Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models by Thomas Sorz-Nechay, Ksenia Brusilovskaya, Philipp Königshofer, Benedikt S. Hofer, Oleksandr Petrenko, Benedikt Simbrunner, Vlad Taru, Katharina Bonitz, Henriette Horstmeier, Kerstin Zinober, Katharina Regnat, Carolin Lackner, Michael Trauner, Peng Sun, Ines Truebenbach, Stefan G. Kauschke, Philipp Schwabl, Thomas Reiberger

“…We further highlight the functional contribution of the pathway via increases in hepatic cGMP during fibrosis regression. …”
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Tuberculous abdominal aortic aneurysm: Management and outcomes by Sree Vani Paladugu, MS, Ajay Savlania, MCh, Gokulkrishnan Hari, MS, Tanuj Singla, MS, Shreyas Srinivasan, MBBS, Ujjwal Gorsi, DM, Mustafa Razi, MD, Pradeep Burli, MD, Prem Chand Gupta, MS

“…Background: Tubercular aortic aneurysms (TBAAs) occur by extension of infection from contagious lesions like lymph nodes, empyema, paraspinal abscess, or hematolymphogenous dissemination and can involve any part of the aortic segment. …”
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Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine by T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva

“…We revealed that mature DCs (CD83+CD1a-) had a high expression of antigen presenting molecules (HLA-DR) and those providing migration of DCs into lymph nodes (CCR7) as well as costimulatory molecules CD80 and CD86 as compared to immature DCs (CD83-CD1a+). …”
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An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primatesResearch in context by Beryl B. Cummings, Page R. Bouchard, Mark N. Milton, Peter F. Moesta, Vyas Ramanan, John W. Trauger, Eleftheria Maratos-Flier, Andrei Voznesensky, Igor Splawski, Amitabh V. Nimonkar, Keith DiPetrillo, Daniel LaSala, Meihui Pan, Meghan M. Flaherty, Francois Huet, Sukhdeep K. Sahambi, Jijun Dong, Deborah Knee, Regis Cebe, Thomas Huber, Joshua Lehrer-Graiwer, Rebecca A. Juliano, Ethan J. Weiss

“…However, development of ANGPTL4 inhibitors has been stalled by adverse findings in Angptl4 knockout mice fed a high-saturated-fat diet (HSFD), which show lipid accumulation in mesenteric lymph nodes (MLNs), systemic inflammation, severe adverse clinical signs, and reduced survival. …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…PLGA/ESL1 effects on EAE symptoms were monitored along with multiple immune cell subsets in target organs at the peak and recovery of EAE. Gut barrier function and microbiota composition were analyzed using qPCR, 16S rRNA sequencing, and metabolomic analyses.Results: ESL1 antigens, released from PLGA and drained via myeloid antigen-presenting cells through lymph nodes, protected the animals from developing EAE symptoms. …”
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Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, a... by Wenjing He, Zhen Wei, Siwei Li, Songji Han, Jing Ma, Lei Wu, Dan Lu, Guang Ta

“…In CKD rat models, rhubarb significantly improved renal function by reducing blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid (UA) levels (p < 0.05). …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…Further, the immune cell composition was evaluated in tumors.Results: The Mg/Al LDH-5-OP-RU/mRNA nanovaccine was efficiently delivered into lung-draining mediastinal lymph nodes (MLNs), and it activated dendritic cells (DCs) and mucosa-associated invariant T (MAIT) cells after intranasal administration. …”
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IMMUNOLOGICAL AND MORPHOLOGICAL PREDICTORS OF CLINICAL HETEROGENEITY OF PATIENTS WITH GRAVES' DISEASE (BASED ON RESEARCH OF THE THYROID GLAND OPERATIONAL MATERIAL) by T. V. Saprina, T. S. Prokhorenko, N. V. Ryazantseva, I. N. Vorozhtsova, S. Yu. Martynova, A. N. Dzyuman, A. P. Zima, O. S. Popov, I. A. Khlusov, K. T. Kasoyan, I. P. Shabalova

“…The goal of the research was to establish immunologic and morphologic predictors of clinical course and functional outcomes of Graves’s disease (GD).Material and methods. …”
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hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer by Jamie Rand, Dave Yamauchi, Shyambabu Chaurasiya, Jianying Zhang, Supriya Deshpande, Leslie Chong, Amanda Seiz, Hans Meisen, Yuman Fong, Yuan Yuan

“…CF33-hNIS-antiPDL1-infected tumor cells express functional human sodium iodide symporter (hNIS) and are visible by single-photon emission computed tomography (SPECT) or positron emission tomography (PET). …”
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Impact of anastomotic orientation (Upward vs. Downward) in Roux-en-Y reconstruction on duodenal stump leakage incidence after radical total gastrectomy: a retrospective comparative... by Zhenrong Gao, Yan Guo, Chao Yue, Yannian Wang, Yanzhi Li, Zhenchang Mo, Ruiqi Gao, Ying Zhang, Xiaohua Li

“…No statistically significant differences were observed between the two groups with respect to operation time, intraoperative blood loss, number of lymph nodes dissected, TNM stage, length of postoperative hospital stay, or postoperative complications unrelated to DSL. …”
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On Channel Transforms to Enhance Reciprocity and Quantization in Physical-Layer Secret Key Generation by Ghalib Hussain, Syed Junaid Nawaz, Shurjeel Wyne, Mohammad N. Patwary

“…Furthermore, for the considered system and channel parameters the proposed algorithm provides an average improvement of 0.06% in KDR compared to cumulative distribution function (CDF)-based non-uniform quantization (CDF-NUQ).…”
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rhIL-7-hyFc and hIL-2/TCB2c combination promotes an immune-stimulatory tumor microenvironment that improves antitumor efficacy of checkpoint inhibitors by Miyoung Kim, Eun Ju Lee, Donghoon Choi, Sara Ferrando-Martinez, Minji Lee, Sun-Kyoung Im, Seungtae Baek, Mankyu Ji, Seung Taek Ji, Daeun Kim, Jun-Young Lee, Alexandra Wolfarth

“…We investigated the underlying mechanisms of rhIL-7-hyFc and hIL-2/TCB2c antitumor activity and the potential synergistic efficacy, specifically focusing on tumor-specific CD8+ cells within the tumor and the tumor-draining lymph nodes (tdLN).Methods MC38 and CT26 tumor-bearing mice were administered with 10 mg/kg rhIL-7-hyFc intramuscularly and 0.9 mg/kg hIL-2/TCB2c intravenously. …”
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Leveraging RRT^*: Probabilistically Interpreted Mechanisms Enhanced With P-HOPE and FLEX-OPT for Complex Path Planning by Yujie Miao, Haiyang Liu, Ziqiang Zhang, Yanju Liang

“…The experimental results suggest that the proposed RRT<inline-formula> <tex-math notation="LaTeX">$^{\ast }$ </tex-math></inline-formula>-PRIME algorithm can reduce the initial solution search time by 76.32%, reduce the number of search nodes by about 80.67%, and improve the search path quality compared with the RRT<inline-formula> <tex-math notation="LaTeX">$^{\ast }$ </tex-math></inline-formula> algorithm. …”
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Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model by Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL

“…Furthermore, all nsTPPgels effectively achieved T-cell recruitment to lymph nodes and tumor sites in tracking studies.Conclusion: In conclusion, we developed relatively convenient injectable thermosensitive D2gel with a desirable gelation temperature window, which have the potential to be used for antibody drug delivery in several biomedical applications. …”
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CRYPTO-RESISTANT METHODS AND RANDOM NUMBER GENERATORS IN INTERNET OF THINGS (IOT) DEVICES by Petro Klimushyn, Tetiana Solianyk, Oleksandr Mozhaiev, Yurii Gnusov, Oleksandr Manzhai, Vitaliy Svitlychny

“…Research methods: method of structural and functional analysis of RNG and IoT devices, cryptographic methods of information protection, methods of random sequence generation, method of stability analysis of systems, methods of construction of autonomous Boolean networks and Boolean chaos analysis, methods of quality assessment of random sequences. …”
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Germline variants in patients from the Iranian hereditary colorectal cancer registry by Lena Goshayeshi, Saeed Hoorang, Benyamin Hoseini, Mohammad Reza Abbaszadegan, Maryam Afrazeh, Maliheh Alimardani, Fatemeh Maghool, Milad Shademan, Morteza Zahedi, Mehrdad Zeinalian, Foroogh Alborzi, Mohammad Reza Keramati, Ashkan Torshizian, Hassan Vosoghinia, Farnood Rajabzadeh, Alireza Bary, Massih Bahar, Ali Javadmanesh, Jamshid Sorouri-Khorashad, Mohammad Hassan Emami, Nasser Ebrahimi Daryani, Hans F.A. Vasen, Ladan Goshayeshi, Hesam Dehghani

“…Topology analysis of the protein-protein interaction networks in high-risk LS cases highlighted stronger connections among nodes for genes such as TP53, ATM, POLD1, CDH1, MUTYH, WRN, NOTCH1, SMAD4, ERCC4, ERCC1, and MSH3. …”
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Research advances in the molecular regulatory mechanisms of fruit coloration in fruit trees by MA Shurui, CHI Fumei, SONG Yang

“…Besides their coloring function, they also have photoprotective, antioxidant, and plant hormone precursor (ABA) synthesis functions. …”
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Community structure and diversity of soil nematodes in different slope directions of wild cherry plum forests in Xinjiang, China by CAO Jing, CUI Dong, JIANG Zhicheng, YAN Jiangchao, WU Yunhao, LIU Junqi, GUO Jinfeng, HAN Yaxin, HAN Shutong

“…Among them, the number of nodes, edges, edge density, and connectivity of the nematode network in the semi shaded slope soil were the highest, indicating that in this habitat, the nematode collinear network was more complex and had a more stable food web structure inside. …”
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APG mergence and topological potential optimization based heuristic user association strategy by Zhirui HU, Meihua BI, Fangmin XU, Meilin HE, Changliang ZHENG

“…In terms of AP exiting APG, the relationship between network coupling degree and user rate was established by topological potential function,which was used as the performance index of AP exiting APG. …”
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Seditious Spaces by Nurul Azreen Azlan

“…Given that public space is shaped by the colonial legacy, how does it facilitate or hinder street protests as a function of democracy, which is also a vestige of colonialism? …”
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