Comparison of One-Year Post-Operative Evolution of Children Born of COVID-19-Positive Mothers vs. COVID-19-Negative Pregnancies Having Congenital Gastrointestinal Malformation and... by Timea Elisabeta Brandibur, Nilima Rajpal Kundnani, Kakarla Ramakrishna, Alexandra Mederle, Aniko Maria Manea, Marioara Boia, Marius Calin Popoiu

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The joint role of the immune microenvironment and N7-methylguanosine for prognosis prediction and targeted therapy in acute myeloid leukemia by Zhixiang Chen, Zhixiang Chen, Zhimei Chen, Xiaobo Huang, Xiaobo Huang, Xiaobo Huang, Xiongbin Yan, Xiongbin Yan, Xiaolin Lai, Xiaolin Lai, Shaoyuan Wang, Shaoyuan Wang

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Comparison of clinical efficacy between tibial cortex transverse transport and platelet-rich plasma treatment for severe diabetic foot ulcers by Pu-Xiang Zhen, Hong-Jie Su, Si-Jie Yang, Xiang Chen, Zhan-Ming Lin, Sai-Nan Liu

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Human papillomavirus vaccine uptake and its determinants among women in Africa: an umbrella review by Berihun Agegn Mengistie, Amlaku Nigusie Yirsaw, Gebeyehu Lakew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Alemken Eyayu Abuhay, Eyob Getachew

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Single-cell and machine learning approaches uncover intrinsic immune-evasion genes in the prognosis of hepatocellular carcinoma by Jiani Wang, Xiaopeng Chen, Donghao Wu, Changchang Jia, Qinghai Lian, Yuhang Pan, Jiumei Yang

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Maximising Embedded Pharmacists in AGed CAre Medication Advisory Committees (MEGA-MAC): protocol for implementing Australia’s new guiding principles for medication management in re... by Amanda J. Cross, Brooke Blakeley, Kate Laver, Terry P. Haines, Sarah N. Hilmer, Atish Manek, Alexandra Bennett, Angelita Martini, Lyntara Quirke, Mary Ann Kulh, Sara L. Whittaker, Dayna R. Cenin, Anthony Hobbs, Joanne Money, Karina Rieniets, Kris Salisbury, Alene Sze Jing Yong, J. Simon Bell

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Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapeutic efficacy for rheumatoid arthritis by Jiaqing Liu, Xing Zhang, Xiangge Zhao, Jinyi Ren, Huina Huang, Cheng Zhang, Xianmei Chen, Weiping Li, Jing Wei, Xia Li

“…To identify the most effective treatment concentration and duration for inducing ERS, we conducted a concentration and time gradient analysis for TG treatment via qRT‒PCR and a CCK‒8 assay. …”
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Development and Implementation of MyPainHub, a Web-Based Resource for People With Musculoskeletal Conditions and Their Health Care Professionals: Mixed Methods Study by Kerrie Evans, Jonathan Ko, Dragana Ceprnja, Katherine Maka, Darren Beales, Michele Sterling, Kim L Bennell, Gwendolen Jull, Paul W Hodges, Marnee J McKay, Trudy J Rebbeck

“…Implementation occurred in different health care settings with the most effective strategies being interactive education via webinars and workshops. …”
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Methodology for Developing a Composite Social Development Index (CSDI): Essential Decisions and Results by Mehdi Mobaraki, Zohre Shahbazi, Najme Mostafavi

“…Furthermore, a composite indicator can capture long-term changes and sustainable impacts, serving as an effective tool for evaluating and monitoring projects and policies. …”
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Dosis-respuesta del entrenamiento excéntrico para prevenir lesiones en isquiotibiales en futbolistas: una revisión sistemática con metaanálisis (Dose-response of eccentric training... by Sebastián Eliseo Avila-Quintero, Sandra Helena Suescún-Carrero, Nelson Fernelly González-Cetina, Sofia Zapata-Gil, Diego Fernando Afanador

“…Therefore, this systematic review with meta-analysis aimed to determine the effects and dose-response of eccentric training on hamstring injuries in soccer players. …”
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Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria by Hironori Ishiguchi, Yu Yasuda, Hiroya Mabuchi, Madoka Yamaguchi, Kei Murakami, Natsu Kinoshita, Takayoshi Kato, Masaaki Yoshida, Kazuhiko Sonoyama, Koji Imoto, Takayuki Okamura, Akihiro Endo, Shigeki Kobayashi, Kazuaki Tanabe, Motoaki Sano, Tsuyoshi Oda

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LINGUO-CULTURAL COMPETENCE AND ITS ROLE IN PROFESSIONAL FORMATION OF FUTURE SPECIALISTS OF EDUCATIONAL INSTITUTIONS by Inna D. Davydchenko

“…We believe that linguo-culturological competence is of great importance for pedagogical and scientific-pedagogical workers, which ensures the effectiveness of their fulfillment of basic professional tasks. …”
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Ensuring the unity of the federal system of scientific and methodological support for teacher professional development: Opportunities and risks by A. V. Zolotareva, L. V. Bayborodova, M. V. Gruzdev, I. G. Kharisova

“…The leading method in the study is the analysis of pedagogical workers’ ideas about effective ways and formats of their professional development in an integrated educational space for more effective implementation of state educational policy, improving the quality of education in general and individual results of educational and pedagogical activities. …”
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SMART SPECIALISATION AS A BASIC COMPONENT OF SOCIO-ECONOMIC DEVELOPMENT by Olena Guzenko, Svitlana Nikolaichuk, Dmytro Ivanenko

“…The authors of the study posit that the successful implementation of the concept of SS regions, the achievement of an appropriate level of competitiveness, and the improvement of socio-economic development can only be achieved through effective co-operation and synergy between local authorities, business, academia, and civil society.…”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Optimization of the Pedagogical Process in Teaching Chemistry to First-Year Students of the Ural State Medical University by E. Yu. Ermishina, N. A. Naronova, N. N. Kataeva, K. O. Golitsyna, N. A. Belokonova

“…To test the hypothesis about the effectiveness of the chosen teaching methodology, Pearson's test of agreement (χ2 ) was calculated for the sample size of students (n ≥ 100). …”
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Migration routes and key stopovers of Anser fabalis fabalis (Anseriformes): critical protection gaps by Sofya B. Rozenfeld, Eugeny G. Strelnikov, Sergey V. Volkov

“…The results of this study can be used to develop an effective strategy for the Anser fabalis fabalis conservation during the period of migrations. …”
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Construction of engineering Trichoderma strains and their characteristics against tomato gray mold by LIU Xian, ZHUANG Jing-hua, GAO Zeng-gui, YANG Chang-cheng, CHEN Jie

“…The transformed Trichoderma strains Ttrm31, Ttrm34 and Ttrm55 were obtained from Trichoderma wild strain T21 mutated by REMI technique for more effective biocontrol of tomato gray mold (Botrytis cinerea) with Trichoderma agent. …”
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Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors by Yan Zhang, Andrés Cervantes, Stephane Champiat, Aurélien Marabelle, Patricia LoRusso, Jason J Luke, Robert Haddad, David J Pinato, Dejan Juric, María de Miguel, Won Seog Kim, Xiaobin Yuan, Peter J Hosein, Anupam M Desai, Yuanxin Rong

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Efficacy of Ferric Carboxymaltose in Iron Deficiency Anaemia Management in Non Dialysis Dependent Chronic Kidney Disease Patients: A Retrospective Observational Study by Anil Kumar Bhalla, Apurva Parekh, Ravinder Singh Bhadoria, Jyothi Hebbur Ramachandra, S Vishwanath, Kishore S Dharan, Ankush Gaikwad, Priti Gajbe, Prajakta Wangikar, Sachin Suryawanshi

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