general, there are many opportunities for researchers in this field to focus on areas of interest which have been neglected (Fu et al, 2019). …”
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ALBI Grade Enables Risk Stratification for Bleeding Events and Refines Prognostic Prediction in Advanced HCC Following Atezolizumab and Bevacizumab by Stefanini B, Fulgenzi CAM, Scheiner B, Korolewicz J, Cheon J, Nishida N, Ang C, Marron TU, Wu YL, Saeed A, Wietharn B, Rimassa L, Pirozzi A, Cammarota A, Pressiani T, Pinter M, Balcar L, Huang YH, Mehan A, Phen S, Vivaldi C, Salani F, Masi G, Bettinger D, Vogel A, Schönlein M, von Felden J, Schulze K, Wege H, Samson A, Galle PR, Kudo M, Manfredi GF, Celsa C, Awosika N, Cortellini A, Singal AG, Sharma R, Chon HJ, Tovoli F, Piscaglia F, Pinato DJ, D'Alessio A

“…Department. of Internal Medicine, Mainz, Germany; 26Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; 27Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; 28Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy*These authors contributed equally to this workCorrespondence: Antonio D’Alessio, Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK, Email a.dalessio@imperial.ac.ukBackground and Aims: Atezolizumab and bevacizumab (A+B) are recommended for treating unresectable hepatocellular carcinoma (HCC). Although highly effective, A+B can lead to potentially life-threatening adverse events including bleeding. …”
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Universalizing Core Human Rights in the 'New' ASEAN: A Reassessment of Culture and Development Justifications Against the Global Rejection of Impunity by Diane Desierto

“…More importantly, it is now the specific obligation of ASEAN Member States to “take all necessary measures, including the enactment of appropriate domestic legislation, to effectively implement the provisions of the Charter and to comply with all obligations of membership”, including the above-stated Organizational Principles.…”
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Human–wildlife interactions by C. Rosell, F. Llimona

“…The third and final paper, by Belotti et al. (2012), addresses the effects of tourism on Eurasian lynx movements and prey usage at Šumava National Park in the Czech Republic. …”
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Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration by Zhi He, Peilun Hu, Zifan Li, Kaige Mao, Jingchuan Zheng, Chun-Yi Yang, Yuyang Luo, Jia Yang, Zheng Cao, Jingsong Lu, Xiaobin Luo, Sengpav Tong, Zhijun He, Kunkoo Kim, Yaosai Liu, Xiaodan Sun, Lingyun Zhao, Yongwei Pan, Yongping Cao, Yu Wang, Xiumei Wang

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Analyzing Macro-Regulation Strategies of the Digital Economy in Selected Countries and Providing Macro Components of Regulation for Iran by Fatemeh Kasaei Najafi, Afsaneh Vahedian, Hassan Yeganeh

“…This has necessitated the development and implementation of strategies to effectively address these challenges. Digital economy policies and strategies are interconnected across various areas and require a comprehensive and coordinated approach. …”
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