Units of fibrinolytic system in mice with urokinase gene knockout in presence of growing B16/F10 melanoma by E. M. Frantsiyants, V. A. Bandovkina, E. I. Surikova, I. V. Kaplieva, Yu. A. Pogorelova, I. V. Neskubina, L. K. Trepitaki, N. D. Cheryarina, N. D. Ushakova, O. G. Ishonina, M. A. Gusareva, I. A. Udalenkova

“…Was to reveal the effect of urokinase gene knockout in male and female mice with transplanted  B16/F10 melanoma on the functions of the fibrinolytic system units.Materials and methods. …”
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Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1 by Zhiyue Qiu, Shirui Wen, Hong Yuan, Ziyi Liu, Yao Wei, Siqi Yanling, Runlong Dai, Xiang Li, Yuxin Gu

“…Under the agglomeration effect of traffic nodes, rapid population agglomeration and land development and utilization have formed around metro stations in cities. …”
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Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth. by Aishwarya P Yadama, Hooman Mirzakhani, Thomas F McElrath, Augusto A Litonjua, Scott T Weiss

“…Of these genes, 43 (25 upregulated) were replicated in the independent cohort of sPTB cases and controls with normal pregnancies (P < 0.05). Functional enrichment and network analyses of the replicated gene signatures suggested several highly connected nodes related to inflammatory and immune responses.…”
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Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity by Ruichen Huang, Qiao Zhou, Jiajun Liu, Yang Xia, Yang Jiao, Bi Zhao, Tangtao Feng, Haosu Zhou, Xiuyan Song, Hao Qin, Jun Wang, Lan Cheng, Yunye Ning, Qinying Sun, Yanfang Liu, Xiaoping Su, Yuchao Dong, Wei Zhang

“…However, numerous neoantigens show poor immunogenicity, and the immune inhibitory factors of present in both tumors and tumor-draining lymph nodes impair the efficacy of cancer neoantigen vaccine. …”
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceResearch in context by Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia F. Thomaidou, Stephane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Ines Alvelos, Eugenia Martin Vazquez, Lorella Marselli, Kara Orr, Jamie L. Felton, Jing Liu, John S. Kaddis, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio L. Eizirik, Carmella Evans-Molina

“…Transcriptional phenotyping of pancreatic islets, pancreatic lymph nodes, and spleen highlighted a role for TYK2 inhibition in modulating signalling pathways associated with inflammation, translational control, stress signalling, secretory function, immunity, and diabetes. …”
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Lipidomic Landscapes of Cryopreserved Sperm from Alpine and Spanish–Creole Bucks by Mustafa Bodu, Mustafa Hitit, Selamawit Woldesenbet, Muhammet Raşit Uğur, Zeynep Erdoğan, Olivia Chika Greenwood, Raheem Davian Murray, Andres Pech Cervantes, Erdoğan Memili

“…Network and pathway analyses revealed that 16:0, 18:1 (cis-9), and 18:2 contributed to the most central nodes of the lipidomic network, which may support membrane stability and cryotolerance. …”
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Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness by Martina Cacciatore, Francesca Giulia Magnani, Filippo Barbadoro, Camilla Ippoliti, Mario Stanziano, Mario Stanziano, Letizia Clementi, Anna Nigri, Lorenzo Nanetti, Silvia Marino, Fabio La Porta, Lucia Francesca Lucca, Francesco Prada, Francesco Prada, Matilde Leonardi

“…Despite the high heterogeneity characterizing the adopted methodologies (e.g., brain stimulation, anesthesia, brain damage), as well as the study population (e.g., either healthy and pathological humans or animals) across studies, the greatest amount of evidence supported a key role of CM-Pf for the generation, modulation, and maintenance of the level of consciousness.DiscussionThough there is more research on the role of intralaminar nuclei, there is proportionally more positive evidence supporting these nuclei (particularly the CM-Pf) as key nodes in the network underlying consciousness compared to other thalamic nuclei. …”
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Advancing diagnosis of feline Leishmania infantum infection through experimental insights by Akhtardanesh Baharak, Mostafavi Ali, Mostafavi Mahshid, Zamani-Ahmadmahmudi Mohamad, Sharifi Iraj, Abbaszadeh Hasiri Mohammad, Kheirandish Reza, Hajipour Pooneh, Barkhordarnasab Azimeh, Shokrollahi Nasim, Keyhani Alireza, Sina kakooei

“…N-PCR of Liver and lymph nodes, were positive in three cats in each experimental groups. …”
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Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan by Zhenjie Ma, Chenhao Li, Wenhao Bai, Wei Xie, Mingjie Zhang, Han Xiao, Cancan Chen, Yang Li, Wenwen Zhang, Deqi Zhai, Yingyuan Liu, Dengfa Zhao, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu

“…Network analysis identified the prelimbic cortex (PrL) and spinal trigeminal nucleus caudalis (SPVC) as hub nodes. The PrL exhibited extensive functional connectivity with addiction-related regions (the insular cortex, IC and nucleus accumbens), whereas the SPVC showed predominant connections with pain-processing areas. …”
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U-Net-based VGG19 model for improved facial expression recognition by Xiaohu ZHAO, Jingyi ZHANG, Mingzhi JIAO, Lixun XIE, Lanfei WANG, Weiqing SUN, Di ZHANG

“…The innovation of the SEAttention module lies in replacing the original activation function with the Mish activation function, which can dynamically adjust the weights of different channels to enhance performance. …”
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Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system by Martta Peltoniemi, Surachet Imlimthan, Sonja C. Jalonen, Niklas Daniel Åke Persson, Terhi J. Lohela, Tuomas O. Lilius, Mirkka Sarparanta

“…However, the cervical lymph nodes were only visualized after the infusion of Al[18F]F-RESCA-RSA, characteristic for macromolecular tracers, indicating that the gallium-68-labeled tracers did not bind fully to endogenous CSF albumin in vivo, but were distributing to different brain areas according to their physicochemical properties. …”
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Factors influencing the accuracy and precision in dating single gene trees by Louvel, Guillaume, Roest Crollius, Hugues

“…By contrast, when dating gene-specific events, fossil calibrations only inform about speciation nodes, and concatenation does not apply to divergences other than speciations. …”
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Exogenous acetylsalicylic acid mitigates cold stress in common bean seedlings by enhancing antioxidant defense and photosynthetic efficiency by Barkat Ali, Sujon Kumar, Xiyu Sui, Jianpo Niu, Junqi Yang, Mengni Zheng, Yi Tang, Huanxiu Li

“…Network analysis further confirmed that ASA2 strengthened the connections between photosynthesis and antioxidant activity, with more resilient and interconnected nodes indicating improved stress adaptability. At 2 mM, ASA upregulated antioxidant genes (APX1, POD1, SODC) and photosynthesis genes (RbcS1, PsbS, POR), reducing cold-induced oxidative stress and preserving chloroplast function, thereby enhancing cold tolerance and crop resilience under climate stress.…”
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Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction by Xuemei Shi, Zhonghan Yan, Ruilin Ding, Fenfen Xia, Yan Du, Xiaojie Wang, Qing Peng

“…GSEA indicated upregulation of oxidative phosphorylation and downregulation of chemokine signaling. ssGSEA revealed negative correlations with several immune cell types. A ceRNA network (51 nodes, 56 edges) was constructed. Machine learning identified PDHB, NDUFA9, and TIMMDC1 as diagnostic genes, with PDHB showing high accuracy (AUC = 0.995 in GSE79962; AUC = 0.960, 0.864, and 0.984 in external datasets). …”
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Short-term outcomes of bronchoplastic lobectomies performed from video-assisted thoracoscopic and thoracotomic approaches by M. A. Atyukov, I. Yu. Zemtsova, A. S. Petrov, O. A. Zhgemchugova-Zelenova, O. V. Novikova, S. A. Mischeryakov, P. K. Yablonskii

“…The groups were similar in gender, age, smoking history, Body Mass Index, concomitant pathology, functional status and stage of the disease. Surgical intervention included ipsilateral systematic lymph dissection and bronchoplastic lobectomy.RESULTS. …”
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TCMHTI: a Transformer-based herb-target interaction prediction model for Qingfu Juanbi Decoction in rheumatoid arthritis by Zhenzhong Liang, Changsong Ding

“…Subsequently, a protein-protein interaction (PPI) network was built based on the predicted targets, with core targets identified as the top nine nodes ranked by degree values. Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the targets predicted by TCMHTI and the targets identified through network pharmacology method for comparison. …”
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Disentangled similarity graph attention heterogeneous biological memory network for predicting disease-associated miRNAs by Yinbo Liu, Qi Wu, Le Zhou, Yuchen Liu, Chao Li, Zhuoyu Wei, Wei Peng, Yi Yue, Xiaolei Zhu

“…However, these methods still face limitations, such as not considering nodes’ deep-level similarity associations and hierarchical learning patterns. …”
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Impact of Chitosan Nanoparticles-Coated Dendritic Cell-Based Vaccine as Cancer Immunotherapy by Jehan S. Alrahimi, Najla S. Alotaibi, Alia M. Aldahlawi, Fatemah S. Basingab, Kawther A. Zaher

“…Histological samples from the spleen and lymph nodes were also collected. <b>Results:</b> Our findings show that co-stimulatory molecules CD80/CD86 and the DC maturation marker CD83 were upregulated in the vaccinated DCs, indicating their maturation. …”
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Calcium-iron crosstalk in epileptogenesis: Unraveling mechanisms and therapeutic opportunities by Xuan Li, Ao-Long Tao, Nayiyuan Wu, Xiu Zhang, Fen Xiao, Jing Wang, Zhi-Bin Wang

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A modified liver retraction method decreases liver dysfunction after laparoscopic gastrectomy by Hao-Jie Li, Lang Zhou, Wei-Han Zhang, Kai Liu, Kun Yang, Jian-Kun Hu, Xiao-Long Chen

“…This study aims to explore the effect of a modified liver retraction method (MLR) we designed on the postoperative liver function of patients receiving laparoscopic radical gastrectomy. …”
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