Single-cell landscape of dynamic changes in CD8+ T cells, CD4+ T cells and exhausted T cells in hepatocellular carcinoma by Rongqiang Liu, Jing Ye, Jianguo Wang, Wangbin Ma, Zhendong Qiu, Jia Yu, Weixing Wang

“…The high dimensional weighted gene co-expression network analysis (hdWGCNA) was used to identify gene modules associated with CD4+ T cells, CD8+ T cells and exhausted T cells. …”
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Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion. by Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn

“…Seventeen of these genes were previously identified with gene-level bulk RNAseq analyses including genes in the IFNγ response that had increased expression among LTBI subjects, findings consistent with a clinical phenotype based on IGRA reactivity. …”
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Government environmental information disclosure and digital transformation of manufacturing companies: evidence from China by Songtao Xu, Xia Chen

“…Logically, this indicates that by emphasizing environmental regulation, GEID can promote corporate digital transformation. …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…Conclusion This study demonstrated that the WRKY family in P. notoginseng plays a significant role in resistance to root rot disease. PnWRKY genes are responsive to MeJA and SA induction as well as C. destructans infection. …”
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Discriminatory Practices against Women in Labour Relations in Nigeria: Interrogating the Position of International Law by Atah Pine, Ochoga Edwin Ochoga

“…The paper adopts face-to-face interview as an instrument of data collection to get opinion of some expertise on gender and international law with a triangulation of secondary sources of information. …”
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NIGERIAN LOCAL GOVERNMENT ADMINISTRATION: A COMPARATIVE ANALYSIS OF THE THIRD AND FOURTH REPUBLICS by Towoju Adedoyin John, Mohammed Idris Danjuma, Ibrahim O Salawu

“…The 1976 Local Government Reform in Nigeria and the subsequent one that followed were geared towards making local governments, the bedrock for socio-economic and political development. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Method: The identified targets’ expression profiles were determined at the mRNA and protein levels using The Breast Cancer Gene-Expression Miner v5.0 (bcGen-ExMiner v5.0) and The Human Protein Atlas datasets, respectively. …”
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The role of cytokine genetic polymorphism in development of acute pancreatitis: analysis of intergenic and environmental interactions by T. A. Samgina, G. A. Zhivotova, P. M. Nazarenko, A. V. Polonikov

“…To study association interleukin-1 (IL-1) gene (rs16944), interleukin-6 (IL-6) gene (rs1800795), interleukin-10 (IL-10) gene (rs1800896) polymorphisms with development of acute pancreatitis (AP) in the Russian population. …”
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Pleiotropic effects of rabeprazole at acid-related diseases by A. V. Zaborovsky, I. V. Mayev, D. N. Andreyev, L. A. Tararina

“…To study association interleukin-1 (IL-1) gene (rs16944), interleukin-6 (IL-6) gene (rs1800795), interleukin-10 (IL-10) gene (rs1800896) polymorphisms with development of acute pancreatitis (AP) in the Russian population. …”
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5-Aminolevulinic acid activates the MdWRKY71-MdMADS1 module to enhance anthocyanin biosynthesis in apple by Liuzi Zhang, Huihui Tao, Jianting Zhang, Yuyan An, Liangju Wang

“…In this study, we firstly demonstrated that ALA upregulates gene expression of the transcription factor MdMADS1, which in turn directly binds to and activates transcription of the key anthocyanin biosynthetic genes, MdCHS and MdUFGT. …”
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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken by Jingwei Yuan, Yuanmei Wang, Yanyan Sun, Yunlei Li, Aixin Ni, Qin Li, Hanhan Yang, Xinying Xu, Yunhe Zong, Hui Ma, Jilan Chen

“…Conclusion Our study characterized the dynamic profile of genome-wide gene expression in ovary and highlighted the role of dominant expression of cell cycle pathway genes in heterosis. …”
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Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida by Qishan Luo, Gan Huang, Xiaohui Lin, Xiaojing Wang, Yaqin Wang

“…Abstract Background The BZR family genes encode plant-specific transcription factors as pivotal regulators of plant BR signaling pathways, critically influencing plant growth and development. …”
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Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…This study reports a causative variant in the TP63 gene in a Chinese family exhibiting limb anomalies associated with SHFM4. …”
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Eco-toxicological effects of pesticide residues on soil biological sentinels by E.I. Atuanya, T Onuoha, E Morka

“…Thus, more efforts should be geared at reducing the indiscriminate and illegal use of pesticides (banned or approved). …”
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NATURAL RESOURCE ENDOWMENT AND ECONOMIC GROWTH: EVIDENCE FROM SOME SELECTED SUB-SAHARAN AFRICAN COUNTRIES by Felix Gbenga Olaifa, Ebenezar Adesoji Olubiyi, Oluwasegun Olawale Benjamin Benjamin, Philip Olugbenga Adebayo Adebayo

“…This scenario has prompted studies geared towards examining the extent to which natural resource endowment has impacted on growth in resource rich Sub-Saharan African countries. …”
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Factors Influencing Human Waste Management in Sanga Town Council- Kiruhura District. by Mugasha, Bindyomunda Athur

“…., to determine the possible interventions geared towards improvement of human waste management in Sanga Town Council. …”
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Design of a Mechanized Road Sweeper by Asiimwe Dianah

“…The major components of the proposed machine were drive wheels, gears, sweeping roller and disc brushes, dust filter, waste container, handle and frame. …”
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A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Abstract Cells are regulated at multiple levels, from regulations of individual genes to interactions across multiple genes. Some recent neural network models can connect molecular changes to cellular phenotypes, but their design lacks modeling of regulatory mechanisms, limiting the decoding of regulations behind key cellular events, such as cell state transitions. …”
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Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus by Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Ingrid E Lundberg, Andreas Jönsen, Niklas Hagberg, Leonid Padyukov, Marie Wahren-Herlenius, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Øyvind Molberg, Dag Leonard, Andrei Alexsson, Maija-Leena Eloranta, Ann-Christine Syvänen, Johanna K Sandling, Gunnel Nordmark, Roland Jonsson, Roald Omdal, Christine Bengtsson, Anders A Bengtsson, Pascal Pucholt, Kerstin Lindblad-Toh, Sergey V Kozyrev, Peter Söderkvist, Johanna Dahlqvist, Jonas Carlsson Almlöf, Daniel Eriksson, Ahmed Sayadi, Åsa Karlsson, Gerli Rosengren Pielberg, Anna Lobell, Eva Murén, Kerstin M Ahlgren, Nils Landegren, Olle Kämpe, Fabiana HG Farias, Argyri Mathioudaki, Jennifer Meadows, Jessika Nordin

“…Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene variants can cause monogenic SLE. …”
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Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus by Liangfang Liu, Tangsong Feng, Mengmeng Shi, Huafeng Zou, Weiqun Lu

“…Transcriptome analysis found a total of 1711 significantly differential expressed genes (DEGs), among which 818 genes were up-regulated and 893 genes were down-regulated in AG flounder compared with JG flounder. …”
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